As filed with the Securities and Exchange Commission on March 14, 2022
Registration No. 333-258467 
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Post-Effective Amendment No. 1
to
FORM S-1
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
Sema4 Holdings Corp.
(Exact Name of Registrant as Specified in Its Charter)
Delaware800085-1966622
(State or Other Jurisdiction of
Incorporation or Organization)		(Primary Standard Industrial
Classification Code Number)		(I.R.S. Employer
Identification Number)
333 Ludlow Street, North Tower, 8th Floor
Stamford, Connecticut 06902
(800) 298-6470
(Address, Including Zip Code, and Telephone Number, Including Area Code, of Registrant’s Principal Executive Offices)
Eric Schadt
Chief Executive Officer
333 Ludlow Street, North Tower, 8th Floor
Stamford, Connecticut 06902
(800) 298-6470
(Name, Address, Including Zip Code, and Telephone Number, Including Area Code, of Agent for Service)
Copies to:
Ethan Skerry
Per B. Chilstrom
Fenwick & West LLP
902 Broadway
New York, New York 10010
(212) 430-2600		Daniel Clark
General Counsel
Sema4 Holdings Corp.
333 Ludlow Street, North Tower, 8th Floor
Stamford, Connecticut 06902
(800) 298-6470
Approximate date of commencement of proposed sale to the public: From time to time after the effective date of this registration statement.
If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, check the following box. x
If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. o
If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. o
If this Form is a post-effective amendment filed pursuant to Rule 462(d) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. x (333-258467)
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
Large accelerated fileroAccelerated filero
Non-accelerated filer☒Smaller reporting company☒
Emerging growth company☒
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. o
THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS REGISTRATION STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(a) OF THE SECURITIES ACT OF 1933, AS AMENDED, OR UNTIL THE REGISTRATION STATEMENT SHALL BECOME EFFECTIVE ON SUCH DATE AS THE SECURITIES AND EXCHANGE COMMISSION ACTING PURSUANT TO SAID SECTION 8(a), MAY DETERMINE.


EXPLANATORY NOTE
This Post-Effective Amendment No. 1 (this “Amendment”) to the Registration Statement on Form S-1 of Sema4 Holdings Corp. (File No. 333-258467), initially filed on August 4, 2021 and declared effective by the Securities and Exchange Commission on August 12, 2021 (the “Registration Statement”), is being filed as an exhibit-only filing solely (i) to file a consent of Ernst & Young LLP with respect to its report dated March 14, 2022 relating to the financial statements of Sema4 Holdings Corp. contained in its Annual Report on Form 10-K for the year ended December 31, 2021, which consent is filed herewith as Exhibit 23.1 (the “Consent”), and (ii) to incorporate by reference certain additional exhibits that were not previously filed with the Registration Statement (the “Additional Exhibits”). Accordingly, this Amendment consists only of the facing page, this explanatory note, Item 16 of Part II of the Registration Statement, the signature pages to the Registration Statement, and the Consent. The prospectus and the balance of Part II of the Registration Statement are unchanged hereby and have been omitted.


Part II-INFORMATION NOT REQUIRED IN PROSPECTUS
Item 16. Exhibits and Financial Statement Schedules.
The following exhibits are filed herewith or incorporated by reference herein:
EXHIBIT INDEX
Incorporated by Reference
Exhibit
Number
DescriptionFormExhibitFiling DateFiled Herewith
2.1*DEFM14AAnnex A07/02/2021
2.2*8-K2.101/18/2022
3.1*8-K3.107/28/2021
3.2*8-K3.207/28/2021
4.1*S-1/A4.308/24/2020
4.2*8-K10.109/04/2020
5.1*S-15.108/04/2021
10.1*8-K10.407/28/2021
10.2*8-K10.102/11/2021
10.3*8-K10.207/28/2021
10.4*8-K10.202/11/2021
10.5*8-K10.607/28/2021
10.6*8-K10.707/28/2021
10.7*8-K10.807/28/2021
10.8*8-K10.507/28/2021
10.9*8-K10.907/28/2021
10.10*8-K10.1007/28/2021
10.11*8-K10.1107/28/2021
10.12*8-K10.1207/28/2021
10.13*8-K10.1307/28/2021
10.14*8-K10.1407/28/2021
10.15*8-K10.1507/28/2021
10.16*8-K10.1607/28/2021


10.17*8-K10.1707/28/2021
10.18*8-K10.1807/28/2021
10.19*8-K10.1907/28/2021
10.20*8-K10.2007/28/2021
10.21*8-K10.2107/28/2021
10.22*8-K10.2207/28/2021
10.23*8-K10.2307/28/2021
10.24*8-K10.2407/28/2021
10.25*8-K10.2507/28/2021
10.26*8-K10.2607/28/2021
10.27*8-K10.2707/28/2021
10.28*S-899.609/27/2021
10.29*10-Q10.2611/15/2021
10.30*8-K10.101/18/2022
10.31*8-K10.201/18/2022
10.32*8-K10.301/18/2022
10.33*8-K10.401/18/2022
10.34*8-K10.101/31/2022
10.35*10-K10.3103/14/2022
21.1*10-K21.103/14/2022


_____________
+     Certain schedules and exhibits to this Exhibit have been omitted pursuant to Item 601(a)(5) or Item 601(b)(10)(iv), as applicable, of Regulation S-K. The Registrant agrees to furnish supplemental copies of all omitted exhibits and schedules to the Securities and Exchange Commission upon its request.
#     Management contract or compensatory plan or arrangement.
*    Previously filed.


SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant has duly caused this post-effective amendment to registration statement on Form S-1 to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Stamford, State of Connecticut, on the 14th day of March, 2022.
SEMA4 HOLDINGS CORP.
By:/s/ Eric Schadt
Eric Schadt
Chief Executive Officer
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Eric Schadt, Daniel Clark and Joshua Ruch, and each of them, as his or her true and lawful attorneys-in-fact, proxies and agents, each with full power of substitution and resubstitution and full power to act without the other, for him or her in any and all capacities, to sign any and all amendments to this registration statement (including post-effective amendments or any abbreviated registration statement and any amendments thereto filed pursuant to Rule 462(b) increasing the number of securities for which registration is sought), and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact, proxies and agents full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully for all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact, proxies and agents, or their or his or her substitute or substitutes, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, as amended, this post-effective amendment to registration statement on Form S-1 has been signed by the following persons in the capacities and on the dates indicated.
Signature
Title
Date
/s/ Eric Schadt
Chief Executive Officer and Director
(Principal Executive Officer)
March 14, 2022
Eric Schadt
/s/ Isaac Ro
Chief Financial Officer
(Principal Financial Officer)
March 14, 2022
Isaac Ro
/s/ Shawn Assad
Chief Accounting Officer
(Principal Accounting Officer)
March 14, 2022
Shawn Assad
*
Executive Chairman and Director
March 14, 2022
Jason Ryan
*
Director
March 14, 2022
Joshua Ruch
*
Director
March 14, 2022
Dennis Charney
*
Director
March 14, 2022
Eli D. Casdin
*
Director
March 14, 2022
Emily Leproust


/s/ Keith MeisterDirector
March 14, 2022
Keith Meister
*
Director
March 14, 2022
Michael Pellini
*
Director
March 14, 2022
Nat Turner
*
Director
March 14, 2022
Rachel Sherman
*By /s/ Dan Clark
March 14, 2022
Dan Clark
Attorney-in-fact

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