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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 10-Q
☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the quarterly period ended June 30, 2024.
OR
☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the transition period from ____________ to ____________
Commission File Number 001-13341
Titan Pharmaceuticals, Inc.
(Exact name of registrant as specified in its charter)
Delaware |
|
94-3171940 |
(State or other jurisdiction of incorporation or organization) |
|
(I.R.S. Employer Identification No.) |
400 Oyster Point Blvd., Suite 505, South San Francisco, California |
|
94080 |
(Address of principal executive offices) |
|
(Zip Code) |
(650) 244-4990
(Registrant’s telephone number, including area code)
Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ☒ No ☐
Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ☒ No ☐
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company.
Large accelerated filer |
☐ |
Accelerated filer |
☐ |
Non-accelerated filer |
☒ |
Smaller reporting company |
☒ |
|
|
Emerging growth company |
☐ |
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ☒
Securities registered pursuant to Section 12(b) of the Act:
Title of each class |
|
Trading Symbol(s) |
|
Name of each exchange on which registered |
Common Stock, par value $0.001 |
|
TTNP |
|
Nasdaq Capital Market |
Indicate the number of shares outstanding of each of the issuer’s classes of common stock, as of the latest practicable date.
Class |
|
Outstanding at August 9, 2024 |
Common Stock, par value $0.001 |
|
914,234 |
Titan Pharmaceuticals, Inc.
Index to Form 10-Q
Part I. Financial Information
Item 1. Financial Statements
TITAN PHARMACEUTICALS, INC.
CONDENSED BALANCE SHEETS
(in thousands, except share and per share data)
|
|
|
|
|
|
|
|
|
|
|
June 30, |
|
|
December 31, |
|
|
|
2024 |
|
|
2023 |
|
|
|
(unaudited) |
|
|
(Note 1) |
|
Assets |
|
|
|
|
|
|
|
|
Current assets: |
|
|
|
|
|
|
|
|
Cash and cash equivalents |
|
$ |
4,092 |
|
|
$ |
6,760 |
|
Restricted cash |
|
|
- |
|
|
|
13 |
|
Receivables |
|
|
38 |
|
|
|
46 |
|
Notes receivable |
|
|
- |
|
|
|
1,000 |
|
Prepaid expenses and other current assets |
|
|
220 |
|
|
|
199 |
|
Total current assets |
|
|
4,350 |
|
|
|
8,018 |
|
Property and equipment, net |
|
|
- |
|
|
|
5 |
|
Operating lease right-of-use assets, net |
|
|
- |
|
|
|
63 |
|
Total assets |
|
$ |
4,350 |
|
|
$ |
8,086 |
|
|
|
|
|
|
|
|
|
|
Liabilities and Stockholders’ Equity |
|
|
|
|
|
|
|
|
Current liabilities: |
|
|
|
|
|
|
|
|
Accounts payable |
|
$ |
356 |
|
|
$ |
348 |
|
Note payable to related party |
|
|
- |
|
|
|
500 |
|
Other accrued liabilities |
|
|
- |
|
|
|
519 |
|
Operating lease liability, current |
|
|
- |
|
|
|
65 |
|
Deferred grant revenue |
|
|
- |
|
|
|
12 |
|
Total current liabilities |
|
|
356 |
|
|
|
1,444 |
|
Total liabilities |
|
|
356 |
|
|
|
1,444 |
|
|
|
|
|
|
|
|
|
|
Commitments and contingencies (Note 4) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Stockholders’ equity: |
|
|
|
|
|
|
|
|
Preferred stock, at amounts paid in, $0.001 par value per share; 5,000,000 shares authorized, 950,000 shares issued and outstanding at June 30, 2024 and December 31, 2023. |
|
|
1 |
|
|
|
1 |
|
Common stock, at amounts paid-in, $0.001 par value per share; 225,000,000 shares authorized, 914,234 and 781,503 shares issued and outstanding at June 30, 2024 and December 31, 2023, respectively. |
|
|
1 |
|
|
|
1 |
|
Additional paid-in capital |
|
|
398,975 |
|
|
|
398,470 |
|
Accumulated deficit |
|
|
(394,983 |
) |
|
|
(391,830 |
) |
Total stockholders’ equity |
|
|
3,994 |
|
|
|
6,642 |
|
Total liabilities and stockholders’ equity |
|
$ |
4,350 |
|
|
$ |
8,086 |
|
See Notes to Condensed Financial Statements.
TITAN PHARMACEUTICALS, INC.
CONDENSED STATEMENTS OF OPERATIONS
(in thousands, except per share amount)
(unaudited)
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended |
|
|
Six Months Ended |
|
|
|
June 30, |
|
|
June 30, |
|
|
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
Revenues: |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
License revenue |
|
$ |
- |
|
|
$ |
1 |
|
|
$ |
- |
|
|
$ |
1 |
|
Grant revenue |
|
|
- |
|
|
|
82 |
|
|
|
- |
|
|
|
180 |
|
Total revenues |
|
|
- |
|
|
|
83 |
|
|
|
- |
|
|
|
181 |
|
Operating expenses: |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and development |
|
|
- |
|
|
|
442 |
|
|
|
- |
|
|
|
1,003 |
|
General and administrative |
|
|
2,074 |
|
|
|
1,229 |
|
|
|
3,137 |
|
|
|
2,463 |
|
Total operating expenses |
|
|
2,074 |
|
|
|
1,671 |
|
|
|
3,137 |
|
|
|
3,466 |
|
Loss from operations |
|
|
(2,074 |
) |
|
|
(1,588 |
) |
|
|
(3,137 |
) |
|
|
(3,285 |
) |
Other income (expense): |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Interest income |
|
|
- |
|
|
|
7 |
|
|
|
1 |
|
|
|
29 |
|
Other expense, net |
|
|
(19 |
) |
|
|
(5 |
) |
|
|
(17 |
) |
|
|
(5 |
) |
Other income (expense), net |
|
|
(19 |
) |
|
|
2 |
|
|
|
(16 |
) |
|
|
24 |
|
Net loss |
|
$ |
(2,093 |
) |
|
$ |
(1,586 |
) |
|
$ |
(3,153 |
) |
|
$ |
(3,261 |
) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Basic and diluted net loss per common share |
|
$ |
(2.29 |
) |
|
$ |
(2.11 |
) |
|
$ |
(3.57 |
) |
|
$ |
(4.34 |
) |
Weighted average shares used in computing basic and diluted net loss per common share |
|
|
914 |
|
|
|
751 |
|
|
|
884 |
|
|
|
751 |
|
See Notes to Condensed Financial Statements.
TITAN PHARMACEUTICALS, INC.
CONDENSED STATEMENTS OF STOCKHOLDERS’ EQUITY (DEFICIT)
(in thousands)
(unaudited)
Six Months Ended June 30, 2024
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Additional |
|
|
|
|
|
Total |
|
|
|
Preferred Stock |
|
|
Common Stock |
|
|
Paid-In |
|
|
Accumulated |
|
|
Stockholders’ |
|
|
|
Shares |
|
|
Amount |
|
|
Shares |
|
|
Amount |
|
|
Capital |
|
|
Deficit |
|
|
Equity |
|
Balances at December 31, 2023 |
|
|
950 |
|
|
$ |
1 |
|
|
|
782 |
|
|
$ |
1 |
|
|
$ |
398,470 |
|
|
$ |
(391,830 |
) |
|
$ |
6,642 |
|
Net loss |
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
(1,060 |
) |
|
|
(1,060 |
) |
Issuance of common stock upon conversion of note payable |
|
|
- |
|
|
|
- |
|
|
|
54 |
|
|
|
- |
|
|
|
504 |
|
|
|
- |
|
|
|
504 |
|
Fractional shares issued due to reverse stock split |
|
|
- |
|
|
|
- |
|
|
|
78 |
|
|
|
- |
|
|
|
1 |
|
|
|
- |
|
|
|
1 |
|
Balances at March 31, 2024 |
|
|
950 |
|
|
$ |
1 |
|
|
|
914 |
|
|
$ |
1 |
|
|
$ |
398,975 |
|
|
$ |
(392,890 |
) |
|
$ |
6,087 |
|
Net loss |
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
(2,093 |
) |
|
|
(2,093 |
) |
Balances at June 30, 2024 |
|
|
950 |
|
|
$ |
1 |
|
|
|
914 |
|
|
$ |
1 |
|
|
$ |
398,975 |
|
|
$ |
(394,983 |
) |
|
$ |
3,994 |
|
Six Months Ended June 30, 2023
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Additional |
|
|
|
|
|
Total
Stockholders’ |
|
|
|
Preferred Stock |
|
|
Common Stock |
|
|
Paid-In |
|
|
Accumulated |
|
|
Equity |
|
|
|
Shares |
|
|
Amount |
|
|
Shares |
|
|
Amount |
|
|
Capital |
|
|
Deficit |
|
|
(Deficit) |
|
Balances at December 31, 2022 |
|
|
- |
|
|
$ |
- |
|
|
|
751 |
|
|
$ |
1 |
|
|
$ |
387,623 |
|
|
$ |
(386,261 |
) |
|
$ |
1,363 |
|
Net loss |
|
|
- |
|
|
|
- |
|
|
|
|
|
|
|
- |
|
|
|
- |
|
|
|
(1,675 |
) |
|
|
(1,675 |
) |
Balances at March 31, 2023 |
|
|
- |
|
|
|
- |
|
|
|
751 |
|
|
$ |
1 |
|
|
$ |
387,623 |
|
|
$ |
(387,936 |
) |
|
$ |
(312 |
) |
Net loss |
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
(1,586 |
) |
|
|
(1,586 |
) |
Stock-based compensation |
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
- |
|
|
|
864 |
|
|
|
- |
|
|
|
864 |
|
Balances at June 30, 2023 |
|
|
- |
|
|
$ |
- |
|
|
|
751 |
|
|
$ |
1 |
|
|
$ |
388,487 |
|
|
$ |
(389,522 |
|
|
$ |
(1,034 |
) |
See Notes to Condensed Financial Statements.
TITAN PHARMACEUTICALS, INC.
