Solid Biosciences Inc (SLDB) Quote

SLDB 10Q due March 13

SLDB new 52 week hi

Thank you for your alerts, monk.

I'm on trading hiatus as I move a warehouse across country

But I'll be very receptive to these alerts, when I jump back in.

Can't wait to!

MG

SLDB new 52 week high

SLDB new 52 week high

Early Barchart 100
https://www.barchart.com/stocks/performance/percent-change/advances?timeFrame=today&viewName=main&screener=overall&orderBy=percentChange&orderDir=desc

SLDB new 52 week high

SLDB $6.13 +79%

Alerted @ 9:04 this morning (at +11%)

SLDB - Was once a $600 stock. It has massive upside potential!

SLDB $5.14...+50%

HOD $5.73

Wow! This is HUGE news! Thank you.

Solid Biosciences Receives FDA Fast Track Designation for Duchenne Muscular Dystrophy Gene Therapy SGT-003
https://www.globenewswire.com/news-release/2023/12/07/2792478/0/en/Solid-Biosciences-Receives-FDA-Fast-Track-Designation-for-Duchenne-Muscular-Dystrophy-Gene-Therapy-SGT-003.html

https://finviz.com/quote.ashx?t=SLDB&ty=c&ta=1&p=d

https://dilutiontracker.com/app/search/SLDB

Private Placement 159,574,463 $0.47 0 $74,999,998 2022-9-30 7:00
Underwritten S-3 21,739,131 $5.75 0 $125,000,003 Jefferies, SVB Leerink, Piper Sandler, Chardan 2021-3-18 21:14
Private Placement 24,324,320 $3.70 0 $89,999,984 Barclays Aspire Capital, Bain, Boxer, EcoR1, Perceptive Advisors, RA Capital 2020-12-11 7:30
Private placement 7,825,797 $5.11 0 $40,000,000 2020-10-23 0:00

SLDB +44%

SLDB 4.07 +0.65 (+19.00%)
As of 10:00AM EST.

SLDB May be worth monitoring for a move up today
https://stockcharts.com/h-sc/ui?s=SLDB

...I'm off to work!

https://investorshub.advfn.com/boards/read_msg.aspx?message_id=173377749

https://investorshub.advfn.com/boards/read_msg.aspx?message_id=173377695

olid Biosciences Announces IND Clearance by FDA for Duchenne Muscular Dystrophy Gene Therapy Candidate SGT-003
– Planning to initiate Phase 1/2 trial in pediatric DMD Patients –

– First cohort to study patients 4 to < 6 years of age –

CHARLESTOWN, Mass., Nov. 14, 2023 (GLOBE NEWSWIRE) -- Solid Biosciences Inc. (Nasdaq: SLDB), a life sciences company developing precision genetic medicines for neuromuscular and cardiac diseases, today announced that it has received U.S. Food and Drug Administration (FDA) clearance of an Investigational New Drug (IND) application for SGT-003, the company’s next-generation Duchenne Muscular Dystrophy (Duchenne) gene therapy candidate.

“We are pleased to have the FDA’s clearance to proceed into the clinic with SGT-003, a new, innovative gene therapy candidate for Duchenne,” said Bo Cumbo, President and CEO at Solid Biosciences. “SGT-003 combines our differentiated microdystrophin transgene with a next generation muscle-tropic capsid and a transient transfection manufacturing process that may help address the unmet needs for the Duchenne community.” Jessie Hanrahan Ph.D. Chief Regulatory Officer added “We appreciate the FDA’s review of the IND and look forward to continuing to work in collaboration with the agency when we initiate dosing of DMD patients.”

SGT-003 uses a proprietary, rationally designed capsid (AAV-SLB101) to deliver a DNA sequence encoding a shortened form of the dystrophin protein (microdystrophin), containing the R16 and R17 nNos binding protein domains. Preclinical data suggests this may be important for both muscular function and durability of benefit in patients.

“IND clearance for SGT-003 is a critical step in bringing a potential next generation gene therapy to the clinic and making a meaningful impact on the lives of those living with Duchenne. We are working closely with clinical sites to dose the first participants, driven by the belief that better therapies are urgently required to treat this devastating disease,” said Gabriel Brooks, M.D., Chief Medical Officer at Solid Biosciences.

