FORM 3
        
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Jacob Jeffrey E.
2. Date of Event Requiring Statement (MM/DD/YYYY)
6/15/2022 

3. Issuer Name and Ticker or Trading Symbol

Panbela Therapeutics, Inc. [PBLA]
(Last)        (First)        (Middle)

712 VISTA BLVD #305
4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__X__ Director                          _____ 10% Owner
_____ Officer (give title below)        _____ Other (specify below)
(Street)

WACONIA, MN 55387      

(City)              (State)              (Zip)
5. If Amendment, Date Original Filed(MM/DD/YYYY)
 

6. Individual or Joint/Group Filing(Check Applicable Line)

_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 261931 D  
Common Stock 17771 I Jointly with spouse 
Common Stock 54374 I By trust 

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(MM/DD/YYYY)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock Option (right to buy)  (1)9/26/2022 Common Stock 41766 $1.2400 D  
Stock Option (right to buy)  (1)9/26/2022 Common Stock 35543 $1.4700 D  
Stock Option (right to buy)  (1)12/28/2030 Common Stock 91523 $0.2200 D  
Stock Option (right to buy)  (1)12/28/2030 Common Stock 177715 $0.2200 D  
Warrants (right to buy)  (1)2/1/2023 Common Stock 5174 $5.6300 I By trust 

Explanation of Responses:
(1) Fully vested.

Remarks:
Exhibit List: Power for Attorney EX-24

Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
Jacob Jeffrey E.
712 VISTA BLVD #305
WACONIA, MN 55387
X



Signatures
/s/ Joshua L. Colburn, Attorney-in-Fact6/25/2022
**Signature of Reporting PersonDate


Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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