Anavex Life Sciences Corporation (AVXL) News

The problem with your theory is that George never stops posting excessively optimistic posts.

AND, If you believe one poster on a message board can manipulate the share price, imagine what the shorts with 20,000,000 shares and over $100,000,000 in capital can do.

To say you are intellectually dishonest is being generous.

You have to understand how this game works. George does what he can to pump up the stock by posting a lot of nonsense knowing that there are greedy, gullible retail investors who will fall for it, then he sells into a rising market. Then he waits for the stock to pull back a bit, then he buys again. Then he does it all over again. The stock doesn’t have to move much one way or the other if he’s buying and selling in sufficient quantity. He leaves bag holders in his wake and cynically invokes God’s blessings in the process. It’s disgusting but I guess it’s a living.

I don't have to understand the complete metallurgy of a nail to use one to build a house. Nor is a complete understanding of how the brain works required to treat the CNS with the knowledge that we do have. The current level of understanding allows for a number of treatments to be helpful. That number will continue to increase as the technology and understanding of the CNS increases. Sure there is a great deal that is not well understood about the CNS and the body overall, that doesn't stop me from going to a Doctor when I'm sick. That is usually a better choice than throwing your hands up and saying the body is not completely understood so I'm not going to see what medicine can do for my problem.

You are creating a straw man that is silly argument at best.

I think you're a little crazy where do you get these dates did our popular CEO call you up and tell you this information to spread all over the Internet which never comes true

Some CEO of a major software company (was it steve Jobs and apple?_) once said that one brilliant software engineer is worth 100 average software engineers. Anavex can hire another 20 scientific advisors. It doesn't matter if they don't have one who has an insight into a product that is real, if developed. Why is this? Because the human body and the CNS in particular is almost perfect, the disease processes themselves the result of millions of years of chemistry that today's earthlings have only a dim or no understanding of. And CNS is the most mysterious thing in creation. It is not muscles or bones or ordinary organs, in fact the CNS should not be considered part of the human body at all, which is merely its vessel
Its chemicals and interactions we have no idea about, or how they truly work, not even a primitive idea, and won't have any understanding probably in the next 10,000 years, if we survive as a life form; the odds of this are unknown but i would say 1000 to 1 against. This also means the anavex speculators are at least 10,000 years too early.

and so all of this is just random throwing of ink on a canvas and hoping that if you throw enough paint on the canvas, you may get, in 10 million years, a Leonardo. Especially in this area of "medicine". ...it is not medicine it should be called, "HOPING FOR A MIRACLE." ..and this is what the Alzheimer's experimentation biotech space is all about. Which explains why none of the drugs in the space, the approved drugs, don't work. Talk about being over matched. We know scarcely more about the CNS space than 17th century physicians who used to bleed people to cure their illnesses.
The small companies in this space want to win the lottery, and for this and other reasons, they will not. The large Big Pharma companies in this space hope for minimal, and transitory "findings" in their fake trials, that they can then HYPE mad use politics and influence on, to leverage the FDA, a drug approval on......but the drugs don't work, that is the bottom line, and they certainly don't work meaningfully and for long. It is all placebo effect which can last up to 2 years.

When you are talking about rehabbing even slightly the CNS, you are talking almost origin of LIFE stuff. A Yale chair professor of physics once said the odds of intelligent life happening at all (i.e. the central nervous system) are far greater than a tornado travelling over a massive junk yard and when it leaves, you will see assembled a magnificent modern airline jet. He then concludes this is not random chance, the math is too staggering. We have no idea about how the CNS works and never will. The processes are in the trillions.

Maybe she heard about the great work culture (all play, vacation, and no work) at Anavex, and she wants to get into the clown's good books. Who wouldn't want a great salary of $300k+ and a fully paid year-round vacation?

Good call. You’re only off by about 9 1/2 years. Chalk it up to a rounding error.

Lay that pipe down; 3-71 is a decade away from any meaningful data. The clown will string along shareholders with the usual buzzwords and timelines.

THE ABSOLUTE BEST TREATMENT FOR SCHIZOPHRENIA

ANAVEX 3-71
Very well tolerated
Very very safe
Very efficacious

There are approximately 24 million people worldwide who have schizophrenia.