Based on the clearance, Solid plans to move expeditiously to submit the study for IRB approval at the clinical trial sites and expects to commence patient screening shortly thereafter. The planned Phase 1/2 trial, SGT-003-101, is a first in human, open-label, multicenter trial to determine the safety and tolerability of SGT-003 in pediatric patients with DMD at a dose of 1E14vg/kg. SGT-003 will be administered as a one-time intravenous infusion to patients in two cohorts with a minimum of three patients each, with the potential for cohort expansion. Cohort 1 will study patients aged 4 to < 6 years of age with DMD. Long-term safety and efficacy will be evaluated for a total of 5 years following treatment.

In an mdx mouse model of Duchenne, SGT-003 demonstrated rapid transduction, showing robust microdystrophin expression levels in the heart, quadriceps, and diaphragm by day 4 post-gene therapy treatment. SGT-003 in nonhuman primates was shown to increase biodistribution to cardiac and skeletal muscle including the diaphragm versus AAV9. These studies suggest increased transgene expression and an improved safety profile compared to first generation microdystrophin gene therapies.

About DMD
Duchenne is a genetic muscle-wasting disease predominantly affecting boys, with symptoms usually appearing between three and five years of age. Duchenne is a progressive, irreversible, and ultimately fatal disease that affects approximately one in every 3,500 to 5,000 live male births and has an estimated prevalence of 5,000 to 15,000 cases in the United States alone.

About Solid Biosciences
Solid Biosciences is a life sciences company focused on advancing a portfolio of gene therapy candidates and neuromuscular and cardiac programs, including SGT-003, for the treatment of Duchenne muscular dystrophy (Duchenne), SGT-501 for the treatment of catecholaminergic polymorphic ventricular tachycardia (CPVT), AVB-401 for the treatment of BAG3-mediated dilated cardiomyopathy, AVB-202-TT for the treatment of Friedreich’s ataxia, and additional assets for the treatment of fatal cardiac diseases. Solid is advancing its diverse pipeline across rare neuromuscular and cardiac diseases, bringing together experts in science, technology, disease management, and care. Patient-focused and founded by those directly impacted, Solid’s mandate is to improve the daily lives of patients living with these devastating diseases. For more information, please visit www.solidbio.com.

Forward-Looking Statements
This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, including statements regarding future expectations, plans and prospects for the company; the ability to successfully achieve and execute on the company’s priorities and achieve key clinical milestones; the company’s SGT-003 program, including expectations for working closely with the FDA and clinical sites, initiating dosing, increasing durability and expression, improving safety, developing an innovative therapy and meeting unmet need; and other statements containing the words “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “would,” “working” and similar expressions. Any forward-looking statements are based on management’s current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in, or implied by, such forward-looking statements. These risks and uncertainties include, but are not limited to, risks associated with the ability to recognize the anticipated benefits of Solid’s acquisition of AavantiBio; the company’s ability to advance SGT-003, SGT-501, AVB-401, AVB-202-TT and other preclinical programs and capsid libraries on the timelines expected or at all; obtain and maintain necessary approvals from the FDA and other regulatory authorities; replicate in clinical trials positive results found in preclinical studies of the company’s product candidates; obtain, maintain or protect intellectual property rights related to its product candidates; compete successfully with other companies that are seeking to develop Duchenne and other neuromuscular and cardiac treatments and gene therapies; manage expenses; and raise the substantial additional capital needed, on the timeline necessary, to continue development of SGT-003, SGT-501, AVB-401, AVB-202-TT and other candidates, achieve its other business objectives and continue as a going concern. For a discussion of other risks and uncertainties, and other important factors, any of which could cause the company’s actual results to differ from those contained in the forward-looking statements, see the “Risk Factors” section, as well as discussions of

SLDB

!5 = 1 RS. 42 = 6.30. Will it hold?

SLDB

SLDB looking for a run up tomorrow, should move after consolidating today

SLDB chart

* * $SLDB Video Chart 02-23-2021 * *

Link to Video - click here to watch the technical chart video

SLDB on Dec 4th was $3.63 today Jan 5th $7.61 works for me.
Thanks to the select group of institutional investors and accredited investors for a $90 million private placement!

Glad I bought in after the $90 Million private placement. Solid BIO doing really well !

I don't care about changing your mind. I really couldn't care less what you think of the company. I'm not trying to convince other people about the company either. I'm stating what's going on here based on my interpretation of the facts that are publicly available. The share price is much too high right now to buy it. I'd buy if it ever hits $4.00 again, but probably not before. There are many other stocks out there that currently have a better risk/reward profile than this does, and I'm buying them.

