GLMD Galmed Pharmaceuticals Ltd

Plan of Distribution

We have entered into an amended and restated sales agreement, or the Sales Agreement, with Stifel and Cantor pursuant to which we may offer and sell our ordinary shares from time to time through the Sales Agents, acting as agents (each, a “sales agent” and together the “sales agents”). Pursuant to this Prospectus Supplement, we may offer and sell $31,900,000 of our ordinary shares. This summary of the material provisions of the Sales Agreement does not purport to be a complete statement of its terms and conditions. The Sales Agreement will be filed as an exhibit to the current report on Form 6-K filed on May 15, 2020, which will be incorporated by reference in this Prospectus Supplement.

Upon delivery of a placement notice and subject to the terms and conditions of the Sales Agreement, the sales agents may sell our ordinary shares by any method permitted by law deemed to be an “at the market offering” as defined in Rule 415(a)(4) promulgated under the Securities Act, including sales made directly on the Nasdaq Capital Market or on any other existing trading market for our ordinary shares. We may instruct the sales agents not to sell our ordinary shares if the sales cannot be effected at or above the price designated by us from time to time. We or the sales agents may suspend the offering of our ordinary shares upon notice and subject to other conditions. We may only instruct one sales agent to issue and sell ordinary shares under the Sales Agreement on any single given day.

We will pay the sales agents commissions, in cash, for their services in acting as agent in the sale of our ordinary shares. The sales agents will be entitled to compensation at a fixed commission rate of up to 3.0% of the aggregate gross sales price per share sold. Because there is no minimum offering amount required as a condition to close this offering, the actual total public offering amount, commissions and proceeds to us, if any, are not determinable at this time.

Settlement for sales of ordinary shares will occur on the second trading day following the date on which any sales are made, or on some other date that is agreed upon by us and the sales agents in connection with a particular transaction, in return for payment of the net proceeds to us. Sales of our ordinary shares as contemplated in this Prospectus Supplement and the accompanying prospectus will be settled through the facilities of The Depository Trust Company or by such other means as we and the sales agents may agree upon. There is no arrangement for funds to be received in an escrow, trust or similar arrangement.

The sales agents will use their commercially reasonable efforts, consistent with their sales and trading practices, to solicit offers to purchase the ordinary shares under the terms and subject to the conditions set forth in the Sales Agreement. In connection with the sale of the ordinary shares on our behalf, each of the sales agents will be deemed to be an “underwriter” within the meaning of the Securities Act and the compensation of the sales agents will be deemed to be underwriting commissions or discounts. We have agreed to provide indemnification and contribution to the sales agents against certain civil liabilities, including liabilities under the Securities Act.

The offering of our ordinary shares pursuant to the Sales Agreement will terminate upon the termination of the Sales Agreement as permitted therein. We and the sales agents may each terminate the Sales Agreement at any time upon ten days’ prior notice.

Each of the sales agents and its affiliates may in the future provide various investment banking, commercial banking and other financial services for us and our affiliates, for which services they may in the future receive customary fees. To the extent required by Regulation M, the sales agents will not engage in any market making activities involving our ordinary shares while the offering is ongoing under this Prospectus Supplement.

This Prospectus Supplement and the accompanying prospectus may be made available on a website maintained by the sales agents and the sales agents may distribute this Prospectus Supplement and accompanying prospectus electronically.

The address of Stifel is 787 7th Avenue, New York, New York 10019 and the address of Cantor is 499 Park Avenue, New York, New York 10022.

Incorporation of Certain Information by Reference

The SEC allows us to “incorporate by reference” the information we file with them, which means that we can disclose important information to you by referring you to those documents instead of having to repeat the information in this Prospectus Supplement. The information incorporated by reference is considered to be part of this Prospectus Supplement, and later information that we file with the SEC will automatically update and supersede this information. We incorporate by reference the document listed below and any future filings made with the SEC (in each case, other than those documents or the portions of those documents deemed to be furnished and not filed in accordance with SEC rules) between the date of this Prospectus Supplement and the termination of the offering and also between the date of the initial registration statement and prior to effectiveness of the registration statement:

This Prospectus Supplement and accompanying prospectus are part of a registration statement on Form F-3 we have filed with the SEC under the Securities Act. This Prospectus Supplement does not contain all of the information in the registration statement. We have omitted certain parts of the registration statement, as permitted by the rules and regulations of the SEC. You may inspect and copy the registration statement, including exhibits, at the SEC’s public reference room or website. Our statements in this Prospectus Supplement about the contents of any contract or other document are not necessarily complete. You should refer to the copy of each contract or other document we have filed as an exhibit to the registration statement for complete information.

We will provide, upon written or oral request, to each person to whom a prospectus is delivered, a copy of any or all of the information that has been incorporated by reference in the prospectus but not delivered with the prospectus. You may request a copy of these filings, at No cost, by writing us at Galmed Pharmaceuticals Ltd., 16 Tiomkin Street, Tel Aviv, Israel, 6578317. Our telephone number is +972-3-693-8448.