PTI Protherics

        
     FORM 8.3 
     DEALINGS BY PERSONS WITH INTERESTS IN SECURITIES REPRESENTING 1% OR MORE 
     (Rule 8.3 of the City Code on Takeovers and Mergers) 
     1.  KEY INFORMATION 
 Name of person dealing(Note 1)                                       TRAFALGAR ASSET MANAGERS LTD
 Company dealt in                                                     PROTHERICS PLC
 Class of relevant security to which the dealings being disclosed     Ordinary CFD
 relate(Note 2)
 Date of dealing                                                      02 December 2008
     2.  INTERESTS, SHORT POSITIONS AND RIGHTS TO SUBSCRIBE 
     (a)  Interests and short positions (following dealing) in the class of relevant security dealt in (Note 3)
                                                       Long              Short
                                                 Number (%)            Number (%)
 (1) Relevant securities                         `                               
 (2) Derivatives (other than options)            6,193,887 (1.77%)               
 (3) Options and agreements to purchase/sell                                     
 Total                                           6,193,887 (1.77%)               
     (b)  Interests and short positions in relevant securities of the company, other than the class dealt in (Note 3)
         Class of relevant security:                Long          Short
                                                 Number (%)     Number (%)
 (1) Relevant securities                                                  
 (2) Derivatives (other than options)                                     
 (3) Options and agreements to purchase/sell                              
 Total                                                                    
     (c)  Rights to subscribe (Note 3)
 Class of relevant security:     Details
     3.  DEALINGS (Note 4)
     (a)  Purchases and sales 
 Purchase/sale     Number of securities     Price per unit(Note 5)
     (b)  Derivatives transactions (other than options) 
 Product           Long/short(Note 6)     Number of securities(Note       Price per unit(Note 5)
 name,e.g. CFD                            7)
 CFD               Long                   29477                           45.7557
 CFD               Long                   33015                           45.7557
     (c)  Options transactions in respect of existing securities 
     (i)  Writing, selling, purchasing or varying 
 Product              Writing, selling,        Number of securities     Exercise     Type, e.g. American,     Expiry    
Option
 name,e.g. call       purchasing, varying      to which the option      price        European etc.            Date      
moneypaid/received
 option               etc.                     relates(Note 7)                                                          
per unit(Note 5)
     (ii)  Exercising 
 Product name, e.g. call option     Number of securities     Exercise price per unit(Note 5)
     (d)  Other dealings (including new securities) (Note 4)
 Nature of transaction(Note 8)     Details     Price per unit (if applicable)()(Note 5)
     4.  OTHER INFORMATION 
     Agreements, arrangements or understandings relating to options or derivatives 
 Full details of any agreement, arrangement or understanding            between the person
 disclosing and any other person relating to the            voting rights of any relevant
 securities under any option referred            to on this form or relating to the voting rights
 or future            acquisition or disposal of any relevant securities to which any
 derivative referred to on this form is referenced. If none, this            should be stated.
     Is a Supplemental Form 8 attached? (Note 9) NO 
 Date of disclosure                                                   03 December 2008
 Contact name                                                         Lisa Jago
 Telephone number                                                     020 7534 6016
 If a connected EFM, name of offeree/offeror with which connected                     
 If a connected EFM, state nature of connection(Note 10)                              
     Notes 
     The Notes on Form 8.3 can be viewed on the Takeover Panel's website at  www.thetakeoverpanel.org.uk  
    
    

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