As filed with the Securities and Exchange Commission on August 30,
2024
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-3
REGISTRATION STATEMENT UNDER THE SECURITIES
ACT OF 1933
RELMADA THERAPEUTICS, INC.
(Exact name of registrant as specified in its charter)
Nevada |
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3949 |
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45-5401931 |
(State or other jurisdiction of |
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(Primary Standard Industrial |
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(I.R.S. Employer |
incorporation or organization) |
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Classification Code Number) |
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Identification Number) |
2222 Ponce de Leon
Blvd., Floor 3
Coral Gables, FL 33134
+1-786-629-1376
(Address, including zip code, and telephone number,
including area code, of registrant’s principal executive offices)
Relmada Therapeutics, Inc.
Attention: Chief Executive Officer
2222 Ponce de Leon
Blvd., Floor 3
Coral Gables, FL 33134
+1-786-629-1376
(Name, address, including zip code, and telephone
number, including area code, of agent for service)
Please send a copy of all communications to:
Gregory Sichenzia, Esq.
Barrett DiPaolo, Esq.
Sichenzia Ross Ference Carmel LLP
1185 Avenue of the Americas
New York, New York 10036
+1-212-930-9700
Approximate date of commencement proposed sale
to the public: From time to time after the effective date of this Registration Statement.
If the only securities being registered on this
Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box. ☐
If any of the securities being registered on this
Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered
only in connection with dividend or interest reinvestment plans, check the following box. ☒
If this Form is filed to register additional securities
for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration
statement number of the earlier effective registration statement for the same offering. ☐
If this Form is a post-effective amendment filed
pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of
the earlier effective registration statement for the same offering. ☐
If this Form is a registration statement pursuant
to General Instruction I.D. or a post-effective amendment thereto that shall become effective upon filing with the Commission pursuant
to Rule 462(e) under the Securities Act, check the following box. ☐
If this Form is a post-effective amendment to
a registration statement filed pursuant to General Instruction I.D. filed to register additional securities or additional classes of securities
pursuant to Rule 413(b) under the Securities Act, check the following box. ☐
Indicate by check mark whether the registrant
is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company.
See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company”
and “emerging growth company” in Rule 12b-2 of the Exchange Act.
Large accelerated filer ☐ |
Accelerated filer ☐ |
Non-accelerated filer ☒ |
Smaller reporting company ☒ |
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Emerging growth company ☐ |
If an emerging growth company, indicate by check
mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting
standards provided pursuant to Section 7(a)(2)(B) of Securities Act. ☐
The registrant hereby amends this Registration
Statement on such date or dates as may be necessary to delay its effective date until the registrant shall file a further amendment which
specifically states that this Registration Statement shall thereafter become effective in accordance with Section 8(a) of the
Securities Act of 1933 or until the Registration Statement shall become effective on such date as the Commission, acting pursuant to said
Section 8(a), may determine.
EXPLANATORY NOTE
This registration statement contains two prospectuses:
| ● | a base prospectus, which covers the offering, issuance and sale by
us of up to $250,000,000 of our common stock, preferred stock, warrants, subscription rights, depositary shares, purchase contracts and/or
units representing two or more of the foregoing securities; and |
| ● | a
sale agreement prospectus supplement which covers the offering, issuance and sale by us of up to a maximum aggregate offering price of
$100,000,000 of our common stock that may be issued and sold from time to time under an Open Market Sale AgreementSM, or the
sale agreement, with Jefferies LLC. |
The base prospectus immediately follows this explanatory
note. The specific terms of any securities to be offered pursuant to the base prospectus will be specified in a prospectus supplement
to the base prospectus.
The sale agreement prospectus immediately follows
the base prospectus. The $100,000,000 of our common stock that may be offered, issued and sold under the sale agreement prospectus is
included in the $250,000,000 of securities that may be offered, issued and sold by us under the base prospectus. Any portion of the $100,000,000
of securities included in the sale agreement prospectus that has not been sold pursuant to the sale agreement will become available for
sale in other offerings pursuant to the base prospectus with a corresponding prospectus supplement.
The information in
this prospectus is not complete and may be changed. A registration statement relating to these securities has been filed with the Securities
and Exchange Commission. These securities may not be sold until the registration statement is declared effective. This prospectus is
not an offer to sell these securities and is not soliciting an offer to buy these securities, nor shall there be any sale of these securities,
in any state or other jurisdiction where such offer, solicitation or sale is not permitted or would be unlawful prior to registration
or qualification under the securities laws of any such jurisdiction.
(Subject to Completion,
dated August 30, 2024)
PROSPECTUS
RELMADA THERAPEUTICS, INC.
$250,000,000
COMMON STOCK
PREFERRED STOCK
WARRANTS
SUBSCRIPTION RIGHTS
DEPOSITARY SHARES
PURCHASE CONTRACTS
UNITS
This prospectus relates to common stock, preferred stock, warrants,
subscription rights, depositary shares, purchase contracts and units that we may sell from time to time in one or more offerings,
for an aggregate initial offering price of up to $250,000,000. We may offer and sell these securities separately or together, in
one or more series or classes and in amounts, at prices and on terms described in one or more offerings. We may offer securities through
underwriting syndicates managed or co-managed by one or more underwriters or dealers, through agents or directly to purchasers. The prospectus
supplement for each offering of securities will describe in detail the plan of distribution for that offering. For general information
about the distribution of securities offered, please see “Plan of Distribution” in this prospectus.
Each time our securities are offered or sold,
we will provide a prospectus supplement containing more specific information about the terms of that particular offering and attach it
to this prospectus. The prospectus supplements may also add, update or change information contained in this prospectus. This prospectus
may not be used to offer or sell securities without a prospectus supplement which includes a description of the method and terms of this
offering.
Our common stock is quoted on the Nasdaq Global Select Market under
the symbol “RLMD.” The last reported sale price of our common stock on The Nasdaq Global Select Market on August 27, 2024,
was $2.72 per share.
If we decide to seek a listing of any preferred
stock, warrants, subscriptions rights, depositary shares or units offered by this prospectus, the related prospectus supplement will disclose
the exchange or market on which the securities will be listed, if any, or where we have made an application for listing, if any.
The
securities offered by this prospectus involve a high degree of risk. Before making any investment decision, you should carefully review
and consider all the information in this prospectus and the documents incorporated by reference herein, including the risks and uncertainties
described under “Risk Factors” beginning on page 2, in addition to Risk Factors contained in the applicable prospectus
supplement. We urge you to carefully read this prospectus and the accompanying prospectus supplement, together with the documents we
incorporate by reference, describing the terms of these securities before investing.
Neither the Securities and Exchange Commission
nor any state securities commission has approved or disapproved of these securities or passed upon the adequacy or accuracy of this prospectus.
Any representation to the contrary is a criminal offense.
The date of this Prospectus is , 2024.
TABLE
OF CONTENTS
The terms “Relmada,” the “Company,”
“we,” “our” or “us” in this prospectus refer to Relmada Therapeutics, Inc. and our subsidiary Relmada
Therapeutics, Inc. (Delaware), unless the context suggests otherwise.
You should rely only on the information contained
or incorporated by reference in this prospectus or any prospectus supplement. We have not authorized anyone to provide you with information
different from that contained or incorporated by reference into this prospectus. If any person does provide you with information that
differs from what is contained or incorporated by reference in this prospectus, you should not rely on it. No dealer, salesperson or other
person is authorized to give any information or to represent anything not contained in this prospectus. You should assume that the information
contained in this prospectus or any prospectus supplement is accurate only as of the date on the front of the document and that any information
contained in any document we have incorporated by reference is accurate only as of the date of the document incorporated by reference,
regardless of the time of delivery of this prospectus or any prospectus supplement or any sale of a security. These documents are not
an offer to sell or a solicitation of an offer to buy these securities in any circumstances under which the offer or solicitation is unlawful.
ABOUT THIS PROSPECTUS
This prospectus is part of a registration statement
on Form S-3 that we filed with the Securities and Exchange Commission, or SEC, utilizing a “shelf” registration process. Under
this shelf registration process, we may offer and sell, either individually or in combination, in one or more offerings, any of the securities
described in this prospectus, for an aggregate initial offering price of up to $250,000,000. This prospectus provides you with a general
description of the securities we may offer. Each time we offer securities under this prospectus, we will provide a prospectus supplement
to this prospectus that will contain more specific information about the terms of that offering. We may also authorize one or more free
writing prospectuses to be provided to you that may contain material information relating to these offerings. The prospectus supplement
and any related free writing prospectus that we may authorize to be provided to you may also add, update or change any of the information
contained in this prospectus or in the documents that we have incorporated by reference into this prospectus.
We urge you to read carefully this prospectus,
any applicable prospectus supplement and any free writing prospectuses we have authorized for use in connection with a specific offering,
together with the information incorporated herein by reference as described under the heading “Incorporation of Documents by Reference,”
before investing in any of the securities being offered. You should rely only on the information contained in, or incorporated by reference
into, this prospectus and any applicable prospectus supplement, along with the information contained in any free writing prospectuses
we have authorized for use in connection with a specific offering. We have not authorized anyone to provide you with different or additional
information. This prospectus is an offer to sell only the securities offered hereby, but only under circumstances and in jurisdictions
where it is lawful to do so.
The information appearing in this prospectus,
any applicable prospectus supplement or any related free writing prospectus is accurate only as of the date on the front of the document
and any information we have incorporated by reference is accurate only as of the date of the document incorporated by reference, regardless
of the time of delivery of this prospectus, any applicable prospectus supplement or any related free writing prospectus, or any sale of
a security.
This prospectus contains summaries of certain
provisions contained in some of the documents described herein, but reference is made to the actual documents for complete information.
All of the summaries are qualified in their entirety by the actual documents. Copies of some of the documents referred to herein have
been filed, will be filed or will be incorporated by reference as exhibits to the registration statement of which this prospectus is a
part, and you may obtain copies of those documents as described below under the section entitled “Where You Can Find Additional
Information.”
This prospectus may also contain trademarks, service
marks and trade names of third parties, which are the property of their respective owners. Our use or display of third parties’
trademarks, service marks, trade names or products in this prospectus is not intended for, and does not imply a relationship with, or
endorsement or sponsorship by us. Solely for convenience, the trademarks, service marks and trade names referred to in this prospectus
may appear without the ®, SM and ™ symbols, but the omission of such references is not intended to indicate, in any way, that
we will not assert, to the fullest extent under applicable law, our rights or the right of the applicable owner of these trademarks, service
marks and trade names.
CAUTIONARY NOTE REGARDING FORWARD LOOKING STATEMENTS
This prospectus and any accompanying prospectus
supplement and the documents incorporated by reference herein may contain forward looking statements that involve risks and uncertainties.
All statements other than statements of historical fact contained in this prospectus and any accompanying prospectus supplement and the
documents incorporated by reference herein, including statements regarding future events, our future financial performance, business strategy,
and plans and objectives of management for future operations, are forward-looking statements. We have attempted to identify forward-looking
statements by terminology including “anticipates,” “believes,” “can,” “continue,” “could,”
“estimates,” “expects,” “intends,” “may,” “plans,” “potential,”
“predicts,” “should,” or “will” or the negative of these terms or other comparable terminology. Although
we do not make forward looking statements unless we believe we have a reasonable basis for doing so, we cannot guarantee their accuracy.
These statements are only predictions and involve known and unknown risks, uncertainties and other factors, including the risks outlined
under “Risk Factors” or elsewhere in this prospectus and the documents incorporated by reference herein, which may cause our
or our industry’s actual results, levels of activity, performance or achievements expressed or implied by these forward-looking
statements. Moreover, we operate in a highly regulated, very competitive, and rapidly changing environment. New risks emerge from time
to time and it is not possible for us to predict all risk factors, nor can we address the impact of all factors on our business or the
extent to which any factor, or combination of factors, may cause our actual results to differ materially from those contained in any forward-looking
statements.
You should read these
forward-looking statements carefully because they discuss our expectations about our future performance, our future operating results
or our future financial condition, or state other “forward-looking” information. Before you invest, you should be aware that
the occurrence of any of the events described in “Risk Factors” or “Item 1A. Risk Factors” in our most recent
Annual Report on Form 10-K, any subsequently filed Quarterly Reports on Form 10-Q, any subsequently filed Current Reports on Form 8-K
(other than, in each case, information furnished rather than filed), all of which are incorporated by reference herein, and any risk factors
included in any applicable prospectus supplement could substantially harm our business, results of operations and financial condition.
In light of these risks, uncertainties and assumptions, the events described in the forward-looking statements might not occur or might
occur to a different extent or at a different time than we have described. Should one or more of the risks or uncertainties described
in this prospectus or the documents incorporated by reference herein occur, or should underlying assumptions prove incorrect, our actual
results and plans could differ materially from those expressed in any forward-looking statements.
Forward-looking statements
contained in this prospectus and all subsequent written and oral forward-looking statements attributable to us or persons acting on our
behalf are expressly qualified in their entirety by this cautionary statement.
Except as otherwise required
by applicable law, we disclaim any duty to update any forward-looking statements, all of which are expressly qualified by the statements
in this section, to reflect events or circumstances after the date of this prospectus.
PROSPECTUS SUMMARY
This
summary highlights selected information contained elsewhere
in this prospectus. This summary does not contain all the information that you should consider before investing in our Company. You should
carefully read the entire prospectus, including all documents incorporated by reference herein. In particular, attention should be directed
to our “Risk Factors,” “Information with Respect to the Company,” “Management’s Discussion and Analysis
of Financial Condition and Results of Operations” and the financial statements and related notes thereto contained herein or otherwise
incorporated by reference hereto, before making an investment decision.
All references to
“we,” “us,” “our,” “Relmada” and the “Company” mean Relmada Therapeutics,
Inc. and its subsidiary Relmada Therapeutics, Inc. (Delaware).
Business Overview
Relmada
Therapeutics, Inc., a Nevada corporation, is a clinical-stage biotechnology company addressing diseases of the central nervous system
(CNS).
Esmethadone
Program (REL-1017)
We
have focused on the development of our lead product candidate, esmethadone (d-methadone, dextromethadone, REL-1017), an N-methyl-D-aspartate
(NMDA) receptor antagonist. Esmethadone, an isomer of methadone, is a new chemical entity (NCE) that potentially addresses areas of high
unmet medical need in the treatment of CNS diseases and other disorders. Esmethadone, is being developed as a rapidly acting, oral agent
for the treatment of depression and other potential indications.
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late 2022, we announced that our Phase 3 clinical trials, RELIANCE I, a trial of REL-1017
as an adjunctive treatment for Major Depressive Disorder (MDD), and RELIANCE III, a monotherapy
trial of REL-1017 for MDD, did not achieve their primary endpoints. |
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our long-term open label study of REL-1017 in patients with MDD, Study 310, which included
both patients who completed the RELIANCE trials and subjects who had not previously participated
in a REL-1017 clinical trial, in September 20, 2023, we announced efficacy results for the
de novo (or new to treatment) patients and safety results for all subjects. Patients treated
daily with REL-1017 for up to one year experienced rapid, clinically meaningful, and sustained
improvements in depressive symptoms and associated functional impairment. REL-1017 was well-tolerated
with long-term dosing, showing low rates of adverse events and discontinuations due to adverse
events. The most commonly reported adverse events deemed to be treatment-related
all occurred included headache, nausea and dizziness. No new safety signals were detected. |
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plan to complete two additional ongoing adjunctive Phase 3 trials (RELIANCE II and RELIGHT)
that build on the knowledge obtained from RELIANCE I,. |
Psilocybin
Program (REL-P11)
We
also intend to enter human studies of our proprietary, modified-release formulation of psilocybin (REL-P11) for metabolic
indications in doses that we believe are lower than those associated with psychedelic effects. The Company plans to commence a
single-ascending dose Phase 1 trial in obese subjects in Canada in 2024 to define the pharmacokinetic, safety and tolerability
profile of REL-P11 in this population, followed by a Phase 2a trial to establish clinical proof-of-concept.
Pre-clinical
data in a rodent model of metabolic dysfunction-associated steatotic liver disease demonstrated beneficial effects of psilocybin on multiple
metabolic parameters, including reduced hepatic steatosis, reduced body weight gain, and fasting blood glucose levels.
Stock Listing
Our common stock is listed on The Nasdaq Global
Select Market under the symbol “RLMD.”
Corporate Information
Our principal executive offices are located at
2222 Ponce de Leon Blvd., Floor 3, Coral Gables, Florida 33134 and our telephone number is +1-786-629-1376. Our website address is www.relmada.com.
The information contained therein or connected thereto shall not be deemed to be incorporated into this prospectus or the registration
statement of which it forms a part. The information on our website is not part of this prospectus.
For additional information about us, please refer
to other documents we have filed with the SEC and that are incorporated by reference into this prospectus, as listed under the heading
“Incorporation of Certain Information by Reference.”
RISK FACTORS
Investing in our securities involves a high degree
of risk. Before making an investment decision, you should consider carefully the risks, uncertainties and other factors, if any, described
under the caption “Risk Factors” in the applicable prospectus supplement, together with all the other information contained
in the prospectus supplement or appearing or incorporated by reference into this prospectus. You should also consider the risks, uncertainties
and assumptions discussed under the caption “Risk Factors” and elsewhere in our most recent Annual Report on Form 10-K,
as supplemented and updated by subsequent Quarterly Reports on Form 10-Q and Current Reports on Form 8-K that we have filed or will file
with the SEC, all of which (other than information furnished therein rather than filed) are deemed incorporated by reference into this
prospectus.
Our business, affairs, prospects, assets, financial
condition, results of operations and cash flows could be materially and adversely affected by these risks. For more information about
our SEC filings, please see “Where You Can Find More Information.”
USE OF PROCEEDS
Unless otherwise indicated in a prospectus supplement,
we intend to use the net proceeds from these sales for working capital and general corporate purposes, which includes, without limitation,
clinical studies required to gain regulatory approvals, implementation of adequate systems and controls to allow for regulatory approvals,
further development of our product candidates, investing in or acquiring companies that are synergistic with or complimentary to our technologies,
licensing activities related to our current and future product candidates and working capital, the development of emerging technologies,
investing in or acquiring companies that are developing emerging technologies, licensing activities, or the acquisition of other businesses.
