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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
_________________________________
FORM 8-K
_________________________________
CURRENT REPORT
Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934
Date of Report (Date of earliest event reported): August 8, 2024
_________________________________
Codexis, Inc.
(Exact name of registrant as specified in its charter)
_________________________________
| | | | | | | | | | | | | | |
Delaware | | 001-34705 | | 71-0872999 |
(State or other jurisdiction of incorporation) | | (Commission File Number) | | (I.R.S. Employer Identification No.) |
200 Penobscot Drive
Redwood City, CA 94063
(Address of Principal Executive Offices) (Zip Code)
Registrant's telephone number, including area code (650) 421-8100
Not Applicable
(Former name or former address, if changed since last report)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below): | | | | | |
☐ | Written communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425) |
☐ | Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) |
☐ | Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) |
☐ | Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) |
Securities registered pursuant to Section 12(b) of the Act: | | | | | | | | |
Title of Each Class | Trading | Name of Each Exchange on Which Registered |
| Symbols(s) | |
Common Stock, par value $0.0001 per share | CDXS | The Nasdaq Global Select Market |
Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).
Emerging growth company ☐ | | | | | |
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. | ☐ |
| | | | | |
Item 2.02 | Results of Operations and Financial Condition. |
On August 8, 2024, Codexis, Inc. announced its financial results for the quarter ended June 30, 2024. The full text of the press release issued in connection with the announcement is furnished as Exhibit 99.1 to this Current Report on Form 8-K.
The information in Item 2.02 of this Current Report on Form 8-K (including Exhibit 99.1) shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference under the Securities Act of 1933, as amended, except as expressly set forth by specific reference in such a filing.
| | | | | |
Item 9.01 | Financial Statement and Exhibits. |
(d) Exhibits. | | | | | | | | |
Exhibit No. | | Exhibit Description |
99.1 | | |
104 | | Cover Page Interactive Data File (the cover page XBRL tags are embedded within the inline XBRL document) |
SIGNATURE
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
Date: August 8, 2024 | | | | | | | | |
| CODEXIS, INC. |
| | |
| By: | /s/ Sriram Ryali |
| Name: | Sriram Ryali |
| Title: | Chief Financial Officer |
Exhibit 99.1
Codexis Reports Second Quarter 2024 Financial Results
Company Reiterates Full-year Financial Guidance; On Track to Achieve Product Revenue Growth of at Least 10% vs. FY2023 Excluding Enzyme Sales Related to PAXLOVID™
Anticipate Entering First Technical Collaboration for ECO Synthesis™ Manufacturing Platform by End of Year
REDWOOD CITY, Calif., August 8, 2024 -- Codexis, Inc. (NASDAQ: CDXS), a leading enzyme engineering company, today announced financial results for the second quarter ended June 30, 2024, and provided a business update.
“We’re pleased that our second quarter revenues are exactly in-line with our expectations. As a result, we are reiterating our 2024 financial guidance and look forward to a strong second half of the year, including fulfilling the first order for our double-stranded RNA ligase. We are confident that we remain on track to deliver double-digit year-over-year revenue growth,” said Stephen Dilly, MBBS, PhD, Chief Executive Officer at Codexis. “Additionally, our technical progress has been faster than expected. Our groundbreaking TIDES USA presentation demonstrating the enzymatic synthesis of a full-length siRNA oligonucleotide is unprecedented. Finally, discussions with multiple potential partners are active and proceeding well and we anticipate entering our first technical collaboration for the ECO Synthesis™ manufacturing platform before year-end.”
Second Quarter and Recent Business Highlights
•At the TIDES USA annual meeting in May 2024, Codexis presented groundbreaking enzymatic synthesis data from its ECO Synthesis™ technology platform to support RNA-based therapeutics manufacturing. During a Spotlight Presentation, the Company announced it had synthesized the full-length, sense strand oligonucleotide of the siRNA therapeutic lumasiran via its enzymatic route. In the manufacturing of this commercially available oligonucleotide—as well as shorter sense strand fragments of a second siRNA therapeutic asset, givosiran—Codexis consistently achieved coupling efficiency greater than 98%, which is equivalent to what is seen with phosphoramidite chemistry; executed the enzymatic addition of a conjugation moiety to the lumasiran strand; and confirmed the lack of notable impurities typically observed in oligonucleotide synthesis via phosphoramidite chemistry. A recording of the presentation, along with slides and the data press release, can be found on the Codexis corporate website.
•Also at the 2024 TIDES USA annual meeting, Codexis launched its double-stranded RNA (dsRNA) ligase screening and optimization services. The dsRNA ligase program is designed to augment and improve traditional phosphoramidite chemistry by stitching together small, manufactured strands of RNA. In addition to enabling the more efficient use of existing chemical synthesis with the potential to reduce overall costs, the dsRNA ligase provides an opportunity to educate potential customers on the benefits of incorporating enzymatic solutions as a complement to their current manufacturing processes. The Company has already received a low-to-mid-single-digit million-dollar order for its dsRNA ligase from a large pharmaceutical customer.