CONDENSED STATEMENTS OF CASH FLOWS
(in thousands)
(unaudited)
|
|
|
|
|
|
|
|
|
|
|
Six months Ended |
|
|
|
June 30, |
|
|
|
2024 |
|
|
2023 |
|
Cash flows from operating activities: |
|
|
|
|
|
|
|
|
Net loss |
|
$ |
(3,153 |
) |
|
$ |
(3,261 |
) |
Adjustments to reconcile net loss to net cash used in operating activities: |
|
|
|
|
|
|
|
|
Depreciation and amortization |
|
|
5 |
|
|
|
82 |
|
Stock-based compensation |
|
|
- |
|
|
|
554 |
|
Other |
|
|
(2 |
) |
|
|
- |
|
Changes in operating assets and liabilities: |
|
|
|
|
|
|
|
|
Receivables |
|
|
8 |
|
|
|
18 |
|
Notes receivable |
|
|
1,000 |
|
|
|
- |
|
Prepaid expenses and other assets |
|
|
(21 |
) |
|
|
76 |
|
Accounts payable |
|
|
8 |
|
|
|
(37 |
) |
Deferred grant revenue |
|
|
(12 |
) |
|
|
(180 |
) |
Other accrued liabilities |
|
|
(514 |
) |
|
|
(263 |
|
Net cash used in operating activities |
|
|
(2,681 |
) |
|
|
(3,011 |
) |
|
|
|
|
|
|
|
|
|
Net decrease in cash, cash equivalents and restricted cash |
|
|
(2,681 |
) |
|
|
(3,011 |
) |
Cash, cash equivalents and restricted cash at beginning of period |
|
|
6,773 |
|
|
|
3,133 |
|
Cash, cash equivalents and restricted cash at end of period |
|
$ |
4,092 |
|
|
$ |
122 |
|
|
|
|
|
|
|
|
|
|
Supplemental cash flow information: |
|
|
|
|
|
|
|
|
Interest paid |
|
$ |
13 |
|
|
$ |
- |
|
Note payable to related party converted to common stock |
|
$ |
500 |
|
|
$ |
- |
|
Accrued interest net of tax converted to common stock |
|
$ |
5 |
|
|
$ |
- |
|
Disposal of fully depreciated property and equipment |
|
$ |
711 |
|
|
$ |
- |
|
Reclassification of inventory to assets held for sale |
|
$ |
- |
|
|
$ |
105 |
|
Reclassification of property and equipment, net to assets held for sale |
|
$ |
- |
|
|
$ |
133 |
|
Reclassification of accrued liabilities to liabilities held for sale |
|
$ |
- |
|
|
$ |
236 |
|
The following table provides a reconciliation of cash, cash equivalents and restricted cash reported within the condensed balance sheets that sum to the total of the same such amounts shown in the condensed statements of cash flows (in thousands):
|
|
June 30, |
|
|
|
2024 |
|
|
2023 |
|
Cash and cash equivalents |
|
$ |
4,092 |
|
|
$ |
105 |
|
Restricted cash |
|
|
- |
|
|
|
17 |
|
Cash, cash equivalents and restricted cash shown in the condensed statements of cash flows |
|
$ |
4,092 |
|
|
$ |
122 |
|
See Notes to Condensed Financial Statements.
TITAN PHARMACEUTICALS, INC.
NOTES TO CONDENSED FINANCIAL STATEMENTS
(unaudited)
| 1. |
Organization and Summary of Significant Accounting Policies |
The Company
Titan Pharmaceuticals, Inc. (“Titan” or the “Company” or “we,” “our” or “us”) is a pharmaceutical company that was previously developing therapeutics utilizing the proprietary long-term drug delivery platform, ProNeura®, for the treatment of select chronic diseases for which steady state delivery of a drug has the potential to provide an efficacy and/or safety benefit. ProNeura consists of a small, solid implant made from a mixture of ethylene-vinyl acetate and a drug substance. The resulting product is a solid matrix that is designed to be administered subdermally in a brief, outpatient procedure and is removed in a similar manner at the end of the treatment period.
Our first product based on the ProNeura technology was Probuphine® (buprenorphine implant), which is approved in the United States, Canada and the European Union (“EU”) for the maintenance treatment of opioid use disorder in clinically stable patients taking 8 milligrams or less a day of oral buprenorphine. While Probuphine continues to be commercialized in the EU (as Sixmo™) by another company that had acquired the rights from us, we discontinued commercialization of the product in the United States during the fourth quarter of 2020 and subsequently sold the product in September 2023. Discontinuation of our commercial operations allowed us to focus our limited resources on product development programs and transition back to a product development company.
In December 2021, we announced
our intention to work with our financial advisor to explore strategic alternatives to enhance stockholder value, potentially including
an acquisition, merger, reverse merger, other business combination, sales of assets, licensing or other transaction. In June 2022,
we implemented a plan to reduce expenses and conserve capital that included a company-wide reduction in salaries and a scale back of
certain operating expenses to enable us to maintain sufficient resources as we pursued potential strategic alternatives. In July 2022,
David Lazar and Activist Investing LLC acquired an approximately 25% ownership interest in Titan, filed a proxy statement and nominated
six additional directors, each of whom was elected to our board of directors (the “Board”) at a special meeting of stockholders
held on August 15, 2022 (the “Special Meeting”). The exploration and evaluation of possible strategic alternatives by
the Board has continued following the Special Meeting. Following the election of the new directors at the Special Meeting, Dr. Marc Rubin
was replaced as our Executive Chairman, and David Lazar assumed the role of Chief Executive Officer. In connection with the termination
of his employment as Executive Chairman, Dr. Rubin received aggregate severance payments of approximately $0.4 million. In December 2022,
we implemented additional cost reduction measures including a reduction in our workforce. In June 2023, David Lazar sold his approximately
25% ownership interest in Titan to Choong Choon Hau. Mr. Lazar resigned his position as the Company’s Chief Executive Officer
in April 2024. Our Chairman of the Board of Directors, Seow Gim Shen, assumed the position as our Chief Executive Officer in April 2024.
On September 1, 2023 (the “Closing Date”), we closed on the sale of certain ProNeura assets, including our portfolio of drug addiction products, in addition to other early development programs based on the ProNeura drug delivery technology (the “ProNeura Assets”). In July 2023, we entered into an asset purchase agreement (the “Asset Purchase Agreement”) with Fedson, Inc., a Delaware corporation (“Fedson”), for the sale of the ProNeura Assets. Our addiction portfolio consisted of the Probuphine and Nalmefene implant programs. The ProNeura Assets constituted only a portion of our assets. In August 2023, we entered into an Amendment and Extension Agreement (the “Amendment”) to the Asset Purchase Agreement, pursuant to which Fedson agreed to purchase our ProNeura Assets for a purchase price of $2.0 million, consisting of (i) $500,000 in readily available funds, paid in full on the Closing Date, (ii) $500,000 in the form of a promissory note due and payable on October 1, 2023 (the “Cash Note”) and (iii) $1,000,000 in the form of a promissory note due and payable on January 1, 2024 (the “Escrow Note”). We will also be eligible to receive potential milestone payments of up to $50 million on future net sales of the products and certain royalties on future net sales of the products. As further consideration, Fedson assumed all liabilities related to a pending employment claim against us. On the Closing Date, Fedson delivered a written guaranty by a principal of Fedson of all of Fedson’s obligations under both the Cash Note and Escrow Note. The Cash Note included provisions, which Fedson has exercised, allowing Fedson to extend the payment of the Cash Note to November 1, 2023 and again to December 1, 2023 upon payment of $5,000 for each extension. The Cash Note and Escrow Note were paid in December 2023 and January 2024, respectively. We received the funds from the escrow account in February 2024.
In April 2024, David Lazar, our Chief Executive Officer, Kate Beebe DeVarney, Ph.D., our President and Chief Operating Officer and a member of our Board of Directors, and three other members of our Board of Directors, Eric Greenberg, Matthew C. McMurdo and David Natan, resigned their positions with the Company. Pursuant to the terms of their respective settlement agreements, we made payments in aggregate of approximately $1.2 million. The Board of Directors subsequently appointed Firdauz Edmin Bin Mokhtar and Francisco Osvaldo Flores García as independent directors of the Company to fill two of the vacancies created by the resignations. In addition, Dato Seow Gim Shen was appointed as Chief Executive Officer and Principal Financial Officer and will continue to serve as the Company’s Chairman of the Board, which he has done since October 12, 2023.
All share and per share amounts give retroactive effect to a 1-for-20 reverse stock split effected on January 8, 2024 (see Note 6. Stockholders’ Equity).
Basis of Presentation
The accompanying unaudited condensed financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“GAAP”) for interim financial information and with the instructions to Form 10-Q and Article 8 of Regulation S-X. Accordingly, they do not include all the information and footnotes required by GAAP for complete financial statement presentation. In the opinion of management, all adjustments (consisting of normal recurring adjustments) considered necessary for a fair presentation have been included. Operating results for the six months ended June 30, 2024 are not necessarily indicative of the results that may be expected for the year ending December 31, 2024, or any future interim periods.
The balance sheet as of December 31, 2023 is derived from the audited financial statements at that date but does not include all the information and footnotes required by GAAP for complete financial statements. These unaudited condensed financial statements should be read in conjunction with the audited financial statements and footnotes thereto included in the Titan Pharmaceuticals, Inc. Annual Report on Form 10-K for the year ended December 31, 2023, as filed with the Securities and Exchange Commission.
The accompanying condensed financial statements have been prepared assuming we will continue as a going concern.
As of June 30, 2024, we had cash and cash equivalents of approximately $4.1 million, which we believe is sufficient to fund our planned operations through the third quarter of 2025. We are exploring several financing and strategic alternatives; however, there can be no assurance that our efforts will be successful.
Going Concern Assessment
We assess going concern
uncertainty in our condensed financial statements to determine if we have sufficient cash on hand and working capital, including
available borrowings on loans, to operate for a period of at least one year from the date the condensed financial statements are
issued or available to be issued, which is referred to as the look-forward period as defined by Accounting Standards Update
(“ASU”) No. 2014-15, Disclosure of Uncertainties about an Entity’s Ability to Continue as a Going Concern.
As part of this assessment, based on conditions that are known and reasonably knowable to us, we will consider various scenarios,
forecasts, projections, estimates and will make certain key assumptions, including the timing and nature of projected cash
expenditures or programs, and its ability to delay or curtail expenditures or programs, if necessary, among other factors. Based on
this assessment, as necessary or applicable, we make certain assumptions around implementing curtailments or delays in the nature
and timing of programs and expenditures to the extent we deem probable those implementations can be achieved, and we have the proper
authority to execute them within the look-forward period in accordance with ASU No. 2014-15.
Based upon the above assessment, we concluded that, at the date of filing the condensed financial statements in this Quarterly Report on Form 10-Q for the six months ended June 30, 2024, we have sufficient cash to fund our operations for the next 12 months without additional funds.
Use of Estimates
The preparation of condensed financial statements in conformity with accounting principles generally accepted in the U.S. requires management to make estimates and assumptions that affect the amounts reported in the condensed financial statements and accompanying notes. Actual results could differ from those estimates.
Stock-Based Compensation
We recognize compensation expense using a fair-value based method for all stock-based payments including stock options and restricted stock awards and stock issued under an employee stock purchase plan. These standards require companies to estimate the fair value of stock-based payment awards on the date of grant using an option pricing model. See Note 2. Stock Plans for a discussion of our stock-based compensation plans.
Cash and Cash Equivalents
Our investment policy emphasizes liquidity and preservation of principal over other portfolio considerations. We select investments that maximize interest income to the extent possible given these two constraints. We satisfy liquidity requirements by investing excess cash in securities with different maturities to match projected cash needs and limit concentration of credit risk by diversifying our investments among a variety of high credit-quality issuers and limit the amount of credit exposure to any one issuer. The estimated fair values have been determined using available market information. We do not use derivative financial instruments in our investment portfolio.