We will retain broad discretion over the use of the net proceeds from the sale of the securities offered hereby. The amounts and timing
of these expenditures will depend on numerous factors, including the development of our current business initiatives.
PLAN OF DISTRIBUTION
We may sell the securities from time to time pursuant
to underwritten public offerings, direct sales to the public, “at the market” offerings, negotiated transactions, block trades
or a combination of these methods. We may sell the securities from time to time to or through underwriters or dealers, through agents,
or directly to one or more purchasers. A distribution of the securities offered by this prospectus may also be effected through the issuance
of derivative securities, including without limitation, warrants, rights to purchase and subscriptions. In addition, the manner in which
we may sell some or all of the securities covered by this prospectus includes, without limitation, through:
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a block trade in which a broker-dealer will attempt to sell as agent, but may position or resell a portion of the block, as principal, in order to facilitate the transaction; |
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purchases by a broker-dealer, as principal, and resale by the broker-dealer for its account; or |
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ordinary brokerage transactions and transactions in which a broker solicits purchasers. |
A prospectus supplement or supplements with respect
to each series of securities will describe the terms of the offering, including, to the extent applicable:
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the terms of the offering; |
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the name or names of the underwriters or agents and the amounts of securities underwritten or purchased by each of them, if any; |
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the public offering price or purchase price of the securities or other consideration therefor, and the proceeds to be received by us from the sale; |
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any delayed delivery requirements; |
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any over-allotment options under which underwriters may purchase additional securities from us; |
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any underwriting discounts or agency fees and other items constituting underwriters’ or agents’ compensation |
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any discounts or concessions allowed or re-allowed or paid to dealers; and |
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any securities exchange or market on which the securities may be listed. |
The offer and sale of the securities described
in this prospectus by us, the underwriters or the third parties described above may be effected from time to time in one or more transactions,
including privately negotiated transactions, either:
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at a fixed price or prices, which may be changed; |
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in an “at the market offering” within the meaning of Rule 415(a)(4) of the Securities Act; |
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at prices related to such prevailing market prices; or |
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at negotiated prices. |
Only underwriters named in the prospectus supplement
will be underwriters of the securities offered by the prospectus supplement.
Underwriters and Agents; Direct Sales
If underwriters are used in a sale, they will
acquire the offered securities for their own account and may resell the offered securities from time to time in one or more transactions,
including negotiated transactions, at a fixed public offering price or at varying prices determined at the time of sale. We may offer
the securities to the public through underwriting syndicates represented by managing underwriters or by underwriters without a syndicate.
Unless the prospectus supplement states otherwise,
the obligations of the underwriters to purchase the securities will be subject to the conditions set forth in the applicable underwriting
agreement. Subject to certain conditions, the underwriters will be obligated to purchase all of the securities offered by the prospectus
supplement, other than securities covered by any over-allotment option. Any public offering price and any discounts or concessions allowed
or re-allowed or paid to dealers may change from time to time. We may use underwriters with whom we have a material relationship. We will
describe in the prospectus supplement, naming the underwriter, the nature of any such relationship.
We may sell securities directly or through agents
we designate from time to time. We will name any agent involved in the offering and sale of securities, and we will describe any commissions
we will pay the agent in the prospectus supplement. Unless the prospectus supplement states otherwise, our agent will act on a best-efforts
basis for the period of its appointment.
We may authorize agents or underwriters to solicit
offers by certain types of institutional investors to purchase securities from us at the public offering price set forth in the prospectus
supplement pursuant to delayed delivery contracts providing for payment and delivery on a specified date in the future. We will describe
the conditions to these contracts and the commissions we must pay for solicitation of these contracts in the prospectus supplement.
Dealers
We may sell the offered securities to dealers
as principals. The dealer may then resell such securities to the public either at varying prices to be determined by the dealer or at
a fixed offering price agreed to with us at the time of resale.
Institutional Purchasers
We may authorize agents, dealers or underwriters
to solicit certain institutional investors to purchase offered securities on a delayed delivery basis pursuant to delayed delivery contracts
providing for payment and delivery on a specified future date. The applicable prospectus supplement or other offering materials, as the
case may be, will provide the details of any such arrangement, including the offering price and commissions payable on the solicitations.
We will enter into such delayed contracts only
with institutional purchasers that we approve. These institutions may include commercial and savings banks, insurance companies, pension
funds, investment companies and educational and charitable institutions.
Indemnification; Other Relationships
We may provide agents, underwriters, dealers and
remarketing firms with indemnification against certain civil liabilities, including liabilities under the Securities Act, or contribution
with respect to payments that the agents or underwriters may make with respect to these liabilities. Agents, underwriters, dealers and
remarketing firms, and their affiliates, may engage in transactions with, or perform services for, us in the ordinary course of business.
This includes commercial banking and investment banking transactions.
Market-Making; Stabilization and Other Transactions
There is currently no market for any of the offered
securities, other than our common stock, which is quoted on the Nasdaq Global Select Market. If the offered securities are traded after
their initial issuance, they may trade at a discount from their initial offering price, depending upon prevailing interest rates, the
market for similar securities and other factors. While it is possible that an underwriter could inform us that it intends to make a market
in the offered securities, such underwriter would not be obligated to do so, and any such market-making could be discontinued at any time
without notice. Therefore, no assurance can be given as to whether an active trading market will develop for the offered securities. We
have no current plans for listing of the preferred stock, warrants or subscription rights on any securities exchange or quotation system;
any such listing with respect to any particular preferred stock, warrants or subscription rights will be described in the applicable prospectus
supplement or other offering materials, as the case may be.
Any underwriter may engage in over-allotment,
stabilizing transactions, short-covering transactions and penalty bids in accordance with Regulation M under the Securities Exchange Act
of 1934, as amended, or the Exchange Act. Over-allotment involves sales in excess of the offering size, which create a short position.
Stabilizing transactions permit bids to purchase the underlying security so long as the stabilizing bids do not exceed a specified maximum
price. Syndicate-covering or other short-covering transactions involve purchases of the securities, either through exercise of the over-allotment
option or in the open market after the distribution is completed, to cover short positions. Penalty bids permit the underwriters to reclaim
a selling concession from a dealer when the securities originally sold by the dealer are purchased in a stabilizing or covering transaction
to cover short positions. Those activities may cause the price of the securities to be higher than it would otherwise be. If commenced,
the underwriters may discontinue any of the activities at any time.
Any underwriters or agents that are qualified
market makers on the Nasdaq Global Select Market may engage in passive market making transactions in our common stock on the Nasdaq Global
Select Market in accordance with Regulation M under the Exchange Act, during the business day prior to the pricing of the offering, before
the commencement of offers or sales of our common stock. Passive market makers must comply with applicable volume and price limitations
and must be identified as passive market makers. In general, a passive market maker must display its bid at a price not in excess of the
highest independent bid for such security; if all independent bids are lowered below the passive market maker’s bid, however, the
passive market maker’s bid must then be lowered when certain purchase limits are exceeded. Passive market making may stabilize the
market price of the securities at a level above that which might otherwise prevail in the open market and, if commenced, may be discontinued
at any time.
Fees and Commissions
If 5% or more of the net proceeds, not including
underwriting compensation, of any offering of securities made under this base prospectus and accompanying prospectus supplement will be
(i) used to reduce or retire the balance of a loan or credit facility extended by a FINRA member participating in the offering, its affiliates
and its associated persons, in the aggregate; or (ii) otherwise directed to such a FINRA member, its affiliates and associated persons,
in the aggregate, the offering pursuant to such prospectus supplement will be conducted in accordance with FINRA Rule 5121.
DESCRIPTION OF SECURITIES WE MAY OFFER
General
This prospectus describes the general terms of
our capital stock. The following description is not complete and may not contain all the information you should consider before investing
in our capital stock. For a more detailed description of these securities, you should read the applicable provisions of Nevada law and
our amended and restated certificate of incorporation, referred to herein as our certificate of incorporation, and our amended and restated
bylaws, referred to herein as our bylaws. The description below is based on and is qualified in its entirety by reference to our certificate
of incorporation and bylaws. When we offer to sell a particular series of these securities, we will describe the specific terms of the
series in a supplement to this prospectus. Accordingly, for a description of the terms of any series of securities, you must refer to
both the prospectus supplement relating to that series and the description of the securities described in this prospectus. To the extent
the information contained in the prospectus supplement differs from this summary description, you should rely on the information in the
prospectus supplement.
We, directly or through agents, dealers or underwriters
designated from time to time, may offer, issue and sell, together or separately:
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common stock; |
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preferred stock; |
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warrants to purchase our securities; |
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subscription rights to purchase our securities; |
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depositary shares; |
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purchase contracts; or |
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units comprised of, or other combinations of, the foregoing securities. |
The preferred stock may also be exchangeable for
and/or convertible into shares of common stock, another series of preferred stock or other securities that may be sold by us pursuant
to this prospectus or any combination of the foregoing. When a particular series of securities is offered, a supplement to this prospectus
will be delivered with this prospectus, which will set forth the terms of the offering and sale of the offered securities.
Authorized Capital Stock; Issued and Outstanding
Capital Stock
We have authorized 350,000,000 shares of capital
stock, par value $0.001 per share, of which 150,000,000 are shares of common stock and 200,000,000 are shares of preferred stock, 3,500,000
of which are designated Class A Convertible Preferred Stock. As of August 27, 2024, there were 30,174,202 shares of common stock issued
and outstanding. There are no shares of preferred stock issued and outstanding.
The authorized and unissued shares of common stock
and the authorized and undesignated shares of preferred stock are available for issuance without further action by our stockholders, unless
such action is required by applicable law or the rules of any stock exchange on which our securities may be listed. Unless approval of
our stockholders is so required, our board of directors does not intend to seek stockholder approval for the issuance and sale of our
common stock or preferred stock.
Common Stock
The holders of our common stock are entitled to
one vote per share. Our certificate of incorporation does not provide for cumulative voting. Our directors are divided into three classes,
with staggered three-year terms. Only one class of directors will be elected at each annual meeting of stockholders, with the other classes
continuing for the remainder of their respective three-year terms. At each annual meeting of stockholders, directors elected to succeed
those directors whose terms expire are elected for a term of office to expire at the third succeeding annual meeting of stockholders after
their election. The holders of our common stock are entitled to receive ratably such dividends, if any, as may be declared by our board
of directors out of legally available funds. However, the current policy of our board of directors is to retain earnings, if any, for
operations and growth. Upon liquidation, dissolution or winding-up, the holders of our common stock are entitled to share ratably in all
assets that are legally available for distribution. The holders of our common stock have no preemptive, subscription or conversion rights
and there are no redemption or sinking fund provisions applicable to the common stock. The rights, preferences and privileges of holders
of our common stock are subject to, and may be adversely affected by, the rights of the holders of any series of preferred stock, which
may be designated solely by action of our board of directors and issued in the future.
Preferred Stock
Authorized Preferred Stock
As of August 27, 2024, there were no shares of
Class A Convertible Preferred Stock issued and outstanding.
The rights and preferences of our Class A Convertible
Preferred Stock include the following:
Liquidation Preference
In the event of any dissolution, liquidation or
winding up of our Company, whether voluntary or involuntary, the holders of our Class A Convertible Preferred Stock are entitled to participate
in any distribution out of our assets of on an equal basis per share with the holders of our common stock.
Dividends
The Class A Convertible Preferred Stock is, with
respect to dividend rights, entitled to two times the amount of any dividend granted by our board of directors to the holders of our common
stock.
Conversion
Optional Conversion. Subject to certain
exceptions, each share of Class A Convertible Preferred Stock is convertible at the option of the holder and without the payment of additional
consideration by the holder, at any time, into shares of our common stock at a conversion rate of one share of our common stock for every
one share of our Class A Convertible Preferred Stock. However, a holder of our Class A Convertible Preferred Stock cannot convert shares
of our Class A Convertible Preferred Stock to shares of our common stock if such conversion would cause the holder or any “group”
(within the meaning of Section 13(d) of the Securities Exchange Act of 1934 (the “Exchange Act”) of which such holder is or
deemed to be a part, to “beneficially own” (within the meaning of Rule 13d-3 under the Exchange Act) more than 9.9% of the
number of shares of our common stock listed as outstanding by in our most recent public filing with the Commission prior to us receiving
the conversion demand.
Automatic Conversion. Subject to the
limitation on conversion described above, on the first day of each month until there are no shares of our Class A Convertible Preferred
Stock outstanding, each share of our Class A Convertible Preferred Stock will convert without the payment of additional consideration
by a holder into shares of our common stock on the automatic conversion date at a conversion rate of one share of our common stock for
every one share of our Class A Convertible Preferred Stock.
Voting
The holders of our Class A Convertible Preferred
Stock are not entitled to vote on any matter submitted to a vote of the holders of our common stock, including the election of directors.
Other Series of Preferred Stock We May Issue
The board of directors is authorized, subject
to any limitations prescribed by law, without further vote or action by our stockholders, to issue from time to time shares of preferred
stock in one or more series. Each such series of preferred stock shall have such number of shares, designations, preferences, voting powers,
qualifications and special or relative rights or privileges as determined by our board of directors, which may include, among others,
dividend rights, voting rights, liquidation preferences, conversion rights and preemptive rights. Issuance of preferred stock by our board
of directors may result in such shares having dividend and/or liquidation preferences senior to the rights of the holders of our common
stock and could dilute the voting rights of the holders of our common stock.
Prior to the issuance of shares of each series
of preferred stock, our board of directors is required by the Nevada Revised Law and our amended and restated certificate of incorporation
to adopt resolutions and file a certificate of designations with the Secretary of State of the State of Nevada, which fixes for each class
or series the designations, powers, preferences, rights, qualifications, limitations and restrictions. We will file as an exhibit to the
registration statement of which this prospectus is a part, or will incorporate by reference from a current report on Form 8-K that we
file with the Commission, the form of any certificate of designations for the series of preferred stock we are offering before the issuance
of the related series of preferred stock. The prospectus supplement relating to any preferred stock that we may offer will contain the
specific terms of the class or series and of the offering, which terms may include the following:
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the title and stated value; |
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the number of shares we are offering; |
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the offering price; |
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the number of shares constituting that series, which number may be increased or decreased (but not below the number of shares then outstanding) from time to time by action of our board of directors; |
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the dividend rate and the manner and frequency of payment of dividends on the shares of that series, whether dividends will be cumulative, and, if so, from which date; |
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whether that series will have voting rights, in addition to any voting rights provided by law, and, if so, the terms of such voting rights; |
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whether that series will have conversion privileges, and, if so, the terms and conditions of such conversion, including provision for adjustment of the conversion rate in such events as our board of directors may determine; |
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whether or not the shares of that series will be redeemable, and, if so, the terms and conditions of such redemption; |
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whether that series will have a sinking fund for the redemption or purchase of shares of that series, and, if so, the terms and amount of such sinking fund; |
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whether or not the shares of the series will have priority over or be on a parity with or be junior to the shares of any other series or class in any respect; |
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the rights of the shares of that series in the event of voluntary or involuntary liquidation, dissolution or winding up of the corporation, and the relative rights or priority, if any, of payment of shares of that series; |
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preemptive rights, if any; |
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restrictions on transfer, sale or other assignment, if any; |
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whether interests in the preferred stock will be represented by depositary shares; |
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a discussion of any material or special United States federal income tax considerations applicable to the preferred stock; |
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any limitations on issuance of any class or series of preferred stock ranking senior to or on a parity with the series of preferred stock as to dividend rights and rights if we liquidate, dissolve or wind up our affairs; and |
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any other relative rights, preferences and limitations of that series. |
Once designated by our board of directors, each
series of preferred stock may have specific financial and other terms that will be described in a prospectus supplement. The description
of the preferred stock that is set forth in any prospectus supplement is not complete without reference to the documents that govern the
preferred stock. These include our amended and restated certificate of incorporation and any certificates of designation that our board
of directors may adopt.
All shares of our preferred stock will, when issued,
be fully paid and non-assessable, including shares of our preferred stock issued upon the exercise of preferred stock warrants or subscription
rights, if any.
Our board of directors may authorize the issuance
of preferred stock with voting or conversion rights that could adversely affect the voting power or other rights of the holders of our
common stock. Preferred stock could be issued quickly with terms designed to delay or prevent a change in control of our Company or make
removal of management more difficult. Additionally, the issuance of preferred stock could have the effect of decreasing the market price
of our common stock.
Although our board of directors has no intention
at the present time of doing so, it could authorize the issuance of a series of preferred stock that could, depending on the terms of
such series, impede the completion of a merger, tender offer or other takeover attempt.
Warrants
We may issue warrants
to purchase our securities or other rights, including rights to receive payment in cash or securities based on the value, rate or price
of one or more specified commodities, currencies, securities or indices, or any combination of the foregoing. Warrants may be issued independently
or together with any other securities that may be sold by us pursuant to this prospectus or any combination of the foregoing and may be
attached to, or separate from, such securities. To the extent warrants that we issue are to be publicly-traded, each series of such warrants
will be issued under a separate warrant agreement to be entered into between us and a warrant agent.
