FORM 3
        
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

DENNER ALEXANDER J		 2. Date of Event Requiring Statement (MM/DD/YYYY)
11/22/2020 

 3. Issuer Name and Ticker or Trading Symbol

Iterum Therapeutics plc [ITRM]
(Last)        (First)        (Middle)

C/O SARISSA CAPITAL MANAGEMENT LP, 660 STEAMBOAT ROAD, 3RD FLOOR		 4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                          ___X___ 10% Owner
_____ Officer (give title below)        _____ Other (specify below)
(Street)

GREENWICH, CT 06830      

(City)              (State)              (Zip)
5. If Amendment, Date Original Filed(MM/DD/YYYY)
 

6. Individual or Joint/Group Filing(Check Applicable Line)

___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		2. Amount of Securities Beneficially Owned
(Instr. 4)		3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		4. Nature of Indirect Beneficial Ownership
(Instr. 5)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 4)		2. Date Exercisable and Expiration Date
(MM/DD/YYYY)		3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		4. Conversion or Exercise Price of Derivative Security5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date ExercisableExpiration DateTitleAmount or Number of Shares
6.500% Exchangeable Senior Subordinated Note due 2025 1/21/2021 1/31/2025 Ordinary Shares 19292768 (1)(2)(3)(4)$.7775 I See footnotes (1)(2)(3)(4)
Explanation of Responses:
(1) See Exhibit 99.1
(2) See Exhibit 99.1
(3) See Exhibit 99.1
(4) See Exhibit 99.1

Remarks:
Exhibit List:
-------------
Exhibit 99.1
Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
DENNER ALEXANDER J
C/O SARISSA CAPITAL MANAGEMENT LP
660 STEAMBOAT ROAD, 3RD FLOOR
GREENWICH, CT 06830
X

Sarissa Capital Management LP
660 STEAMBOAT ROAD
3RD FLOOR
GREENWICH, CT 06830
X

Sarissa Capital Offshore Master Fund LP
C/O SARISSA CAPITAL MANAGEMENT
660 STEAMBOAT ROAD 3RD FLOOR
GREENWICH, CT 06830
X

Sarissa Capital Catapult Fund LLC
C/O SARISSA CAPITAL MANAGEMENT LP
660 STEAMBOAT ROAD, 3RD FLOOR
GREENWICH, CT 06830
X

Sarissa Capital Hawkeye Fund LP
C/O SARISSA CAPITAL MANAGEMENT LP
660 STEAMBOAT ROAD, 3RD FLOOR
GREENWICH, CT 06830
X

Sarissa Capital Master Fund II LP
C/O SARISSA CAPITAL MANAGEMENT LP
660 STEAMBOAT ROAD, 3RD FLOOR
GREENWICH, CT 06830
X
Signatures
SARISSA CAPITAL MANAGEMENT LP; By: /s/ Mark DePaolo, Senior Partner, General Counsel11/23/2020
**Signature of Reporting PersonDate

SARISSA CAPITAL OFFSHORE MASTER FUND LP; By: /s/ Mark DiPaolo, Authorized Person11/23/2020
**Signature of Reporting PersonDate

SARISSA CAPITAL CATAPULT FUND LLC; /s/ Mark DiPaolo, Authorized Person11/23/2020
**Signature of Reporting PersonDate

SARISSA CAPITAL HAWKEYE FUND LP; By: /s/ Mark DiPaolo, Authorized Person11/23/2020
**Signature of Reporting PersonDate

SARISSA CAPITAL MASTER FUND II LP; By: /s/ Mark DiPaolo, Authorized Person11/23/2020
**Signature of Reporting PersonDate

/s/ Alexander J. Denner11/23/2020
**Signature of Reporting PersonDate
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