Panbela Therapeutics, Inc. (Nasdaq: PBLA), a clinical stage
biopharmaceutical company developing disruptive therapeutics for
the treatment of patients with cancer announces a poster
presentation highlighting the results for SBP-101 as a polyamine
metabolism modulator in ovarian cancer at the American Association
for Cancer Research (AACR), taking place April 8-13, 2022. The work
reflects the Company’s ongoing collaboration with Johns Hopkins
University School of Medicine.
“The treatment of C57Bl/6 mice injected with VDID8+ ovarian
cancer with SBP-101 was observed to significantly prolong survival
and decrease overall tumor burden," said Jennifer K. Simpson, PhD,
MSN, CRNP, President & Chief Executive Officer of Panbela. “We
are grateful to our collaborators at Johns Hopkins University
School of Medicine, who are on the leading edge of cancer research.
This data supports our efforts to initiate an ovarian cancer
program this year. Additionally, we are excited to review these
results on an R&D call planned for May 3, 9:00 AM EST.”
"The results suggest that SBP-101 may have a role in the
clinical management of ovarian cancer,” said Dr. Simpson, “We look
forward to continuing our studies in ovarian, and other cancers, to
develop effective therapeutics for patients with unmet medical
needs.”
The poster highlights the role of naturally occurring
polyamines, putrescine, spermidine and spermine, as essential for
cellular growth and proliferation. As such, many cancers are
reliant on elevated polyamine levels that are maintained through
dysregulated polyamine metabolism. Polyamine metabolism is thus a
promising target for cancer therapeutics, and modulation of
polyamine metabolism has been attempted with numerous enzyme
inhibitors and polyamine analogues. SBP-101 (diethyl
dihydroxyhomospermine) is a novel spermine analogue that has shown
efficacy in slowing pancreatic tumor progression both in vitro and
in vivo.
This study determined the effect of SBP-101 treatment on
polyamine metabolism in a variety of cancer cell types in vitro
including lung, ovarian, prostate, pancreatic and breast. In
addition, the activity of four enzymes involved in the polyamine
pathway following treatment with either SBP-101 or the
well-characterized spermine analogue, BENSpm
(N1,N11-bisethylnorspermine) was evaluated. These
results indicate that SBP-101 likely exerts its effects
predominately through decreased polyamine biosynthesis with minor
upregulation of catabolism, in contrast to the structurally similar
BENSpm where the increase in polyamine catabolism is the
predominant response.
The efficacy of SBP-101 utilizing the VDID8+ murine ovarian
cancer model (ID8+ C57Bl/6 ovarian cells overexpressing both VEGF
and Defensin) was evaluated. The mice were treated with SBP-101 at
either 24 mg/kg or 6 mg/kg alternating MWF. Both doses of SBP-101
produced a statistically significant prolongation of survival
(24mg/kg p=.0049, 6 mg/kg p=.0042). There was no significant
difference in response between the two SBP-101 doses. The prolonged
survival was correlated with a delay in the production of ascites,
the indication of tumor burden in this model. Additionally, when
SBP-101 treated mice succumbed to the disease, their overall tumor
burden was lower when compared to control mice.
The poster concludes that the treatment of C57Bl/6 mice injected
with VDID8+ ovarian cancer with SBP-101 significantly prolonged
survival and decreased overall tumor burden. Future studies will be
designed to evaluate the effects of SBP-101 in combination with
other polyamine metabolism modulators as well as with immune
modulators.
Details of the presentation are as follows:
Poster Presentation
Title: The potential of spermine analogue
SBP-101 (diethyl dihydroxyhomospermine) as a polyamine metabolism
modulator in ovarian cancerSession Category:
Experimental and Molecular TherapeuticsSession
Title: Small Molecule Therapeutic Agents Abstract #:
5488
Additional meeting information can be found on the AACR
website: Abstracts |
AACR Annual Meeting 2022 | April 8-13, 2022 | New
Orleans
The poster will also be available on the Company's website
at https://panbela.com/events-presentations/ .