We will file as exhibits
to the registration statement of which this prospectus is a part, or will incorporate by reference from a current report on Form 8-K that
we file with the Commission, forms of the warrant and warrant agreement, if any. The prospectus supplement relating to any warrants that
we may offer will contain the specific terms of the warrants and a description of the material provisions of the applicable warrant agreement,
if any. These terms may include the following:
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the title of the warrants; |
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the aggregate number of warrants; |
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the price or prices at which the warrants will be offered; |
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the designation, amount and terms of the securities or other rights for which the warrants are exercisable; |
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the designation and terms of the other securities, if any, with which the warrants are to be issued and the number of warrants issued with each other security; |
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if applicable, the date on and after which the warrants and the related securities will be separately transferable; |
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the price or prices at which the securities or other rights purchasable upon exercise of the warrants may be purchased; |
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any provisions for adjustment of the number or amount of securities receivable upon exercise of the warrants or the exercise price of the warrants; |
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the manner of exercise of the warrants, including any cashless exercise rights; |
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the terms of any rights of us to redeem or call the warrants; |
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the identities of any warrant agent and any calculation or other agent for the warrants; |
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a discussion of any material U.S. federal income tax considerations applicable to the exercise of the warrants; |
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the date on which the right to exercise the warrants will commence, and the date on which the right will expire; |
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If any, the maximum or minimum number of warrants that may be exercised at any time; |
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information with respect to book-entry procedures, if any; and |
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any other terms of the warrants, including terms, procedures and limitations relating to the exchange and exercise of the warrants. |
Exercise of Warrants. Each
warrant will entitle the holder of warrants to purchase the amount of securities or other rights, at the exercise price stated or determinable
in the prospectus supplement for the warrants. Warrants may be exercised at any time up to the close of business on the expiration date
shown in the applicable prospectus supplement, unless otherwise specified in such prospectus supplement. After the close of business on
the expiration date, if applicable, unexercised warrants will become void. Warrants may be exercised in the manner described in the applicable
prospectus supplement. When the warrant holder makes the payment and properly completes and signs the warrant certificate at the corporate
trust office of the warrant agent, if any, or any other office indicated in the prospectus supplement, we will, as soon as possible, forward
the securities or other rights that the warrant holder has purchased. If the warrant holder exercises less than all of the warrants represented
by the warrant certificate, we will issue a new warrant certificate for the remaining warrants.
Enforceability of
Rights By Holders of Warrants. Any warrant agent will act solely as our agent under the applicable warrant agreement and will
not assume any obligation or relationship of agency or trust with any holder of any warrant. A single bank or trust company may act as
warrant agent for more than one issue of warrants. A warrant agent will have no duty or responsibility in case of any default by us under
the applicable warrant agreement or warrant, including any duty or responsibility to initiate any proceedings at law or otherwise, or
to make any demand upon us. Any holder of a warrant may, without the consent of the related warrant agent or the holder of any other warrant,
enforce by appropriate legal action the holder’s right to exercise, and receive the securities purchasable upon exercise of, its
warrants in accordance with their terms.
Warrant Agreement
Will Not Be Qualified Under Trust Indenture Act. No warrant agreement will be qualified as an indenture, and no warrant agent
will be required to qualify as a trustee, under the Trust Indenture Act. Therefore, holders of warrants issued under a warrant agreement
will not have the protection of the Trust Indenture Act with respect to their warrants.
Outstanding Warrants
As of August 27, 2024, we have outstanding warrants
to purchase up to 1,813,455 shares of our common stock, at a weighted average exercise price of $23.72 per share, with remaining terms
of approximately between 1 month and 7.2 years.
Subscription Rights
We may issue rights to
purchase our securities. The rights may or may not be transferable by the persons purchasing or receiving the rights. In connection with
any rights offering, we may enter into a standby underwriting or other arrangement with one or more underwriters or other persons pursuant
to which such underwriters or other persons would purchase any offered securities remaining unsubscribed for after such rights offering.
In connection with a rights offering to holders of our capital stock a prospectus supplement will be distributed to such holders on the
record date for receiving rights in the rights offering set by us.
We will file as exhibits
to the registration statement of which this prospectus is a part, or will incorporate by reference from a current report on Form 8-K that
we file with the Commission, forms of the subscription rights, standby underwriting agreement or other agreements, if any. The prospectus
supplement relating to any rights that we offer will include specific terms relating to the offering, including, among other matters:
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the date of determining the security holders entitled to the rights distribution; |
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the aggregate number of rights issued and the aggregate amount of securities purchasable upon exercise of the rights; |
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the exercise price; |
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the aggregate number of rights to be issued; |
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the date, if any, on and after which the rights will be separately transferable; |
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the conditions to completion of the rights offering; |
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the date on which the right to exercise the rights will commence and the date on which the rights will expire; |
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any applicable federal income tax considerations; and |
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any other terms of the rights, including terms, procedures and limitations relating to the distribution, exchange and exercise of the rights. |
Each right would entitle
the holder of the rights to purchase the principal amount of securities at the exercise price set forth in the applicable prospectus supplement.
Rights may be exercised at any time up to the close of business on the expiration date for the rights provided in the applicable prospectus
supplement. After the close of business on the expiration date, all unexercised rights will become void.
Holders may exercise
rights as described in the applicable prospectus supplement. Upon receipt of payment and the rights certificate properly completed and
duly executed at the corporate trust office of the rights agent, if any, or any other office indicated in the prospectus supplement, we
will, as soon as practicable, forward the securities purchasable upon exercise of the rights. If less than all of the rights issued in
any rights offering are exercised, we may offer any unsubscribed securities directly to persons other than stockholders, to or through
agents, underwriters or dealers or through a combination of such methods, including pursuant to standby underwriting arrangements, as
described in the applicable prospectus supplement.
Depositary Shares
General. We
may offer fractional shares of preferred stock, rather than full shares of preferred stock. If we decide to offer fractional shares of
our preferred stock, we will issue receipts for depositary shares. Each depositary share will represent a fraction of a share of a particular
series of our preferred stock, and the applicable prospectus supplement will indicate that fraction. The shares of preferred stock represented
by depositary shares will be deposited under a deposit agreement between us and a depositary that is a bank or trust company that meets
certain requirements and is selected by us. The depositary will be specified in the applicable prospectus supplement. Each owner of a
depositary share will be entitled to all of the rights and preferences of the preferred stock represented by the depositary share. The
depositary shares will be evidenced by depositary receipts issued pursuant to the deposit agreement. Depositary receipts will be distributed
to those persons purchasing the fractional shares of our preferred stock in accordance with the terms of the offering. We will file as
exhibits to the registration statement of which this prospectus is a part, or will incorporate by reference from a current report on Form
8-K that we file with the Commission, forms of the deposit agreement, form of certificate of designation of underlying preferred stock,
form of depositary receipts and any other related agreements.
Dividends and Other
Distributions. The depositary will distribute all cash dividends or other cash distributions received by it in respect
of the preferred stock to the record holders of depositary shares relating to such preferred shares in proportion to the numbers of depositary
shares held on the relevant record date.
In the event of a distribution
other than in cash, the depositary will distribute securities or property received by it to the record holders of depositary shares in
proportion to the numbers of depositary shares held on the relevant record date, unless the depositary determines that it is not feasible
to make such distribution. In that case, the depositary may make the distribution by such method as it deems equitable and practicable.
One such possible method is for the depositary to sell the securities or property and then distribute the net proceeds from the sale as
provided in the case of a cash distribution.
Redemption of Depositary
Shares. Whenever we redeem the preferred stock, the depositary will redeem a number of depositary shares representing
the same number of shares of preferred stock so redeemed. If fewer than all of the depositary shares are to be redeemed, the depositary
shares to be redeemed will be selected by lot, pro rata or by any other equitable method as the depositary may determine.
Voting of Underlying
Shares. Upon receipt of notice of any meeting at which the holders of our preferred stock of any series are entitled to vote, the
depositary will mail the information contained in the notice of the meeting to the record holders of the depositary shares relating to
that series of preferred stock. Each record holder of the depositary shares on the record date will be entitled to instruct the depositary
as to the exercise of the voting rights represented by the number of shares of preferred stock underlying the holder’s depositary
shares. The depositary will endeavor, to the extent it is practical to do so, to vote the number of whole shares of preferred stock underlying
such depositary shares in accordance with such instructions. We will agree to take all action that the depositary may deem reasonably
necessary in order to enable the depositary to do so. To the extent the depositary does not receive specific instructions from the holders
of depositary shares relating to such preferred shares, it will abstain from voting such shares of preferred stock.
Withdrawal of Shares.
Upon surrender of depositary receipts representing any number of whole shares at the depositary’s office, unless the related depositary
shares previously have been called for redemption, the holder of the depositary shares evidenced by the depositary receipts will be entitled
to delivery of the number of whole shares of the related series of preferred stock and all money and other property, if any, underlying
such depositary shares. However, once such an exchange is made, the preferred stock cannot thereafter be re-deposited in exchange for
depositary shares. Holders of depositary shares will be entitled to receive whole shares of the related series of preferred stock on the
basis set forth in the applicable prospectus supplement. If the depositary receipts delivered by the holder evidence a number of depositary
shares representing more than the number of whole shares of preferred stock of the related series to be withdrawn, the depositary will
deliver to the holder at the same time a new depositary receipt evidencing the excess number of depositary shares.
Amendment and Termination
of Depositary Agreement. The form of depositary receipt evidencing the depositary shares and any provision of the applicable
depositary agreement may at any time be amended by agreement between us and the depositary. We may, with the consent of the depositary,
amend the depositary agreement from time to time in any manner that we desire. However, if the amendment would materially and adversely
alter the rights of the existing holders of depositary shares, the amendment would need to be approved by the holders of at least a majority
of the depositary shares then outstanding.
The depositary agreement
may be terminated by us or the depositary if:
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Resignation and Removal
of Depositary. The depositary may resign at any time by delivering to us notice of its election to do so. We may remove a depositary
at any time. Any resignation or removal will take effect upon the appointment of a successor depositary and its acceptance of appointment.
Charges of Depositary. We
will pay all transfer and other taxes and governmental charges arising solely from the existence of any depositary arrangements. We will
pay all charges of each depositary in connection with the initial deposit of the preferred shares of any series, the initial issuance
of the depositary shares, any redemption of such preferred shares and any withdrawals of such preferred shares by holders of depositary
shares. Holders of depositary shares will be required to pay any other transfer taxes.
Notices. Each
depositary will forward to the holders of the applicable depositary shares all notices, reports and communications from us which are delivered
to such depositary and which we are required to furnish the holders of the preferred stock represented by such depositary shares.
Miscellaneous.
The depositary agreement may contain provisions that limit our liability and the liability of the depositary to the holders of depositary
shares. Both the depositary and we are also entitled to an indemnity from the holders of the depositary shares prior to bringing, or defending
against, any legal proceeding. We or any depositary may rely upon written advice of counsel or accountants, or information provided by
persons presenting preferred shares for deposit, holders of depositary shares or other persons believed by us to be competent and on documents
believed by us or them to be genuine.
Purchase Contracts
We may issue purchase
contracts, representing contracts obligating holders to purchase from us, and us to sell to the holders, a specific or varying number
of common stock, preferred stock, warrants, depositary shares or any combination of the above, at a future date or dates. Alternatively,
the purchase contracts may obligate us to purchase from holders, and obligate holders to sell to us, a specific or varying number of common
stock, preferred stock, warrants, depositary shares, or any combination of the above. The price of the securities and other property subject
to the purchase contracts may be fixed at the time the purchase contracts are issued or may be determined by reference to a specific formula
set forth in the purchase contracts. The purchase contracts may be issued separately or as a part of a unit that consists of (a) a purchase
contract and (b) one or more of the other securities that may be sold by us pursuant to this prospectus or any combination of the foregoing,
which may secure the holders’ obligations to purchase the securities under the purchase contract. The purchase contracts may require
us to make periodic payments to the holders or require the holders to make periodic payments to us. These payments may be unsecured or
prefunded and may be paid on a current or on a deferred basis. The purchase contracts may require holders to secure their obligations
under the contracts in a manner specified in the applicable prospectus supplement.
We will file as exhibits
to the registration statement of which this prospectus is a part, or will incorporate by reference from a current report on Form 8-K that
we file with the Commission, forms of the purchase contracts and purchase contract agreement, if any. The applicable prospectus supplement
will describe the terms of any purchase contracts in respect of which this prospectus is being delivered, including, to the extent applicable,
the following:
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whether the purchase contracts obligate the holder or us to purchase or sell, or both purchase and sell, the securities subject to purchase under the purchase contract, and the nature and amount of each of those securities, or the method of determining those amounts; |
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whether the purchase contracts are to be prepaid or not; |
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whether the purchase contracts are to be settled by delivery, or by reference or linkage to the value, performance or level of the securities subject to purchase under the purchase contract; |
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any acceleration, cancellation, termination or other provisions relating to the settlement of the purchase contracts; |
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whether the purchase contracts will be issued in fully registered or global form; and |
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any applicable federal income tax considerations; and |
Units
We may issue units consisting
of any combination of the other types of securities offered under this prospectus in one or more series. We may evidence each series of
units by unit certificates that we may issue under a separate agreement. We may enter into unit agreements with a unit agent. Each unit
agent, if any, may be a bank or trust company that we select. We will indicate the name and address of the unit agent, if any, in the
applicable prospectus supplement relating to a particular series of units. Specific unit agreements, if any, will contain additional important
terms and provisions. We will file as an exhibit to the registration statement of which this prospectus is a part, or will incorporate
by reference from a current report that we file with the Commission, the form of unit and the form of each unit agreement, if any, relating
to units offered under this prospectus.
If we offer any units,
certain terms of that series of units will be described in the applicable prospectus supplement, including, without limitation, the following,
as applicable
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the title of the series of units; |
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identification and description of the separate constituent securities comprising the units; |
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the price or prices at which the units will be issued; |
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the date, if any, on and after which the constituent securities comprising the units will be separately transferable; |
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a discussion of certain United States federal income tax considerations applicable to the units; and |
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any other material terms of the units and their constituent securities. |
Forum for Adjudication of Disputes
Pursuant to our bylaws, to the fullest extent
permitted by law, and unless we consent in writing to the selection of an alternative forum, the Eighth Judicial District Court of Clark
County, Nevada, shall be the sole and exclusive forum for any stockholder (including a beneficial owner of stock) to bring (a) any derivative
action or proceeding brought in the name or right of the Company or on our behalf, (b) any action asserting a claim of, or a claim based
on, breach of any fiduciary duty owed by any current or former director, officer, employee, agent or stockholder of the Company to the
Company or the Company’s stockholders, (c) any action arising or asserting a claim arising pursuant to any provision of NRS Chapters
78 or 92A or any provision of the certificate of incorporation or our bylaws or (d) any action asserting a claim against us or any current
or former director, officer, employee or stockholder (including a beneficial owner of stock) governed by the internal affairs doctrine,
including, without limitation, any action to interpret, apply, enforce or determine the validity of the certificate of incorporation or
our bylaws. To the fullest extent permitted by law, our forum selection provision applies to actions arising under the Securities Act
or Exchange Act. Section 27 of the Exchange Act creates exclusive federal jurisdiction over all suits brought to enforce any duty or liability
created by the Exchange Act or the rules and regulations thereunder. The Company does not intend for its exclusive forum jurisdiction
provision to apply to Exchange Act claims. Furthermore, Section 22 of the Securities Act creates concurrent jurisdiction for federal and
state courts over all suits brought to enforce any duty or liability created by the Securities Act or the rules and regulations thereunder.
Although our certificate of incorporation contain the choice of forum provision described above, it is possible that a court could rule
that such a provision is inapplicable for a particular claim or action or that such provision is unenforceable.
Anti-takeover Effects of Our Certificate of
Incorporation and By-laws
Our certificate of incorporation and bylaws contain
certain provisions that may have anti-takeover effects, making it more difficult for or preventing a third party from acquiring control
of our Company or changing our Board of Directors and management. According to our bylaws and certificate of incorporation, neither the
holders of our common stock nor the holders of our preferred stock have cumulative voting rights in the election of our directors. The
combination of the present ownership by a few stockholders of a significant portion of our issued and outstanding common stock and lack
of cumulative voting makes it more difficult for other stockholders to replace our Board of Directors or for a third party to obtain control
of our Company by replacing our Board of Directors.
Anti-takeover Effects of Nevada Law
Business Combinations
The “business combination” provisions
of Sections 78.411 to 78.444, inclusive, of the Nevada Revised Statutes, or NRS, generally prohibit a Nevada corporation with at least
200 stockholders of record, a “resident domestic corporation,” from engaging in various “combination” transactions
with any “interested stockholder” unless certain conditions are met or the corporation has elected in its articles of incorporation
to not be subject to these provisions.
A “combination” is generally defined
to include (a) a merger or consolidation of the resident domestic corporation or any subsidiary of the resident domestic corporation with
the interested stockholder or affiliate or associate of the interested stockholder; (b) any sale, lease, exchange, mortgage, pledge, transfer,
or other disposition, in one transaction or a series of transactions, by the resident domestic corporation or any subsidiary of the resident
domestic corporation to or with the interested stockholder or affiliate or associate of the interested stockholder having: (i) an aggregate
market value equal to 5% or more of the aggregate market value of the assets of the resident domestic corporation, (ii) an aggregate market
value equal to 5% or more of the aggregate market value of all outstanding shares of the resident domestic corporation, or (iii) representing
10% or more of the earning power or net income of the resident domestic corporation; (c) the issuance or transfer in one transaction or
series of transactions of shares of the resident domestic corporation or any subsidiary of the resident domestic corporation having an
aggregate market value equal to 5% or more of the resident domestic corporation to the interested stockholder or affiliate or associate
of the interested stockholder; and (d) certain other transactions with an interested stockholder or affiliate or associate of the interested
stockholder.
An “interested stockholder” is generally
defined as a person who, together with affiliates and associates, owns (or within three years, did own) 10% or more of a corporation’s
voting stock. An “affiliate” of the interested stockholder is any person that directly or indirectly through one or more intermediaries
is controlled by or is under common control with the interested stockholder. An “associate” of an interested stockholder is
any (a) corporation or organization of which the interested stockholder is an officer or partner or is directly or indirectly the beneficial
owner of 10% or more of any class of voting shares of such corporation or organization; (b) trust or other estate in which the interested
stockholder has a substantial beneficial interest or as to which the interested stockholder serves as trustee or in a similar fiduciary
capacity; or (c) relative or spouse of the interested stockholder, or any relative of the spouse of the interested stockholder, who has
the same home as the interested stockholder.