The expected competition’s pricing

“…health-benefit price benchmark (HBPB) for KarXT to be between $16,000 to $20,000 per year.…”

“…The most common adverse events with KarXT versus placebo were constipation (27 [21%] vs 13 [10%]), dyspepsia (24 [19%] vs 10 [8%]), headache (17 [14%] vs 15 [12%]), nausea (24 [19%] vs seven [6%]), vomiting (18 [14%] vs one [1%]), hypertension (12 [10%] vs one [1%]), dizziness (11 [9%] vs four [3%]), gastro-oesophageal reflux disease (eight [6%] vs zero [0%]), and diarrhoea (seven [6%] vs four [3%]).…”

Good luck and GOD bless,

Within the next 3 weeks expect Part A of the phase 2 Anavex 3-71 schizophrenia will be completed and that the entire phase 2 Anavex 3-71 schizophrenia trial will be completed before the end of summer 2024.

There are approximately 24 million people worldwide who have schizophrenia.

https://www.anavex.com/_files/ugd/850d88_80ed72201c1f4173a87f87a09470aa46.pdf

Good luck and GOD bless,
🇺🇲

What do you think happens next?

No slight at XenaLives whatsoever, but it really doesn't matter what anyone here "thinks" at this juncture. You've been on this board long enough to have read 100% of the possible future scenarios dozens of times. What anyone thinks will not give you the comfort in AVXL that you seek. AVXL has long now been a broken stock due to reasons most of us understand. There is a huge short interest that has been hugely successful to date and that short interest can easily defend its turf for the here and now--the recent past and current share price is testament to that. AVXL is facing a binary event with Blarcamesine. Assuming AVXL files an MAA in Europe, that will set up the ultimate binary event wrapped around regulatory approval. Success there will mean success for you the shareholder and AVXL's future prospects will look bright. Failure there will, at a minimum, mean another 50% haircut in the stock price and questions about the long-term viability of AVXL. Failure will mean a languishing stock price for the foreseeable future with ability to raise equity capital very much in question and a relatively short cash runway. Shareholders will be praying for Blarcamesine for schizophrenia as a Hail Mary. Am I optimistic about European regulatory approval for Blarcamesine in AD? Just put me in the hopeful category. So much for what I think!

Due to being slightly bored I was on linked in and saw that the 'clinical development and medical affairs leader' of avxl posted this a few days ago https://www.linkedin.com/posts/sahatapas_alzheimers-drug-adoption-in-us-slowed-by-activity-7201581717000794112-pTBf?utm_source=share&utm_medium=member_desktop which is a kind of soft bash of Lequembi.
I also noted that the post was "loved" by this person who seems to work in sales and medical communications and on her activity she seems to like or love every avxl post - https://www.linkedin.com/in/stacy-witham/
Obv she does 'like' other companies too such as ardelyx and others but seems to be a slight pattern of the ones she 'likes'. She works for 'the Lockwood group' who are 'medical communicators' who work with "their clients medical affairs teams" seemingly on communications, client publications and commerical strategies etc.
I started to wonder if potentially avxl are working with the lockwood group. Obv it may not be I'm basing it purely on her 'loving' of posts. It may also be that they are working together due to RETT, though she did specifically "love" his AD post.

Xena--"Hmmm.."--and these blocks mean what ?????? Buying interest ??selling interest ???? Just don't know !!!!!!

Hmmm... Blocks >=5K Xena
Appreciate your efforts to help (me+) w/the moving parts.

What do you think happens next? More of the same roller coaster game? or Solid links to real progress and evidence of CNS science stability and direction provided by AVXL research?

BTW, it is still not clear to me that WS-BP really want to see legitimate science and real confidence in CNS diseases futures.

Imagine the losses the shorters will have when the price AVXL goes to $40.00 per share or higher!!!

Good luck and GOD bless,

21,860,442 shares short probably has something to do with that.

A share price increase from the current $4.00 to $10 would impact the short position by -$131,162,652.
Do you think that maybe, just maybe, there is some effort to prevent that huge Dollar cost from happening?

No offense, but it’s not fun AT ALL as long as the ticker is under $10

Never ever belong this low, but somehow….it is

Excellent all around. Glad Xena posted the amounts and times. Maybe Monday might be interesting.

BTW, Leo NC too cold. Me SXM, AUA, CUR, MBJ, STU and a few others 26 yrs

John k9uwa

Thanks Xena.

Monday might be interesting.
John k9uwa

Simple answer: contractual obligation.

sarcasm noted

Xena, Thank you very much!!!