All investments with original maturities of three months or less are considered to be cash equivalents. We had no money market funds as of June 30, 2024 and December 31, 2023, included in our cash and cash equivalents.
We maintain significant cash balances at financial institutions which throughout the year regularly exceed the federally insured limit of $250,000. Any loss incurred or a lack of access to such funds could have a significant adverse impact on our financial condition, results of operations, and cash flows.
Restricted Cash
In accordance with ASU No. 2016-18, Statement of Cash Flows (Topic 230): Restricted Cash, we explain the change during the period in the total of cash, cash equivalents and restricted cash, and include restricted cash with cash and cash equivalents when reconciling the beginning-of-period and end-of-period total amounts shown on the condensed statements of cash flows.
Prepaid Expenses and Other Current Assets
Prepaid Expenses and Other Current Assets consist primarily of prepaid insurance, prepaid rent, prepaid payroll and other expenses. Prepaid expenses are recorded at cost and are amortized over the periods benefited using the straight-line method. The Company reviews prepaid expenses at each balance sheet date and adjusts the carrying amounts as necessary to reflect the remaining estimated benefit.
Property and Equipment
Property and equipment are
recorded at cost and depreciated using the straight-line method over the estimated useful lives of the assets ranging from three 3
to 5 five years. Leasehold improvements are amortized over the shorter of the lease term or the estimated useful life of the
assets.
Revenue Recognition
We generate revenue principally from collaborative research and development arrangements and government grants.
Grant Revenue
We had contracts with National Institute on Drug Abuse or NIDA, within the U.S. Department of Health and Human Services, the Bill & Melinda Gates Foundation, and other government-sponsored organizations for research and development related activities that provided for payments for reimbursed costs, which may have included overhead and general and administrative costs. We recognized revenue from these contracts as we performed services under these arrangements when the funding was committed. Associated expenses were recognized when incurred as research and development expense. Revenues and related expenses are presented gross in the condensed statements of operations.
Receivables
The following table presents the activity related to our receivables for the six months ended June 30, 2024.
Schedule of activity related to our accounts receivable |
|
|
|
|
(in thousands) |
|
|
|
Balance at January 1, 2024 |
|
$ |
46 |
|
Deductions |
|
|
(8 |
) |
Balance at June 30, 2024 |
|
$ |
38 |
|
Research and Development Costs and Related Accrual
Research and development expenses include internal and external costs. Internal costs include salaries and employment related expenses, facility costs, administrative expenses and allocations of corporate costs. External expenses consist of costs associated with outsourced contract research organization activities, sponsored research studies, product registration, and investigator sponsored trials. Significant judgments and estimates must be made and used in determining the accrued balance in any accounting period. Actual results could differ from those estimates under different assumptions. Revisions are charged to expense in the period in which the facts that give rise to the revision become known.
Leases
We determine whether the arrangement is or contains a lease at inception. Operating lease right-of-use assets and lease liabilities are recognized at the present value of the future lease payments at commencement date. The interest rate implicit in lease contracts is typically not readily determinable, and therefore, we utilize our incremental borrowing rate, which is the rate incurred to borrow on a collateralized basis over a similar term an amount equal to the lease payments in a similar economic environment. Certain adjustments to the right-of-use asset may be required for items such as initial direct costs paid or incentives received.
Lease expense is recognized over the expected term on a straight-line basis. Operating leases are recognized on our condensed balance sheets as right-of-use assets, operating lease liabilities current and operating lease liabilities non-current.
The operating lease expired on June 30, 2024.
Recent Accounting Pronouncements
There are no recent
accounting pronouncements that will have a material impact on our condensed financial statements.
Fair Value Measurements
Financial instruments, including receivables, accounts payable and accrued liabilities, are carried at cost, and their fair values are approximated due to the short-term nature of these instruments.
The following table summarizes option activity:
Schedule of our option activity |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Options (in thousands) |
|
|
Weighted
Average Exercise
Price per share |
|
|
Weighted
Average Remaining Option Term (in years) |
|
|
Aggregate Intrinsic Value (in thousands) |
|
Outstanding at December 31, 2023 |
|
|
93 |
|
|
$ |
73.46 |
|
|
|
8.35 |
|
|
$ |
- |
|
Outstanding at June 30, 2024 |
|
|
93 |
|
|
|
72.76 |
|
|
|
7.55 |
|
|
|
- |
|
Exercisable at June 30, 2024 |
|
|
93 |
|
|
|
72.76 |
|
|
|
7.55 |
|
|
|
- |
|
The following table summarizes the stock-based compensation expense recorded for awards under our stock option plans:
Schedule of the stock-based compensation expense |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended |
|
|
Six Months Ended |
|
|
|
June 30, |
|
|
June 30, |
|
(in thousands) |
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
Research and development |
|
$ |
- |
|
|
$ |
26 |
|
|
$ |
- |
|
|
$ |
54 |
|
Selling, general and administrative |
|
|
- |
|
|
|
239 |
|
|
|
- |
|
|
|
500 |
|
Total stock-based compensation |
|
$ |
- |
|
|
$ |
265 |
|
|
$ |
- |
|
|
$ |
554 |
|
We use the Black-Scholes-Merton option-pricing model to estimate the fair value of our stock options. There were no options granted or shares awarded during the six months ended June 30, 2024 and 2023.
As of June 30, 2024, there was no unrecognized compensation expense related to non-vested stock options.
The table below presents common shares underlying stock options and warrants that are excluded from the calculation of the weighted average number of common shares outstanding used for the calculation of diluted net loss per common share. These are excluded from the calculation due to their anti-dilutive effect:
Schedule of antidilutive securities excluded from computation of net loss per common share |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended |
|
|
Six Months Ended |
|
|
|
June 30, |
|
|
June 30, |
|
(in thousands) |
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
Weighted-average anti-dilutive common shares resulting from options |
|
|
93 |
|
|
|
47 |
|
|
|
93 |
|
|
|
46 |
|
Weighted-average anti-dilutive common shares resulting from convertible note |
|
|
- |
|
|
|
- |
|
|
|
8 |
|
|
|
- |
|
Weighted-average anti-dilutive common shares resulting from convertible preferred |
|
|
380 |
|
|
|
- |
|
|
|
355 |
|
|
|
- |
|
Weighted-average anti-dilutive common shares resulting from warrants |
|
|
476 |
|
|
|
369 |
|
|
|
476 |
|
|
|
338 |
|
|
|
|
949 |
|
|
|
416 |
|
|
|
932 |
|
|
|
384 |
|
4. |
Commitments and Contingencies |
Lease Commitments
We leased our office facility under an operating lease that expired in June 2024. Rent expense associated with this lease was approximately $32,000 for the three months ended June 30, 2024 and 2023, and $64,000 for the six months ended June 30, 2024 and 2023.
Legal Proceedings
In 2020, a legal proceeding was initiated against us by a former employee alleging wrongful termination, retaliation, infliction of emotional distress, negligent supervision, hiring and retention and slander. An independent investigation into this individual’s allegations of whistleblower retaliation, while still an employee, was conducted utilizing an outside investigator and concluded that such allegations were not substantiated. In September 2023, Fedson, as consideration for the Asset Purchase Agreement, agreed to assume all liabilities related to this pending employment claim (see Note 5. Asset Sale).
In July 2023, we entered into the Asset Purchase Agreement with Fedson for the sale of the ProNeura Assets, with closing occurring on September 1, 2023. The ProNeura Assets constituted only a portion of our assets. In August 2023, we entered into an Amendment to the Asset Purchase Agreement, pursuant to which Fedson agreed to purchase our ProNeura Assets for a purchase price of $2.0 million, consisting of (i) $500,000 in readily available funds, paid in full on the Closing Date, (ii) $500,000 in the form of the Cash Note and (iii) $1,000,000 in the form of the Escrow Note. We will also be eligible to receive potential milestone payments of up to $50 million on future net sales of the products and certain royalties on future net sales of the products. As further consideration, Fedson assumed all liabilities related to a pending employment claim against us. On the Closing Date, Fedson delivered a written guaranty by a principal of Fedson of all of Fedson’s obligations under both the Cash Note and Escrow Note. The Cash Note included provisions, which Fedson has exercised, allowing Fedson to extend the maturity date of the Cash Note to November 1, 2023 and again to December 1, 2023 upon payment of $5,000 for each extension. The Cash Note and Escrow Note were paid in December 2023 and January 2024, respectively. We received the funds from the escrow account in February 2024.
Our common stock outstanding was 914,234 and 781,503 as of June 30, 2024 and December 31, 2023, respectively.
Reverse Split
On January 8, 2024, pursuant to prior stockholder authorization, our Board effected a reverse split of the outstanding shares of our common stock at a ratio of one share for every twenty shares then outstanding (the “Reverse Split”). Pursuant to their respective terms, the number of shares underlying our outstanding options and warrants was reduced and their respective exercise prices increased by the Reverse Split ratio. The number of shares of common stock authorized and the par value of $0.001 per share did not change as a result of the Reverse Split. All share and per share amounts contained in this Quarterly Report on Form 10-Q give retroactive effect to the Reverse Split.
Choong Choon Hau Note Conversion
In August 2023, we received $500,000 in funding in exchange for the issuance of a convertible promissory note for that principal amount to Choong Choon Hau (the “Hau Promissory Note”). Pursuant to the Hau Promissory Note, the principal amount accrues interest at a rate of 10% per annum and is payable monthly. All principal and accrued interest was due and payable on January 8, 2024, unless extended as provided. All or part of the Hau Promissory Note could be converted into our common stock at a conversion price of $9.32 per share from time to time following the issuance date and ending on the maturity date. In March 2024, the Hau Promissory Note, along with accrued interest of approximately $4,511, was converted into 54,132 shares of our common stock.
| 7. |
Related Party Transactions |
During the six months ended June 30, 2024 and 2023, we made payments related to legal and consulting fees of approximately $9,225 and approximately $75,000, respectively, to a law firm operated by one of our Board members.
In August 2023, we received $500,000 in funding in exchange for the issuance of the Hau Promissory Note. In March 2024, the Hau Promissory Note, along with accrued interest of approximately $4,511, was converted into 54,132 shares of our common stock (see Note 6. Stockholders’ Equity).
The Company performed a review of events subsequent from the condensed balance sheet date through the date the condensed financial statements were issued and determined that there were no events requiring recognition or disclosure in the condensed financial statements.
Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations
Forward-Looking Statements
This Quarterly Report on Form 10-Q or in the documents incorporated by reference herein may contain “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933 (the “Securities Act”) and Section 21E of the Securities Exchange Act of 1934 (the “Exchange Act”) that involve substantial risks and uncertainties. We have attempted to identify forward-looking statements by terminology including “anticipates,” “believes,” “can,” “continue,” “could,” “estimates,” “expects,” “intends,” “may,” “plans,” “potential,” “predicts,” “should,” or “will” or the negative of these terms or other comparable terminology. Although we do not make forward looking statements unless we believe we have a reasonable basis for doing so, we cannot guarantee their accuracy. Forward-looking statements included or incorporated by reference in this report or our other filings with the Securities and Exchange Commission, or the SEC, include, but are not necessarily limited to, those relating to uncertainties relating to:
|
● |
Our ability to complete one or more strategic transactions that will maximize our assets or otherwise provide value to stockholders; |
|
● |
our ability to raise capital when needed; |
|
● |
difficulties or delays in the product development and regulatory process; and |
|
● |
protection for our patents and other intellectual property or trade secrets. |
Forward-looking statements should not be read as a guarantee of future performance or results and will not necessarily be accurate indications of the times at, or by which, that performance or those results will be achieved. Forward-looking statements are based on information available at the time they are made and/or management’s good faith belief as of that time with respect to future events, and are subject to risks and uncertainties, including the risks outlined under “Risk Factors” or elsewhere in this report, that could cause actual performance or results to differ materially from what is expressed in or suggested by the forward-looking statements.
Forward-looking statements speak only as of the date they are made. You should not put undue reliance on any forward-looking statements. We assume no obligation to update forward-looking statements to reflect actual results, changes in assumptions or changes in other factors affecting forward-looking information, except to the extent required by applicable securities laws. If we do update one or more forward-looking statements, no inference should be drawn that we will make additional updates with respect to those or other forward-looking statements. We caution you not to give undue weight to such projections, assumptions and estimates.
References herein to “we,” “us,” “Titan,” and “our company” refer to Titan Pharmaceuticals, Inc. unless the context otherwise requires.
Probuphine® and ProNeura® are trademarks of Fedson, Inc. This Quarterly Report on Form 10-Q also includes trade names and trademarks of other companies besides Titan.
All share and per share data in this report gives retroactive effect to a 1-for-20 reverse stock split effected on January 9, 2024.
Overview
We are a pharmaceutical company that was previously developing therapeutics utilizing the proprietary long-term drug delivery platform, ProNeura®, for the treatment of select chronic diseases for which steady state delivery of a drug has the potential to provide an efficacy and/or safety benefit. ProNeura consists of a small, solid implant made from a mixture of ethylene-vinyl acetate (“EVA”) and a drug substance. The resulting product is a solid matrix that is designed to be administered subdermally in a brief, outpatient procedure and is removed in a similar manner at the end of the treatment period.
Our first product based on the ProNeura technology was Probuphine® (buprenorphine implant), which is approved in the United States, Canada and the European Union (“EU”) for the maintenance treatment of opioid use disorder in clinically stable patients taking 8 mg or less a day of oral buprenorphine. While Probuphine continues to be commercialized in the EU (as Sixmo™) by another company that had acquired the rights from Titan, we discontinued commercialization of the product in the United States during the fourth quarter of 2020 and subsequently sold the product in September 2023. Discontinuation of our commercial operations has allowed us to focus our limited resources on important product development programs and transition back to a product development company.
In December 2021, we announced our intention to work with our financial advisor to explore strategic alternatives to enhance stockholder value, potentially including an acquisition, merger, reverse merger, other business combination, sales of assets, licensing or other transaction. In June 2022, we implemented a plan to reduce expenses and conserve capital that included a company-wide reduction in salaries and a scale back of certain operating expenses to enable us to maintain sufficient resources as we pursued potential strategic alternatives. In July 2022, David Lazar and Activist Investing LLC (collectively, “Activist”) acquired an approximately 25% ownership interest in Titan, filed a proxy statement and nominated six additional directors, each of whom was elected to our board of directors (the “Board”) at a special meeting of stockholders held on August 15, 2022 (the “Special Meeting”). The exploration and evaluation of possible strategic alternatives by the Board has continued following the Special Meeting. Following the election of the new directors at the Special Meeting, Dr. Marc Rubin was replaced as our Executive Chairman, and David Lazar assumed the role of Chief Executive Officer. In connection with the termination of his employment as Executive Chairman, Dr. Rubin received aggregate severance payments of approximately $0.4 million. In December 2022, we implemented additional cost reduction measures including a reduction in our workforce. In June 2023, David Lazar sold his approximately 25% ownership interest in Titan to Choong Choon Hau. Mr. Lazar resigned his position as the Company’s Chief Executive Officer in April 2024. Our Chairman of the Board of Directors, Seow Gim Shen, assumed the position as our Chief Executive Officer in April 2024.
In April 2024, David Lazar, our Chief Executive Officer, Kate Beebe DeVarney, Ph.D., our President and Chief Operating Officer and a member of our Board of Directors, and three other members of our Board of Directors, Eric Greenberg, Matthew C. McMurdo and David Natan, resigned their positions with the Company. Pursuant to the terms of their respective settlement agreements, we made payments in aggregate of approximately $1.2 million. The Board of Directors subsequently appointed Firdauz Edmin Bin Mokhtar and Francisco Osvaldo Flores García as independent directors of the Company to fill two of the vacancies created by the resignations. In addition, Dato Seow Gim Shen was appointed as Chief Executive Officer and Principal Financial Officer and will continue to serve as the Company’s Chairman of the Board, which he has done since October 12, 2023.
On September 1, 2023, (the “Closing Date”), we closed on the sale of certain ProNeura assets, including our portfolio of drug addiction products, in addition to other early development programs based on the ProNeura drug delivery technology (the “ProNeura Assets”). In July 2023, we entered into an asset purchase agreement (the “Asset Purchase Agreement”) with Fedson, Inc., a Delaware corporation (“Fedson”) for the sale of the ProNeura Assets. Our addiction portfolio consisted of the Probuphine and Nalmefene implant programs. The ProNeura Assets constituted only a portion of our assets. In August 2023, we entered into an Amendment and Extension Agreement (the “Amendment”) to the Asset Purchase Agreement, pursuant to which Fedson agreed to purchase our ProNeura Assets for a purchase price of $2.0 million, consisting of (i) $500,000 in readily available funds, paid in full on the Closing Date, (ii) $500,000 in the form of a promissory note due and payable on October 1, 2023 (the “Cash Note”) and (iii) $1,000,000 in the form of a promissory note due and payable on January 1, 2024 (the “Escrow Note”). We will also be eligible to receive potential milestone payments of up to $50 million on future net sales of the products and certain royalties on future net sales of the products. As further consideration, Fedson assumed all liabilities related to a pending employment claim against us. On the Closing Date, Fedson delivered a written guaranty by a principal of Fedson of all of Fedson’s obligations under both the Cash Note and Escrow Note. The Cash Note included provisions, which Fedson has exercised, allowing Fedson to extend the payment of the Cash Note to November 1, 2023 and again to December 1, 2023 upon payment of $5,000 for each extension. The Cash Note and Escrow Note were paid in December 2023 and January 2024, respectively. We received the funds from the escrow account in February 2024.
We operate in only one business segment, the development of pharmaceutical products. We make available free of charge through our website, www.titanpharm.com, our periodic reports as soon as reasonably practicable after we electronically file such material with, or furnish it to, the SEC.
Recent Accounting Pronouncements
See Note 1 to our financial statements included in our 2023 Annual Report on Form 10-K for information on recent accounting pronouncements.
Results of Operations for the Three and Six Months ended June 30, 2024 and June 30, 2023
Revenues
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
(in thousands) |
|
2024 |
|
|
2023 |
|
|
Change |
|
|
2024 |
|
|
2023 |
|
|
Change |
|
Revenues: |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
License revenue |
|
$ |
- |
|
|
$ |
1 |
|
|
$ |
(1 |
) |
|
$ |
- |
|
|
$ |
1 |
|
|
$ |
(1 |
) |
Grant revenue |
|
|
- |
|
|
|
82 |
|
|
|
(82 |
) |
|
|
- |
|
|
|
180 |
|
|
|
(180 |
) |
Total revenues |
|
$ |
- |
|
|
$ |
83 |
|
|
$ |
(83 |
) |
|
$ |
- |
|
|
$ |
181 |
|
|
$ |
(181 |
) |
The decrease in total revenues for the three and six months ended June 30, 2024 was primarily due to the completion of activities related to development grants in February 2024.
Operating Expenses
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
(in thousands) |
|
2024 |
|
|
2023 |
|
|
Change |
|
|
2024 |
|
|
2023 |
|
|
Change |
|
Operating expenses: |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and development |
|
$ |
- |
|
|
$ |
442 |
|
|
$ |
(442 |
) |
|
$ |
- |
|
|
$ |
1,003 |
|
|
$ |
(1,003 |
) |
General and administrative |
|
|
2,074 |
|
|
|
1,229 |
|
|
|
845 |
|
|
|
3,137 |
|
|
|
2,463 |
|
|
|
674 |
|
Total operating expenses |
|
$ |
2,074 |
|
|
$ |
1,671 |
|
|
$ |
403 |
|
|
$ |
3,137 |
|
|
$ |
3,466 |
|
|
$ |
(329 |
) |
The decrease in research and development costs for the three and six months ended June 30, 2024 was primarily associated with the completion of activities related to our development grants, decreases in expenses related to initial non-clinical proof of concept studies related to our TP-2021 implant program and decreases in research and development personnel-related costs and other expenses. Other research and development expenses include internal operating costs such as research and development personnel-related expenses, non-clinical and clinical product development related travel expenses, and allocation of facility and corporate costs. As a result of the risks and uncertainties inherently associated with pharmaceutical research and development activities described elsewhere in this document, we are unable to estimate the specific timing and future costs of our clinical development programs or the timing of material cash inflows, if any, from our product candidates.
The increase in general and administrative expenses for the three and six months ended June 30, 2024 was primarily related to increases in severance expenses and board payments offset by decreases in non-cash stock based compensation.
Other Income (Expense), Net
|
|
Three Months Ended June 30, |
|
|
Six Months Ended June 30, |
|
(in thousands) |
|
2024 |
|
|
2023 |
|
|
Change |
|
|
2024 |
|
|
2023 |
|
|
Change |
|
Other income (expense): |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Interest income (expense), net |
|
$ |
- |
|
|
$ |
7 |
|
|
$ |
(7 |
) |
|
$ |
1 |
|
|
$ |
29 |
|
|
$ |
(28 |
) |
Other expense, net |
|
|
(19 |
) |
|
|
(5 |
) |
|
|
(14 |
) |
|
|
(17 |
) |
|
|
(5 |
) |
|
|
(12 |
) |
Other income (expense), net |
|
$ |
(19 |
) |
|
$ |
2 |
|
|
$ |
(21 |
) |
|
$ |
(16 |
) |
|
$ |
24 |
|
|
$ |
(40 |
) |
The decrease in other income (expense), net for the three and six months ended June 30, 2024 was primarily due to decreases in interest income and non-income tax related expenses.
Net Loss and Net Loss per Share
Our net loss from operations for the three-month period ended June 30, 2024 was approximately $2.1 million, or approximately $2.29 per share, compared to our net loss from operations of approximately $1.6 million, or approximately $2.11 per share, for the comparable period in 2023. Our net loss from operations for the six-month period ended June 30, 2024 was approximately $3.2 million, or approximately $3.57 per share, compared to our net loss from operations of approximately $3.3 million, or approximately $4.34 per share, for the comparable period in 2023.