About SBP-101
SBP-101 is a proprietary polyamine analogue designed to induce
polyamine metabolic inhibition (PMI) by exploiting an observed high
affinity of the compound for pancreatic ductal adenocarcinoma and
other tumors. The molecule has shown signals of tumor growth
inhibition in clinical studies of US and Australian metastatic
pancreatic cancer patients, demonstrating a median overall survival
(OS) of 12.0 months which is not yet final, and an objective
response rate (ORR) of 48%, both exceeding what is seen typically
with the standard of care of gemcitabine + nab-paclitaxel
suggesting potential complementary activity with the existing
FDA-approved standard chemotherapy regimen. In data evaluated from
clinical studies to date, SBP-101 has not shown exacerbation of
bone marrow suppression and peripheral neuropathy, which can be
chemotherapy-related adverse events. Serious visual adverse events
have been evaluated and patients with a history of retinopathy or
at risk of retinal detachment will be excluded from future SBP-101
studies. The safety data and PMI profile observed in the current
Panbela sponsored clinical trial provides support for continued
evaluation of SBP-101 in a randomized clinical trial. For more
information, please
visit https://clinicaltrials.gov/ct2/show/NCT03412799 .
About Panbela
Panbela Therapeutics, Inc. is a clinical-stage biopharmaceutical
company developing disruptive therapeutics for patients with urgent
unmet medical needs. The company’s initial product candidate,
SBP-101, is for the treatment of patients with metastatic
pancreatic ductal adenocarcinoma, the most common type of
pancreatic cancer. Panbela Therapeutics, Inc. is dedicated to
treating patients with pancreatic cancer, ovarian cancer, and
exploring SBP-101’s potential for efficacy in combination with
other agents in other cancer indications. Further information can
be found
at www.panbela.com. Panbela
Therapeutics, Inc. common stock is listed on The Nasdaq Stock
Market LLC under the symbol PBLA.
Cautionary Statement Regarding Forward-Looking
Statements
This press release contains “forward-looking
statements,” including within the meaning of the Private Securities
Litigation Reform Act of 1995. Forward-looking statements can be
identified by words such as: “believe,” “design,” “expect,” “feel,”
“intend,” “may,” “plan,” “scheduled,” and “will.” Examples of
forward-looking statements include statements we make regarding
results of collaborations with third parties and future studies.
All statements other than statements of historical fact are
statements that should be deemed forward-looking
statements. Forward-looking statements are neither historical
facts nor assurances of future performance. Instead, they are
based only on our current beliefs, expectations, and assumptions
regarding the future of our business, future plans and
strategies, projections, anticipated events and trends, the economy
and other future conditions. Because forward-looking statements
relate to the future, they are subject to inherent uncertainties,
risks and changes in circumstances that are difficult to predict
and many of which are outside of our control. Our actual
results and financial condition may differ materially and adversely
from the forward-looking statements. Therefore, you should not
rely on any of these forward-looking statements. Important
factors that could cause our actual results and financial condition
to differ materially from those indicated in the forward-looking
statements include, among others, the following: (i) our ability to
obtain additional funding to complete clinical trials; (ii)
progress and success of our Phase 1 clinical trial; (iii) the
impact of the current COVID-19 pandemic on our ability to complete
monitoring and reporting in our current clinical trial and procure
the active ingredient; (iv) our ability to demonstrate the safety
and effectiveness of our SBP-101 product candidate (v) our ability
to obtain regulatory approvals for our SBP-101 product
candidate in the United States, the European Union or other
international markets; (vi) the market acceptance and level of
future sales of our SBP-101 product candidate; (vii) the cost and
delays in product development that may result from changes in
regulatory oversight applicable to our SBP-101 product
candidate; (viii) the rate of progress in establishing
reimbursement arrangements with third-party payors; (ix) the effect
of competing technological and market developments; (x) the costs
involved in filing and prosecuting patent applications and
enforcing or defending patent claims; and (xi) such other factors
as discussed in Part I, Item 1A under the caption “Risk Factors” in
our most recent Annual Report on Form 10-K, any additional risks
presented in our Quarterly Reports on Form 10-Q and our Current
Reports on Form 8-K. Any forward-looking statement made by us in
this press release is based on information currently available to
us and speaks only as of the date on which it is made. We
undertake no obligation to publicly update any forward-looking
statement or reasons why actual results would differ from those
anticipated in any such forward-looking statement, whether
written or oral, whether as a result of new
information, future developments or otherwise.
Contact Information:
Investors: James Carbonara Hayden IR (646)
755-7412 james@haydenir.com
Media: Tammy Groene Panbela Therapeutics,
Inc. (952) 479-1196 IR@panbela.com
Panbela Therapeutics (NASDAQ:PBLA)
Historical Stock Chart
From Mar 2024 to Apr 2024
Panbela Therapeutics (NASDAQ:PBLA)
Historical Stock Chart
From Apr 2023 to Apr 2024