Amgen Inc. said its fourth-quarter earnings rose 30% as the biopharmaceutical company reported sales growth for most of its products.

For 2014, the company forecast per-share earnings of $7.90 to $8.20 and revenue of $19.2 billion to $19.6 billion. Analysts polled by Thomson Reuters expected per-share profit of $8.18 and revenue of $19.58 billion.

Amgen reported a profit of $1.02 billion, or $1.33 a share, up from $788 million, or $1.01 a share, a year earlier. Excluding acquisition-related charges and other items, adjusted earnings rose to $1.82 from $1.40. Revenue increased 13% to $5.01 billion.

Analysts polled by Thomson Reuters expected per-share profit of $1.68 and revenue of $4.82 billion.

Like more traditional drug makers, biotechnology companies such as Amgen have been aiming to find new sources of revenue to help offset declines among some of their older drugs. Many of the company's core products face the potential of new competition as they lose patent protection in coming years.

With its October acquisition of Onyx Pharmaceuticals Inc., Amgen gained Onyx's flagship product, Kyprolis. The drug was approved in the U.S. in 2012 as a treatment for a blood-cancer known as multiple myeloma. Amgen is betting that current studies of Kyprolis will lead to approvals for additional uses. In the latest quarter, Kyprolis sales were $73 million.

Some of the company's largest franchises, including the drug Neulasta, reported sales growth. In the latest quarter, global Neulasta sales rose 10% from a year earlier. Sales of arthritis drug Enbrel rose 3%

The company's osteoporosis drugs, Xgeva and Prolia, reported sales growth of 33% and 53%, respectively.

Write to Tess Stynes at tess.stynes@wsj.com

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