FORM 3
        
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Crum Brian T

 2. Date of Event Requiring Statement (MM/DD/YYYY)
10/28/2019 

 3. Issuer Name and Ticker or Trading Symbol

LEXICON PHARMACEUTICALS, INC. [LXRX]

(Last)        (First)        (Middle)

8800 TECHNOLOGY FOREST PL

 4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                          _____ 10% Owner
___X___ Officer (give title below)        _____ Other (specify below)
VP, General Counsel & Secr. /

(Street)

THE WOODLANDS, TX 77381      

(City)              (State)              (Zip)
5. If Amendment, Date Original Filed(MM/DD/YYYY)

 

6. Individual or Joint/Group Filing(Check Applicable Line)

_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person


Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		2. Amount of Securities Beneficially Owned
(Instr. 4)		3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 22925 D  

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 4)		2. Date Exercisable and Expiration Date
(MM/DD/YYYY)		3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		4. Conversion or Exercise Price of Derivative Security5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock Option (Right to Buy)  (1)2/15/2020 Common Stock 2857 $13.30 D  
Stock Option (Right to Buy)  (2)2/23/2021 Common Stock 10000 $12.67 D  
Stock Option (Right to Buy)  (3)2/15/2022 Common Stock 10571 $12.60 D  
Stock Option (Right to Buy)  (4)2/8/2023 Common Stock 8747 $14.63 D  
Stock Option (Right to Buy)  (5)2/6/2024 Common Stock 13499 $12.04 D  
Stock Option (Right to Buy)  (6)2/5/2025 Common Stock 19391 $6.23 D  
Stock Option (Right to Buy)  (7)2/11/2026 Common Stock 23470 $8.20 D  
Restricted Stock Units  (8) (8)Common Stock 2515  (9)D  
Stock Option (Right to Buy)  (10)2/9/2027 Common Stock 14160 $14.44 D  
Restricted Stock Units  (11) (11)Common Stock 3035  (9)D  
Stock Option (Right to Buy)  (12)2/8/2028 Common Stock 23040 $9.79 D  
Restricted Stock Units  (13) (13)Common Stock 10237  (9)D  
Stock Option (Right to Buy)  (14)2/7/2029 Common Stock 49950 $5.16 D  
Restricted Stock Units  (15) (15)Common Stock 33300  (9)D  
Stock Option (Right to Buy)  (16)5/17/2020 Common Stock 7142 $10.64 D  
Explanation of Responses:
(1) Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant (2/15/2011) and vests 1/48th per month for each month of service thereafter.
(2) Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant (2/23/2012) and vests 1/48th per month for each month of service thereafter.
(3) Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant (2/15/2013) and vests 1/48th per month for each month of service thereafter.
(4) Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant (2/8/2014) and vests 1/48th per month for each month of service thereafter
(5) Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant (2/6/15) and vests 1/48th per month for each month of service thereafter.
(6) Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant (2/5/16) and vests 1/48th per month for each month of service thereafter.
(7) Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant (2/11/2017) and vests 1/48th per month for each month of service thereafter.
(8) Restricted stock units vest with respect to 25% of the shares subject to the restricted stock units on February 28, 2017 and vest an additional 25% on February 28 of each of the three succeeding years thereafter.
(9) Each restricted stock unit represents a contingent right to receive one share of common stock.
(10) Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant (2/9/2018) and vests 1/48th per month for each month of service thereafter
(11) Restricted stock units vest with respect to 25% of the shares subject to the restricted stock units on February 28, 2018 and vest an additional 25% on February 28 of each of the three succeeding years thereafter.
(12) Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant (2/8/2019) and vests 1/48th per month for each month of service thereafter.
(13) Restricted stock units vest with respect to one third of the shares subject to the restricted stock units on February 28, 2019 and vest an additional one third on February 28 of each of the two succeeding years thereafter.
(14) Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant (2/7/2020) and vests 1/48th per month for each month of service thereafter
(15) Restricted stock units vest with respect to one third of the shares subject to the restricted stock units on February 28, 2020 and vest an additional one third on February 28 of each of the two succeeding years thereafter.
(16) Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant (5/17/2011) and vests 1/48th per month for each month of service thereafter.
Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
Crum Brian T
8800 TECHNOLOGY FOREST PL
THE WOODLANDS, TX 77381

VP, General Counsel & Secr.
Signatures
/s/ Brian T. Crum11/4/2019
**Signature of Reporting PersonDate
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