If applicable, the prohibition is for a period
of two years after the date of the transaction in which the person became an interested stockholder, unless such transaction is approved
by the board of directors prior to the date the interested stockholder obtained such status; or the combination is approved by the board
of directors and thereafter is approved at a meeting of the stockholders by the affirmative vote of stockholders representing at least
60% of the outstanding voting power held by disinterested stockholders; and extends beyond the expiration of the two-year period, unless
(a) the combination was approved by the board of directors prior to the person becoming an interested stockholder; (b) the transaction
by which the person first became an interested stockholder was approved by the board of directors before the person became an interested
stockholder; (c) the transaction is approved by the affirmative vote of a majority of the voting power held by disinterested stockholders
at a meeting called for that purpose no earlier than two years after the date the person first became an interested stockholder; or (d)
if the consideration to be paid to all stockholders other than the interested stockholder is, generally, at least equal to the highest
of: (i) the highest price per share paid by the interested stockholder within the three years immediately preceding the date of the announcement
of the combination or in the transaction in which it became an interested stockholder, whichever is higher, plus compounded interest and
less dividends paid, (ii) the market value per share of common shares on the date of announcement of the combination and the date the
interested stockholder acquired the shares, whichever is higher, plus compounded interest and less dividends paid, or (iii) for holders
of preferred stock, the highest liquidation value of the preferred stock, plus accrued dividends, if not included in the liquidation value.
With respect to (i) and (ii) above, the interest is compounded at the rate for one-year United States Treasury obligations from time to
time in effect.
Applicability of the Nevada business combination
law would discourage parties interested in taking control of our company if they cannot obtain the approval of our board of directors.
These provisions could prohibit or delay a merger or other takeover or change in control attempt and, accordingly, may discourage attempts
to acquire our company even though such a transaction may offer our stockholders the opportunity to sell their stock at a price above
the prevailing market price. The Company has elected to not be governed by the Nevada business combination provisions.
Control Share Acquisitions
The “control share” provisions of
Sections 78.378 to 78.3793, inclusive, of the NRS, apply to “issuing corporations,” which are Nevada corporations with at
least 200 stockholders of record, including at least 100 stockholders of record who are Nevada residents, and which conduct business directly
or indirectly in Nevada, unless the corporation has elected to not be subject to these provisions.
The control share statute prohibits an acquirer
of shares of an issuing corporation, under certain circumstances, from voting its shares of a corporation’s stock after crossing
certain ownership threshold percentages, unless the acquirer obtains approval of the target corporation’s disinterested stockholders.
The statute specifies three thresholds: (a) one-fifth or more, but less than one-third, (b) one-third or more, but less than a majority,
and (c) a majority or more, of the outstanding voting power. Generally, once a person acquires shares in excess of any of the thresholds,
those shares and any additional shares acquired within 90 days thereof become “control shares” and such control shares are
deprived of the right to vote until disinterested stockholders restore the right. These provisions also provide that if control shares
are accorded full voting rights and the acquiring person has acquired a majority or more of all voting power, all other stockholders who
do not vote in favor of authorizing voting rights to the control shares are entitled to demand payment for the fair value of their shares
in accordance with statutory procedures established for dissenters’ rights.
A corporation may elect to not be governed by,
or “opt out” of, the control share provisions by making an election in its articles of incorporation or bylaws, provided that
the opt-out election must be in place on the 10th day following the date an acquiring person has acquired a controlling interest, that
is, crossing any of the three thresholds described above. We have opted out of the control share statutes, and, provided the “opt
out” election remains in place, we will not be subject to the control share statutes.
The effect of the Nevada control share statute
is that the acquiring person, and those acting in association with the acquiring person, will obtain only such voting rights in the control
shares as are conferred by a resolution of the stockholders at an annual or special meeting. The Nevada control share law, if applicable,
could have the effect of discouraging takeovers of our company.
Listing
Our common stock is listed on The Nasdaq Global
Select Market under the symbol “RLMD.”
Transfer Agent
The transfer agent and registrar for our common
stock is Empire Stock Transfer Inc. The transfer agent’s address 1859 Whitney Mesa Dr., Henderson, NV 89014, and its telephone number
is (702) 818-5898.
FORMS OF SECURITIES
Each security may be
represented either by a certificate issued in definitive form to a particular investor or by one or more global securities representing
the entire issuance of securities. Certificated securities in definitive form and global securities will be issued in registered form.
Definitive securities name you or your nominee as the owner of the security, and in order to transfer or exchange these securities or
to receive payments other than interest or other interim payments, you or your nominee must physically deliver the securities to the trustee,
registrar, paying agent or other agent, as applicable. Global securities name a depositary or its nominee as the owner of the warrants
or units represented by these global securities. The depositary maintains a computerized system that will reflect each investor’s
beneficial ownership of the securities through an account maintained by the investor with its broker/dealer, bank, trust company or other
representative, as we explain more fully below.
Registered Global
Securities
We may issue the securities
in the form of one or more fully registered global securities that will be deposited with a depositary or its nominee identified in the
applicable prospectus supplement and registered in the name of that depositary or nominee. In those cases, one or more registered global
securities will be issued in a denomination or aggregate denominations equal to the portion of the aggregate principal or face amount
of the securities to be represented by registered global securities. Unless and until it is exchanged in whole for securities in definitive
registered form, a registered global security may not be transferred except as a whole by and among the depositary for the registered
global security, the nominees of the depositary or any successors of the depositary or those nominees.
The specific terms of
the depositary arrangement with respect to any securities to be represented by a registered global security will be described in the prospectus
supplement relating to those securities. We anticipate that the following provisions will apply to all depositary arrangements.
Ownership of beneficial
interests in a registered global security will be limited to persons, called participants, that have accounts with the depositary or persons
that may hold interests through participants. Upon the issuance of a registered global security, the depositary will credit, on its book-entry
registration and transfer system, the participants’ accounts with the respective principal or face amounts of the securities beneficially
owned by the participants. Any dealers, underwriters or agents participating in the distribution of the securities will designate the
accounts to be credited. Ownership of beneficial interests in a registered global security will be shown on, and the transfer of ownership
interests will be effected only through, records maintained by the depositary, with respect to interests of participants, and on the records
of participants, with respect to interests of persons holding through participants. The laws of some states may require that some purchasers
of securities take physical delivery of these securities in definitive form. These laws may impair your ability to own, transfer or pledge
beneficial interests in registered global securities.
So long as the depositary,
or its nominee, is the registered owner of a registered global security, that depositary or its nominee, as the case may be, will be considered
the sole owner or holder of the securities represented by the registered global security for all purposes under the applicable indenture,
warrant agreement or unit agreement.
Except as described below,
owners of beneficial interests in a registered global security will not be entitled to have the securities represented by the registered
global security registered in their names, will not receive or be entitled to receive physical delivery of the securities in definitive
form and will not be considered the owners or holders of the securities under the applicable indenture, warrant agreement or unit agreement.
Accordingly, each person owning a beneficial interest in a registered global security must rely on the procedures of the depositary for
that registered global security and, if that person is not a participant, on the procedures of the participant through which the person
owns its interest, to exercise any rights of a holder under the applicable indenture, warrant agreement or unit agreement. We understand
that under existing industry practices, if we request any action of holders or if an owner of a beneficial interest in a registered global
security desires to give or take any action that a holder is entitled to give or take under the applicable indenture, warrant agreement
or unit agreement, the depositary for the registered global security would authorize the participants holding the relevant beneficial
interests to give or take that action, and the participants would authorize beneficial owners owning through them to give or take that
action or would otherwise act upon the instructions of beneficial owners holding through them.
Payments to holders with
respect to securities represented by a registered global security registered in the name of a depositary or its nominee will be made to
the depositary or its nominee, as the case may be, as the registered owner of the registered global security. None of the Company, the
trustees, the warrant agents, the unit agents or any other agent of the Company, agent of the trustees, the warrant agents or unit agents
will have any responsibility or liability for any aspect of the records relating to payments made on account of beneficial ownership interests
in the registered global security or for maintaining, supervising or reviewing any records relating to those beneficial ownership interests.
We expect that the depositary
for any of the securities represented by a registered global security, upon receipt of any payment of principal, premium, interest or
other payment or distribution to holders of that registered global security, will immediately credit participants’ accounts in amounts
proportionate to their respective beneficial interests in that registered global security as shown on the records of the depositary. We
also expect that payments by participants to owners of beneficial interests in a registered global security held through participants
will be governed by standing customer instructions and customary practices, as is now the case with the securities held for the accounts
of customers or registered in “street name,” and will be the responsibility of those participants.
If the depositary for
any of these securities represented by a registered global security is at any time unwilling or unable to continue as depositary or ceases
to be a clearing agency registered under the Exchange Act and a successor depositary registered as a clearing agency under the Exchange
Act is not appointed by us within 90 days, we will issue securities in definitive form in exchange for the registered global security
that had been held by the depositary. Any securities issued in definitive form in exchange for a registered global security will be registered
in the name or names that the depositary gives to the relevant trustee, warrant agent, unit agent or other relevant agent of ours or theirs.
It is expected that the depositary’s instructions will be based upon directions received by the depositary from participants with
respect to ownership of beneficial interests in the registered global security that had been held by the depositary.
LEGAL MATTERS
Unless otherwise indicated in the applicable prospectus
supplement, the validity of the securities offered by this prospectus and certain other legal matters as to Nevada law will be passed
upon for us by Sichenzia Ross Ference Carmel LLP, New York, New York. If legal matters in connection with offerings made by this prospectus
are passed on by counsel for the underwriters, dealers or agents, if any, that counsel will be named in the applicable prospectus supplement.
EXPERTS
The consolidated financial statements of Relmada
Therapeutics, Inc., as of and for the years ended December 31, 2023 and 2022, appearing in the Company’s Annual Report on Form
10-K for the year ended December 31, 2023, incorporated by reference into this prospectus, have been so included in reliance on the
reports of Marcum LLP, an independent registered public accounting firm, incorporated by reference herein, given on the authority of said
firm as experts in auditing and accounting.
WHERE YOU CAN FIND MORE INFORMATION
We file annual, quarterly and special reports,
along with other information with the SEC. Our SEC filings are available to the public over the Internet at the SEC’s website at
http://www.sec.gov.
This prospectus is part of a registration statement
on Form S-3 that we filed with the SEC to register the securities offered hereby under the Securities Act of 1933, as amended. This prospectus
does not contain all of the information included in the registration statement, including certain exhibits and schedules. You may obtain
the registration statement and exhibits to the registration statement from the SEC from the SEC’s internet site.
INCORPORATION OF DOCUMENTS BY REFERENCE
We are “incorporating by reference”
in this prospectus certain documents we file with the Commission, which means that we can disclose important information to you by referring
you to those documents. The information in the documents incorporated by reference is considered to be part of this prospectus. Statements
contained in documents that we file with the Commission and that are incorporated by reference in this prospectus will automatically update
and supersede information contained in this prospectus, including information in previously filed documents or reports that have been
incorporated by reference in this prospectus, to the extent the new information differs from or is inconsistent with the old information.
We have filed or may file the following documents with the Commission and they are incorporated herein by reference as of their respective
dates of filing.
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Our Annual Report on Form 10-K for the year ended December 31, 2023, filed with the SEC on March 19, 2024; |
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Our Quarterly Report on Form 10-Q for the quarter ended March 31, 2024, filed with the SEC on May 8, 2024; |
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Our Quarterly Report on Form 10-Q for the quarter ended June 30, 2024, filed with the SEC on August 7, 2024; |
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Our Current Reports on Form 8-K filed with the SEC on January 3, 2024, January 11, 2024 and May 30, 2024; and |
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The description of our common stock contained in our Registration Statement on Form 8-A filed on October 8, 2019, and as it may further be amended from time to time. |
All documents that we filed with the Commission
pursuant to Sections 13(a), 13(c), 14, and 15(d) of the Exchange Act on or after the date of the initial filing of the registration statement
of which this prospectus forms a part and prior to the filing of a post-effective amendment to this registration statement that indicates
that all securities offered under this prospectus have been sold, or that deregisters all securities then remaining unsold, will be deemed
to be incorporated in this registration statement by reference and to be a part hereof from the date of filing of such documents.
Any statement contained in a document incorporated
or deemed to be incorporated by reference in this prospectus shall be deemed modified, superseded or replaced for purposes of this prospectus
to the extent that a statement contained in this prospectus, or in any subsequently filed document that also is deemed to be incorporated
by reference in this prospectus, modifies, supersedes or replaces such statement. Any statement so modified, superseded or replaced shall
not be deemed, except as so modified, superseded or replaced, to constitute a part of this prospectus. None of the information that we
disclose under Items 2.02 or 7.01 of any Current Report on Form 8-K or any corresponding information, either furnished under Item 9.01
or included as an exhibit therein, that we may from time to time furnish to the Commission will be incorporated by reference into, or
otherwise included in, this prospectus, except as otherwise expressly set forth in the relevant document. Subject to the foregoing, all
information appearing in this prospectus is qualified in its entirety by the information appearing in the documents incorporated by reference.
You may request, orally or in writing, a copy
of these documents, which will be provided to you at no cost (other than exhibits, unless such exhibits are specifically incorporate by
reference), by contacting our chief financial officer, c/o Relmada Therapeutics, Inc., at 222 Ponce de Leon Blvd., Floor 3, Coral Gables,
FL 33134. Our telephone number is 1-786-629-1376. Information about us is also available at our website at www.relmada.com.
However, the information in our website is not a part of this prospectus and is not incorporated by reference.
RELMADA THERAPEUTICS, INC.
$250,000,000
COMMON STOCK
PREFERRED STOCK
WARRANTS
SUBSCRIPTION RIGHTS
DEPOSITARY SHARES
PURCHASE CONTRACTS
UNITS
PROSPECTUS
, 2024
The information in
this prospectus supplement is not complete and may be changed. We may not sell these securities or accept an offer to buy these securities
until the registration statement of which this prospectus forms a part filed with the Securities and Exchange Commission is effective.
This prospectus is not an offer to sell these securities, and it is not soliciting offers to buy these securities in any jurisdiction
where such offer or sale is not permitted.
Subject to completion,
dated August 30, 2024
PROSPECTUS SUPPLEMENT
RELMADA THERAPEUTICS, INC.
Up to $100,000,000
Common Stock
We have previously entered into an Open Market
Sale AgreementSM (the “Sale Agreement”), with Jefferies LLC (“Jefferies”), relating to shares
of our common stock offered by this prospectus supplement and the accompanying prospectus. In accordance with the terms of the Sale Agreement,
under this prospectus supplement and the accompanying prospectus, we may offer and sell shares of our common stock having an aggregate
offering price of up to $100,000,000 from time to time through Jefferies, acting as our sales agent.
Our common stock is listed on The Nasdaq Global
Select Market (“Nasdaq”) under the symbol “RLMD.” On August 27, 2024, the last reported sale price of our common
stock on Nasdaq was $2.72 per share.
Sales of our common stock, if any, under this
prospectus supplement and the accompanying prospectus may be made in sales deemed to be “at the market offerings” as defined
in Rule 415(a)(4) promulgated under the Securities Act of 1933, as amended (the “Securities Act”). Jefferies is not required
to sell any specific amount of our common stock, but will act as our sales agent and use commercially reasonable efforts to sell on our
behalf all of the shares of common stock requested to be sold by us, consistent with its normal trading and sales practices, on mutually
agreed terms between Jefferies and us. There is no arrangement for funds to be received in any escrow, trust or similar arrangement.
Jefferies will receive from us a commission of
up to 3.0% of the gross proceeds of any shares of common stock sold through it under the Sale Agreement. In connection with the sale
of our common stock on our behalf, Jefferies will be deemed to be an “underwriter” within the meaning of the Securities Act
and the compensation of Jefferies will be deemed to be underwriting commissions or discounts. We have also agreed to provide indemnification
and contribution to Jefferies with respect to certain liabilities, including liabilities under the Securities Act. See “Plan
of Distribution” beginning on page S-7
for additional information regarding the compensation to be paid to the sales agent.
An investment
in our securities involves a high degree of risk. Please read “Risk Factors” on page S-3 of this prospectus supplement and
in the documents incorporated by reference into this prospectus supplement before investing in our securities.
Neither the Securities and Exchange Commission
nor any state securities commission has approved or disapproved of these securities or passed upon the adequacy or accuracy of this prospectus
supplement or the accompanying prospectus. Any representation to the contrary is a criminal offense.
Jefferies
The
date of this prospectus supplement is , 2024
TABLE OF CONTENTS
ABOUT THIS PROSPECTUS SUPPLEMENT
This prospectus supplement and the accompanying
prospectus are part of registration statement on Form S-3 that we have filed with the Securities and Exchange Commission, or the SEC,
using a “shelf” registration process. Under the shelf registration process, we may offer shares of our common stock having
an aggregate offering price of up to $250,000,000 from time to time at prices and on terms to be determined by market conditions at the
time of the offering. The $100,000,000 of shares of our common stock that may be sold under this prospectus supplement are included in
the $250,000,000 of our securities that may be sold under the registration statement.
Before buying any of the common stock that we
are offering, we urge you to carefully read this prospectus supplement and the accompanying prospectus, together with the information
incorporated by reference as described under the headings “Where You Can Find More Information” and “Incorporation of
Certain Information by Reference” in this prospectus supplement. These documents contain important information that you should consider
when making your investment decision.
This document is in two parts. The first part
is this prospectus supplement, which describes the specific terms of this offering and also adds to and updates information contained
in the accompanying prospectus and the documents incorporated by reference herein or therein. The second part, the accompanying prospectus,
provides more general information. To the extent there is a conflict between the information contained in this prospectus supplement or
the accompanying prospectus, on the one hand, and the information contained in any document incorporated by reference into this prospectus
supplement that was filed with the Securities and Exchange Commission (the “SEC”), before the date of this prospectus supplement,
on the other hand, you should rely on the information in this prospectus supplement. If any statement in one of these documents is inconsistent
with a statement in another document having a later date—for example, a document incorporated by reference into this prospectus
supplement—the statement in the document having the later date modifies or supersedes the earlier statement.
