Washington, D.C. 20549






Proxy Statement Pursuant to Section 14(a) of
the Securities Exchange Act of 1934 (Amendment No.     )




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Filed by a Party other than the Registrant  ¨
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¨ Preliminary Proxy Statement
¨ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))
¨ Definitive Proxy Statement
x Definitive Additional Materials
¨ Soliciting Material under §240.14a-12
Zynerba Pharmaceuticals, Inc.
(Name of Registrant as Specified In Its Charter)
Not Applicable
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important notice of availability of Proxy materials for the Stockholder meeting of ZYnerBa PharmaCeUtiCaLS, inC. to Be held on:   June 10, 2020 at 8:00 a.m.   80 w. Lancaster avenue, Suite 300, Devon, Pa 19333*     ComPanY nUmBer   aCCoUnt nUmBer   ControL nUmBer   this communication presents only an overview of the more complete proxy materials that are available to you on the internet. we encourage you to access and review all of the important information contained in the proxy materials before voting. if you want to receive a paper or e-mail copy of the proxy materials you must request one. there is no charge to you for requesting a copy. to facilitate timely delivery please make the request as instructed below before 05/31/20. Please visit http://www.astproxyportal.com/ast/20275/, where the following materials are available for view: • Notice of Annual Meeting of Stockholders Proxy Statement Form of Electronic Proxy Card Annual Report on Form 10-K   to reqUeSt materiaL: teLePhone: 888-Proxy-na (888-776-9962) 718-921-8562 (for international callers) e-maiL: info@astfinancial.com weBSite: https://us.astfinancial.com/onlineProxyVoting/ProxyVoting/requestmaterials to Vote: onLine: To access your online proxy card, please visit www.voteproxy.com and follow the on-screen instructions or scan the QR code with your smartphone. You may enter your voting instructions at www.voteproxy.com up until 11:59 PM Eastern Time the day before the cut-off or meeting date. in PerSon: You may vote your shares in person by attending the Annual Meeting. teLePhone: To vote by telephone, please visit www.voteproxy.com to view the materials and to obtain the toll free number to call. maiL: You may request a card by following the instructions above.   *NOTE: Depending on evolving conditions related to coronavirus (COVID-19), Zynerba Pharmaceuticals, Inc. may hold a virtual Annual Meeting of Stockholders. The determination to hold a virtual meeting will be announced in a press release available at www.zynerba.com as soon as practicable before the meeting. In that event, the Annual Meeting of Stockholders will be conducted on the above date and time, via live audio teleconferencing and/or audio webcast. Please retain the Control Number listed above to facilitate your participation if a virtual meeting is held.   1. Election of Directors:   nomineeS:   2. Ratification of appointment of KPMG LLP as Independent Registered Public Accounting Firm for the 2020 Fiscal Year. Armando Anido John P. Butler Dr. Warren D. Cooper William J. Federici Daniel L. Kisner, M.D. Kenneth I. Moch Pamela Stephenson   the BoarD of DireCtorS reCommenDS a Vote "for" the eLeCtion of DireCtorS anD "for" ProPoSaL 2.                           Please note that you cannot use this notice to vote by mail.



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