Liquidity and Capital Resources
We have funded our operations since inception primarily through the sale of our securities and the issuance of debt, as well as with proceeds from warrant and option exercises, corporate licensing and collaborative agreements, and government-sponsored research grants. At June 30, 2024, we had a working capital of approximately $4.0 million compared to working capital of approximately $6.6 million at December 31, 2023.
In September 2023, we entered into a purchase agreement with Sire Group, pursuant to which we agreed to issue 950,000 shares of our Series AA Convertible Preferred Stock at a price of $10.00 per share, for an aggregate purchase price of $9.5 million. The purchase price consisted of (i) $5.0 million in cash at closing and (ii) $4.5 million in the form of a promissory note from Sire Group which was paid in September 2023. The net cash proceeds from this transaction were approximately $9.5 million.
In September 2023, we closed on the sale of the ProNeura Assets pursuant to the Asset Purchase Agreement with Fedson. The ProNeura Assets constituted only a portion of our assets. In August 2023, we entered into an Amendment to the Asset Purchase Agreement, pursuant to which Fedson agreed to purchase our ProNeura Assets for a purchase price of $2.0 million, consisting of (i) $500,000 in readily available funds, paid in full on the Closing Date, (ii) $500,000 in the form of the Cash Note and (iii) $1,000,000 in the form of the Escrow Note. We will also be eligible to receive potential milestone payments of up to $50 million on future net sales of the products and certain royalties on future net sales of the products. As further consideration, Fedson assumed all liabilities related to a pending employment claim against us. On the Closing Date, Fedson delivered a written guaranty by a principal of Fedson of all of Fedson’s obligations under both the Cash Note and Escrow Note. The Cash Note included provisions, which Fedson has exercised, allowing Fedson to extend the payment of the Cash Note to November 1, 2023 and again to December 1, 2023 upon payment of $5,000 for each extension. The Cash Note and Escrow Note were paid in December 2023 and January 2024, respectively. We received the funds from the escrow account in February 2024.
In August 2023, we received $500,000 in funding in exchange for the issuance of a convertible promissory note for that principal amount to Choong Choon Hau (the “Hau Promissory Note”). Pursuant to the Hau Promissory Note, the principal amount will accrue interest at a rate of 10% per annum and will be payable monthly. All principal and accrued interest shall be due and payable on January 8, 2024, unless extended as provided. All or part of the Hau Promissory Note could be converted into our common stock at a conversion price of $9.32 per share from time to time following the issuance date and ending on the maturity date. In March 2024, the Hau Promissory Note, along with accrued interest, was converted into 54,132 shares of our common stock.
At June 30, 2024, we had cash and cash equivalents of approximately $4.1 million, which we believe is sufficient to fund our planned operations through the third quarter of 2025. We are exploring several financing and strategic alternatives; however, there can be no assurance that our efforts will be successful.
Sources and Uses of Cash
|
|
Six months Ended June 30, |
|
(in thousands) |
|
2024 |
|
|
2023 |
|
Net cash used in operating activities |
|
$ |
(2,681 |
) |
|
$ |
(3,011 |
) |
Net decrease in cash and cash equivalents |
|
$ |
(2,681 |
) |
|
$ |
(3,011 |
) |
Net cash used in operating activities for the six months ended June 30, 2024 consisted primarily of our net loss of approximately $3.2 million, offset by approximately $0.5 million related to net changes in operating assets and liabilities. Net cash used in operating activities for the six months ended June 30, 2023 consisted primarily of our net loss of approximately $3.3 million, approximately $0.4 million related to net changes in operating assets and liabilities, partially offset by approximately $0.6 million of non-cash charges primarily related to stock-based compensation and depreciation and amortization.
Item 3. Quantitative and Qualitative Disclosures About Market Risk
Our market risk disclosures set forth in our Annual Report on Form 10-K for the year ended December 31, 2023 have not materially changed.
Item 4. Controls and Procedures
(a) Evaluation of Disclosure Controls and Procedures: Our principal executive and financial officers reviewed and evaluated the effectiveness of our disclosure controls and procedures (as defined in Exchange Act Rule 13a-15(e)) as of the end of the period covered by this Quarterly Report on Form 10-Q. Based on that evaluation, our principal executive and financial officers concluded that our disclosure controls and procedures were not effective for the timely provision of material information relating to Titan, as required to be disclosed in the reports we file under the Exchange Act due to the identification of a material weakness in internal control over financial reporting described below.
Notwithstanding the conclusion by principal executive and financial officers that the disclosure controls and procedures as of June 30, 2024 and December 31, 2023 were not effective and the material weakness identified in internal controls over financial reporting described below, management believes that the consolidated financial statements and related financial information included in this Quarterly Report on Form 10-Q fairly present in all material respects our financial condition, results of operations and cash flows as of the dates presented, and for the periods ended on such dates, in conformity with accounting principles generally accepted in the United States (US GAAP).
(b) Management’s Annual Report on Internal Control Over Financial Reporting:
Internal control over financial reporting refers to the process designed by, or under the supervision of, our principal executive officer and principal financial officer, and effected by our Board, management and other personnel, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles, and includes those policies and procedures that:
|
(1) |
Pertain to the maintenance of records that in reasonable detail accurately and fairly reflect the transactions and dispositions of our assets; |
|
(2) |
Provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that our receipts and expenditures are being made only in accordance with authorization of our management and directors; and |
|
(3) |
Provide reasonable assurance regarding prevention or timely detection of unauthorized acquisitions, use or disposition of our assets that could have a material effect on the financial statements. |
Internal control over financial reporting cannot provide absolute assurance of achieving financial reporting objectives because of its inherent limitations. Internal control over financial reporting is a process that involves human diligence and compliance and is subject to lapses in judgment and breakdowns resulting from human failures. Internal control over financial reporting can also be circumvented by collusion or improper management overrides. Due to such limitations, there is a risk that material misstatements may not be prevented or detected on a timely basis by internal control over financial reporting. However, these inherent limitations are known features of the financial reporting process. Therefore, it is possible to design into the process safeguards to reduce, though not eliminate, this risk. Management is responsible for establishing and maintaining adequate internal control over financial reporting for Titan.
Management has used the framework set forth in the report entitled Internal Control—Integrated Framework published by the Committee of Sponsoring Organizations of the Treadway Commission (2013 framework), known as COSO, to evaluate the effectiveness of Titan’s internal control over financial reporting. Based on this assessment, management has concluded that our internal controls over financial reporting were not effective as of June 30, 2024 and December 31, 2023.
A material weakness is a deficiency, or a combination of deficiencies, in internal control over financial reporting, such that a reasonable possibility exists that a material misstatement of the annual or interim financial statements would not be prevented or detected on a timely basis. Our management identified a deficiency in our internal control over financial reporting that gave rise to a material weakness. The deficiency was primarily related to limited finance and accounting staffing levels not commensurate with our complexity and our financial accounting and reporting requirements. We underwent organizational changes in 2023 and 2022, including multiple reductions in workforce and operate with a very lean finance and accounting department. This limited staffing resulted in a lack of resources to fully monitor and operate our internal controls over financial reporting as of December 31, 2023, resulting in a deficiency being discovered during our annual auditing process.
Management discovered a material weakness in our internal controls over financial reporting which resulted in the misclassification of issuance costs of approximately $0.4 million related to the issuance of preferred stock during the three months ended September 30, 2023.
Remediation Activities
Management continues to evaluate the material weakness discussed above, has created a remediation plan that it has already begun implementing and continues to finalize that plan’s implementation. For example, we will be hiring a new Chief Financial Officer to oversee our controls environment and continue to utilize a Sarbanes-Oxley compliance firm to assist in testing and implementing additional controls and procedures in our finance and accounting department. We have corrected the deficiency discovered during our annual audit process prior to the filing of the annual report. However, assurance as to when all remediation efforts will be complete cannot be provided and the material weakness cannot be considered remedied until the applicable controls have operated for a sufficient period of time and management has concluded, through testing, that these controls are operating effectively. Management cannot provide assurances that the measures that have been taken to date, and are continuing to be implemented, will be sufficient to remediate the material weakness identified or to avoid potential future material weaknesses.
(c) Changes in Internal Control Over Financial Reporting: Other than with respect to the ongoing remediation efforts described above, there were no other changes in our internal control over financial reporting (as defined in Rules 13(a)-15(f) and 15(d)-15(f) under the Securities Act) during our most recent fiscal quarter that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.
We are a smaller reporting company and a non-accelerated filer, and therefore our independent registered public accounting firm has not issued a report on the effectiveness of internal control over financial reporting.
PART II. Other Information
Item 1. Legal Proceedings
In September 2023, Fedson, as further consideration for the Asset Purchase Agreement, agreed to assume all liabilities related to a pending employment claim initiated by a former employee alleging wrongful termination, retaliation, infliction of emotional distress, negligent supervision, hiring and retention and slander. See Note 4. Commitments and Contingencies.
Item 1A. Risk Factors
In addition to the other information set forth in this report, you should carefully consider the factors discussed in Part I, “Item 1A. Risk Factors” in our 2023 10-K, which could materially affect our business, financial condition or future results. The risks described in our 2023 10-K are not the only risks facing our company. Except as noted below, the risks and uncertainties described in “Item 1A – Risk Factors” have not materially changed. Additional risks and uncertainties not currently known to us or that we currently deem to be immaterial also may materially adversely affect our business, financial condition and/or operating results.
Item 2. Unregistered Sales of Equity Securities and Use of Proceeds.
In August 2023, we received $500,000 in funding in exchange for the issuance of a convertible promissory note for that principal amount to Choong Choon Hau (the “Hau Promissory Note”). Pursuant to the Hau Promissory Note, the principal amount accrues interest at a rate of 10% per annum and is payable monthly. All principal and accrued interest was due and payable on January 8, 2024, unless extended as provided. All or part of the Hau Promissory Note could be converted into our common stock at a conversion price of $9.32 per share from time to time following the issuance date and ending on the maturity date.
On March 18, 2024, we issued 54,132 shares of our common stock to Mr. Hau in connection with the conversion of the $500,000 unpaid principal amount and accrued interest of the Hau Promissory Note. Pursuant to the terms of the Hau Promissory Note, Mr. Hau was permitted to convert the unpaid principal amount and accrued interest thereof into shares of our common stock at a conversion price of $9.32 per share at any time following the issuance date of August 8, 2023. Following the conversion of the Convertible Note, Mr. Hau owns approximately 241,531 shares of our common stock, or approximately 26.4% of the shares outstanding.
The issuance of common stock was made pursuant to the exemption from the registration requirements of the Securities Act of 1933, as amended (the “Securities Act”), provided by Section 3(a)(9) of the Securities Act.
Item 5. Other Information.
None of our directors or executive officers adopted or terminated a Rule 10b5-1 trading arrangement or a non-Rule 10b5-1 trading arrangement during the six months ended June 30, 2024, as such terms are defined under Item 408(a) or Regulation S-K.