We further note that the representations, warranties
and covenants made by us in any agreement that is filed as an exhibit to any document that is incorporated by reference herein or in the
accompanying prospectus were made solely for the benefit of the parties to such agreement, including, in some cases, for the purpose of
allocating risk among the parties to such agreement, and should not be deemed to be a representation, warranty or covenant to you. Moreover,
such representations, warranties or covenants were accurate only as of the date when made. Accordingly, such representations, warranties
and covenants should not be relied on as accurately representing the current state of our affairs.
You should rely only on the information contained
or incorporated by reference in this prospectus supplement and the accompanying prospectus and any free writing prospectuses we may provide
to you in connection with this offering. We have not, and Jefferies has not, authorized any other person to provide you with different
information. If anyone provides you with different or inconsistent information, you should not rely on it. We are not, and Jefferies is
not, making an offer to sell or seeking an offer to buy our common stock under this prospectus supplement and the accompanying prospectus
in any jurisdiction where the offer or sale is not permitted. Persons outside the United States who come into possession of this prospectus
supplement and the accompanying prospectus must inform themselves about, and observe any restrictions relating to, the offering of the
securities and the distribution of this prospectus outside the United States. Furthermore, you should not consider this prospectus supplement
and the accompanying prospectus to be an offer or solicitation relating to the securities if the person making the offer or solicitation
is not qualified to do so, or if it is unlawful for you to receive such an offer or solicitation. You should not assume that the information
contained in this prospectus supplement and the accompanying prospectus or free writing prospectus is accurate as of any date other than
the date on the front cover of those documents, or that the information contained in any document incorporated by reference is accurate
as of any date other than the date of the document incorporated by reference, regardless of the time of delivery of this prospectus supplement
and the accompanying prospectus or any sale of a security. Our business, financial condition, results of operations and prospects may
have changed since those dates. It is important for you to read and consider all information contained in this prospectus supplement,
the accompanying prospectus, the documents incorporated by reference herein and therein, and any free writing prospectus prepared by or
on behalf of us that we may authorize for use in connection with this offering, in their entirety, before making an investment decision.
You should also read and consider the information in the documents to which we have referred you in the sections entitled “Where
You Can Find More Information” and “Incorporation of Certain Information by Reference” in this prospectus supplement
and in the accompanying prospectus.
In this prospectus supplement and the accompanying
prospectus, unless the context otherwise requires, references to “Relmada,” “we,” “our” and “us”
refer, collectively, to Relmada Therapeutics, Inc., a Nevada corporation, and its subsidiary, Relmada Therapeutics, Inc., a Delaware corporation.
This prospectus supplement and the accompanying
prospectus, including information incorporated herein and therein by reference, contain references to our trademarks and to trademarks
belonging to other entities. Solely for convenience, trademarks and trade names referred to in this prospectus supplement and the accompanying
prospectus, including logos, artwork and other visual displays, may appear without the ® or TM symbols, but such references
are not intended to indicate, in any way, that their respective owners will not assert, to the fullest extent under applicable law, their
rights thereto. We do not intend our use or display of other companies’ trade names or trademarks to imply a relationship with,
or endorsement or sponsorship of us by, any other companies.
PROSPECTUS SUPPLEMENT SUMMARY
This
summary highlights certain information about this offering
and selected information contained elsewhere in or incorporated by reference into this prospectus supplement and the accompanying prospectus.
This summary is not complete and does not contain all of the information that you should consider before deciding whether to invest in
our shares of common stock. You should carefully read this entire prospectus supplement and accompanying prospectus, including the information
incorporated herein and therein, including the “Risk Factors” section contained in this prospectus supplement and the other
documents incorporated by reference into this prospectus supplement.
Business Overview
Relmada
Therapeutics, Inc., a Nevada corporation, is a clinical-stage biotechnology company addressing diseases of the central nervous system
(CNS).
Esmethadone
Program (REL-1017)
We
have focused on the development of our lead product candidate, esmethadone (d-methadone, dextromethadone, REL-1017), an N-methyl-D-aspartate
(NMDA) receptor antagonist. Esmethadone, an isomer of methadone, is a new chemical entity (NCE) that potentially addresses areas of high
unmet medical need in the treatment of CNS diseases and other disorders. Esmethadone, is being developed as a rapidly acting, oral agent
for the treatment of depression and other potential indications.
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late 2022, we announced that our Phase 3 clinical trials, RELIANCE I, a trial of REL-1017
as an adjunctive treatment for Major Depressive Disorder (MDD), and RELIANCE III, a monotherapy
trial of REL-1017 for MDD, did not achieve their primary endpoints. |
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our long-term open label study of REL-1017 in patients with MDD, Study 310, which included
both patients who completed the RELIANCE trials and subjects who had not previously participated
in a REL-1017 clinical trial, in September 20, 2023, we announced efficacy results for the
de novo (or new to treatment) patients and safety results for all subjects. Patients treated
daily with REL-1017 for up to one year experienced rapid, clinically meaningful, and sustained
improvements in depressive symptoms and associated functional impairment. REL-1017 was well-tolerated
with long-term dosing, showing low rates of adverse events and discontinuations due to adverse
events. The most commonly reported adverse events deemed to be treatment-related
all occurred included headache, nausea and dizziness. No new safety signals were detected. |
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plan to complete two additional ongoing adjunctive Phase 3 trials (RELIANCE II and RELIGHT)
that build on the knowledge obtained from RELIANCE I,. |
Psilocybin
Program (REL-P11)
We
also intend to enter human studies of our proprietary, modified-release formulation of psilocybin (REL-P11) for metabolic
indications in doses that we believe are lower than those associated with psychedelic effects. The Company plans to commence a
single-ascending dose Phase 1 trial in obese subjects in Canada in 2024 to define the pharmacokinetic, safety and tolerability
profile of REL-P11 in this population, followed by a Phase 2a trial to establish clinical proof-of-concept.
Pre-clinical
data in a rodent model of metabolic dysfunction-associated steatotic liver disease demonstrated beneficial effects of psilocybin on multiple
metabolic parameters, including reduced hepatic steatosis, reduced body weight gain, and fasting blood glucose levels.
Stock Listing
Our common stock is listed on The Nasdaq Global
Select Market under the symbol “RLMD.”
Corporate Information
Our principal executive offices are located at
2222 Ponce de Leon Blvd., Floor 3, Coral Gables, Florida 33134 and our telephone number is +1-786-629-1376. Our website address is www.relmada.com.
The information contained therein or connected thereto shall not be deemed to be incorporated into this prospectus supplement and the
accompanying prospectus or the registration statement of which they form a part. The information on our website is not part of this prospectus
supplement and the accompanying prospectus.
For additional information about us, please refer
to other documents we have filed with the SEC and that are incorporated by reference into this prospectus supplement, as listed under
the heading “Incorporation of Certain Information by Reference.
THE OFFERING
Common stock offered by us |
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Shares of our common stock having an aggregate offering price of up to $100,000,000. |
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Common stock to be outstanding after this offering |
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Up to 66,938,908 shares of common stock (as more fully described in the notes following this table), assuming sales of 36,764,706 shares of our common stock in this offering at an offering price of $2.72 per share, which was the last reported sale price of our common stock on Nasdaq on August 27, 2024. The actual number of shares issued will vary depending on the sales price under this offering. |
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Plan of Distribution |
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“At the market offering” that may be made from time to time through our sales agent, Jefferies. See the section entitled “Plan of Distribution” on page S-7 of this prospectus supplement. |
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Use of Proceeds |
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We intend to use the net proceeds from this offering for working capital and general corporate purposes, which includes, without limitation, clinical studies required to gain regulatory approvals, implementation of adequate systems and controls to allow for regulatory approvals, further development of our product candidates, investing in or acquiring companies that are synergistic with or complimentary to our technologies, licensing activities related to our current and future product candidates and working capital, the development of emerging technologies, investing in or acquiring companies that are developing emerging technologies, licensing activities, or the acquisition of other businesses. See the section titled “Use of Proceeds” on page S-5 of this prospectus supplement. |
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Risk Factors |
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See “Risk Factors” beginning on page S-3 of this prospectus supplement and in the documents incorporated by reference herein for a discussion of factors you should consider carefully before investing in our common stock. |
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Nasdaq Global Select Market symbol |
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“RLMD” |
The number of shares of our common stock to be
outstanding after this offering is based on 30,174,202 shares of our common stock outstanding as of June 30, 2024, and excludes as of
that date:
|
● |
13,052,592 shares of our common stock issuable upon the exercise of stock options, at a weighted average exercise price of $16.47 per share; and |
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1,813,455 shares of our common stock issuable upon the exercise of warrants outstanding, at a weighted average exercise price of $23.72 per share. |
RISK FACTORS
An investment in our common stock involves
a high degree of risk. Prior to making a decision about investing in our common stock, you should carefully consider the risk factors
described below and the risk factors discussed in the sections entitled “Risk Factors” contained in our most recent Annual
Report on Form 10-K, and our other filings with the SEC and incorporated by reference in this prospectus supplement, together with all
of the other information contained in this prospectus supplement. Additional risks and uncertainties not presently known to us, or that
we currently view as immaterial, may also impair our business. Our business, financial condition and results of operations could be materially
and adversely affected as a result of these risks. This could cause the trading price of our common stock to decline, resulting in a loss
of all or part of your investment.
Risks Related to this Offering
We will have broad discretion in the use
of the net proceeds from this offering and, despite our efforts, we may use the net proceeds in a manner that does not increase the value
of your investment.
We currently intend to use the net proceeds from
this offering for working capital and general corporate purposes, which includes, without limitation, clinical studies required to gain
regulatory approvals, implementation of adequate systems and controls to allow for regulatory approvals, further development of our product
candidates, investing in or acquiring companies that are synergistic with or complimentary to our technologies, licensing activities related
to our current and future product candidates and working capital, the development of emerging technologies, investing in or acquiring
companies that are developing emerging technologies, licensing activities, or the acquisition of other businesses. However, we have not
determined the specific allocation of the net proceeds among these potential uses. Our management will have broad discretion over the
use and investment of the net proceeds from this offering, and, accordingly, investors in this offering will need to rely upon the judgment
of our management with respect to the use of proceeds, with only limited information concerning our specific intentions. These proceeds
could be applied in ways that do not improve our operating results or increase the value of your investment.
You may experience immediate and substantial
dilution in the net tangible book value per share of the common stock you purchase in the offering. In addition, we may issue additional
equity or convertible debt securities in the future, which may result in additional dilution to you.
The offering price per share in this offering may exceed the pro forma
net tangible book value per share of our common stock outstanding as of June 30, 2024. Assuming that an aggregate of 36,764,706 shares
of our common stock are sold at a price of $2.72 per share, the last reported sale price of our common stock on Nasdaq on August 27, 2024,
for aggregate gross proceeds of approximately $100,000,000, and after deducting commissions and estimated aggregate offering expenses
payable by us, you will experience immediate dilution of $0.36 per share, representing the difference between our pro forma as adjusted
net tangible book value per share as of June 30, 2024, after giving effect to this offering and the assumed offering price. The exercise
of outstanding stock options could result in further dilution of your investment. See the section titled “Dilution” below
for a more detailed illustration of the dilution you would incur if you participate in this offering. In addition, to the extent we need
to raise additional capital in the future and we issue additional shares of common stock or securities convertible or exchangeable for
our common stock, our then existing stockholders may experience dilution and the new securities may have rights senior to those of our
common stock offered in this offering.
You may experience future dilution as a
result of future equity offerings.
To raise additional capital, we may in the future
offer additional shares of our common stock or other securities convertible into or exchangeable for our common stock at prices that may
not be the same as the price per share in this offering. We may sell shares or other securities in any other offering at a price per share
that is less than the price per share paid by investors in this offering, and investors purchasing shares or other securities in the future
could have rights superior to existing stockholders. The price per share at which we sell additional shares of our common stock, or securities
convertible or exchangeable into common stock, in future transactions may be higher or lower than the price per share paid by investors
in this offering.
The actual number of shares we will issue
under the Sale Agreement, at any one time or in total, is uncertain.
Subject to certain limitations in the Sale Agreement
and compliance with applicable law, we have the discretion to deliver instruction to Jefferies to sell shares of our common stock at any
time throughout the term of the Sale Agreement. The number of shares that are sold through Jefferies after our instruction will fluctuate
based on a number of factors, including the market price of our common stock during the sales period, the limits we set with Jefferies
in any instruction to sell shares, and the demand for our common stock during the sales period. Because the price per share of each share
sold will fluctuate during this offering, it is not currently possible to predict the number of shares that will be sold or the gross
proceeds to be raised in connection with those sales.
The common stock offered hereby will be
sold in “at the market offerings,” and investors who buy shares at different times will likely pay different prices.
Investors who purchase shares in this offering
at different times will likely pay different prices, and so may experience different levels of dilution and different outcomes in their
investment results. We will have discretion, subject to market demand, to vary the timing, prices, and numbers of shares sold in this
offering. Investors may experience a decline in the value of the shares they purchase in this offering as a result of sales made at prices
lower than the prices they paid.
CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS
This prospectus supplement, the accompanying prospectus
and the information incorporated by reference herein and therein contain or incorporate forward-looking statements within the meaning
of Section 27A of the Securities Act and Section 21E of the Securities Exchange Act of 1934, as amended (the “Exchange Act”).
These forward-looking statements reflect management’s beliefs and assumptions. In addition, these forward-looking statements reflect
management’s current views with respect to future events or our financial performance, and involve certain known and unknown risks,
uncertainties and other factors, including those identified below, which may cause our or our industry’s actual or future results,
levels of activity, performance or achievements to differ materially from those expressed or implied by any forward-looking statements
or from historical results. We intend the forward-looking statements to be covered by the safe harbor provisions for forward-looking statements
contained in Section 27A of the Securities Act and Section 21E of the Exchange Act. Forward-looking statements include information concerning
our possible or assumed future results of operations and statements preceded by, followed by, or that include the words “may,”
“will,” “could,” “would,” “should,” “believe,” “expect,” “plan,”
“anticipate,” “intend,” “estimate,” “predict,” “potential” or similar expressions.
Forward-looking statements are inherently subject
to risks and uncertainties, many of which we cannot predict with accuracy and some of which we might not even anticipate. Although we
believe that the expectations reflected in the forward-looking statements are based upon reasonable assumptions at the time made, we can
give no assurance that the expectations will be achieved. Future events and actual results, financial and otherwise, may differ materially
from the results discussed in the forward-looking statements. Readers are cautioned not to place undue reliance on these forward-looking
statements.
The factors described under “Risk Factors”
in this prospectus supplement and the accompanying prospectus and in any documents incorporated by reference herein, and other factors
could cause our or our industry’s future results to differ materially from historical results or those anticipated or expressed
in any of our forward-looking statements. We operate in a continually changing business environment, and new risk factors emerge from
time to time. Other unknown or unpredictable factors also could have material adverse effects on our future results, performance or achievements.
We cannot assure you that projected results or events will be achieved or will occur.
You should read this prospectus supplement and
the accompanying prospectus, and the information incorporated by reference herein, completely and with the understanding that our actual
future results may be materially different from what we expect. Any forward-looking statement speaks only as of the date of this prospectus
supplement. We do not assume any obligation to update any forward-looking statements, whether as a result of new information, future events
or otherwise, except as required by law.
USE OF PROCEEDS
We may issue and sell shares of our common stock
having aggregate gross sales proceeds of up to $100,000,000 from time to time. Because there is no minimum offering amount required as
a condition to close this offering, the actual total public offering amount, commissions and proceeds to us, if any, are not determinable
at this time.
We will retain broad discretion over the use of
the net proceeds from the sale of the securities offered hereby. We currently intend to use the net proceeds from this offering for working
capital and general corporate purposes, which includes, without limitation, clinical studies required to gain regulatory approvals, implementation
of adequate systems and controls to allow for regulatory approvals, further development of our product candidates, investing in or acquiring
companies that are synergistic with or complimentary to our technologies, licensing activities related to our current and future product
candidates and working capital, the development of emerging technologies, investing in or acquiring companies that are developing emerging
technologies, licensing activities, or the acquisition of other businesses. The precise amount and timing of the application of such proceeds
will depend upon our funding requirements and the availability and cost of other capital. As of the date of this prospectus supplement,
we cannot specify with certainty all of the particular uses for the net proceeds that we will have from the sale of the shares of our
common stock. Pending the use of the net proceeds from this offering, if any, we may invest the net proceeds in investment grade, short-term
interest-bearing obligations, such as money-market funds, certificates of deposit, or direct or guaranteed obligations of the United States
government, or hold the net proceeds as cash.
DILUTION
If you purchase shares of our common stock in
this offering, your interest will be diluted to the extent of the difference between the public offering price per share and the net tangible
book value per share of our common stock after this offering. We calculate net tangible book value per share by dividing our net tangible
assets (tangible assets less total liabilities) by the number of shares of our common stock issued and outstanding as of June 30, 2024.
