DarthYoda
1 month ago
Same goes for ASD..."Multiple inflammasome complexes are activated in autistic spectrum disorders":
2016 Mar 12
Abstract
Background: Inflammasomes are multimeric protein platforms involved in the regulation of inflammatory responses whose activity results in the production of proinflammatory cytokines. Because neuroinflammation is observed in autistic spectrum disorders (ASD), a neurologic condition of childhood resulting in a complex behavioural impairment, we analyzed the inflammasomes activity in ASD. Additionally we verified whether alterations of the gastrointestinal (GI) barriers might play a role in inflammasomes activation.
Methods: The activity of the inflammasomes, the concentration of the inflammasomes-derived proinflammatory cytokines interleukin (IL)-1ß and IL-18, and serum parameters of GI damage were analyzed in 25 ASD children, 23 healthy siblings (HS) and 30 unrelated age-matched healthy controls (HC).
Results: A significant upregulation of the AIM2 and the NLRP3 inflammasomes and an increased production of IL-1ß and IL-18 that was associated with a consistent reduction of IL-33, an anti inflammation cytokine were observed in ASD alone. Notably, in a possible immune-mediated attempt to dampen inflammation, IL-37, a suppressor of innate inflammatory responses, was significantly augmented in these same children. Finally, intestinal fatty acid binding protein (IFABP), an index of altered GI permeability, was significantly increased in serum of ASD and HS.
Conclusions: These results show that the inflammasomes are activated in ASD and shed light on the molecular mechanisms responsible for ASD-associated neuroinflammation. The observation that GI alterations could be present as well in ASD offers a possible link between such alterations and neuroinflammation. Therapeutic strategies targeting inflammasome activation could be useful in ASD.
https://pubmed.ncbi.nlm.nih.gov/26979869/
DarthYoda
1 month ago
"Inflammasomes"...Looks like we're on to something here...CBD/Hemp extract has shown promise for all of these conditions as well...
"...Inflammasome Activation Is Pathogenic in Multiple Neurological Diseases":
Feb. 14, 2024
This article provides increasing evidence that activation of several types of inflammasomes and extracellular ASC specks contribute to the development and progression of multiple neurological diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), epilepsy, traumatic brain injury (TBI), and stroke.
Many neurological conditions involve an underlying chronic inflammasome-mediated inflammatory process that worsens the trajectory of these conditions.
Beyond NLRP3, evidence suggests that other inflammasomes, including but not restricted to NLRP1, NLRC4, and AIM2, and their downstream effectors contribute to neuropathology in AD, PD, ALS, MS, stroke, epilepsy, and TBI.
https://markets.businessinsider.com/news/stocks/zyversa-therapeutics-highlights-review-article-substantiating-that-inflammasome-activation-is-pathogenic-in-multiple-neurological-diseases-1033066259
DarthYoda
1 month ago
I am aware of the very real effect of full spectrum hemp extract on Autism and I think that should be one of the best and most widespread uses for it. I am still waiting for an autistic spectrum relative's federal legal situation(drug tests) to finish up after many years so they can try it for the first time. I think it could be a life changer for them. My pessimism here comes only from the business side, not the science side at all.
I also am not a fan of corporate America's version of "social equity". "Get woke, go broke" is a well known saying now for a reason. I'd like to see CW drop the B corp designation, donate to an appropriate charity when it makes sense, and stop giving away money, products, and company IP based on sexual preference and skin color. Corporate wokeness is just racism and bigotry and was supposed to be illegal in America. I grew up in a genuinely multicutural way, in one of the most multicultural neighborhoods in America, with friends and girlfriends of all races, so the fake woke shit is just nails on a chalk board to me. Gay people are not victims who deserve free money just because they are gay and it's not ok to give away shareholder IP to farmers just because they are Black farmers and not White or Asian farmers.
I honestly can't believe I've found my self explaining this stuff to adults who run million or billion dollar corporations in 2024, but here we are, that's our country now, a confused cult. I never expected Big Tobacco to be involved here, and am surprised I stuck around after they showed up. However, if they can stick to CW's original mission, I am all for their redemption. This company's social goals were originally supposed to be about disabled children and adults who lacked access to the plant. That is a mission I can respect. Those people really do need the products and support. I wont be lead astray like the kids today though into cheering for a social philosophy that I know is the exact opposite direction of where the country was headed 15-25 years ago, when we were much more on the right track. I want to see the original mission succeed and will criticize deviation from that, especially when it is morally bankrupt and detrimental to shareholders.
DarthYoda
1 month ago
https://defloria.bio/ On April 6, 2023, the Company announced the formation of DeFloria LLC, a Delaware limited liability company (“DeFloria”) with AJNA BioSciences PBC (“AJNA”), and a subsidiary of British American Tobacco PLC (LSE: BATS and NYSE: BTI) (“BAT”). BAT holds a 100% equity interest in the preferred units of DeFloria and the Company and AJNA each hold 50% of the joint venture’s voting common units. The Company’s contribution to the joint venture was a license permitting the use of certain proprietary hemp intellectual properties, including clinical and consumer data.
Effective February 12, 2024, the Company and DeFloria entered into a Master Services Agreement (“Services Agreement”) pursuant to which the Company will be compensated for the provision of certain services to DeFloria. The services include assistance with Standard Operating Procedures (SOPs), product testing, stability testing, lab liaison, sampling of product, sample submission, data review, Out of Specification (OOS) evaluation, BMCS, document creation, documentation transition project, BR review, spec/RF creation, clinical trials advisory, OOS and risk mitigation testing.
https://www.otcmarkets.com/filing/html?id=17276969&guid=8dd-keHwt05eJth
GE_Jim
2 months ago
That’s a good overview. CBD or THC, grass, the story has the same roadblocks. Doesn’t matter if its Congress, HHS, DEA, FDA, it’s all about somebody in government to sign off on it. It’s been a long road already and still many more pitfalls to go, IMO.
I do believe at some point everything will be given a green light for some real open field running, but until then were all just waiting on the government.