XERS Xeris Biopharma Holdings Inc

Total revenue increased 48% YoY to over $60 million

Recorlev® revenue grew 141% on YoY basis

Tightens full-year total revenue 2025 guidance to $260 million to $275 million

Announces upcoming Investor and Analyst Day on June 3rd in New York City

Hosts conference call and webcast today at 8:30 a.m. ET

Xeris Biopharma Holdings, Inc. (Nasdaq: XERS), a fast-growing biopharmaceutical company committed to improving patient lives by developing and commercializing innovative products across a range of therapies, today announced financial results for the first quarter ended March 31, 2025, and updated its fiscal 2025 total revenue guidance.

“We’re very pleased with our strong start to the year, delivering another quarter of outstanding revenue growth,” said John Shannon, Xeris’ Chief Executive Officer. “Our performance reflects sustained momentum across the portfolio, led by strong demand for Recorlev and is a testament to the disciplined execution of our growth strategy.” Mr. Shannon continued, “Given our exceptional first quarter performance, as well as strong continued momentum and confidence in the business, we have tightened full-year 2025 total revenue guidance to $260 million to $275 million. This revision from our previous range of $255 million to $275 million underscores the success of our strategic initiatives and our commitment to driving sustainable growth while delivering value to our patients and shareholders.”

First Quarter 2025 Highlights

 

Three months ended March 31,

 

Change

 

2025

 

2024

 

$

%

Product revenue (in thousands):

 

 

 

 

 

 

Recorlev

$

25,530

 

$

10,599

 

$

14,931

 

140.9

 

Gvoke

 

20,845

 

 

16,579

 

 

4,266

 

25.7

 

Keveyis

 

11,427

 

 

13,085

 

 

(1,658

)

(12.7

)

Product revenue, net

 

57,802

 

 

40,263

 

 

17,539

 

43.6

 

Royalty, contract and other revenue

 

2,317

 

 

375

 

 

1,942

 

517.9

 

Total revenue

$

60,119

 

$

40,638

 

$

19,481

 

47.9

 

• Recorlev®: First quarter net revenue was $25.5 million – an increase of approximately 141% compared to the first quarter of 2024. This growth was primarily driven by the average number of patients on Recorlev increasing 124% from the same period in 2024.
• Gvoke®: First quarter net revenue was $20.8 million – an increase of approximately 26% compared to the first quarter of 2024. Gvoke prescriptions grew 8% compared to the same period in 2024.
• Keveyis®: First quarter net revenue was $11.4 million – a decrease of approximately 13% compared to the first quarter of 2024. This decrease was primarily driven by a reduction in product shipments in the period. On a sequential basis, net revenue and total patients on Keveyis were both slightly up.
• Royalty, contract and other revenue: In the first quarter, Xeris obtained FDA approval for Gvoke VialDxTM and received an approval-based milestone from its partner, American Regent, which made up a majority of Other Revenue.

Cost of goods sold (COGS) increased $2.8 million or 46% in the first quarter of 2025 compared to the same period in 2024. This increase was primarily due to an increase in product revenue.

Research and development (R&D) expenses were relatively flat in the first quarter of 2025 compared to the same period last year. Expenses in the quarter supported the Company's pipeline, notably XP-8121, and included personnel related expenses and continued investment in the Company's technology platforms and partnerships.

Selling, general and administrative (SG&A) expenses increased $5.6 million or 15% in the first quarter of 2025 compared to the same period last year. This increase was primarily due to incremental investment in the Recorlev commercial organization starting in the third quarter of 2024 as well as other personnel related expenses.

Net Loss for the first quarter was $9.2 million or ($0.06) per share.

Adjusted EBITDA1 for the first quarter was positive $4.4 million, an improvement of $8.4 million compared to the first quarter of 2024.

Total Shares Outstanding were 160,155,000 at April 30, 2025.