Our historical net tangible book value at June
30, 2024 was $61,491,628 or approximately $2.04 per share of our common stock. After giving effect to the sale of our common stock in
the aggregate amount of $100,000,000 in this offering, at an assumed offering price of $2.72 per share, the last reported sale price of
our common stock on Nasdaq on August 27, 2024, and after deducting estimated offering expenses and commissions payable by us (net proceeds
of $96,815,240), our adjusted net tangible book value as of June 30, 2024, would have been approximately $158,306,868 million, or approximately
$2.36 per share of our common stock. This represents an immediate increase in the net tangible book value of $0.32 per share of our common
stock to our existing stockholders and an immediate dilution in net tangible book value of approximately $0.36 per share of our common
stock to new investors. The following table illustrates per share dilution:
Assumed public offering price per share | |
| | | |
$ | 2.72 | |
Net tangible book value per share as of June 30, 2024 | |
$ | 2.04 | | |
| | |
Increase in net tangible book value per share attributable to this offering | |
$ | 0.32 | | |
| | |
Adjusted net tangible book value per share as of June 30, 2024, after giving effect to this offering | |
| | | |
$ | 2.36 | |
Dilution per share to new investors purchasing shares in this offering | |
| | | |
$ | 0.36 | |
The table above assumes for illustrative purposes that an aggregate
of 36,764,706 shares of our common stock are sold at a price of $2.72 per share, the last reported sale price of our common stock on Nasdaq
on August 27, 2024, for aggregate gross proceeds of $100,000,000. The shares sold in this offering, if any, will be sold from time to
time at various prices. An increase of $1.00 per share in the price at which the shares are sold from the assumed offering price of $2.72
per share shown in the table above, assuming all of our common stock in the aggregate amount of $100,000,000 is sold at that price, would
increase our adjusted net tangible book value per share after the offering to $2.77 per share and would increase the dilution in net tangible
book value per share to new investors in this offering to $0.95 per share, after deducting estimated offering expenses and commissions
payable by us. A decrease of $1.00 per share in the price at which the shares are sold from the assumed offering price of $2.72 per share
shown in the table above, assuming all of our common stock in the aggregate amount of $100,000,000 is sold at that price, would decrease
our adjusted net tangible book value per share after the offering to $1.79 per share and would not result in any dilution in net tangible
book value per share to new investors in this offering. This information is supplied for illustrative purposes only.
The number of shares of our common stock to be
outstanding after this offering is based on 30,174,202 shares of our common stock outstanding as of June 30, 2024, and excludes as of
that date:
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13,052,592 shares of our common stock issuable upon the exercise of stock options, at a weighted average exercise price of $16.47 per share; and |
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1,813,455 shares of our common stock issuable upon the exercise of warrants outstanding, at a weighted average exercise price of $23.72 per share. |
To the extent that outstanding options are exercised,
or we issue other shares, investors purchasing shares in this offering could experience further dilution. In addition, we may choose to
raise additional capital due to market conditions or strategic considerations, even if we believe we have sufficient funds for our current
or future operating plans. To the extent that we raise additional capital through the sale of equity or convertible debt securities, the
issuance of those securities could result in further dilution to our stockholders.
PLAN OF DISTRIBUTION
We have previously entered into a Sale Agreement
with Jefferies on April 7, 2022, under which we may offer and sell shares of our common stock from time to time through Jefferies acting
as agent. Pursuant to this prospectus supplement and accompanying prospectus, we may offer and sell up to $100,000,000 shares of our common
stock. Sales of our shares of common stock, if any, under this prospectus supplement and the accompanying prospectus will be made by any
method that is deemed to be an “at the market offering” as defined in Rule 415(a)(4) under the Securities Act.
Each time we wish to issue and sell shares of
common stock under the Sale Agreement, we will notify Jefferies of the number of shares to be issued, the dates on which such sales are
anticipated to be made, any limitation on the number of shares to be sold in any one day and any minimum price below which sales may not
be made. Once we have so instructed Jefferies, unless Jefferies declines to accept the terms of such notice, Jefferies has agreed to use
its commercially reasonable efforts consistent with its normal trading and sales practices to sell such shares up to the amount specified
on such terms. The obligations of Jefferies under the Sale Agreement to sell our shares of common stock are subject to a number of conditions
that we must meet.
The settlement of sales of shares between us and
Jefferies is generally anticipated to occur on the first trading day following the date on which the sale was made. Sales of our shares
of common stock as contemplated in this prospectus supplement will be settled through the facilities of The Depository Trust Company or
by such other means as we and Jefferies may agree upon. There is no arrangement for funds to be received in an escrow, trust or similar
arrangement.
We will pay Jefferies a commission of up to 3.0% of the aggregate gross
proceeds we receive from each sale of our shares of common stock. Because there is no minimum offering amount required as a condition
to close this offering, the actual total public offering amount, commissions and proceeds to us, if any, are not determinable at this
time. In addition, we have agreed to reimburse Jefferies for the fees and disbursements of its counsel, payable upon execution of the
Sale Agreement, in an amount not to exceed $75,000, in addition to certain ongoing disbursements of its legal counsel, unless we and Jefferies
otherwise agree. We estimate that the total expenses for the offering, excluding any commissions or expense reimbursement payable to Jefferies
under the terms of the Sale Agreement, will be approximately $190,000. The remaining sale proceeds, after deducting any other transaction
fees, will equal our net proceeds from the sale of such shares.
Jefferies will provide written confirmation to
us before the open on Nasdaq on the day following each day on which shares of common stock are sold under the Sale Agreement. Each confirmation
will include the number of shares sold on that day, the aggregate gross proceeds of such sales and the proceeds to us.
In connection with the sale of our shares of common
stock on our behalf, Jefferies will be deemed to be an “underwriter” within the meaning of the Securities Act, and the compensation
of Jefferies will be deemed to be underwriting commissions or discounts. We have agreed to indemnify Jefferies against certain civil liabilities,
including liabilities under the Securities Act. We have also agreed to contribute to payments Jefferies may be required to make in respect
of such liabilities.
The offering of our shares of common stock pursuant
to the Sale Agreement will terminate in accordance with the terms set forth therein.
This summary of the material provisions of the
Sale Agreement does not purport to be a complete statement of its terms and conditions. A copy of the Sale Agreement is filed as an exhibit
to the registration statement of which this prospectus supplement forms a part.
Jefferies and its affiliates may in the future
provide various investment banking, commercial banking, financial advisory and other financial services for us and our affiliates, for
which services they may in the future receive customary fees. In the course of its business, Jefferies may actively trade our securities
for its own account or for the accounts of customers, and, accordingly, Jefferies may at any time hold long or short positions in such
securities.
A prospectus supplement and the accompanying prospectus
in electronic format may be made available on a website maintained by Jefferies, and Jefferies may distribute the prospectus supplement
and the accompanying prospectus electronically.
LEGAL MATTERS
The validity of the issuance of the common stock
offered by this prospectus supplement will be passed upon for us by Sichenzia Ross Ference Carmel LLP, New York, New York. Jefferies LLC
is being represented in connection with this offering by Cooley LLP, New York, New York.
EXPERTS
The consolidated financial statements of Relmada
Therapeutics, Inc., as of and for the years ended December 31, 2023 and 2022, appearing in the Company’s Annual Report on Form
10-K for the year ended December 31, 2023, incorporated by reference into this prospectus supplement, have been so included in reliance
on the reports of Marcum LLP, an independent registered public accounting firm, incorporated by reference herein, given on the authority
of said firm as experts in auditing and accounting.
WHERE YOU CAN FIND MORE INFORMATION
We file annual, quarterly and current reports,
proxy statements and other information with the SEC. Our SEC filings are also available to the public at the SEC’s web site at http://www.sec.gov.
We make available free of charge on or through
our Internet website www.relmada.com, our annual reports on Form 10-K, quarterly reports on Form 10-Q, current reports on Form 8–K,
and amendments to those reports filed or furnished pursuant to Section 13(a) or 15(d) of the Exchange Act as soon as reasonably practicable
after we electronically file the material with, or furnish it to, the SEC. The references to www.relmada.com in this prospectus
supplement, the accompanying prospectus and the documents incorporated by reference herein or therein are inactive textual references
only, and the information found on our internet website is not incorporated by reference into, and should not be considered part of, this
prospectus supplement, the accompanying prospectus or the documents incorporated by reference herein or therein. Investors should not
rely on any such information in deciding whether to invest in our common stock.
INCORPORATION OF CERTAIN INFORMATION BY REFERENCE
The SEC allows us to incorporate by reference
information contained in documents we file with it, which means that we can disclose important information to you by referring you to
those documents already on file with the SEC that contain that information. The information incorporated by reference is considered to
be part of this prospectus supplement, and later information that we file with the SEC will automatically update and supersede this information.
We incorporate by reference the documents listed below and any future information filed (rather than furnished) with the SEC under Sections
13(a), 13(c), 14 or 15(d) of the Exchange Act, between the date of the initial filing of the registration statement of which this prospectus
supplement forms a part the termination of the offering of the securities covered by this prospectus supplement, provided, however, that
we are not incorporating any information furnished under any of Item 2.02 or Item 7.01 of any Current Report on Form 8-K (and exhibits
filed on such form that are related to such items):
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Our Annual Report on Form 10-K for the year ended December 31, 2023, filed with the SEC on March 19, 2024; |
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Our Quarterly Report on Form 10-Q for the quarter ended March 31, 2024, filed with the SEC on May 8, 2024; |
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Our Quarterly Report on Form 10-Q for the quarter ended June 30, 2024, filed with the SEC on August 7, 2024; |
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Our Current Reports on Form 8-K filed with the SEC on January 3, 2024, January 11, 2024 and May 30, 2024; and |
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The description of our common stock contained in our Registration Statement on Form 8-A filed on October 8, 2019, and as it may further be amended from time to time. |
Any statement contained in this prospectus supplement
or the accompanying prospectus or in a document incorporated or deemed to be incorporated by reference in this prospectus supplement shall
be deemed to be modified or superseded for purposes of this prospectus supplement to the extent that a statement contained herein or in
any other subsequently filed document which also is or is deemed to be incorporated by reference modifies or supersedes the statement.
Any statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this prospectus.
Upon written or oral request, we will provide
at no cost to the requester a copy of all of the information that has been incorporated by reference in this prospectus supplement but
not delivered with this prospectus supplement. You may obtain copies of these documents from us, without charge (other than exhibits,
unless the exhibits are specifically incorporated by reference), by contacting our chief financial officer, c/o Relmada Therapeutics,
Inc., at 2222 Ponce de Leon Blvd., Floor 3, Coral Gables, Florida 33134. Our telephone number is +1-786-629-1376.
You may also access the documents incorporated
by reference in this prospectus supplement through our website at www.relmada.com. Except for the specific incorporated documents listed
above, no information available on or through our website shall be deemed to be incorporated in this prospectus supplement or the registration
statement of which it forms a part.
RELMADA THERAPEUTICS, INC.
Up to $100,000,000
Common Stock
PROSPECTUS
SUPPLEMENT
Jefferies
August 30, 2024
PART II
INFORMATION NOT REQUIRED IN PROSPECTUS
Item 14. Other Expenses of Issuance and Distribution.
The following table sets forth all expenses to
be paid by the Registrant. All amounts shown are estimates except for the SEC registration fee and the FINRA filing fee.
SEC registration fee | |
$ | 36,900 | (1) |
FINRA filing fee | |
| 38,000 | |
Printing | |
| | (2) |
Legal fees and expenses | |
| | (2) |
Accounting fees and expenses | |
| | (2) |
Trustees’ Fees and Expenses | |
| | (2) |
Warrant Agent Fees and Expenses | |
| | (2) |
Miscellaneous | |
| | (2) |
| (1) | In
accordance with Rule 415(a)(6) under the Securities Act, the filing fee previously paid in connection with the securities registered
in the registration statement on Form S-3 (File No. 333-245054) initially filed on August 12, 2020, and effective on August 21, 2020
and on Form S-3 (File No. 333-234262) initially filed on October 18, 2019, and effective on October 31, 2019, which remain unsold and
unallocated will continue to be applied to the securities registered under this Registration Statement. Please see the registration fee
table contained in Exhibit 107 to this registration statement for more information. |
| (2) | These
fees are calculated based on the securities offered and the number of issuances and accordingly cannot be estimated at this time. The
applicable prospectus supplement will set forth the estimated amount of expenses of any offering of securities. |
Item 15. Indemnification of Directors and Officers.
The Registrant is a Nevada corporation and generally
governed by the Nevada Private Corporations Code, Title 78 of the Nevada Revised Statutes, or NRS.
Section 78.138 of the NRS provides that, unless
the corporation’s Articles of Incorporation provide otherwise, a director or officer will not be individually liable unless it is
proven that (i) the director’s or officer’s acts or omissions constituted a breach of his or her fiduciary duties, and (ii)
such breach involved intentional misconduct, fraud, or a knowing violation of the law. Our Articles of Incorporation provide that no director
or officer shall be personally liable to the corporation or any of its stockholders for damages for any breach of fiduciary duty as a
director or officer except for liability of a director or officer for (i) acts or omissions involving intentional misconduct, fraud, or
a knowing violation of law or (ii) payment of dividends in violation of Section 78-300 of the NRS.
Section 78.7502 of the NRS permits a company to
indemnify its directors and officers against expenses, judgments, fines, and amounts paid in settlement actually and reasonably incurred
in connection with a threatened, pending, or completed action, suit, or proceeding, if the officer or director (i) is not liable pursuant
to NRS 78.138, or (ii) acted in good faith and in a manner the officer or director reasonably believed to be in or not opposed to the
best interests of the corporation and, if a criminal action or proceeding, had no reasonable cause to believe the conduct of the officer
or director was unlawful. Section 78.7502 of the NRS also precludes indemnification by the corporation if the officer or director has
been adjudged by a court of competent jurisdiction, after exhaustion of all appeals, to be liable to the corporation or for amounts paid
in settlement to the corporation, unless and only to the extent that the court determines that in view of all the circumstances, the person
is fairly and reasonably entitled to indemnity for such expenses and requires a corporation to indemnify its officers and directors if
they have been successful on the merits or otherwise in defense of any claim, issue, or matter resulting from their service as a director
or officer.
Section 78.751 of the NRS permits a Nevada company
to indemnify its officers and directors against expenses incurred by them in defending a civil or criminal action, suit, or proceeding
as they are incurred and in advance of final disposition thereof, upon determination by the stockholders, the disinterested board members,
or by independent legal counsel. Section 78.751 of NRS requires a corporation to advance expenses as incurred upon receipt of an undertaking
by or on behalf of the officer or director to repay the amount if it is ultimately determined by a court of competent jurisdiction that
such officer or director is not entitled to be indemnified by the company if so provided in the corporations articles of incorporation,
bylaws, or other agreement. Section 78.751 of the NRS further permits the company to grant its directors and officers additional rights
of indemnification under its articles of incorporation, bylaws, or other agreement.
Section 78.752 of the NRS provides that a Nevada
company may purchase and maintain insurance or make other financial arrangements on behalf of any person who is or was a director, officer,
employee, or agent of the company, or is or was serving at the request of the company as a director, officer, employee, or agent of another
company, partnership, joint venture, trust, or other enterprise, for any liability asserted against him and liability and expenses incurred
by him in his capacity as a director, officer, employee, or agent, or arising out of his status as such, whether or not the company has
the authority to indemnify him against such liability and expenses.
The Bylaws implement the indemnification and insurance
provisions permitted by Chapter 78 of the NRS.
At the present time, except as provided in “Legal
Proceedings” in the reports incorporated by reference herein, there is no pending litigation or proceeding involving a director,
officer, employee, or other agent of ours in which indemnification would be required or permitted. Except as described in “Legal
Proceedings” in the reports incorporated by reference herein, we are not aware of any threatened litigation or proceeding that may
result in a claim for such indemnification.
Each of our executive officers and directors also
has a standard indemnification agreement with the Company.
Item 16. Exhibits.
Certain of the agreements filed or to be filed
as exhibits to this Registration Statement contain representations and warranties by the parties to the agreements that have been made
solely for the benefit of the parties to the agreement. These representations and warranties:
| ● | may
have been qualified by disclosures that were made to the other parties in connection with the negotiation of the agreements, which disclosures
are not necessarily reflected in the agreements; |
| ● | may
apply standards of materiality that differ from those of a reasonable investor; and |
| ● | were
made only as of specified dates contained in the agreements and are subject to subsequent developments and changed circumstances. |
Accordingly, these representations and warranties
may not describe the actual state of affairs as of the date that these representations and warranties were made or at any other time.
