FORM 3
        
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      
1. Name and Address of Reporting Person * Varadan Anand 2. Date of Event Requiring Statement (MM/DD/YYYY)
4/22/2020 

3. Issuer Name and Ticker or Trading Symbol CHIASMA, INC [CHMA]
(Last)       (First)       (Middle)
C/O CHIASMA, INC., 140 KENDRICK STREET, BUILDING C
4. Relationship of Reporting Person(s) to Issuer (Check all applicable)_____ Director                          _____ 10% Owner
___X___ Officer (give title below)        _____ Other (specify below)
EVP, Chief Commerical Officer /
(Street)
NEEDHAM, MA 02494      
(City)             (State)             (Zip)
5. If Amendment, Date Original Filed(MM/DD/YYYY)
 

6. Individual or Joint/Group Filing(Check Applicable Line)_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(MM/DD/YYYY)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (Right to Buy)  2/23/2018 (1) 2/23/2028  Common Stock  36069  $1.52  D   
Stock Option (Right to Buy)  2/14/2019 (1) 2/14/2029  Common Stock  13692  $3.75  D   
Stock Option (Right to Buy)  10/15/2019 (2) 10/15/2029  Common Stock  112441  $4.84  D   

Explanation of Responses:
(1)  The shares of Common Stock underlying the option vested in equal quarterly installments over one (1) year from the date of grant.
(2)  25% of the shares of Common Stock underlying the option vested on January 1, 2020 and the remaining shares will vest in three equal quarterly installments thereafter.

Remarks:
Exhibit 24.1 Power of Attorney

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
Varadan Anand
C/O CHIASMA, INC.
140 KENDRICK STREET, BUILDING C
NEEDHAM, MA 02494


EVP, Chief Commerical Officer

Signatures
Mark Fitzpatrick, as Attorney-in-Fact 4/22/2020
**Signature of Reporting Person Date
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