SAN FRANCISCO, May 20, 2018 /PRNewswire/ -- While nocturia and
poor sleep quality have been linked to such daytime problems as
difficulty concentrating, a general lack of energy and irritability
or impulsive behaviors, three new studies presented at the
113th Annual Scientific Meeting of the American
Urological Association (AUA) are proving poor sleep quality can
lead to serious health risks. During a joint press conference at
the Moscone Convention Center in San
Francisco, CA, May 20 at
9:00 a.m. (PT), researchers will
share data highlighting their association between poor sleep
quality, nocturia, low testosterone, erectile function, elevated
body mass index (BMI) and even death. This press session will be
moderated by Tobias S. Köhler, MD, MPH, FACS, men's health
specialist and urologist with the Mayo Clinic in Rochester, MN.
Study Details
Publication #: MP04-15
Nocturia is Associated with an Increased Risk of Death:
Results from REDUCE: Nocturia is a common complaint among aging
men and is when a patient wakes up two or more times each night to
urinate. While nocturia is known to be associated with an increased
risk of falls, it is less clear if nocturia correlates with
long-term overall health or a higher risk of death. Researchers
from around the country conducted a study using data from the
REDUCE, a four year study to reduce the incidence of prostate
cancer in men who are at increased risk. Cox proportional hazards
models were used to test the association between nocturia (modeled
per 1-unit increase in episodes on a continuous scale 0-5) and risk
of death in nearly 7,700 men. Multivariable models were adjusted
for age, treatment arm, body mass index, coronary artery disease,
diabetes, geographic region, and race. Secondary analysis adjusted
for IPSS score and a validated sleep survey.
Results showed:
- More nocturia episodes were associated with increased hazard of
death on univariable (HR 1.23, p=0.003) and multivariable analyses
(HR 1.16, p=0.048).
- After adjusting for composite IPSS score without nocturia among
men with complete IPSS surveys or sleep survey questions, the
relationship between nocturia and death was slightly lower, but
overall, little changed and nocturia remained associated with an
increased risk of death.
If confirmed through additional studies, understanding the link
between nocturia and death will be crucial and specifically testing
whether treatments aimed at reducing nocturia and improving overall
survival will be warranted.
Study Details
Publication Number: PD09-10
Impaired Sleep is Associated with Low Testosterone in U.S.
Adult Males: Results from the National Health and Nutrition
Survey: Testosterone deficiency has been linked to several
adverse health outcomes including cardiovascular disease, erectile
dysfunction and metabolic syndrome; however, recent data has
suggested abnormal sleep quality may also result in lower
testosterone levels. Using data from the 2011-2012 National Health
and Nutrition Surveys (NHANES), researchers set out to assess the
effect of sleep patterns on testosterone levels in males 16 years
and older.
Using a 2011-2012 NHANES dataset, researchers extracted serum
total testosterone level, sleep duration, physical activity,
demographic and comorbidities for nearly 2,700 men aged 16 years
and older. Univariate and multivariate linear regression was used
to estimate the association between the number of hours slept,
prior comorbidities, physical activity level and demographics with
serum testosterone.
Results showed:
- Among men aged 16-80 in the U.S., low testosterone was
associated with impaired sleep and an elevated BMI.
- Researchers concluded that future evaluations of reduced
testosterone levels should focus on diet and exercise, as well as
sleep quality and habits.
Study Details
Publication #: PD27-08
Poor Sleep Quality is Associated with Clinically Significant
Erectile Dysfunction: Questionnaires were utilized to assess
the relationship between sleep quality and erectile function in 377
men, with a mean age of 46. Patients were asked about
comorbidities, smoking and shift work status, BMI, as well as daily
caffeine and medication use. Researchers assessed the relationship
between sleep and erectile function while controlling for age, BMI,
burden of comorbidity, testosterone and PDE5 inhibitor use.
Caffeine, melatonin, and other sleep medication use, CPAP use,
shift work, smoking, depression status and antidepressant use were
also assessed.
Results showed:
- As measured using the PSQI (Pittsburgh Sleep Quality Index),
men had worse erectile function as sleep quality decreased.
- Sleep apnea was not associated with worse erectile function
while melatonin use was associated with significantly worse
erectile function.
- Age, depression and increased comorbidities were associated
with worse erectile function.
"These studies point to some very alarming consequences for men
with impaired sleep habits," said Dr. Köhler. "Men should be aware
that a commitment to improving one's sleep habits could lead to
improved erectile function along with a host of many other
established health benefits that accompany a good night's
sleep."
About the American Urological Association: The 113th
Annual Meeting of the American Urological Association takes place
May 18-21 at the Moscone Center in
San Francisco, CA.
Founded in 1902 and headquartered near Baltimore, Maryland, the American Urological
Association is a leading advocate for the specialty of urology, and
has more than 21,000 members throughout the world. The AUA is a
premier urologic association, providing invaluable support to the
urologic community as it pursues its mission of fostering the
highest standards of urologic care through education, research and
the formulation of health policy.
Contact:
Christine Frey, AUA
410-689-3731, cfrey@AUAnet.org
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SOURCE American Urological Association