Investors should not rely on them as statements of fact.
| * | If
applicable, to be filed by an amendment or as an exhibit to a report pursuant to section 13(a) or section 15(d) of the Exchange Act and
incorporated by reference |
Item 17. Undertakings.
| (a) | The undersigned registrant hereby undertakes: |
| (1) | To file, during any period in which offers or sales are being
made, a post-effective amendment to this registration statement: |
| (i) | To include any prospectus required by section 10(a)(3) of the Securities Act of 1933; |
| (ii) | To reflect in the prospectus any facts or events arising after the effective date of the registration
statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change
in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities
offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or
high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule
424(b) if, in the aggregate, the changes in volume and price represent no more than a 20% change in the maximum aggregate offering price
set forth in the forth in the “Calculation of Filing Fee Tables” or “Calculation of Registration Fee” table, as
applicable, in the effective registration statement. |
| (iii) | To include any material information with respect to the plan of distribution not previously disclosed
in the registration statement or any material change to such information in the registration statement; |
provided, however, that: Paragraphs
(a)(1)(i), (a)(1)(ii) and (a)(1)(iii) of this section do not apply if the registration statement is on Form S-3 and the information required
to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by
the registrant pursuant to section 13 or section 15(d) of the Securities Exchange Act of 1934 that are incorporated by reference in the
registration statement, or, as to a registration statement on Form S-3, is contained in a form of prospectus filed pursuant to Rule 424(b)
that is part of the registration statement.
| (2) | That, for the purpose of determining any liability under
the Securities Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities
offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof. |
| (3) | To remove from registration by means of a post-effective
amendment any of the securities being registered which remain unsold at the termination of the offering. |
| (4) | That, for the purpose of determining liability under the
Securities Act of 1933 to any purchaser: |
| (A) | Each prospectus filed by the registrant pursuant to Rule 424(b)(3)
shall be deemed to be part of the registration statement as of the date the filed prospectus was deemed part of and included in the registration
statement; and |
| (B) | Each prospectus required to be filed pursuant to Rule 424(b)(2),
(b)(5), or (b)(7) as part of a registration statement in reliance on Rule 430B relating to an offering made pursuant to Rule 415(a)(1)(i),
(vii), or (x) for the purpose of providing the information required by section 10(a) of the Securities Act of 1933 shall be deemed
to be part of and included in the registration statement as of the earlier of the date such form of prospectus is first used after effectiveness
or the date of the first contract of sale of securities in the offering described in the prospectus. As provided in Rule 430B, for
liability purposes of the issuer and any person that is at that date an underwriter, such date shall be deemed to be a new effective
date of the registration statement relating to the securities in the registration statement to which that prospectus relates, and the
offering of such securities at that time shall be deemed to be the initial bona fide offering thereof. Provided, however,
that no statement made in a registration statement or prospectus that is part of the registration statement or made in a document incorporated
or deemed incorporated by reference into the registration statement or prospectus that is part of the registration statement will, as
to a purchaser with a time of contract of sale prior to such effective date, supersede or modify any statement that was made in the registration
statement or prospectus that was part of the registration statement or made in any such document immediately prior to such effective
date. |
| (5) | That, for the purpose of determining liability of the registrant
under the Securities Act of 1933 to any purchaser in the initial distribution of the securities, the undersigned registrant undertakes
that in a primary offering of securities of the undersigned registrant pursuant to this registration statement, regardless of the underwriting
method used to sell the securities to the purchaser, if the securities are offered or sold to such purchaser by means of any of the following
communications, the undersigned registrant will be a seller to the purchaser and will be considered to offer or sell such securities
to such purchaser: |
| (i) | Any preliminary prospectus or prospectus of the undersigned
registrant relating to the offering required to be filed pursuant to Rule 424; |
| (ii) | Any free writing prospectus relating to the offering prepared
by or on behalf of the undersigned registrant or used or referred to by the undersigned registrant; |
| (iii) | The portion of any other free writing prospectus relating
to the offering containing material information about the undersigned registrant or its securities provided by or on behalf of the undersigned
registrant; and |
| (iv) | Any other communication that is an offer in the offering made
by the undersigned registrant to the purchaser. |
| (b) | The undersigned registrant hereby undertakes that, for purposes
of determining any liability under the Securities Act of 1933, each filing of the registrant’s annual report pursuant to section
13(a) or section 15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit plan’s
annual report pursuant to section 15(d) of the Securities Exchange Act of 1934) that is incorporated by reference in the registration
statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof. |
| (c) | Insofar as indemnification for liabilities arising under
the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing
provisions, or otherwise, the registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification
is against public policy as expressed in the Securities Act of 1933 and is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling
person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling
person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been
settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against
public policy as expressed in the Securities Act of 1933 and will be governed by the final adjudication of such issue. |
SIGNATURES
Pursuant
to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-3 and has duly caused this registration statement to be signed on its behalf by the undersigned,
thereunto duly authorized, in the City of Coral Gables, State of Florida, on August 30, 2024.
|
RELMADA THERAPEUTICS, INC. |
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By: |
/s/ Sergio Traversa |
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Sergio Traversa |
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Chief Executive Officer
(Duly Authorized Officer and Principal Executive Officer) |
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By: |
/s/ Maged Shenouda |
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Chief Financial Officer
(Duly Authorized Officer and Principal Financial and Accounting Officer) |
POWER OF ATTORNEY
KNOW ALL PERSONS
BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Sergio Traversa and Maged Shenouda, and each
of them severally, as his true and lawful attorney-in-fact and agent, with full power of substitution, for him or her and in his or her
name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this registration
statement, and to sign any registration statement for the same offering covered by the registration statement that is to be effective
upon filing pursuant to Rule 462(b) promulgated under the Securities Act, and all post-effective amendments thereto, and to file the same,
with all exhibits thereto and all documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact
and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done
in and about the premises, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all
that said attorneys-in-fact and agents or any of them, or his or their substitute or substitutes, each acting alone, may lawfully do or
cause to be done or by virtue hereof.
Pursuant to the requirements of the Securities
Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates indicated.
Signature |
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Capacity |
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Date |
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/s/ Sergio Traversa |
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Chief Executive Officer and Director |
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August 30, 2024 |
Sergio Traversa |
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(Principal Executive Officer) |
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/s/ Maged Shenouda |
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Chief Financial Officer |
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August 30, 2024 |
Maged Shenouda |
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(Principal Financial and Accounting Officer) |
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/s/ Charles J. Casamento |
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Director, Chairman of the Board |
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August 30, 2024 |
Charles J. Casamento |
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/s/ Paul Kelly |
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Director |
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August 30, 2024 |
Paul Kelly |
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/s/ John Glasspool |
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Director |
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August 30, 2024 |
John Glasspool |
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/s/ Fabiana Fedeli |
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Director |
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August 30, 2024 |
Fabiana Fedeli |
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Exhibit 5.1
August 30, 2024
Relmada Therapeutics, Inc.
2222 Ponce de Leon Blvd., Floor 3
Coral Gables, FL 33134
| Re: | Registration Statement on Form S-3 |
Ladies and Gentlemen:
We have acted as counsel to Relmada Therapeutics,
Inc., a Nevada corporation (the “Company”), in connection with the preparation of a registration statement on Form S-3 (the
“Registration Statement”), filed by the Company with the Securities and Exchange Commission (the “Commission”)
pursuant to the Securities Act of 1933, as amended (the “Securities Act”), on August 30, 2024, relating to the offer and sale
from time to time by the Company of an indeterminate amount of the following securities (each a “Company Security” and collectively,
or in any combination, the “Company Securities”):
| (i) | shares
of the Company’s common stock, $0.001 par value per share (the “Common Stock”); |
| (ii) | shares
of the Company’s preferred stock, $0.001 par value per share, of one or more classes or series of (the “Preferred Stock”); |
| (iii) | warrants
to purchase Common Stock, Preferred Stock, other Company Securities or other rights, or any combination thereof; |
| (iv) | subscription
rights to purchase Company Securities; |
| (vi) | purchase
contracts entitling or obligating holders to purchase from or sell to the Company, and for the Company to sell to or purchase from such
holders, a specific or varying number of Company Securities or securities issued an entity other than the Company at a future date or
dates; and |
| (vii) | units
consisting of any combination of the foregoing securities. |
The Company Securities may be issued and sold
by the Company pursuant to applicable provisions of Rule 415 under the Securities Act, in amounts, at prices and on terms to be determined
in light of market conditions at the time of sale, and as set forth in the Registration Statement, any amendment thereto, the prospectus
contained therein (the “Prospectus”) and any supplements to the Prospectus (each, a “Prospectus Supplement”).
The Company Securities may be issued from time to time on a delayed or continuous basis, and this opinion is limited to the laws, including
the rules and regulations, as in effect on the date hereof, which laws are subject to change with possible retroactive effect.
1185 Avenue of the Americas |
31st Floor | New York, NY 10036
T +1.212.930.9700 |
F +1.212.930.9725 | www.srfc.law
Relmada Therapeutics, Inc.
August 30, 2024
Page 2
You have requested our opinion as to the matters
set forth below in connection with the Registration Statement. For purposes of rendering the opinions set forth below, we have examined
(i) the Registration Statement, including the exhibits filed therewith or incorporated by reference therein, (ii) the Prospectus, (iii)
the Company’s amended and restated articles of incorporation, as amended or supplemented (the “Articles of Incorporation”),
(iv) the Company’s amended and restated bylaws, as amended (the “Bylaws”), (v) the corporate resolutions and other actions
of the Company that authorize and provide for the filing of the Registration Statement, and we have made such other investigation as we
have deemed appropriate. We have not independently established any of the facts so relied on.
For purposes of this opinion letter, we have assumed
the accuracy and completeness of each document submitted to us, the genuineness of all signatures on original documents, the authenticity
of all documents submitted to us as originals, the conformity to original documents of all documents submitted to us as facsimile, electronic,
certified, conformed or photostatic copies thereof, and the due execution and delivery of all documents where due execution and delivery
are prerequisites to the effectiveness thereof. We have further assumed the legal capacity of natural persons, that persons identified
to us as officers of the Company are actually serving in such capacity, that the representations of officers and employees of the Company
are correct as to questions of fact, that the board of directors will have taken all action necessary to set the issuance price of the
Company Securities to be offered and sold and that each party to the documents we have examined or relied on (other than the Company)
has the power, corporate or other, to enter into and perform all obligations thereunder and also have assumed the due authorization by
all requisite action, corporate or other, the execution and delivery by such parties of such documents, and the validity and binding effect
thereof on such parties. We have not independently verified any of these assumptions.
The opinions expressed in this opinion letter
are limited to the Private Corporations Law of the State of Nevada (the “NPCL”) and the reported judicial decisions interpreting
such statute and provisions and the laws of the state of New York and the federal laws of the United States of America. We are not opining
on, and we assume no responsibility for, the applicability to or effect on any of the matters covered herein of (a) any other laws of
the State of Nevada; (b) the laws of any other jurisdiction; or (c) the laws of any county, municipality or other political subdivision
or local governmental agency or authority.
All references in this opinion letter to the board
of directors of the Company are intended to include an authorized committee thereof empowered and authorized to act under the NPCL in
lieu of the full board of directors of the Company.
|
www.srfc.law |
Relmada Therapeutics, Inc.
August 30, 2024
Page 3
Based on the foregoing and in reliance thereon,
and subject to the assumptions, qualifications, limitations and exceptions set forth below, we are of the opinion that:
| 1. | With
respect to shares of Common Stock, when (a) the board of directors of the Company has taken all necessary corporate action to approve
the issuance and terms of the offering thereof and related matters, including without limitation the due reservation of any Common Stock
for issuance, and (b) certificates representing the shares of Common Stock have been duly executed, countersigned, registered and delivered,
in each case in accordance with the Articles of Incorporation and Bylaws and either (i) in accordance with the applicable definitive
purchase, underwriting or similar agreement approved by the board of directors of the Company upon payment of the consideration therefor
(which consideration shall not be less than the par value of the Common Stock) provided for in such definitive purchase, underwriting
or similar agreement, as applicable, or (ii) upon conversion, exchange or exercise of any other Company Security in accordance with the
terms of such Company Security or the instrument governing such Company Security providing for the conversion, exchange or exercise as
approved by the board of directors of the Company, for the consideration therefor set forth in the applicable agreement and approved
by the board of directors of the Company, which consideration shall not be less than the par value of the Common Stock, such shares of
Common Stock will be validly issued, fully paid, and non-assessable. |
| 2. | With
respect to shares of any series of Preferred Stock, when (a) the board of directors of the Company has taken all necessary corporate
action to approve the issuance and terms of the shares of such series, the terms of the offering thereof and related matters, including
the adoption of a Articles of designations or amendment to the Articles of Incorporation fixing and determining the terms of such Preferred
Stock conforming to the NPCL, the filing of a certificate or amendment, as applicable, with the Secretary of State of Nevada, the payment
in full of any filing fees attendant thereto, and the due reservation of any Common Stock and Preferred Stock for issuance, and (b) certificates
representing the shares of such series of Preferred Stock have been duly executed, countersigned, registered and delivered, in each case
in accordance with the Articles of Incorporation and Bylaws and either (i) in accordance with the applicable definitive purchase, underwriting
or similar agreement approved by the board of directors of the Company upon payment of the consideration therefor (which consideration
shall not be less than the par value of the Preferred Stock) provided for in such definitive purchase, underwriting or similar agreement,
as applicable, or (ii) upon conversion, exchange or exercise of any other Company Security in accordance with the terms of such Company
Security or the instrument governing such Company Security providing for the conversion, exchange or exercise as approved by the board
of directors of the Company, for the consideration therefor set forth in the applicable agreement and approved by the board of directors
of the Company, which consideration shall not be less than the par value of the Preferred Stock, the shares of such series of Preferred
Stock will be validly issued, fully paid, and non-assessable. |
|
www.srfc.law |
Relmada Therapeutics, Inc.
August 30, 2024
Page 4
| 3. | With
respect to the warrants, when (a) the board of directors of the Company has taken all necessary corporate action to approve the warrant
agreement to be entered into in connection with the issuance of any warrants and such warrant agreement has been validly executed and
delivered by the warrant agent and Company, (b) the board of directors of the Company has taken all necessary corporate action to approve
the specific issuance and terms of any warrants duly established in accordance with the applicable warrant agreement and (c) such warrants
have been duly executed, countersigned, registered, issued and delivered in accordance with the warrant agreement and the applicable
definitive purchase, underwriting or similar agreement, as applicable, for the consideration therefor set forth in the applicable agreement
and approved by the board of directors of the Company (assuming the securities issuable upon exercise of the warrants have been duly
authorized and reserved for issuance by all necessary corporate action and in accordance with applicable law), such warrants will constitute
valid and binding obligations of the Company, enforceable against the Company in accordance with their terms, subject to applicable bankruptcy,
insolvency and similar laws affecting creditors’ rights generally, concepts of reasonableness and equitable principles of general
applicability. |
| 4. | With
respect to the subscription rights, when (a) the board of directors of the Company has taken all necessary corporate action to authorize
the issuance and the specific terms of such subscription rights, the terms of the offering thereof, and related matters and (b) such
subscription rights and agreements relating to the subscription rights have been duly executed and delivered in accordance with the terms
thereof (assuming the securities issuable upon exercise of the subscription rights have been duly authorized and reserved for issuance
by all necessary corporate action and in accordance with applicable law), then such subscription rights will be valid and binding obligations
of the Company, enforceable against the Company in accordance with their terms. |
| 5. | With
respect to the depositary shares, when (a) the board of directors of the Company has taken all necessary corporate action to approve
the issuance and terms of the depositary shares, the terms of the offering thereof and related matters, including the adoption of a Articles
of designation relating to any series of Preferred Stock underlying the depositary shares as required by applicable law and the filing
of the Articles of designation with the Secretary of State of the State of Nevada as required by applicable law; (b) the depositary agreement
or agreements relating to the depositary shares and the related depositary receipts have been duly authorized and validly executed and
delivered by the board of directors of the Company and the depositary appointed by the Company; (c) the shares of Preferred Stock underlying
the depositary shares have been duly authorized, validly issued and deposited with the depositary under the applicable depositary agreement;
and (d) the depositary receipts representing the depositary shares have been duly executed, countersigned, registered and delivered in
accordance with the appropriate depositary agreement approved by the Company, upon payment of the consideration therefor provided for
in the applicable definitive purchase, underwriting or similar agreement, the depositary shares will be legally issued and will entitle
their holders to the rights specified in the deposit agreement and the depositary receipt. |
|
www.srfc.law |
Relmada Therapeutics, Inc.
August 30, 2024
Page 5
| 6. | With
respect to the purchase contracts, when (a) the board of directors of the Company has taken all necessary corporate action to approve
the purchase contract agreement to be entered into in connection with the issuance of any purchase contracts and such purchase contract
agreement has been validly executed and delivered by the purchase contract agent and Company, (b) the board of directors of the Company
has taken all necessary corporate action to approve the specific issuance and terms of any purchase contracts duly established in accordance
with the applicable purchase contract agreement and (c) such purchase contracts have been duly executed, countersigned, registered, issued
and delivered in accordance with the purchase contract agreement and the applicable definitive purchase, underwriting or similar agreement,
as applicable, for the consideration therefor set forth in the applicable agreement and approved by the board of directors of the Company
(assuming the securities issuable upon exercise of the purchase contracts, if any, have been duly authorized and reserved for issuance
by all necessary corporate action and in accordance with applicable law), such purchase contracts will constitute valid and binding obligations
of the Company, enforceable against the Company in accordance with their terms, subject to applicable bankruptcy, insolvency and similar
laws affecting creditors’ rights generally, concepts of reasonableness and equitable principles of general applicability. |
| 7. | With
respect to the units, when (a) the board of directors of the Company has taken all necessary corporate action to approve the unit agreement,
if any, to be entered into in connection with the issuance of any units and such unit agreement, if any, has been validly executed and
delivered by the unit agent, if any, and Company, (b) the board of directors of the Company has taken all necessary corporate action
to approve the specific issuance and terms of any units duly established in accordance with the applicable unit agreement, if any, and
(c) such units have been duly executed, countersigned, registered, issued and delivered in accordance with the unit agreement, if any,
and the applicable definitive purchase, underwriting or similar agreement, as applicable, for the consideration therefor set forth in
the applicable agreement and approved by the board of directors of the Company (assuming the securities underlying the units have been
duly authorized, and validly issued by all necessary corporate action and in accordance with applicable law), such units will constitute
valid and binding obligations of the Company, enforceable against the Company in accordance with their terms, subject to applicable bankruptcy,
insolvency and similar laws affecting creditors’ rights generally, concepts of reasonableness and equitable principles of general
applicability. |
The opinions set forth above are subject to the
following additional assumptions:
| (i) | the
Registration Statement and any amendments thereto (including post-effective amendments) will have become effective under the Securities
Act, and such effectiveness shall not have been terminated, suspended or rescinded; |
(ii)
all Company Securities will be issued and sold in compliance with applicable federal and state securities laws, rules and regulations
and solely in the manner provided in the Registration Statement and Prospectus and the appropriate Prospectus Supplement, and there will
not have occurred any change in law or fact affecting the validity of any of the opinions rendered herein;
| (iii) | a
definitive purchase, underwriting or similar agreement and any other necessary agreements with respect to any Company Securities offered
or issued will have been duly authorized and duly executed and delivered by the Company and the other parties thereto; |
|
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Relmada Therapeutics, Inc.