Upcoming Events

• Craig-Hallum Institutional Investor Conference: Senior management will participate in 1x1 meetings on May 28, 2025, in Minneapolis, MN. Please contact the sponsor to arrange meetings with management.
• Analyst & Investor Day: Xeris will host an in-person and virtual Analyst and Investor Day on June 3, 2025, at 10:00 a.m. Eastern Time in New York City. The event will feature key opinion leaders (KOLs) who will join Company management to discuss the opportunity for the Company's key near- and long-term growth drivers, specifically, Recorlev, and XP-8121. To register for the event, please use this link: https://edge.media-server.com/mmc/p/e4niwx3r/
• Jefferies Global Healthcare Conference: Senior management will participate in a fireside chat and 1x1 meetings on June 4, 2025 in New York City. Please contact the sponsor to arrange meetings with management.

Conference Call and Webcast Details

Xeris will host a conference call and webcast at 8:30 a.m. Eastern Time today to discuss the Company's financial and operational results. To pre-register for the conference call, please use the following link: https://www.netroadshow.com/events/login?show=7ba30d1f&confId=80481

After registering, a confirmation email will be sent, including dial-in details and a unique code for entry. The Company recommends registering a minimum of ten minutes prior to the start of the call. Following the conference call, a replay will be available until Thursday, May 22, 2025 at US:1 929 458 6194, US Toll Free: 1 866 813 9403, UK: 0204 525 0658, Canada: 1 226 828 7578, or all other locations: +44 204 525 0658 Access Code: 570802.

To join the webcast, please visit “Events” on investor relations page of the Company’s website at www.xerispharma.com or use this link: https://events.q4inc.com/attendee/798286025

Note Regarding Use of Non-GAAP Financial Measures

This press release includes financial results prepared in accordance with generally accepted accounting principles in the United States (GAAP) and also certain historical and forward-looking non-GAAP financial measures, namely Adjusted EBITDA. This non-GAAP financial measure is not meant to be considered in isolation and should be read in conjunction with the Company's consolidated financial statements prepared in accordance with GAAP, and was not prepared under any comprehensive set of accounting rules or principles. Non-GAAP financial measures are not an alternative for financial measures prepared in accordance with GAAP, and the calculation of the non-GAAP financial measure included herein may differ from similarly titled measures used by other companies. The Company believes that the presentation of Adjusted EBITDA, when viewed in conjunction with actual GAAP results, provides investors with a more meaningful understanding of the Company's ongoing and projected operating performance, exclusive of factors that do not directly affect what the Company considers to be its core operating performance, as well as unusual events. The Company believes this non-GAAP financial measure helps indicate underlying trends in the Company’s business and is important in comparing current results with prior period results and understanding expected operating performance. Also, management uses this non-GAAP financial measure to establish budgets and operational goals, and to manage the Company’s business and evaluate its performance. In addition, management believes that Adjusted EBITDA is important in evaluating the administrative costs of operating the Company’s business.

Adjusted EBITDA is GAAP net income (loss) before income tax (benefit) expense, plus interest and other income, less depreciation and amortization, interest expenses, share based compensation and debt refinancing fees.

About Xeris

Xeris (Nasdaq: XERS) is a fast-growing biopharmaceutical company committed to improving patient lives by developing and commercializing innovative products across a range of therapies. Xeris has three commercially available products: Recorlev®, for the treatment of endogenous Cushing’s syndrome; Gvoke®, a ready-to-use liquid glucagon for the treatment of severe hypoglycemia; and Keveyis®, a proven therapy for primary periodic paralysis. Xeris also has a pipeline of development programs led by XP-8121, a Phase 3-ready, once-weekly subcutaneous injection for hypothyroidism, as well as multiple early-stage programs leveraging Xeris’ technology platforms, XeriSol® and XeriJect®, for its partners.

Xeris Biopharma Holdings is headquartered in Chicago, IL. For more information, visit www.xerispharma.com, or follow us on X, LinkedIn, or Instagram.