Item 6. Exhibits
SIGNATURE
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.
|
TITAN PHARMACEUTICALS, INC. |
|
|
|
Dated: August 15, 2024 |
By: |
/s/ Dato Seow Gim Shen |
|
Name: |
Dato Seow Gim Shen |
|
Title: |
Chief Executive Officer |
|
|
(Principal Executive Officer) |
Exhibit
31.1
CERTIFICATION
I,
Dato Seow Gim Shen, certify that:
1.
I have reviewed this Quarterly Report on Form 10-Q of Titan Pharmaceuticals, Inc.;
2.
Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary
to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to
the period covered by this report;
3.
Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all
material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented
in this report;
4.
I am responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e)
and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f) for
the registrant and have:
|
(a) |
Designed
such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under my supervision,
to ensure that material information relating to the registrant is made known to me by others within those entities, particularly
during the period in which this report is being prepared; |
|
|
|
|
(b) |
Designed
such internal control over financial reporting, or caused such internal control over financial reporting to be designed under
my supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial
statements for external purposes in accordance with generally accepted accounting principles; |
|
|
|
|
(c) |
Evaluated
the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions
about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based
on such evaluation; and |
|
|
|
|
(d) |
Disclosed
in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s
most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially
affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting;
and |
5.
I have disclosed, based on my most recent evaluation of internal control over financial reporting, to the registrant’s auditors
and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):
|
(a) |
All
significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting
which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial
information; and |
|
|
|
|
(b) |
Any
fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s
internal control over financial reporting. |
Date:
August 15, 2024 |
|
|
|
|
|
/s/
Dato Seow Gim Shen |
|
Name: |
Dato
Seow Gim Shen |
|
Title: |
Chief
Executive Officer |
|
|
(Principal
Executive Officer and Principal Financial Officer) |
|
Exhibit
32.1
CERTIFICATION
PURSUANT TO
18
U.S.C. SECTION 1350,
AS
ADOPTED PURSUANT TO SECTION 906
OF
THE SARBANES-OXLEY ACT OF 2002
In
connection with this quarterly report on Form 10-Q of Titan Pharmaceuticals, Inc. (the “Company”) for the period ended
June 30, 2024, as filed with the Securities and Exchange Commission on the date hereof (the “Report”), the undersigned
officer of the Company hereby certifies, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the
Sarbanes-Oxley Act of 2002, that to the best of his knowledge:
(1)
The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and
(2)
The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations
of the Company.
Date:
August 15, 2024 |
|
|
|
|
|
/s/
Dato Seow Gim Shen |
|
Name: |
Dato
Seow Gim Shen |
|
Title: |
Chief
Executive Officer |
|
|
(Principal
Executive Officer and Principal Financial Officer) |
|
v3.24.2.u1
Cover - shares
|
6 Months Ended |
|
Jun. 30, 2024 |
Aug. 09, 2024 |
Cover [Abstract] |
|
|
Document Type |
10-Q
|
|
Amendment Flag |
false
|
|
Document Quarterly Report |
true
|
|
Document Transition Report |
false
|
|
Document Period End Date |
Jun. 30, 2024
|
|
Document Fiscal Period Focus |
Q2
|
|
Document Fiscal Year Focus |
2024
|
|
Current Fiscal Year End Date |
--12-31
|
|
Entity File Number |
001-13341
|
|
Entity Registrant Name |
Titan Pharmaceuticals, Inc.
|
|
Entity Central Index Key |
0000910267
|
|
Entity Tax Identification Number |
94-3171940
|
|
Entity Incorporation, State or Country Code |
DE
|
|
Entity Address, Address Line One |
400 Oyster Point Blvd.
|
|
Entity Address, Address Line Two |
Suite 505
|
|
Entity Address, City or Town |
South San Francisco
|
|
Entity Address, State or Province |
CA
|
|
Entity Address, Postal Zip Code |
94080
|
|
City Area Code |
(650)
|
|
Local Phone Number |
244-4990
|
|
Title of 12(b) Security |
Common Stock, par value $0.001
|
|
Trading Symbol |
TTNP
|
|
Security Exchange Name |
NASDAQ
|
|
Entity Current Reporting Status |
Yes
|
|
Entity Interactive Data Current |
Yes
|
|
Entity Filer Category |
Non-accelerated Filer
|
|
Entity Small Business |
true
|
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v3.24.2.u1
CONDENSED BALANCE SHEETS (Unaudited) - USD ($) $ in Thousands |
Jun. 30, 2024 |
Dec. 31, 2023 |
Current assets: |
|
|
Cash and cash equivalents |
$ 4,092
|
$ 6,760
|
Restricted cash |
|
13
|
Receivables |
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|
46
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Notes receivable |
|
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|
Prepaid expenses and other current assets |
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|
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|
Total current assets |
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|
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|
Property and equipment, net |
|
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|
Operating lease right-of-use assets, net |
|
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|
Total assets |
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|
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|
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|
Note payable to related party |
|
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|
Other accrued liabilities |
|
519
|
Operating lease liability, current |
|
65
|
Deferred grant revenue |
|
12
|
Total current liabilities |
356
|
1,444
|
Total liabilities |
356
|
1,444
|
Stockholders’ equity: |
|
|
Preferred stock, at amounts paid in, $0.001 par value per share; 5,000,000 shares authorized, 950,000 shares issued and outstanding at June 30, 2024 and December 31, 2023. |
1
|
1
|
Common stock, at amounts paid-in, $0.001 par value per share; 225,000,000 shares authorized, 914,234 and 781,503 shares issued and outstanding at June 30, 2024 and December 31, 2023, respectively. |
1
|
1
|
Additional paid-in capital |
398,975
|
398,470
|
Accumulated deficit |
(394,983)
|
(391,830)
|
Total stockholders’ equity |
3,994
|
6,642
|
Total liabilities and stockholders’ equity |
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v3.24.2.u1
CONDENSED BALANCE SHEETS (Unaudited) (Parenthetical) - $ / shares
|
Jun. 30, 2024 |
Dec. 31, 2023 |
Statement of Financial Position [Abstract] |
|
|
Preferred stock, par value |
$ 0.001
|
$ 0.001
|
Preferred stock, shares authorized |
5,000,000
|
5,000,000
|
Preferred stock, shares issued |
950,000
|
950,000
|
Preferred stock, shares outstanding |
950,000
|
950,000
|
Common stock, par value |
$ 0.001
|
$ 0.001
|
Common stock, shares authorized |
225,000,000
|
225,000,000
|
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914,234
|
781,503
|
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914,234
|
781,503
|
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v3.24.2.u1
CONDENSED STATEMENTS OF OPERATIONS (Unaudited) - USD ($) shares in Thousands, $ in Thousands |
3 Months Ended |
6 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Jun. 30, 2024 |
Jun. 30, 2023 |
Revenues: |
|
|
|
|
Total revenues |
|
$ 83
|
|
$ 181
|
Operating expenses: |
|
|
|
|
Research and development |
|
442
|
|
1,003
|
General and administrative |
2,074
|
1,229
|
3,137
|
2,463
|
Total operating expenses |
2,074
|
1,671
|
3,137
|
3,466
|
Loss from operations |
(2,074)
|
(1,588)
|
(3,137)
|
(3,285)
|
Other income (expense): |
|
|
|
|
Interest income |
|
7
|
1
|
29
|
Other expense, net |
(19)
|
(5)
|
(17)
|
(5)
|
Other income (expense), net |
(19)
|
2
|
(16)
|
24
|
Net loss |
$ (2,093)
|
$ (1,586)
|
$ (3,153)
|
$ (3,261)
|
Basic net loss per common share |
$ (2.29)
|
$ (2.11)
|
$ (3.57)
|
$ (4.34)
|
Diluted net loss per common share |
$ (2.29)
|
$ (2.11)
|
$ (3.57)
|
$ (4.34)
|
Weighted average shares used in computing basic net loss per common share |
914
|
751
|
884
|
751
|
Weighted average shares used in computing diluted net loss per common share |
914
|
751
|
884
|
751
|
License [Member] |
|
|
|
|
Revenues: |
|
|
|
|
Total revenues |
|
$ 1
|
|
$ 1
|
Grant [Member] |
|
|
|
|
Revenues: |
|
|
|
|
Total revenues |
|
$ 82
|
|
$ 180
|
X |
- DefinitionThe amount of net income (loss) for the period per each share of common stock or unit outstanding during the reporting period.
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v3.24.2.u1
CONDENSED STATEMENTS OF STOCKHOLDERS' EQUITY (DEFICIT) (Unaudited) - USD ($) shares in Thousands, $ in Thousands |
Preferred Stock [Member] |
Common Stock [Member] |
Additional Paid-in Capital [Member] |
Retained Earnings [Member] |
Total |
Beginning balance, value at Dec. 31, 2022 |
|
$ 1
|
$ 387,623
|
$ (386,261)
|
$ 1,363
|
Beginning balance, shares at Dec. 31, 2022 |
|
751
|
|
|
|
Net loss |
|
|
|
(1,675)
|
(1,675)
|
Ending balance, value at Mar. 31, 2023 |
|
$ 1
|
387,623
|
(387,936)
|
(312)
|
Ending balance, shares at Mar. 31, 2023 |
|
751
|
|
|
|
Net loss |
|
|
|
(1,586)
|
(1,586)
|
Stock-based compensation |
|
|
864
|
|
864
|
Ending balance, value at Jun. 30, 2023 |
|
$ 1
|
388,487
|
(389,522)
|
(1,034)
|
Ending balance, shares at Jun. 30, 2023 |
|
751
|
|
|
|
Beginning balance, value at Dec. 31, 2023 |
$ 1
|
$ 1
|
398,470
|
(391,830)
|
6,642
|
Beginning balance, shares at Dec. 31, 2023 |
950
|
782
|
|
|
|
Net loss |
|
|
|
(1,060)
|
(1,060)
|
Issuance of common stock upon conversion of note payable |
|
|
504
|
|
504
|
Issuance of common stock upon conversion of note payable, shares |
|
54
|
|
|
|
Fractional shares issued due to reverse stock split |
|
|
1
|
|
1
|
Fractional shares issued due to reverse stock split, shares |
|
78
|
|
|
|
Ending balance, value at Mar. 31, 2024 |
$ 1
|
$ 1
|
398,975
|
(392,890)
|
6,087
|
Ending balance, shares at Mar. 31, 2024 |
950
|
914
|
|
|
|
Net loss |
|
|
|
(2,093)
|
(2,093)
|
Ending balance, value at Jun. 30, 2024 |
$ 1
|
$ 1
|
$ 398,975
|
$ (394,983)
|
$ 3,994
|
Ending balance, shares at Jun. 30, 2024 |
950
|
914
|
|
|
|
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v3.24.2.u1
CONDENSED STATEMENTS OF CASH FLOWS (unaudited) - USD ($) $ in Thousands |
6 Months Ended |
Jun. 30, 2024 |
Jun. 30, 2023 |
Cash flows from operating activities: |
|
|
Net loss |
$ (3,153)
|
$ (3,261)
|
Adjustments to reconcile net loss to net cash used in operating activities: |
|
|
Depreciation and amortization |
5
|
82
|
Stock-based compensation |
|
554
|
Other |
(2)
|
|
Changes in operating assets and liabilities: |
|
|
Receivables |
8
|
18
|
Notes receivable |
1,000
|
|
Prepaid expenses and other assets |
(21)
|
76
|
Accounts payable |
8
|
(37)
|
Deferred grant revenue |
(12)
|
(180)
|
Other accrued liabilities |
(514)
|
(263)
|
Net cash used in operating activities |
(2,681)
|
(3,011)
|
Net decrease in cash, cash equivalents and restricted cash |
(2,681)
|
(3,011)
|
Cash, cash equivalents and restricted cash at beginning of period |
6,773
|
3,133
|
Cash, cash equivalents and restricted cash at end of period |
4,092
|
122
|
Supplemental cash flow information: |
|
|
Interest paid |
13
|
|
Note payable to related party converted to common stock |
500
|
|
Accrued interest net of tax converted to common stock |
5
|
|
Disposal of fully depreciated property and equipment |
711
|
|
Reclassification of inventory to assets held for sale |
|
105
|
Reclassification of property and equipment, net to assets held for sale |
|
133
|
Reclassification of accrued liabilities to liabilities held for sale |
|
236
|
Cash and cash equivalents |
4,092
|
105
|
Restricted cash |
|
17
|
Cash, cash equivalents and restricted cash shown in the condensed statements of cash flows |
$ 4,092
|
$ 122
|
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v3.24.2.u1
Organization and Summary of Significant Accounting Policies
|
6 Months Ended |
Jun. 30, 2024 |
Accounting Policies [Abstract] |
|
Organization and Summary of Significant Accounting Policies |
| 1. |
Organization and Summary of Significant Accounting Policies |
The Company
Titan Pharmaceuticals, Inc. (“Titan” or the “Company” or “we,” “our” or “us”) is a pharmaceutical company that was previously developing therapeutics utilizing the proprietary long-term drug delivery platform, ProNeura®, for the treatment of select chronic diseases for which steady state delivery of a drug has the potential to provide an efficacy and/or safety benefit. ProNeura consists of a small, solid implant made from a mixture of ethylene-vinyl acetate and a drug substance. The resulting product is a solid matrix that is designed to be administered subdermally in a brief, outpatient procedure and is removed in a similar manner at the end of the treatment period.
