RNS Number:5500J
Alizyme PLC
02 April 2003


Immediate Release                                                                                      2 April 2003

                                  ALIZYME PLC

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES


Cambridge, UK, 2 April, 2003: Alizyme plc (London Stock Exchange: AZM) announces
that it received, yesterday, the following notification, under Companies Act
1985 ss.198-202 (as amended), from Merrill Lynch Investment Managers Limited:



'We are advised that for the purposes of the above provisions Merrill Lynch
Investment Managers Limited has interests in the relevant share capital of your
company which are disclosable pursuant to section 199(2) of the above Act. Save
where specifically identified to the contrary such interests arise by reason of
discretionary investment management arrangements entered into by us or by our
affiliates in the Merrill Lynch Investment Managers Limited. Each such affiliate
is interested in the relevant share capital to the extent set out in the
attachment and, where applicable, this letter constitutes disclosure on behalf
of such affiliates. Relevant details of such interests are set out in the
attachment to this letter.



'Total Interest held by Merrill Lynch Investment Managers Limited in Alizyme plc
2p Ordinary Shares is 13,929,105 (10.17%) on 28 March 2003, made up as follows:


'Registered Holder                                                                                Number of Shares

Nutraco Nominees Limited                                                                                 4,676,064

Rowan Nominees Limited                                                                                   8,000,424

Merrill Lynch Pensions Nominees Limited                                                                    313,256
A/C NONCERT

Mercury Grosvenor Trust plc                                                                                939,361

Total                                                                                                  13,929,105'





For further information, please contact:
Mr Tim McCarthy, Finance Director
ALIZYME plc                                                                               Tel No: + 44 (0)1223 896000

Lisa Baderoon
BUCHANAN COMMUNICATIONS                                                                 Tel No: + 44 (0) 20 7466 5000



Further information on Alizyme can be found on the Company's website:
www.alizyme.com


                      This information is provided by RNS
            The company news service from the London Stock Exchange
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