•In July 2024, the Company further strengthened its commercial leadership with the appointment of Britton Jimenez to Senior Vice President, Commercial Operations, reporting to Kevin Norrett, Chief Operating Officer. Mr. Jimenez brings more than 20 years’ experience with Contract Development and Manufacturing Organizations to Codexis, which will provide valuable insights as we position Codexis for our next phase of growth.
•Codexis announced in July 2024 that the Company had finalized a purchase agreement with Crosswalk Therapeutics for two gene therapy assets. Under the terms of the agreement, Crosswalk acquired the Company’s investigational Fabry and Pompe disease compounds, and Codexis is eligible to receive future development and commercial milestone payments in addition to a low-to-mid single-digit percentage net sales-based royalty. Both programs were previously part of Codexis’ collaboration agreement with Takeda. In April 2023, Takeda discontinued its efforts in adeno-associated virus (AAV) gene therapy, which included these development programs.
Upcoming Milestones for Second Half 2024
•Codexis continues to expect to enter its first technical collaboration with the ECO Synthesis™ manufacturing platform by the end of 2024.
•The Company expects to complete the build-out of its ECO Synthesis™ Innovation Lab around the end of 2024.
2024 Financial Guidance Reiterated
Codexis reiterated its full-year 2024 financial guidance originally issued on February 28, 2024, as follows:
•Product revenues are expected to be in the range of $38 million to $42 million, excluding revenue related to PAXLOVID™.
•R&D revenues are expected to be in the range of $18 million to $22 million.
•Gross margin on product revenue is expected to be in the range of 58% to 63%, excluding revenue related to PAXLOVID™.
Second Quarter 2024 Financial Highlights
•As of June 30, 2024, the Company had $73.2 million in cash, cash equivalents and short-term investments, which is expected to fund planned operations through positive cash flow, anticipated around the end of 2026.
•Product and R&D revenues for the second quarter 2024 were in-line with guidance provided during the Company’s Q1 2024 financial results call. Total revenues were $8.0 million for second quarter 2024 compared to $21.3 million in second quarter 2023. Product revenues were $6.3 million for second quarter 2024 compared to $11.0 million in second quarter 2023, driven by timing of customer orders. R&D revenues for second quarter 2024 were $1.7 million compared to $10.3 million in second quarter 2023; the decrease was primarily due to lower non-recurring items, including for Biotherapeutics programs that the Company previously discontinued and a one-time, non-cash license fee.
•Product gross margin was 45% for second quarter 2024 compared to 71% in second quarter 2023. The decline in gross margin was largely due to variability in the product mix.
•R&D expenses for second quarter 2024 were $11.4 million compared to $17.3 million in second quarter 2023; the decrease was primarily driven by a decrease in costs associated with lower headcount, lower use of outside services related to Chemistry, Manufacturing and Controls and lower regulatory expenses, a decrease in lease and facilities costs due to the assignment of the Company’s San Carlos facility lease during the fourth quarter of 2023, and lower stock-based compensation costs.
•Selling, General & Administrative expenses for second quarter 2024 were $15.7 million compared to $13.4 million in second quarter 2023; the increase was primarily due to higher stock-based
compensation expense, including a one-time, non-cash modification expense of $2 million, and an increase in facilities associated costs, partially offset by a decrease in costs associated with lower headcount.
•The net loss for second quarter 2024 was $22.8 million, or $0.32 per share, compared to a net loss of $11.5 million, or $0.17 per share, for second quarter 2023.
Conference Call and Webcast
Codexis will hold a conference call and webcast today beginning at 4:30 pm ET. A live webcast and slide presentation to accompany the conference call will be available on the Investors section of the Company website at www.codexis.com/investors. The conference call dial-in numbers are 877-705-2976 for domestic callers and 201-689-8798 for international callers.
A telephone recording of the call will be available for 48 hours beginning approximately two hours after the completion of the call by dialing 877-660-6853 for domestic callers or 201-612-7415 for international callers. Please use the passcode 13726635 to access the recording. A webcast replay will be available on the Investors section of the Company website for at least 90 days, beginning approximately two hours after the completion of the call.
About Codexis
Codexis is a leading enzyme engineering company leveraging its proprietary CodeEvolver® technology platform to discover, develop and enhance novel, high-performance enzymes and other classes of proteins. Codexis enzymes solve for real-world challenges associated with small molecule pharmaceuticals manufacturing and nucleic acid synthesis. The Company is currently developing its proprietary ECO Synthesis™ manufacturing platform to enable the scaled manufacture of RNAi therapeutics through an enzymatic route. Codexis’ unique enzymes can drive improvements such as higher yields, reduced energy usage and waste generation, improved efficiency in manufacturing and greater sensitivity in genomic and diagnostic applications. For more information, visit https://www.codexis.com.