Our first product based on the ProNeura technology was Probuphine® (buprenorphine implant), which is approved in the United States, Canada and the European Union (“EU”) for the maintenance treatment of opioid use disorder in clinically stable patients taking 8 milligrams or less a day of oral buprenorphine. While Probuphine continues to be commercialized in the EU (as Sixmo™) by another company that had acquired the rights from us, we discontinued commercialization of the product in the United States during the fourth quarter of 2020 and subsequently sold the product in September 2023. Discontinuation of our commercial operations allowed us to focus our limited resources on product development programs and transition back to a product development company.
In December 2021, we announced
our intention to work with our financial advisor to explore strategic alternatives to enhance stockholder value, potentially including
an acquisition, merger, reverse merger, other business combination, sales of assets, licensing or other transaction. In June 2022,
we implemented a plan to reduce expenses and conserve capital that included a company-wide reduction in salaries and a scale back of
certain operating expenses to enable us to maintain sufficient resources as we pursued potential strategic alternatives. In July 2022,
David Lazar and Activist Investing LLC acquired an approximately 25% ownership interest in Titan, filed a proxy statement and nominated
six additional directors, each of whom was elected to our board of directors (the “Board”) at a special meeting of stockholders
held on August 15, 2022 (the “Special Meeting”). The exploration and evaluation of possible strategic alternatives by
the Board has continued following the Special Meeting. Following the election of the new directors at the Special Meeting, Dr. Marc Rubin
was replaced as our Executive Chairman, and David Lazar assumed the role of Chief Executive Officer. In connection with the termination
of his employment as Executive Chairman, Dr. Rubin received aggregate severance payments of approximately $0.4 million. In December 2022,
we implemented additional cost reduction measures including a reduction in our workforce. In June 2023, David Lazar sold his approximately
25% ownership interest in Titan to Choong Choon Hau. Mr. Lazar resigned his position as the Company’s Chief Executive Officer
in April 2024. Our Chairman of the Board of Directors, Seow Gim Shen, assumed the position as our Chief Executive Officer in April 2024.
On September 1, 2023 (the “Closing Date”), we closed on the sale of certain ProNeura assets, including our portfolio of drug addiction products, in addition to other early development programs based on the ProNeura drug delivery technology (the “ProNeura Assets”). In July 2023, we entered into an asset purchase agreement (the “Asset Purchase Agreement”) with Fedson, Inc., a Delaware corporation (“Fedson”), for the sale of the ProNeura Assets. Our addiction portfolio consisted of the Probuphine and Nalmefene implant programs. The ProNeura Assets constituted only a portion of our assets. In August 2023, we entered into an Amendment and Extension Agreement (the “Amendment”) to the Asset Purchase Agreement, pursuant to which Fedson agreed to purchase our ProNeura Assets for a purchase price of $2.0 million, consisting of (i) $500,000 in readily available funds, paid in full on the Closing Date, (ii) $500,000 in the form of a promissory note due and payable on October 1, 2023 (the “Cash Note”) and (iii) $1,000,000 in the form of a promissory note due and payable on January 1, 2024 (the “Escrow Note”). We will also be eligible to receive potential milestone payments of up to $50 million on future net sales of the products and certain royalties on future net sales of the products. As further consideration, Fedson assumed all liabilities related to a pending employment claim against us. On the Closing Date, Fedson delivered a written guaranty by a principal of Fedson of all of Fedson’s obligations under both the Cash Note and Escrow Note. The Cash Note included provisions, which Fedson has exercised, allowing Fedson to extend the payment of the Cash Note to November 1, 2023 and again to December 1, 2023 upon payment of $5,000 for each extension. The Cash Note and Escrow Note were paid in December 2023 and January 2024, respectively. We received the funds from the escrow account in February 2024.
In April 2024, David Lazar, our Chief Executive Officer, Kate Beebe DeVarney, Ph.D., our President and Chief Operating Officer and a member of our Board of Directors, and three other members of our Board of Directors, Eric Greenberg, Matthew C. McMurdo and David Natan, resigned their positions with the Company. Pursuant to the terms of their respective settlement agreements, we made payments in aggregate of approximately $1.2 million. The Board of Directors subsequently appointed Firdauz Edmin Bin Mokhtar and Francisco Osvaldo Flores García as independent directors of the Company to fill two of the vacancies created by the resignations. In addition, Dato Seow Gim Shen was appointed as Chief Executive Officer and Principal Financial Officer and will continue to serve as the Company’s Chairman of the Board, which he has done since October 12, 2023.
All share and per share amounts give retroactive effect to a 1-for-20 reverse stock split effected on January 8, 2024 (see Note 6. Stockholders’ Equity).
Basis of Presentation
The accompanying unaudited condensed financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“GAAP”) for interim financial information and with the instructions to Form 10-Q and Article 8 of Regulation S-X. Accordingly, they do not include all the information and footnotes required by GAAP for complete financial statement presentation. In the opinion of management, all adjustments (consisting of normal recurring adjustments) considered necessary for a fair presentation have been included. Operating results for the six months ended June 30, 2024 are not necessarily indicative of the results that may be expected for the year ending December 31, 2024, or any future interim periods.
The balance sheet as of December 31, 2023 is derived from the audited financial statements at that date but does not include all the information and footnotes required by GAAP for complete financial statements. These unaudited condensed financial statements should be read in conjunction with the audited financial statements and footnotes thereto included in the Titan Pharmaceuticals, Inc. Annual Report on Form 10-K for the year ended December 31, 2023, as filed with the Securities and Exchange Commission.
The accompanying condensed financial statements have been prepared assuming we will continue as a going concern.
As of June 30, 2024, we had cash and cash equivalents of approximately $4.1 million, which we believe is sufficient to fund our planned operations through the third quarter of 2025. We are exploring several financing and strategic alternatives; however, there can be no assurance that our efforts will be successful.
Going Concern Assessment
We assess going concern
uncertainty in our condensed financial statements to determine if we have sufficient cash on hand and working capital, including
available borrowings on loans, to operate for a period of at least one year from the date the condensed financial statements are
issued or available to be issued, which is referred to as the look-forward period as defined by Accounting Standards Update
(“ASU”) No. 2014-15, Disclosure of Uncertainties about an Entity’s Ability to Continue as a Going Concern.
As part of this assessment, based on conditions that are known and reasonably knowable to us, we will consider various scenarios,
forecasts, projections, estimates and will make certain key assumptions, including the timing and nature of projected cash
expenditures or programs, and its ability to delay or curtail expenditures or programs, if necessary, among other factors. Based on
this assessment, as necessary or applicable, we make certain assumptions around implementing curtailments or delays in the nature
and timing of programs and expenditures to the extent we deem probable those implementations can be achieved, and we have the proper
authority to execute them within the look-forward period in accordance with ASU No. 2014-15.
Based upon the above assessment, we concluded that, at the date of filing the condensed financial statements in this Quarterly Report on Form 10-Q for the six months ended June 30, 2024, we have sufficient cash to fund our operations for the next 12 months without additional funds.
Use of Estimates
The preparation of condensed financial statements in conformity with accounting principles generally accepted in the U.S. requires management to make estimates and assumptions that affect the amounts reported in the condensed financial statements and accompanying notes. Actual results could differ from those estimates.
Stock-Based Compensation
We recognize compensation expense using a fair-value based method for all stock-based payments including stock options and restricted stock awards and stock issued under an employee stock purchase plan. These standards require companies to estimate the fair value of stock-based payment awards on the date of grant using an option pricing model. See Note 2. Stock Plans for a discussion of our stock-based compensation plans.
Cash and Cash Equivalents
Our investment policy emphasizes liquidity and preservation of principal over other portfolio considerations. We select investments that maximize interest income to the extent possible given these two constraints. We satisfy liquidity requirements by investing excess cash in securities with different maturities to match projected cash needs and limit concentration of credit risk by diversifying our investments among a variety of high credit-quality issuers and limit the amount of credit exposure to any one issuer. The estimated fair values have been determined using available market information. We do not use derivative financial instruments in our investment portfolio.
All investments with original maturities of three months or less are considered to be cash equivalents. We had no money market funds as of June 30, 2024 and December 31, 2023, included in our cash and cash equivalents.
We maintain significant cash balances at financial institutions which throughout the year regularly exceed the federally insured limit of $250,000. Any loss incurred or a lack of access to such funds could have a significant adverse impact on our financial condition, results of operations, and cash flows.
Restricted Cash
In accordance with ASU No. 2016-18, Statement of Cash Flows (Topic 230): Restricted Cash, we explain the change during the period in the total of cash, cash equivalents and restricted cash, and include restricted cash with cash and cash equivalents when reconciling the beginning-of-period and end-of-period total amounts shown on the condensed statements of cash flows.
