By Lisa Beilfuss And Julie Steinberg 

Fifth Third Bancorp said its first-quarter profit rose 20% as a positive valuation adjustment and a gain on the sale of residential mortgage loans helped offset a decline in mortgage banking.

Results beat Wall Street estimates.

The Cincinnati-based regional lender said its profit rose to $382 million, from $318 million a year earlier. On a per-share basis, earnings rose to 44 cents from 36 cents.

Revenue edged up to $1.51 billion from $1.45 billion a year earlier.

Analysts polled by Thomson Reuters had expected the bank to report a profit of 37 cents a share on revenue of $1.45 billion. Shares were up about 1% in early morning trading.

The latest period's results included a $70 million pretax position valuation adjustment on the warrant Fifth Third holds in Vantiv Inc., and a $37 million pretax gain on the sale of residential mortgage loans.

Mortgage banking revenue, however, slid 21% from a year ago to $86 million.

Like other lenders, Fifth Third has faced pressure on its mortgage business as prolonged low interest rates have limited interest income and prompted cost-cutting. Sequentially, mortgage revenue rose 41%.

Net interest margin, a key measure of lending profitability, dropped to 2.86% from 3.22% a year earlier. The bank said that net interest income was affected by previously announced changes to its deposit advance product as well as fewer days in the quarter.

The bank reported record investment advisory revenue of $108 million, up 6% from a year earlier, as a result of an increase in personal asset management fees and increased securities and brokerage fees.

In the latest quarter, noninterest expense fell 3% to $923 million.

Executives warned in January that noninterest income, generated from businesses like investment advisory and mortgage banking, would be lower due in part to seasonal factors, and said net interest income would decline over the period.

On a call with analysts on Tuesday, bank executives said they expect net interest income to grow year over year, and expect it to be higher in the second quarter than in the first. Net interest margin is expected to drop slightly in the second quarter, but remain relatively stable for the rest of the year.

Executives also said they are expecting higher noninterest income in the second quarter than in the first quarter, driven by card and processing revenue among other factors.

Write to Julie Steinberg at julie.steinberg@wsj.com

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