Forward-Looking Statements
This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. In some cases, you can identify forward-looking statements by terminology such as “aim,” “anticipate,” “assume,” “believe,” “contemplate,” “continue,” “could,” “design,” “due,” “estimate,” “expect,” “goal,” “intend,” “may,” “objective,” “plan,” “positioned,” “potential,” “predict,” “seek,” “should,” “suggest,” “target,” “on track,” “will,” “would” and other similar expressions that are predictions of or indicate future events and future trends, or the negative of these terms or other comparable terminology. To the extent that statements contained in this press release are not descriptions of historical facts, they are forward-looking statements reflecting the current beliefs and expectations of management, including but not limited to statements regarding anticipated milestones, including product launches, technical milestones, data releases and public announcements related thereto; whether Codexis will be able to, and the timing of it entering its first technical collaboration with its ECO Synthesis™ manufacturing platform in 2024; whether Codexis will be able to, and the timing of it substantially completing, the build-out of its planned ECO Synthesis™ Innovation Lab around the end of 2024; Codexis’ expectations regarding 2024 product revenues, R&D revenues and gross margin on product revenue, as well as its ability to fund planned operations through the end of 2026; Codexis’ ability to achieve positive cash flow around the end of 2026; the potential of such dsRNA ligase to, among other things, augment and improve traditional phosphoramidite chemistry, enable more efficient use of existing manufacturing infrastructure and reduce overall costs; potential receipt by Codexis of certain milestone and royalty payments pursuant to its recent asset purchase agreement with Crosswalk Therapeutics; the potential of the ECO Synthesis™ manufacturing platform, including its ability to be broadly utilized and to enable commercial-scale manufacture of RNAi therapeutics through an enzymatic route; and expectations regarding future demand for dsRNA. You should not place undue reliance on these forward-looking statements because they involve known and unknown risks, uncertainties and other factors that are, in some cases, beyond Codexis’ control and that could materially affect actual results. Factors that could materially affect actual results include, among others: Codexis’ dependence on its licensees and collaborators; if any of its
collaborators terminate their development programs under their respective license agreements with Codexis; Codexis may need additional capital in the future in order to expand its business; if Codexis is unable to successfully develop new technology such as its ECO Synthesis™ manufacturing platform and dsRNA ligase; Codexis’ dependence on a limited number of products and customers, and potential adverse effects to Codexis’ business if its customers’ products are not received well in the markets; if Codexis is unable to develop and commercialize new products for its target markets; if competitors and potential competitors who have greater resources and experience than Codexis develop products and technologies that make Codexis’ products and technologies obsolete; Codexis’ ability to comply with debt covenants under its loan facility; if Codexis is unable to accurately forecast financial and operational performance; and market and economic conditions may negatively impact Codexis business, financial condition and share price. Additional information about factors that could materially affect actual results can be found in Codexis’ Annual Report on Form 10-K filed with the Securities and Exchange Commission (SEC) on February 28, 2024 and in Codexis’ Quarterly Report on Form 10-Q filed with the SEC on or about the date hereof, including under the caption “Risk Factors,” and in Codexis’ other periodic reports filed with the SEC. Codexis expressly disclaims any intent or obligation to update these forward-looking statements, except as required by law. Codexis’ results for the quarter ended June 30, 2024, are not necessarily indicative of our operating results for any future periods.
For More Information
Investor Contact
Carrie McKim
(336) 608-9706
ir@codexis.com
Media Contact
Lauren Musto
(650) 421-8205
media@codexis.com
Codexis, Inc.