I find the following most interesting:


05/31/24 16:18:21 4.06 4.00 4.39 25,585
05/31/24 16:12:27 4.06 4.00 4.60 6,020
05/31/24 16:09:33 4.06 4.00 4.60 17,976
05/31/24 16:08:06 4.06 4.00 4.60 6,102
05/31/24 16:07:44 4.0615 4.00 4.60 218,296
05/31/24 16:04:43 4.0602 4.00 4.60 42,212
05/31/24 16:00:16 4.06 4.00 4.60 113,930
05/31/24 16:00:06 4.0604 4.05 4.09 19,502
05/31/24 16:00:04 4.06 4.05 4.09 10,985
05/31/24 16:00:02 4.07 4.05 4.09 1,781,715
05/31/24 16:00:00 4.06 4.05 4.09 75,971

Good luck and GOD bless,

Hmmm... Blocks >=5K



05/31/24 16:18:21 4.06 4.00 4.39 25,585
05/31/24 16:12:27 4.06 4.00 4.60 6,020
05/31/24 16:09:33 4.06 4.00 4.60 17,976
05/31/24 16:08:06 4.06 4.00 4.60 6,102
05/31/24 16:07:44 4.0615 4.00 4.60 218,296
05/31/24 16:04:43 4.0602 4.00 4.60 42,212
05/31/24 16:00:16 4.06 4.00 4.60 113,930
05/31/24 16:00:06 4.0604 4.05 4.09 19,502
05/31/24 16:00:04 4.06 4.05 4.09 10,985
05/31/24 16:00:02 4.07 4.05 4.09 1,781,715
05/31/24 16:00:00 4.06 4.05 4.09 75,971
05/31/24 15:58:32 4.065 4.06 4.07 5,462
05/31/24 15:57:34 4.045 4.05 4.06 8,190
05/31/24 15:57:00 4.045 4.04 4.05 34,843
05/31/24 15:51:01 4.085 4.08 4.09 6,492
05/31/24 15:50:00 4.10 4.12 4.10 11,204
05/31/24 15:05:10 4.1015 4.10 4.11 5,007
05/31/24 15:03:34 4.11 4.10 4.11 9,867
05/31/24 15:00:23 4.115 4.11 4.12 7,485
05/31/24 14:12:35 4.15 4.15 4.16 16,533
05/31/24 14:12:21 4.16 4.15 4.16 10,341
05/31/24 14:07:02 4.095 4.12 4.13 7,376
05/31/24 13:02:54 4.10 4.09 4.10 5,768
05/31/24 11:13:41 4.11 4.10 4.11 5,983
05/31/24 10:55:23 4.085 4.09 4.10 7,410
05/31/24 10:08:01 4.17 4.16 4.17 7,471
05/31/24 10:01:52 4.1903 4.19 4.20 6,024
05/31/24 09:58:44 4.17 4.16 4.17 5,904
05/31/24 09:55:29 4.16 4.16 4.17 7,107
05/31/24 09:53:18 4.14 4.14 4.16 10,629
05/31/24 09:34:20 4.13 4.12 4.14 6,210
05/30/24 16:04:48 4.139 3.97 4.21 8,656
05/30/24 16:00:04 4.14 4.11 4.15 5,588
05/30/24 16:00:01 4.14 4.11 4.15 6,787
05/30/24 16:00:00 4.14 4.11 4.14 172,132
05/30/24 15:58:28 4.12 4.11 4.12 8,510
05/30/24 15:57:58 4.125 4.11 4.12 5,281
05/30/24 15:55:00 4.11 4.11 4.12 8,343
05/30/24 15:21:15 4.10 4.10 4.11 9,792
05/30/24 15:00:57 4.145 4.14 4.15 8,438
05/30/24 14:28:11 4.115 4.11 4.12 9,869
05/30/24 11:59:49 4.07 4.06 4.07 8,506
05/30/24 11:44:55 4.065 4.06 4.07 8,994
05/30/24 11:15:25 4.04 4.03 4.04 5,056
05/30/24 10:54:19 4.005 4.00 4.01 5,310
05/30/24 10:35:21 3.975 3.97 3.98 6,415
05/30/24 10:14:54 3.995 4.00 4.01 9,138
05/30/24 09:48:10 3.955 3.95 3.96 9,544
05/30/24 09:37:48 4.0001 4.00 4.02 5,003
