By Joshua Kirby

 

Shares in Swiss drug maker Roche Holding AG slid in early trade Monday after Phase 3 studies of a candidate Alzheimer's treatment failed to meet their primary endpoints.

At 0830 GMT, shares traded 4.4% lower at 311.15 Swiss francs.

In two Phase 3 studies, Roche's gantenerumab--a proposed treatment for sufferers of early Alzheimer's disease--didn't meet their primary endpoint of slowing clinical decline, Roche said. Compared against placebos, the drug showed no statistically significant effect in the two studies, the company said.

Despite the results weighing on investor sentiment, gantenerumab's failure was likely widely assumed, and longer-term buyers of the stock should mitigate losses, analysts at Jefferies said in a note following the news.

Roche said it will keep working on novel diagnostics and treatments for Alzheimer's.

 

Write to Joshua Kirby at joshua.kirby@wsj.com; @joshualeokirby

 

(END) Dow Jones Newswires

November 14, 2022 03:54 ET (08:54 GMT)

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