August 30, 2024
Page 6
| (iv) | the
Company shall have taken any action required to be taken by the Company, based on the type of Company Security being offered, to authorize
the offer and issuance theeof, and such authorization shall remain in effect and unchanged at all times during which the Company Securities
are offered and issued and shall not have been modified or rescinded (subject to the further assumption that the sale of any Company
Security takes place in accordance with such authorization), the board of directors of the Company shall have duly established the terms
of such Company Security and duly authorized and taken any other necessary corporate action to approve the issuance and sale of such
Company Security in conformity with the Articles of Incorporation and Bylaws (subject to the further assumption that neither the Articles
of Incorporation nor Bylaws have been amended from the date hereof in a manner that would affect the validity of any of the opinions
rendered herein), and such authorization shall remain in effect and unchanged at all times during which the Company Securities are offered
and issued and shall not have been modified or rescinded (subject to the further assumption that the sale of any Company Security takes
place in accordance with such authorization); |
| (v) | there
will exist, under the Articles of Incorporation, the requisite number of authorized but unissued shares of Common Stock or Preferred
Stock (and securities of any class into which any of the Preferred Stock may be convertible), as the case may be; and |
| (vi) | to
the extent they purport to relate to liabilities resulting from or based upon gross negligence, recklessness or other conduct committed
or omitted willfully or in bad faith or any violation of federal or state securities or blue sky laws, we express no opinions concerning
the enforceability of indemnification provisions. |
The opinions above are subject to the effects
of (i) bankruptcy, insolvency, fraudulent conveyance, fraudulent transfer, reorganization, receivership, moratorium and other similar
laws relating to or affecting enforcement of creditors’ rights or remedies generally, (ii) general principles of equity, whether
such principles are considered in a proceeding of law or at equity, and (iii) an implied covenant of good faith, reasonableness and fair
dealing and standards of materiality.
We express no opinion as to any provision in any
stock purchase contract, unit purchase agreement, other agreement pursuant to which any Company Securities are to be issued or governed,
or the Articles of Incorporation or Bylaws (i) that purports to waive forum non conveniens or trial by jury; (ii) that
relates to judgments in currencies other than U.S. dollars; (iii) that releases, exculpates or exempts a party from, or requires indemnification
or contribution of a party for, liability for its own negligence or misconduct; (iv) that purports to allow any party to unreasonably
interfere in the conduct of the business of another party; (v) that purports to require any party to pay any amounts due to another party
without a reasonable accounting of the sums purported to be due; (vi) that purports to prohibit the assignment of rights that that may
be assigned pursuant to applicable law regardless of an agreement not to assign such rights; (vii) that purports to require that amendments
to any agreement be in writing; (viii) relating to powers of attorney, severability or set-off; (ix) that purports to limit access exclusively
to any particular courts; (x) that provides a waiver of stay, extension or usury laws or of unknown future rights; and (xi) providing
that decisions by a party are conclusive or may be made in its sole discretion. We express no opinion concerning whether a U.S. federal
court would accept jurisdiction in any dispute, action, suit or proceeding arising out of or relating to any agreement or the transactions
contemplated thereby.
|
www.srfc.law |
Relmada Therapeutics, Inc.
August 30, 2024
Page 7
We hereby consent to the filing of this opinion
as an exhibit to the Registration Statement and to the use of our name under the caption “Legal Matters” in the Prospectus.
In giving our consent, we do not thereby admit that we are experts with respect to any part of the Registration Statement, the Prospectus
or any Prospectus Supplement within the meaning of the term “expert” as used in Section 11 of the Securities Act or the rules
and regulations promulgated thereunder by the Commission, nor do we admit that we are in the category of persons whose consent is required
under Section 7 of the Securities Act or the rules and regulations thereunder.
Very truly yours,
/s/ Sichenzia Ross Ference Carmel
LLP
Sichenzia Ross Ference Carmel LLP
|
www.srfc.law |
Exhibit 5.2
August 30, 2024
Relmada Therapeutics, Inc.
2222 Ponce de Leon Blvd., Floor 3
Coral Gables, FL 33134
| Re: | Open Market Sale Agreement with Jefferies LLC |
Ladies and Gentlemen:
We have acted as counsel to Relmada Therapeutics,
Inc., a Nevada corporation (the “Company”), in connection with the sale through Jefferies LLC as the sales agent (the
“Sales Agent”) from time to time by the Company of shares of the Company’s common stock, $0.001 par value per
share (the “Common Stock”), having an aggregate offering price of up to $100,000,000 (the “Shares”),
all of which are authorized but heretofore unissued shares to be offered and sold pursuant to a Registration Statement on Form S-3 (the
“Registration Statement”) filed by the Company with the Securities and Exchange Commission (the “Commission”)
under the Securities Act of 1933, as amended (the “Securities Act”), on August 30, 2024, and the prospectus contained
therein dated August 30, 2024, as supplemented by the prospectus supplement for the sale of the Shares dated August 30, 2024 (as so supplemented,
the “Prospectus”), and that certain Open Market Sale AgreementSM dated as of April 7, 2022, between
the Sales Agent and the Company (the “Sales Agreement”).
In connection with the preparation of this opinion,
we have examined the Registration Statement and the Prospectus and such documents and considered such questions of law as we have deemed
necessary or appropriate. We have assumed the authenticity of all documents submitted to us as originals, the conformity to originals
of all documents submitted to us as copies thereof and the genuineness of all signatures. As to questions of fact material to our opinions,
we have relied upon the certificates of certain officers of the Company without independent investigation or verification. We have
also assumed that there will exist, under the Company’s amended and restated articles of incorporation, as amended or supplemented,
the requisite number of authorized but unissued shares of Common Stock.
Based on the foregoing, we are of the opinion
that the Shares have been duly authorized and, when issued and sold in the manner described in the Sales Agreement and in accordance with
the Registration Statement and the Prospectus, will be validly issued, fully paid and non-assessable.
1185 Avenue of the Americas |
31st Floor | New York, NY 10036
T +1.212.930.9700 |
F +1.212.930.9725 | www.srfc.law
Relmada Therapeutics, Inc.
August 30, 2024
Page 2
The opinions expressed in this opinion letter
are limited to the Private Corporations Law of the State of Nevada and the reported judicial decisions interpreting such statute and provisions
and the laws of the state of New York and the federal laws of the United States of America. We are not opining on, and we assume no responsibility
for, the applicability to or effect on any of the matters covered herein of (a) any other laws of the State of Nevada; (b) the laws of
any other jurisdiction; or (c) the laws of any county, municipality or other political subdivision or local governmental agency or authority.
We hereby consent to the use of this opinion as
an exhibit to the Registration Statement and to the use of our name under the caption “Legal Matters” in the Prospectus. In
giving our consent, we do not thereby admit that we are experts with respect to any part of the Registration Statement or the Prospectus
within the meaning of the term “expert” as used in Section 11 of the Securities Act or the rules and regulations promulgated
thereunder by the Commission, nor do we admit that we are in the category of persons whose consent is required under Section 7 of the
Securities Act or the rules and regulations thereunder.
Very truly yours,
/s/ Sichenzia Ross Ference Carmel
LLP
Sichenzia Ross Ference Carmel LLP
|
www.srfc.law |
Exhibit 23.1
Independent
Registered Public Accounting Firm’s Consent
We consent to the incorporation by reference in
this Registration Statement of Relmada Therapeutics, Inc. on Form S-3 of our report dated March 19, 2024 with respect to our audits of
the consolidated financial statements of Relmada Therapeutics, Inc. as of December 31, 2023 and 2022 and for the years ended December
31, 2023 and 2022 appearing in the Annual Report on Form 10-K of Relmada Therapeutics, Inc. for the year ended December 31, 2023. We also
consent to the reference to our firm under the heading “Experts” in the Prospectus, which is part of this Registration Statement.
/s/ Marcum llp
Marcum llp
Houston, Texas
August 30, 2024
Exhibit
107.1
Calculation
of Filing Fee Tables
FORM
S-3
Registration
Statement under the Securities Act of 1933
(Form
Type)
Relmada
Therapeutics, Inc.
(Exact
Name of Registrant as Specified in its Charter)
| |
Security
Type | |
Security
Class Title | |
Fee
Calculation or Carry Forward Rule | | |
Amount
Registered (2) | | |
Proposed
Maximum Offering Price per Unit (3) | | |
Maximum
Aggregate Offering Price | | |
Fee
Rate | | |
Amount
of Registration Fee | | |
Carry
Forward Form Type | | |
Carry
Forward File Number | | |
Carry
Forward Initial Effective Date | |
| Filing
Fee Previously Paid in Connection with Unsold Securities to Be Carried Forward |
Newly
Registered Securities |
Fees
to be Paid | |
Equity(1) | |
Common
Stock, $0.001 par value per share | |
| Rule
457(o) | | |
| | (2) | |
| | (3) | |
| | (3) | |
| - | | |
| - | | |
| - | | |
| - | | |
|
- | |
| |
- |
| |
Equity(1) | |
Preferred
Stock, $0.001 par value per share | |
| | | |
| | (2) | |
| | (3) | |
| | (3) | |
| - | | |
| - | | |
| - | | |
| - | | |
|
- | |
| |
- |
| |
Equity(1) | |
Depositary
Shares | |
| | | |
| | (2) | |
| | (3) | |
| | (3) | |
| - | | |
| - | | |
| - | | |
| - | | |
|
- | |
| |
- |
| |
Other(1) | |
Subscription
Rights | |
| | | |
| | (2) | |
| | (3) | |
| | (3) | |
| - | | |
| - | | |
| - | | |
| - | | |
|
- | |
| |
- |
| |
Other(1) | |
Warrants
(4) | |
| | | |
| | (2) | |
| | (3) | |
| | (3) | |
| - | | |
| - | | |
| - | | |
| - | | |
|
- | |
| |
- |
| |
Other(1) | |
Purchase
Contracts | |
| | | |
| | (2) | |
| | (3) | |
| | (3) | |
| - | | |
| - | | |
| - | | |
| - | | |
|
- | |
| |
- |
| |
Other(1) | |
Units | |
| | | |
| | (2) | |
| | (3) | |
| | (3) | |
| - | | |
| - | | |
| - | | |
| - | | |
|
- | |
| |
- |
| |
Unallocated
(Universal) Shelf (1) | |
- | |
| | | |
| | (2) | |
| | (3) | |
$ | 250,000,000 | (5) | |
| $147.60 per $1,000,000 | | |
$ | 36,900 | (5) | |
| | | |
| | | |
|
| |
| |
|
Fees
Previously Paid | |
| |
- | |
| - | | |
| - | | |
| - | | |
| - | | |
| - | | |
| - | | |
| | | |
| | | |
|
| |
| |
|
| |
| |
| |
| | | |
| | | |
| | | |
| | | |
| | | |
| | | |
| | | |
| | | |
|
| |
| |
|
Carry
Forward Securities |
Carry
Forward Securities | |
Equity | |
Common
Stock, $0.001 par value per share | |
| Rule
415(a)(6) | | |
| | (1)(6) | |
| | (3) | |
| | (3) | |
| - | | |
| - | | |
| | | |
| | | |
|
| |
| |
|
| |
Equity | |
Preferred
Stock, $0.001 par value per share | |
| Rule
415(a)(6) | | |
| | (1)(6) | |
| | (3) | |
| | (3) | |
| | | |
| | | |
| | | |
| | | |
|
| |
| |
|
| |
Equity | |
Depositary
Shares | |
| Rule
415(a)(6) | | |
| | (1)(6) | |
| | (3) | |
| | (3) | |
| | | |
| | | |
| | | |
| | | |
|
| |
| |
|
| |
Other | |
Subscription
Rights | |
| Rule
415(a)(6) | | |
| | (1)(6) | |
| | (3) | |
| | (3) | |
| | | |
| | | |
| | | |
| | | |
|
| |
| |
|
| |
Other | |
Warrants
(4) | |
| Rule
415(a)(6) | | |
| | (1)(6) | |
| | (3) | |
| | (3) | |
| | | |
| | | |
| | | |
| | | |
|
| |
| |
|
| |
Other | |
Purchase
Contracts | |
| Rule
415(a)(6) | | |
| | (1)(6) | |
| | (3) | |
| | (3) | |
| | | |
| | | |
| | | |
| | | |
|
| |
| |
|
| |
Other | |
Units | |
| Rule
415(a)(6) | | |
| | (1)(6) | |
| | (3) | |
| | (3) | |
| | | |
| | | |
| | | |
| | | |
|
| |
| |
|
| |
| |
| |
| | | |
| | | |
| | | |
$ | 77,500,000 | | |
| | | |
| | | |
| S-3 | | |
| 333-245054 | | |
|
August 12, 2020 | |
| $ |
7,184 |
| |
| |
| |
| | | |
| | | |
| | | |
| | | |
| | | |
| | | |
| | | |
| | | |
|
| |
| |
|
| |
Equity | |
Common
Stock, $0.001 par value per share | |
| Rule
415(a)(6) | | |
| | (1)(7) | |
| | (3) | |
| | (3) | |
| | | |
| | | |
| | | |
| | | |
|
| |
| |
|
| |
Equity | |
Preferred
Stock, $0.001 par value per share | |
| Rule
415(a)(6) | | |
| | (1)(7) | |
| | (3) | |
| | (3) | |
| | | |
| | | |
| | | |
| | | |
|
| |
| |
|
| |
Equity | |
Depositary
Shares | |
| Rule
415(a)(6) | | |
| | (1)(7) | |
| | (3) | |
| | (3) | |
| | | |
| | | |
| | | |
| | | |
|
| |
| |
|
| |
Other | |
Subscription
Rights | |
| Rule
415(a)(6) | | |
| | (1)(7) | |
| | (3) | |
| | (3) | |
| | | |
| | | |
| | | |
| | | |
|
| |
| |
|
| |
Other | |
Warrants
(4) | |
| Rule
415(a)(6) | | |
| | (1)(7) | |
| | (3) | |
| | (3) | |
| | | |
| | | |
| | | |
| | | |
|
| |
| |
|
| |
Other | |
Purchase
Contracts | |
| Rule
415(a)(6) | | |
| | (1)(7) | |
| | (3) | |
| | (3) | |
| | | |
| | | |
| | | |
| | | |
|
| |
| |
|
| |
Other | |
Units | |
| Rule
415(a)(6) | | |
| | (1)(7) | |
| | (3) | |
| | (3) | |
| | | |
| | | |
| | | |
| | | |
|
| |
| |
|
| |
| |
| |
| | | |
| | | |
| | | |
$ | 9,999,980 | | |
| | | |
| | | |
| S-3 | | |
| 333-234262 | | |
|
October 18, 2019 | |
| $ |
927 |
| |
| |
| |
| | | |
| | | |
| | | |
| | | |
| | | |
| | | |
| | | |
| | | |
|
| |
| $ |
8,111 |
| |
| |
| |
| | | |
| | | |
| | | |
| | | |
| | | |
| | | |
| | | |
| | | |
|
| |
| |
|
| |
| |
Total
Offering Amounts | | |
| | | |
$ | 250,000,000 | | |
| | | |
$ | 36,900 | | |
| | | |
| | | |
|
| |
| |
|
| |
| |
Total
Fees Previously Paid | | |
| | | |
| | | |
| | | |
$ | 8,111 | | |
| | | |
| | | |
|
| |
| |
|
| |
| |
Total
Fee Offsets | | |
| | | |
| | | |
| | | |
| - | | |
| | | |
| | | |
|
| |
| |
|
| |
| |
Net
Fee Due | | |
| | | |
| | | |
| | | |
$ | 28,789 | | |
| | | |
| | | |
|
| |
| |
|
(1) |
Represents securities that
may be offered and sold from time to time in one or more offerings by Relmada Therapeutics, Inc. (the “Registrant”) |
(2) |
An indeterminate aggregate
initial offering price or number of securities of each identified class is being registered as may from time to time be issued at
indeterminate prices and as may be issuable upon conversion, redemption, exchange, exercise or settlement of any securities registered
hereunder, including under any applicable antidilution provisions. Any securities registered hereunder may be sold separately or
together with other securities registered hereunder. In no event will the aggregate offering price of all types of securities issued
by the Registrant pursuant to this registration statement exceed $250,000,000. Pursuant to Rule 416(a) under the Securities Act of
1933, as amended, or the Securities Act, this registration statement also covers any additional securities that may be offered or
issued in connection with any stock split, stock dividend or similar transaction. |
(3) |
The proposed maximum aggregate
offering price per class of security will be determined from time to time by the Registrant in connection with the issuance by the
Registrant of the securities registered hereunder and is not specified as to each class of security pursuant to General Instruction
II.D. of Form S-3 under the Securities Act. |
|
|
(4) |
The warrants covered by
this registration statement may be warrants for common stock, preferred stock, depositary shares or securities of third
parties or other securities or rights. |
|
|
(5) |
Estimated solely to calculate
the registration fee in accordance with Rule 457(o) under the Securities Act. The aggregate maximum offering price of all securities
issued pursuant to this registration statement will not exceed $250,000,000. |
|
|
(6) |
Pursuant to Rule 415(a)(6)
under the Securities Act, this registration statement includes $77,500,000 of unsold securities (the “Unsold Securities”)
that had previously been registered under the Registrant’s registration statement on Form S-3 (File No. 333-245054) initially
filed on August 12, 2020, and effective on August 21, 2020 (the “Prior Registration Statement”) and paid a filing fee
of $32,450 for an aggregate of $250,000,000 of securities that could have been issued under the Prior Registration Statement.
Pursuant to Rule 415(a)(6), the Registrant is carrying forward to this registration statement the Unsold Securities that were previously
registered on the Prior Registration Statement, and the aggregate filing fees of approximately $7,184 previously paid in connection
with the Unsold Securities will continue to be applied to the Unsold Securities that are being carried forward to this registration
statement. |
|
|
(7) |
Pursuant to Rule 415(a)(6)
under the Securities Act, this registration statement includes $9,999,980 of unsold securities (the “Unsold Securities”)
that had previously been registered under the Registrant’s registration statement on Form S-3 (File No. 333-234262) initially
filed on October 18, 2019, and effective on October 31, 2019 (“Prior Registration Statement”) and paid a filing fee of
$25,960 for an aggregate of $200,000,000 of securities that could have been issued under the Prior Registration Statement. Pursuant
to Rule 415(a)(6), the Registrant is carrying forward to this registration statement the Unsold Securities that were previously registered
on the Prior Registration Statements, and the aggregate filing fees of approximately $927 previously paid in connection with the
Unsold Securities will continue to be applied to the Unsold Securities that are being carried forward to this registration statement.
A filing fee of $9,270 with respect to the remaining $100,000,000 of securities registered hereunder is being paid herewith. Pursuant
to Rule 415(a)(6), the offering of the Unsold Securities registered under the Prior Registration Statements will be deemed terminated
as of the date of effectiveness of this registration statement. |
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