05/30/24 09:32:29 4.02 4.00 4.04 5,408
05/29/24 16:00:01 3.89 3.89 3.92 139,815
05/29/24 15:59:32 3.895 3.89 3.90 24,967
05/29/24 15:58:36 3.905 3.90 3.91 6,290
05/29/24 15:56:49 3.905 3.91 3.92 6,312
05/29/24 15:53:30 3.93 3.92 3.93 5,151
05/29/24 15:15:55 3.945 3.94 3.95 6,146
05/29/24 15:08:20 3.93 3.92 3.93 5,179
05/29/24 14:56:56 3.91 3.90 3.91 6,302
05/29/24 12:28:06 3.97 3.98 3.99 51,584
05/29/24 11:21:24 3.975 3.97 3.98 15,119
05/29/24 09:31:45 4.00 3.97 4.01 15,300
05/29/24 09:30:07 4.0001 4.00 4.07 9,681
05/29/24 09:30:01 4.02 4.00 4.07 13,112
05/28/24 16:02:15 4.07 3.80 4.15 14,825
05/28/24 16:00:00 4.07 4.03 4.07 147,971
05/28/24 15:59:46 4.055 4.05 4.06 5,078
05/28/24 15:58:29 4.075 4.07 4.08 11,660
05/28/24 15:57:40 4.06 4.06 4.07 7,044
05/28/24 15:55:01 4.075 4.07 4.08 5,675
05/28/24 15:55:00 4.085 4.08 4.09 6,097
05/28/24 15:54:50 4.085 4.08 4.09 8,143
05/28/24 15:54:37 4.075 4.06 4.07 8,644
05/28/24 15:51:41 4.07 4.07 4.08 9,490
05/28/24 15:51:34 4.055 4.05 4.06 8,211
05/28/24 15:22:02 4.025 4.02 4.03 5,475
05/28/24 15:11:26 4.045 4.04 4.05 6,755
05/28/24 14:45:18 3.985 3.98 3.99 5,550
05/28/24 14:30:19 4.00 3.99 4.00 5,813
05/28/24 14:21:21 4.02 4.01 4.02 5,045
05/28/24 13:40:07 4.04 4.03 4.04 5,238
05/28/24 13:28:07 4.06 4.05 4.06 15,402
05/28/24 12:24:46 4.045 4.04 4.05 9,831
05/28/24 11:42:44 4.07 4.08 4.09 5,805
05/28/24 11:31:50 4.055 4.05 4.06 10,014
05/28/24 10:12:45 4.0301 4.02 4.03 5,427
05/28/24 09:49:05 4.0503 4.05 4.06 5,000
05/28/24 09:30:00 4.06 4.02 4.06 8,994
05/24/24 16:02:30 4.00 3.80 4.23 13,636
05/24/24 16:00:05 4.00 3.98 4.02 9,956
05/24/24 16:00:00 4.00 3.98 4.02 116,473
05/24/24 16:00:00 4.00 3.99 4.00 7,101
05/24/24 15:59:46 3.9899 3.99 4.00 6,077
05/24/24 15:58:13 3.99 3.99 4.00 6,601
05/24/24 15:57:07 3.9899 3.99 4.00 12,535
05/24/24 15:54:40 3.97 3.98 3.99 7,959
05/24/24 15:43:06 3.98 3.97 3.98 5,595
05/24/24 15:38:41 3.97 3.97 3.98 6,061
05/24/24 15:37:33 3.97 3.96 3.97 23,362
05/24/24 15:37:04 3.9811 3.98 3.99 16,551
05/24/24 15:36:13 4.00 4.00 4.01 34,855
05/24/24 15:34:53 4.015 4.01 4.02 10,137
05/24/24 15:29:46 4.0201 4.02 4.03 10,641
05/24/24 14:48:48 4.04 4.03 4.04 6,073
05/24/24 14:28:31 4.07 4.06 4.07 5,566
05/24/24 13:58:20 4.0701 4.07 4.08 6,603
05/24/24 13:03:28 4.065 4.06 4.07 5,131
05/24/24 11:47:07 4.10 4.09 4.10 8,857
05/24/24 11:01:45 4.10 4.10 4.11 5,575
05/24/24 10:49:19 4.07 4.06 4.07 6,121
05/24/24 10:43:31 4.0519 4.05 4.06 6,010
05/24/24 10:43:05 4.10 4.09 4.10 6,790