There's nothing you can say that will change my mind that this company is a pump-and-dump. You should use your energy to convince other people about this company.

Let it go.

I'm not sure in what way it is recognizable, but it is interesting that you think so. We should agree to disagree. Oddly enough, I haven't invested in this yet - I was thinking about it at $3.70, as Ultragenyx clearly knew what they were doing putting in $40 million at $5.11, but I thought I had more time before they developed further. The $90 million investment at $3.70 changed the whole game, and now the floor is clearly $3.70 unless they have a developmental mishap. I think it's overpriced right now, but when the flurry of activity dwindles and it slowly sinks back toward $4.00 assuming the absence of any major near-term news, I could be very interested in getting in dependent on their future progress.

Your defense of the company is recognizable. Which is questionable.

I think this company is a scam.
You think the company is not a scam.
And that's where it ends.

Good luck in your investment with this company.
But I'll pass.

The impression you should be getting is that of a person who knows how to analyze publicly-available information and make informed conclusions. I've seen more POS stocks in my investing experience on these boards of the type with which you are apparently familiar than I can count, and I can tell you that this is not one of them.

I'm starting to get the impression you're a stock promoter for the company.

* * $SLDB Video Chart 12-15-2020 * *

Link to Video - click here to watch the technical chart video

On what information do you base your allegations? Have you read the publicly-available information? By rule of logic then, the reverse scamming must have pulled it up to over $6 so far today.

It's still a scam company. And they scamming pulled this under $5.00 today.

They have to sell shares to finance the company's development - do you really think knowledgeable investors would invest $90 million at $3.70 per share if they didn't see something worth investing in here? As someone said in some old movie - follow the money.

As long as the company continues to sell shares...this is going nowhere.

You can make money on the swings, but I'm not interested in swinging this POS.

Good luck to you if you stay in.

Definitely a good strategy. I would have sold out too if I had bought on Thursday at $3.70 as I should have.

I sold out.
If price goes down I'll buy again

There's $90 million of capital that just went into this that doesn't think it's a pumping scam. The people behind that infusion are more knowledgeable than you or I with regard to what's going on at this company.

I guess I would have only had to wait a week. I didn't pull the trigger in time, and it cost me a 50% profit. I thought I had much more time, and didn't expect news like that. It's clear that the floor is now $3.70, and when the euphoria subsides and it slides gradually down again towards that if there is no further news, it'll be buying time anywhere close to that and under $5.11 where Ultragenyx got in. I like this one long-term, especially after $90 million more of infused capital says it's going places.

* * $SLDB Video Chart 12-11-2020 * *

Link to Video - click here to watch the technical chart video

50% today. Nice for a Friday. glta

When I invest in small cap biotechs, I have a three-year time frame in mind. The appeal of this type of stock to me is seeing something that others don't and being able to assess whether they've got technology that will eventually generate discounted cash flows that aren't yet fully reflected in the share price. In this case, Ultragenyx seems to have done that for me, as they specialize in this sort of thing.

The only issue is youl need to wait a few months for that profit

Which is why I'll be happy to buy at $3.70 when some investment capital frees up if they were willing to pay $5.11. They know something I don't.

And another 200million upon completion of the study

I have seen more pumping scams than I can count, and this isn't one of them. Do you really think a company like Ultragenyx is stupid enough to put $40 million into a pumping scam?

I know a pumping scam when I see them. And this company has the red flags.

Thanks very much. I figure that they must be far more informed than I am if they're willing to put up $5.11 per share for $40 million of stock. I'll be putting my available investment capital here for the foreseeable future - I have a good feeling about this company.

Thanks for the very informative post. I have 3000+ shares of SLDB that I bought recently around $3.50 PPS. What you posted gives me comfort that strategic investors have invested at a higher PPS than mine.

46,101,794 shares plus the 7,825,797 shares they sold to Ultragenyx for $40 million plus the 6,302,632 shares they sold in their ATM offering for $23,209,000 equals 60,230,223 shares, with the unaccounted for 219,118 shares probably going for stock compensation to the executives. Thus, they received $63,209,000 for the 14,128,429 shares issued above, or an average of 4.47 per share. If you call that dumping, you haven't been playing this game very long.

Well...the OS on 08/01/2020 was 46,101,794
The OS on 11/01/2020 was 60,449,341
That's an increase of 14,347,547

Proceeds from sale and maturities of available-for-sale securities = $7.9 million

I knew this company was dumping shares.