Condensed Consolidated Statements of Operations
(Unaudited)
(In Thousands, Except Per Share Amounts)
| | | | | | | | | | | | | | | | | | | | | | | | | | | |
| Three Months Ended June 30, | | Six Months Ended June 30, | | |
| 2024 | | 2023 | | 2024 | | 2023 | | | | |
Revenues: | | | | | | | | | | | |
Product revenue | $ | 6,259 | | | $ | 11,048 | | | $ | 15,810 | | | $ | 19,412 | | | | | |
Research and development revenue | 1,720 | | | 10,275 | | | 9,242 | | | 14,893 | | | | | |
Total revenues | 7,979 | | | 21,323 | | | 25,052 | | | 34,305 | | | | | |
Costs and operating expenses: | | | | | | | | | | | |
Cost of product revenue | 3,462 | | | 3,178 | | | 8,317 | | | 7,698 | | | | | |
Research and development | 11,413 | | | 17,334 | | | 22,659 | | | 33,988 | | | | | |
Selling, general and administrative | 15,671 | | | 13,365 | | | 28,531 | | | 28,765 | | | | | |
Restructuring charges | — | | | 72 | | | — | | | 145 | | | | | |
Asset impairment and other charges | 165 | | | — | | | 165 | | | — | | | | | |
Total costs and operating expenses | 30,711 | | | 33,949 | | | 59,672 | | | 70,596 | | | | | |
Loss from operations | (22,732) | | | (12,626) | | | (34,620) | | | (36,291) | | | | | |
Interest income | 972 | | | 1,121 | | | 1,881 | | | 2,209 | | | | | |
Interest and other expense, net | (985) | | | (9) | | | (1,500) | | | (33) | | | | | |
Loss before income taxes | (22,745) | | | (11,514) | | | (34,239) | | | (34,115) | | | | | |
Provision for income taxes | 10 | | | 9 | | | 21 | | | 25 | | | | | |
Net loss | $ | (22,755) | | | $ | (11,523) | | | $ | (34,260) | | | $ | (34,140) | | | | | |
| | | | | | | | | | | |
Net loss per share, basic and diluted | $ | (0.32) | | | $ | (0.17) | | | $ | (0.49) | | | $ | (0.51) | | | | | |
Weighted average common stock shares used in computing net loss per share, basic and diluted | 70,376 | | | 67,573 | | | 70,115 | | | 66,756 | | | | | |
| | | | | | | | | | | |
Codexis, Inc.
Condensed Consolidated Statements of Comprehensive Loss
(Unaudited)
(In Thousands)
| | | | | | | | | | | | | | | | | | | | | | | |
| Three Months Ended June 30, | | Six Months Ended June 30, |
| 2024 | | 2023 | | 2024 | | 2023 |
Net loss | $ | (22,755) | | | $ | (11,523) | | | $ | (34,260) | | | $ | (34,140) | |
Other comprehensive loss: | | | | | | | |
Unrealized loss on available-for-sale short-term investments, net of tax | (7) | | | — | | | (23) | | | — | |
Comprehensive loss | $ | (22,762) | | | $ | (11,523) | | | $ | (34,283) | | | $ | (34,140) | |
| | | | | | | |
Codexis, Inc.
Condensed Consolidated Balance Sheets
(Unaudited)
(In Thousands)
| | | | | | | | | | | |
| June 30, 2024 | | December 31, 2023 |
Assets | | | |
Current assets: | | | |
Cash and cash equivalents | $ | 18,595 | | | $ | 65,116 | |
Restricted cash, current | 517 | | | 519 | |
Short-term investments | 54,604 | | | — | |
Financial assets: | | | |
Accounts receivable | 4,860 | | | 10,036 | |
Contract assets | 3,213 | | | 815 | |
Unbilled receivables | 4,380 | | | 9,142 | |
Total financial assets | 12,453 | | | 19,993 | |
Less: allowances | (65) | | | (65) | |
Total financial assets, net | 12,388 | | | 19,928 | |
Inventories | 2,232 | | | 2,685 | |
Prepaid expenses and other current assets | 3,062 | | | 5,218 | |
Total current assets | 91,398 | | | 93,466 | |
Restricted cash | 1,062 | | | 1,062 | |
Investment in non-marketable equity securities | 9,700 | | | 9,700 | |
Right-of-use assets - Operating leases, net | 11,576 | | | 13,137 | |
Property and equipment, net | 13,966 | | | 15,487 | |
Goodwill | 2,463 | | | 2,463 | |
Other non-current assets | 1,841 | | | 1,246 | |
Total assets | $ | 132,006 | | | $ | 136,561 | |
| | | |
Liabilities and Stockholders' Equity | | | |
Current liabilities: | | | |
Accounts payable | $ | 3,685 | | | $ | 5,947 | |
Accrued compensation | 7,658 | | | 11,246 | |
Other accrued liabilities | 5,417 | | | 4,735 | |
Current portion of lease obligations - Operating leases | 3,979 | | | 3,781 | |
Deferred revenue | 9,800 | | | 10,121 | |
Total current liabilities | 30,539 | | | 35,830 | |
Deferred revenue, net of current portion | 200 | | | 640 | |
Long-term lease obligations - Operating leases | 10,191 | | | 12,243 | |
Long-term debt | 28,365 | | | — | |
Other long-term liabilities | 1,264 | | | 1,233 | |
Total liabilities | 70,559 | | | 49,946 | |
| | | |
Stockholders' equity: | | | |
Common stock | 7 | | | 7 | |
Additional paid-in capital | 593,253 | | | 584,138 | |
Accumulated other comprehensive income | (23) | | | — | |
Accumulated deficit | (531,790) | | | (497,530) | |
Total stockholders' equity | 61,447 | | | 86,615 | |
Total liabilities and stockholders' equity | $ | 132,006 | | | $ | 136,561 | |
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Codexis (NASDAQ:CDXS)
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