05/24/24 10:15:26 4.1901 4.19 4.20 8,052
05/24/24 09:51:58 4.19 4.18 4.19 8,686
05/24/24 09:39:18 4.19 4.17 4.19 10,020
05/24/24 09:37:27 4.18 4.18 4.19 5,583
05/23/24 16:02:02 4.17 4.10 4.51 9,884
05/23/24 16:00:06 4.17 4.17 4.21 7,781
05/23/24 16:00:00 4.17 4.17 4.19 379,986
05/23/24 15:59:09 4.175 4.17 4.18 6,128
05/23/24 15:59:07 4.18 4.18 4.19 5,796
05/23/24 15:58:47 4.175 4.17 4.18 8,814
05/23/24 15:56:34 4.175 4.17 4.18 5,771
05/23/24 15:52:21 4.168 4.16 4.17 9,255
05/23/24 15:50:21 4.145 4.14 4.15 6,578
05/23/24 15:50:10 4.145 4.14 4.15 13,079
05/23/24 15:38:05 4.1499 4.14 4.15 6,514
05/23/24 15:32:38 4.14 4.14 4.15 8,595
05/23/24 15:28:35 4.13 4.13 4.14 6,804
05/23/24 15:21:57 4.1399 4.13 4.14 8,018
05/23/24 15:14:48 4.14 4.13 4.14 13,529
05/23/24 15:07:19 4.13 4.12 4.13 5,110
05/23/24 15:01:37 4.12 4.12 4.13 10,122
05/23/24 14:52:29 4.115 4.11 4.12 5,311
05/23/24 14:44:20 4.14 4.13 4.14 5,088
05/23/24 13:45:06 4.18 4.18 4.19 12,066
05/23/24 13:40:01 4.195 4.19 4.20 9,503
05/23/24 13:31:20 4.245 4.24 4.25 13,432
05/23/24 13:29:19 4.25 4.24 4.26 8,437
05/23/24 13:25:00 4.2399 4.24 4.25 6,296
05/23/24 12:33:17 4.28 4.28 4.29 6,893
05/23/24 10:41:03 4.38 4.38 4.39 9,620
05/23/24 10:06:42 4.38 4.39 4.39 5,051
05/23/24 09:45:54 4.41 4.40 4.42 7,314
05/23/24 09:42:18 4.43 4.43 4.44 5,273
05/23/24 09:30:28 4.51 4.50 4.55 27,075
05/23/24 09:30:01 4.49 4.41 4.49 23,082
05/22/24 16:01:44 4.50 4.10 4.58 6,367
05/22/24 16:00:08 4.50 4.48 4.51 11,573
05/22/24 16:00:01 4.50 4.49 4.51 174,396
05/22/24 15:59:44 4.50 4.49 4.50 9,257
05/22/24 15:58:10 4.475 4.47 4.48 6,922
05/22/24 15:54:40 4.48 4.47 4.48 6,169
05/22/24 15:52:30 4.45 4.45 4.46 5,548
05/22/24 15:50:37 4.448 4.44 4.45 7,450
05/22/24 14:44:20 4.47 4.46 4.47 9,266
05/22/24 14:42:37 4.46 4.45 4.46 14,765
05/22/24 12:22:31 4.51 4.51 4.52 7,487
05/22/24 12:20:59 4.495 4.49 4.50 18,012
05/22/24 12:19:17 4.495 4.49 4.50 7,000
05/22/24 10:42:19 4.51 4.50 4.51 5,321
05/22/24 10:42:09 4.50 4.49 4.50 10,685
05/22/24 10:07:23 4.38 4.40 4.41 12,227
05/22/24 09:43:04 4.37 4.36 4.37 7,518
05/21/24 16:02:38 4.35 4.30 4.65 13,636
05/21/24 16:00:00 4.35 4.35 4.37 113,875
05/21/24 15:58:50 4.355 4.35 4.36 7,028
05/21/24 15:54:40 4.36 4.35 4.36 6,612
05/21/24 15:19:25 4.31 4.32 4.34 5,261
05/21/24 14:56:45 4.3101 4.31 4.32 6,491
05/21/24 14:55:11 4.335 4.32 4.33 12,480
05/21/24 14:55:09 4.32 4.32 4.33 7,027
05/21/24 14:54:34 4.3323 4.33 4.34 5,049
05/21/24 14:32:04 4.335 4.33 4.34 6,127
05/21/24 13:12:53 4.40 4.40 4.41 8,010