Forward-Looking Statements

Any statements in this press release other than statements of historical fact are forward-looking statements. Forward-looking statements include, but are not limited to, statements about future expectations, plans and prospects for Xeris Biopharma Holdings, Inc. including statements regarding full year total revenue guidance for 2025, including the potential for revenue growth and Adjusted EBITDA, the potential for 2025 to be financially transformative, advancing its strategic initiatives, the ability to continue to demonstrate sustained momentum across the portfolio and maintain disciplined execution of the Company's growth strategy, its ability to drive more value for patients and shareholders, the market and therapeutic potential of its products and product candidates, the potential utility of its formulation platforms, the advancement of its pipeline (including XP-8121), and other statements containing the words "achieve," "continue," “will,” “would,” “continue,” “expect,” “should,” “anticipate” and similar expressions, constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. These forward-looking statements are based on numerous assumptions and assessments made in light of Xeris’ experience and perception of historical trends, current conditions, business strategies, operating environment, future developments, geopolitical factors and other factors it believes appropriate. By their nature, forward-looking statements involve known and unknown risks and uncertainties because they relate to events and depend on circumstances that will occur in the future. The various factors that could cause Xeris’ actual results, performance or achievements, industry results and developments to differ materially from those expressed in or implied by such forward-looking statements, include, but are not limited to, its financial position and need for financing, including to fund its product development programs or commercialization efforts, whether its products will achieve and maintain market acceptance in a competitive business environment, its reliance on third-party suppliers, including single-source suppliers, its reliance on third parties to conduct clinical trials, the ability of its product candidates to compete successfully with existing and new drugs, its and collaborators’ ability to protect its intellectual property and proprietary technology, and general macroeconomic and geopolitical conditions, including the possibility of an economic downturn, changes in governmental priorities and resources, announced or implemented tariffs and market volatility. No assurance can be given that such expectations will be realized and persons reading this communication are, therefore, cautioned not to place undue reliance on these forward-looking statements. Additional risks and information about potential impacts of financial, operational, economic, competitive, regulatory, governmental, technological, and other factors that may affect Xeris can be found in Xeris’ filings, including its most recently filed Annual Report on Form 10-K and subsequent filings with the U.S. Securities and Exchange Commission, the contents of which are not incorporated by reference into, nor do they form part of, this communication. Forward-looking statements in this communication are based on information available to management, as of the date of this communication and, while the Company believes its assumptions are reasonable, actual results may differ materially. Subject to any obligations under applicable law, the Company does not undertake any obligation to update any forward-looking statement whether as a result of new information, future developments or otherwise, or to conform any forward-looking statement to actual results, future events, or to changes in expectations.

1 Adjusted EBITDA is a non-GAAP financial measure. See "Note Regarding Use of Non-GAAP Financial Measures" and the corresponding financial tables at the end of this press release for definitions and reconciliations of non-GAAP measures.

XERIS BIOPHARMA HOLDINGS, INC.

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS

(in thousands, except share and per share data)

 

 

Three Months Ended March 31,

 

 

2025

 

 

 

2024

 

 

(unaudited)

 

(unaudited)

Product revenue, net

$

57,802

 

 

$

40,263

 

Royalty, contract and other revenue

 

2,317

 

 

 

375

 

Total revenue

 

60,119

 

 

 

40,638

 

Costs and expenses:

 

 

 

Cost of goods sold

 

8,728

 

 

 

5,971

 

Research and development

 

7,753

 

 

 

7,821

 

Selling, general and administrative

 

44,018

 

 

 

38,380

 

Amortization of intangible assets

 

2,710

 

 

 

2,711

 

Total costs and expenses

 

63,209

 

 

 

54,883

 

Loss from operations

 

(3,090

)

 

 

(14,245

)

Other expenses

 

(6,130

)

 

 

(4,428

)

Net loss before benefit from income taxes

 

(9,220

)

 

 

(18,673

)

Benefit from income taxes

 

—

 

 

 

(307

)

Net loss

$

(9,220

)

 

$

(18,980

)

 

 

 

 

Net loss per common share - basic and diluted

$

(0.06

)

 

$

(0.14

)

 

 

 

 

Weighted average common shares outstanding - basic and diluted

 

152,445,935

 

 

 

140,513,907

 

XERIS BIOPHARMA HOLDINGS, INC.

