FORM 3
        
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Perrin Steven
2. Date of Event Requiring Statement (MM/DD/YYYY)
9/14/2020 

3. Issuer Name and Ticker or Trading Symbol

Novus Therapeutics, Inc. [NVUS]
(Last)        (First)        (Middle)

C/O NOVUS THERAPEUTICS, INC., 19900 MACARTHUR BLVD., SUITE 550
4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__X__ Director                          _____ 10% Owner
___X___ Officer (give title below)        _____ Other (specify below)
See Remarks /
(Street)

IRVINE, CA 92612      

(City)              (State)              (Zip)
5. If Amendment, Date Original Filed(MM/DD/YYYY)
 

6. Individual or Joint/Group Filing(Check Applicable Line)

_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(MM/DD/YYYY)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock Option (Right to Buy)  (1)9/14/2030 Series X1 Convertible Preferred Stock (2)7856.409 $500.00 D  
Stock Option (Right to Buy)  (3)1/28/2030 Series X1 Convertible Preferred Stock (2)2078.859 $495.00 D  
Stock Option (Right to Buy)  (3)1/28/2030 Common Stock 48896 $0.495 D  
Stock Option (Right to Buy)  (3)1/28/2030 Series X1 Convertible Preferred Stock (2)2514.285 $495.00 D  
Stock Option (Right to Buy)  (3)1/28/2030 Common Stock 56719 $0.495 D  
Stock Option (Right to Buy)  (3)9/7/2030 Series X1 Convertible Preferred Stock (2)10672.926 $380.80 D  
Stock Option (Right to Buy)  (3)9/7/2030 Common Stock 240767 $0.3808 D  
Stock Option (Right to Buy)  (4)1/28/2030 Series X1 Convertible Preferred Stock (2)432.257 $495.00 D  
Stock Option (Right to Buy)  (4)1/28/2030 Common Stock 9751 $0.495 D  
Stock Option (Right to Buy)  (4)1/28/2030 Series X1 Convertible Preferred Stock (2)656.165 $495.00 D  
Stock Option (Right to Buy)  (4)1/28/2030 Common Stock 14802 $0.495 D  

Explanation of Responses:
(1) This option represents a right to purchase a total of 7,856.409 shares of the Issuer's Series X1 Convertible Preferred Stock, with 1,949.260 shares vesting in equal monthly installments over a period of one year from the grant date, and with the remaining 5,907.149 shares vesting over a period of two years from the grant date, subject to the Reporting Person's continued service to the Issuer through each vesting date.
(2) Each share of Series X1 Convertible Preferred Stock will be convertible into 1,000 shares of Common Stock upon receipt of the requisite approval of the stockholders of the Issuer.
(3) The option vests in equal monthly installments over a period of four years from January 1, 2019, the vesting start date.
(4) The option is fully vested.

Remarks:
President and Chief Scientific Officer

Ex. 24 - Power of Attorney

Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
Perrin Steven
C/O NOVUS THERAPEUTICS, INC.
19900 MACARTHUR BLVD., SUITE 550
IRVINE, CA 92612
X
See Remarks

Signatures
/s/ Ryan A. Murr, as attorney-in-fact for Steven Perrin9/24/2020
**Signature of Reporting PersonDate

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