Um.... UC Anschutz is the largest training institute for medical practitioners in Colorado.

Maybe you should limit your posts to your own planet.

The GREAT NEWS is that all of the bashers, FUDsters and shorters will NOT be posting any longer after the SHORT SQUEEZE that is coming SOON!!!

Good luck and GOD bless,

The heat is on and going to get hotter. Set back and grab the popcorn

Is the great news you plan on leaving this board forever...enough poop emojis already

Got it. Thanks for the clarification.

You seem to be here every time I pass through. I thought you were a Monday through Friday person.

That volume is nothing more than funds trading back and forth remember last month we went up to like 8 million and the price still goes down totally meaningless

Please stop throwing darts, you've never even hit the board in years

You’re responding to me on a weekend. What does that make you?

Expect GREAT NEWS within the next 3 weeks!!!

Good luck and GOD bless,

Helpful. Our brain volume data is hopefully accompanied by clinical benefit correlations in the paper.

The EMA's receptiveness to an MAA is encouraging, given the amount of resources - both ours and theirs - it will entail. We apparently 'have a shot', primarily facing trial size and duration concerns. Hopefully, supplemental OLE data (assuming it's positive) can alleviate some of that.

The post-Rett disappointment selling is likely over at this point, five months on. The AD OLE should be done, 371 is in the clinic, and some new 273 trials are "soon" underway (albeit per Missling).

Thanks for that information. The discussions were very interesting and highlights the ambiguous nature of determining the meaning of short term brain volume loss in drug trials. Alas, longer term data is instructive but delays the approval process. Drug approval already takes a long time. Science is a slow process. This also highlights how much we know and how much more we don't know about disease and treatment.

It is unfortunate the the BP will not release the raw trial data to researchers so they can tease apart some of the questions raised in the paper.

Yes ZIG, I know you understand MOC. I only posted the rules and how they process "Market On Close" Orders for those who don't understand. Me? I am curious as to WHO bought the 3.2Million shares. Also interested in where did the shares come from to fill the order?
John k9uwa

Pathetic. It’s truly sad.

That your working the weekends.

Quote: "In a prior report, patients on high-dose blarcamesine showed significant improvements compared to the placebo group at the end of the double-blind period. This included a relative improvement of 18.9% in MDS-UPDRS total score. Additionally, gene expression levels related to neurodegenerative processes were notably restored by blarcamesine treatment."

Below is the prior report referenced above.

ANAVEX®2-73 (Blarcamesine) Shows Clinical Benefit in Long-Term 48Week Phase 2 Extension Study in PDD
March 23, 2023

- Study successfully achieved both primary and secondary objectives

- ANAVEX®2-73 treatment resulted in improvements of all efficacy endpoints over 48 Weeks

- Anavex plans to proceed to ANAVEX®2-73 pivotal trial for Parkinson’s disease

Anavex Life Sciences Corp. (“Anavex” or the “Company”) (Nasdaq: AVXL), a clinical-stage biopharmaceutical company developing differentiated therapeutics for the treatment of neurodegenerative and neurodevelopmental disorders including Alzheimer’s disease, Parkinson’s disease, Rett syndrome, and other Central Nervous System (CNS) disorders, reports preliminary 48-week open-label extension Parkinson’s disease dementia ANAVEX®2-73-PDD-EP-001 Phase 2 study data which demonstrated longitudinal beneficial effects of ANAVEX®2-73 on the prespecified primary and secondary objectives, as well as planned primary and key secondary endpoints which will be utilized in a forthcoming pivotal study of ANAVEX®2-73 in Parkinson’s disease.

ANAVEX®2-73 (blarcamesine) is an oral small-molecule activator of the sigma-1 receptor (SIGMAR1), which data suggests is pivotal to restoring neural cell homeostasis and promoting neuroplasticity.[1]

Parkinson’s disease (PD) is a chronic, debilitating CNS disease and the second largest age-related disorder after Alzheimer’s disease.[2] This study demonstrates for the first-time that patients’ clinical symptoms consistently improve longitudinally during the 48-week ANAVEX2-73-PDD-EP-001 Phase 2 study under active ANAVEX®2-73 treatment in Parkinson’s disease.

The 48-week ANAVEX2-73-PDD-EP-001 (NCT04575259) Phase 2 study assessed safety, tolerability and efficacy, measuring among others, Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS)[3]Parts I, II, III, REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ), Clinical Global Impression – Improvement (CGI-I), as well as cognitive efficacy endpoint Montreal Cognitive Assessment (MoCA) over a 48-week period.