Prepaid Expenses and Other Current Assets
Prepaid Expenses and Other Current Assets consist primarily of prepaid insurance, prepaid rent, prepaid payroll and other expenses. Prepaid expenses are recorded at cost and are amortized over the periods benefited using the straight-line method. The Company reviews prepaid expenses at each balance sheet date and adjusts the carrying amounts as necessary to reflect the remaining estimated benefit.
Property and Equipment
Property and equipment are
recorded at cost and depreciated using the straight-line method over the estimated useful lives of the assets ranging from three 3
to 5 five years. Leasehold improvements are amortized over the shorter of the lease term or the estimated useful life of the
assets.
Revenue Recognition
We generate revenue principally from collaborative research and development arrangements and government grants.
Grant Revenue
We had contracts with National Institute on Drug Abuse or NIDA, within the U.S. Department of Health and Human Services, the Bill & Melinda Gates Foundation, and other government-sponsored organizations for research and development related activities that provided for payments for reimbursed costs, which may have included overhead and general and administrative costs. We recognized revenue from these contracts as we performed services under these arrangements when the funding was committed. Associated expenses were recognized when incurred as research and development expense. Revenues and related expenses are presented gross in the condensed statements of operations.
Receivables
The following table presents the activity related to our receivables for the six months ended June 30, 2024.
Schedule of activity related to our accounts receivable |
|
|
|
|
(in thousands) |
|
|
|
Balance at January 1, 2024 |
|
$ |
46 |
|
Deductions |
|
|
(8 |
) |
Balance at June 30, 2024 |
|
$ |
38 |
|
Research and Development Costs and Related Accrual
Research and development expenses include internal and external costs. Internal costs include salaries and employment related expenses, facility costs, administrative expenses and allocations of corporate costs. External expenses consist of costs associated with outsourced contract research organization activities, sponsored research studies, product registration, and investigator sponsored trials. Significant judgments and estimates must be made and used in determining the accrued balance in any accounting period. Actual results could differ from those estimates under different assumptions. Revisions are charged to expense in the period in which the facts that give rise to the revision become known.
Leases
We determine whether the arrangement is or contains a lease at inception. Operating lease right-of-use assets and lease liabilities are recognized at the present value of the future lease payments at commencement date. The interest rate implicit in lease contracts is typically not readily determinable, and therefore, we utilize our incremental borrowing rate, which is the rate incurred to borrow on a collateralized basis over a similar term an amount equal to the lease payments in a similar economic environment. Certain adjustments to the right-of-use asset may be required for items such as initial direct costs paid or incentives received.
Lease expense is recognized over the expected term on a straight-line basis. Operating leases are recognized on our condensed balance sheets as right-of-use assets, operating lease liabilities current and operating lease liabilities non-current.
The operating lease expired on June 30, 2024.
Recent Accounting Pronouncements
There are no recent
accounting pronouncements that will have a material impact on our condensed financial statements.
Fair Value Measurements
Financial instruments, including receivables, accounts payable and accrued liabilities, are carried at cost, and their fair values are approximated due to the short-term nature of these instruments.
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v3.24.2.u1
Stock Plans
|
6 Months Ended |
Jun. 30, 2024 |
Share-Based Payment Arrangement [Abstract] |
|
Stock Plans |
The following table summarizes option activity:
Schedule of our option activity |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Options (in thousands) |
|
|
Weighted
Average Exercise
Price per share |
|
|
Weighted
Average Remaining Option Term (in years) |
|
|
Aggregate Intrinsic Value (in thousands) |
|
Outstanding at December 31, 2023 |
|
|
93 |
|
|
$ |
73.46 |
|
|
|
8.35 |
|
|
$ |
- |
|
Outstanding at June 30, 2024 |
|
|
93 |
|
|
|
72.76 |
|
|
|
7.55 |
|
|
|
- |
|
Exercisable at June 30, 2024 |
|
|
93 |
|
|
|
72.76 |
|
|
|
7.55 |
|
|
|
- |
|
The following table summarizes the stock-based compensation expense recorded for awards under our stock option plans:
Schedule of the stock-based compensation expense |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended |
|
|
Six Months Ended |
|
|
|
June 30, |
|
|
June 30, |
|
(in thousands) |
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
Research and development |
|
$ |
- |
|
|
$ |
26 |
|
|
$ |
- |
|
|
$ |
54 |
|
Selling, general and administrative |
|
|
- |
|
|
|
239 |
|
|
|
- |
|
|
|
500 |
|
Total stock-based compensation |
|
$ |
- |
|
|
$ |
265 |
|
|
$ |
- |
|
|
$ |
554 |
|
We use the Black-Scholes-Merton option-pricing model to estimate the fair value of our stock options. There were no options granted or shares awarded during the six months ended June 30, 2024 and 2023.
As of June 30, 2024, there was no unrecognized compensation expense related to non-vested stock options.
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v3.24.2.u1
Net Loss Per Share
|
6 Months Ended |
Jun. 30, 2024 |
Earnings Per Share [Abstract] |
|
Net Loss Per Share |
The table below presents common shares underlying stock options and warrants that are excluded from the calculation of the weighted average number of common shares outstanding used for the calculation of diluted net loss per common share. These are excluded from the calculation due to their anti-dilutive effect:
Schedule of antidilutive securities excluded from computation of net loss per common share |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended |
|
|
Six Months Ended |
|
|
|
June 30, |
|
|
June 30, |
|
(in thousands) |
|
2024 |
|
|
2023 |
|
|
2024 |
|
|
2023 |
|
Weighted-average anti-dilutive common shares resulting from options |
|
|
93 |
|
|
|
47 |
|
|
|
93 |
|
|
|
46 |
|
Weighted-average anti-dilutive common shares resulting from convertible note |
|
|
- |
|
|
|
- |
|
|
|
8 |
|
|
|
- |
|
Weighted-average anti-dilutive common shares resulting from convertible preferred |
|
|
380 |
|
|
|
- |
|
|
|
355 |
|
|
|
- |
|
Weighted-average anti-dilutive common shares resulting from warrants |
|
|
476 |
|
|
|
369 |
|
|
|
476 |
|
|
|
338 |
|
|
|
|
949 |
|
|
|
416 |
|
|
|
932 |
|
|
|
384 |
|
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v3.24.2.u1
Commitments and Contingencies
|
6 Months Ended |
Jun. 30, 2024 |
Commitments and contingencies (Note 4) |
|
Commitments and Contingencies |
4. |
Commitments and Contingencies |
Lease Commitments
We leased our office facility under an operating lease that expired in June 2024. Rent expense associated with this lease was approximately $32,000 for the three months ended June 30, 2024 and 2023, and $64,000 for the six months ended June 30, 2024 and 2023.
Legal Proceedings
In 2020, a legal proceeding was initiated against us by a former employee alleging wrongful termination, retaliation, infliction of emotional distress, negligent supervision, hiring and retention and slander. An independent investigation into this individual’s allegations of whistleblower retaliation, while still an employee, was conducted utilizing an outside investigator and concluded that such allegations were not substantiated. In September 2023, Fedson, as consideration for the Asset Purchase Agreement, agreed to assume all liabilities related to this pending employment claim (see Note 5. Asset Sale).
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v3.24.2.u1
Asset Sale
|
6 Months Ended |
Jun. 30, 2024 |
Asset Sale |
|
Asset Sale |
In July 2023, we entered into the Asset Purchase Agreement with Fedson for the sale of the ProNeura Assets, with closing occurring on September 1, 2023. The ProNeura Assets constituted only a portion of our assets. In August 2023, we entered into an Amendment to the Asset Purchase Agreement, pursuant to which Fedson agreed to purchase our ProNeura Assets for a purchase price of $2.0 million, consisting of (i) $500,000 in readily available funds, paid in full on the Closing Date, (ii) $500,000 in the form of the Cash Note and (iii) $1,000,000 in the form of the Escrow Note. We will also be eligible to receive potential milestone payments of up to $50 million on future net sales of the products and certain royalties on future net sales of the products. As further consideration, Fedson assumed all liabilities related to a pending employment claim against us. On the Closing Date, Fedson delivered a written guaranty by a principal of Fedson of all of Fedson’s obligations under both the Cash Note and Escrow Note. The Cash Note included provisions, which Fedson has exercised, allowing Fedson to extend the maturity date of the Cash Note to November 1, 2023 and again to December 1, 2023 upon payment of $5,000 for each extension. The Cash Note and Escrow Note were paid in December 2023 and January 2024, respectively. We received the funds from the escrow account in February 2024.
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v3.24.2.u1
Stockholders’ Equity
|
6 Months Ended |
Jun. 30, 2024 |
Equity [Abstract] |
|
Stockholders’ Equity |
Our common stock outstanding was 914,234 and 781,503 as of June 30, 2024 and December 31, 2023, respectively.
Reverse Split
On January 8, 2024, pursuant to prior stockholder authorization, our Board effected a reverse split of the outstanding shares of our common stock at a ratio of one share for every twenty shares then outstanding (the “Reverse Split”). Pursuant to their respective terms, the number of shares underlying our outstanding options and warrants was reduced and their respective exercise prices increased by the Reverse Split ratio. The number of shares of common stock authorized and the par value of $0.001 per share did not change as a result of the Reverse Split. All share and per share amounts contained in this Quarterly Report on Form 10-Q give retroactive effect to the Reverse Split.
Choong Choon Hau Note Conversion
In August 2023, we received $500,000 in funding in exchange for the issuance of a convertible promissory note for that principal amount to Choong Choon Hau (the “Hau Promissory Note”). Pursuant to the Hau Promissory Note, the principal amount accrues interest at a rate of 10% per annum and is payable monthly. All principal and accrued interest was due and payable on January 8, 2024, unless extended as provided. All or part of the Hau Promissory Note could be converted into our common stock at a conversion price of $9.32 per share from time to time following the issuance date and ending on the maturity date. In March 2024, the Hau Promissory Note, along with accrued interest of approximately $4,511, was converted into 54,132 shares of our common stock.
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v3.24.2.u1
Related Party Transactions
|
6 Months Ended |
Jun. 30, 2024 |
Related Party Transactions [Abstract] |
|
Related Party Transactions |
| 7. |
Related Party Transactions |
During the six months ended June 30, 2024 and 2023, we made payments related to legal and consulting fees of approximately $9,225 and approximately $75,000, respectively, to a law firm operated by one of our Board members.
In August 2023, we received $500,000 in funding in exchange for the issuance of the Hau Promissory Note. In March 2024, the Hau Promissory Note, along with accrued interest of approximately $4,511, was converted into 54,132 shares of our common stock (see Note 6. Stockholders’ Equity).
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v3.24.2.u1
Subsequent Events
|
6 Months Ended |
Jun. 30, 2024 |
Subsequent Events [Abstract] |
|
Subsequent Events |
The Company performed a review of events subsequent from the condensed balance sheet date through the date the condensed financial statements were issued and determined tha |