Non-GAAP Financial Measures - EBITDA and Adjusted EBITDA

(in thousands, unaudited)

 

 

Three Months Ended March 31,

 

 

2025

 

 

 

2024

 

GAAP Net Loss

$

(9,220

)

 

$

(18,980

)

Adjustments

 

 

 

Interest and other income

 

(1,175

)

 

(1,923

)

Interest expense

 

7,305

 

 

 

7,032

 

Income tax (benefit) expense

 

—

 

 

 

307

 

Depreciation and amortization

 

3,025

 

 

 

3,037

 

EBITDA

 

(65

)

 

 

(10,527

)

Adjustments

 

 

 

Share-based compensation (a)

 

4,443

 

 

 

3,767

 

Debt refinancing fees (b)

 

—

 

 

 

2,690

 

Adjusted EBITDA

 

4,378

 

 

 

(4,070

)

 

(a) Includes non-cash, stock-based compensation, net of forfeitures.

 

(b) Represents non-recurring fees related to financing activities. Including debt refinancing fees which related to advisory and legal fees to refinance the term loan in 2024.

XERIS BIOPHARMA HOLDINGS, INC.

CONDENSED CONSOLIDATED BALANCE SHEETS

(in thousands)

 

 

March 31, 2025

 

December 31, 2024

 

(unaudited)

 

 

Assets

 

 

 

Current assets:

 

 

 

Cash and cash equivalents

$

58,440

 

 

$

71,621

 

Trade accounts receivable, net

 

46,330

 

 

 

40,415

 

Inventory

 

52,690

 

 

 

48,175

 

Prepaid expenses and other current assets

 

6,034

 

 

 

7,451

 

Total current assets

 

163,494

 

 

 

167,662

 

Property and equipment, net

 

5,260

 

 

 

5,562

 

Intangible assets, net

 

96,211

 

 

 

98,921

 

Goodwill

 

22,859

 

 

 

22,859

 

Operating lease right-of-use assets

 

22,531

 

 

 

22,649

 

Other assets

 

5,098

 

 

 

5,407

 

Total assets

$

315,453

 

 

$

323,060

 

Liabilities and Stockholders’ Equity

 

 

 

Current liabilities:

 

 

 

Accounts payable

$

6,352

 

 

$

2,290

 

Current portion of long-term debt

 

11,959

 

 

 

15,102

 

Current operating lease liabilities

 

6,117

 

 

 

6,080

 

Other accrued liabilities

 

20,050

 

 

 

27,716

 

Accrued trade discounts and rebates

 

30,734

 

 

 

29,084

 

Accrued returns reserve

 

19,704

 

 

 

19,082

 

Other current liabilities

 

156

 

 

 

1,089

 

Total current liabilities

 

95,072

 

 

 

100,443

 

Long-term debt, net of unamortized debt issuance costs

 

217,805

 

 

 

217,006

 

Non-current operating lease liabilities

 

32,870

 

 

 

33,259

 

Other liabilities

 

4,834

 

 

 

1,967

 

Total liabilities

 

350,581

 

 

 

352,675

 

Total stockholders’ equity (deficit)

 

(35,128)

 

 

(29,615)

Total liabilities and stockholders’ equity (deficit)

$

315,453

 

 

$

323,060

 

 

View source version on businesswire.com: https://www.businesswire.com/news/home/20250508156644/en/

Investor Contact Allison Wey Senior Vice President, Investor Relations and Corporate Communications awey@xerispharma.com