Preliminary analysis reveals that ANAVEX®2-73 (blarcamesine) was found to be generally safe and well tolerated; and safety findings in this study are consistent with the known safety profile of ANAVEX®2-73. In respect to efficacy, across all efficacy endpoints, patients performed better while on ANAVEX®2-73.
The 48-week Open Label Extension (OLE) ANAVEX2-73-PDD-EP-001 Phase 2 study was offered to participants after completion of the double-blind placebo-controlled ANAVEX2-73-PDD-001 Phase 2 study. Study participants were allowed to stay on a stable regimen of anti-Parkinson's disease medications (including levodopa, dopamine agonists, MAO-B inhibitors, or entacapone).

Previously, in the double-blind ANAVEX2-73-PDD-001 Phase 2 study, ANAVEX®2-73 treatment demonstrated statistically significant improvements compared to placebo (ITT population) for MDS-UPDRS Total score. From baseline to the end of the trial at 14 weeks, the MDS-UPDRS Total score improved by -10.98 points in the ANAVEX®2-73 high dose group and worsened by 3.53 points in the placebo group, an adjusted mean difference of -14.51 points (p = 0.034). This corresponds to a relative improvement of 18.9% over 14 weeks.[4] This data was also consistent with expression levels of pathological dysregulated neurodegenerative genes, including Parkinson’s disease genes, which were significantly restored by the therapeutic effect of ANAVEX®2-73 (p

Pathetic. It’s truly sad.

Great sarcastic post.

Good luck and GOD bless,

lol. Such rubbish. Yeah, that’d be a great idea. Shortly after the EMA reviews the data and urges us to submit for full approval we should shut the company down. You are a true business genius.

well stated! A lot of these hires are former government workers. Should tell you something. Picking them up on the downside is loserville. Sheat in, Sheat out. Ding-a Lings. If they had any real talent they would never have worked for the government in the first place. Your post sums it all up so well.
All of them scurrying over a non product. They should shut the company down and distribute the net cash to the shareholders, or announce they are shutting down their foray into the CNS space across the board, and that they will scour the world in another area of medicine or perhaps medical products, and lay off 90 percent of the employees in this event.

Maybe it was Misleading who bought it. He knows what kind of miracle drug he has.

But YOU don’t question why anyone would purchase over 2.3 million shares of AVXL yesterday, Friday May 31, 2024???

GOD bless,

I wonder why someone or a group of people would want to sell 2.3 million share at 1 time. Seems like the more interesting question to ask.

We can always count on you, Investor and other soldiers (👺sters) to come to the defense of collusive manipulation through denial and mockery. So obvious to everyone here. Fooling no one.

WOW! WOWZERS! AWESOME! CAN'T BELIEVE IT!

4.09 and 4.14...those are crazy high numbers...so close to $5, $10, $15, $20, $25, and $30.

I feel like Monday we see $1249!

Yes, i understand the concept...still doesn't change my remark. The high was 4.22 near the open.

There is an excellent high level and referenced discussion of atrophy vs pseudoatrophy in regards to anti-amyloid MAb's at this link among experts in the field. Some science and imaging knowledge is necessary to fully understand some of the posts. An open mind also helps. It reads well as no trolls on either side. The comments by Doody et al and Boche/Nicoll near the end are very interesting. My opinion is one year without re-baselining after 6-12 months is not meaningful. I would like to see donanemab and lecanemab 6 to 18 month or 12 to 18 month data.

I discussed some of the issues also mentioned in the above chain back in April 2023 :
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=171598095
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=172879630 (point #2)

Although a different disease, in MS, pseudoatrophy during the first 6-12 months is so well established that studies only consider MRI volume loss between 1 and 2 year to be a meaningful and truer measure of neuronal loss while 0 to 6 months is meaningless (due to pseudoatrophy) and 0 to 12 months is mixed (pseudoatrophy first 6 months, transitioning to atrophy next 6) --- very efficacious treatments show significantly more volume loss compared to placebo or weaker therapies between month 0 and 6 but significantly less atrophy between year 1 and year 2 in practically every study.

Did anyone really need your Cliff Notes of K9's explanation?

Give us a break George.......

BTW, K9,,,SRQ, EYW, and Satellite Beach during our 12 years there.
Holden Beach and NC for the first time this Season.