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Aptose Biosciences Inc

Aptose Biosciences Inc (APTO)

0.703
-0.007
(-0.99%)
At close: July 15 4:00PM
0.729
0.026
( 3.70% )
After Hours: 5:47PM

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Key stats and details

Current Price
0.729
Bid
0.72
Ask
0.7289
Volume
79,570
0.671 Day's Range 0.72
0.67 52 Week Range 5.10
Market Cap
Previous Close
0.71
Open
0.72
Last Trade Time
17:46:37
Financial Volume
$ 55,530
VWAP
0.697877
Average Volume (3m)
59,225
Shares Outstanding
20,164,393
Dividend Yield
-
PE Ratio
-0.28
Earnings Per Share (EPS)
-2.54
Revenue
-
Net Profit
-51.21M

About Aptose Biosciences Inc

Aptose Biosciences Inc is a clinical-stage biotechnology company committed to discovering and developing personalized therapies addressing unmet medical needs in oncology. The company has two clinical-stage programs and a second program that is discovery-stage and partnered with another company. Lux... Aptose Biosciences Inc is a clinical-stage biotechnology company committed to discovering and developing personalized therapies addressing unmet medical needs in oncology. The company has two clinical-stage programs and a second program that is discovery-stage and partnered with another company. Luxeptinib, its panFMS-like tyrosine kinase 3 / pan-Bruton's tyrosine kinase inhibitor, is enrolling patients in a Phase 1, multicenter, open label, dose-escalation study with expansions to assess the safety, tolerability, PK, and preliminary efficacy of CG-806 in patients with chronic lymphocytic leukemia (CLL/SLL) or non-Hodgkin lymphomas (NHL). HM43239 is an oral potent myeloid kinome inhibitor, targeting a constellation of kinases operative in myeloid malignancies. Show more

Sector
Pharmaceutical Preparations
Industry
Pharmaceutical Preparations
Website
Headquarters
Mississauga, Ontario, Can
Founded
1970
Aptose Biosciences Inc is listed in the Pharmaceutical Preparations sector of the NASDAQ with ticker APTO. The last closing price for Aptose Biosciences was $0.71. Over the last year, Aptose Biosciences shares have traded in a share price range of $ 0.67 to $ 5.10.

Aptose Biosciences currently has 20,164,393 shares outstanding. The market capitalization of Aptose Biosciences is $14.32 million. Aptose Biosciences has a price to earnings ratio (PE ratio) of -0.28.

APTO Latest News

PeriodChangeChange %OpenHighLowAvg. Daily VolVWAP
1-0.0647-8.151694594940.79370.79370.67527690.71913955CS
4-0.1769-19.52754167130.90590.9260.67469090.76300004CS
12-0.501-40.73170731711.231.2780.67592251.00208686CS
26-1.531-67.74336283192.262.41980.67778431.51236559CS
52-3.751-83.72767857144.485.10.67626662.08962942CS
156-44.121-98.374581939844.8546.8750.6735254322.47279513CS
260-41.571-98.276595744742.3138.78750.6776684364.82696879CS

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APTO Discussion

View Posts
Monksdream Monksdream 3 weeks ago
APTO new 52 week low
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Zeppo Zeppo 3 weeks ago
True to form, no revenue projections for the foreseeable future has relegated APTO to a pre-reverse split value of $.05.
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gp22 gp22 3 weeks ago
PDYN : PallaDyne AI Corp: ,,,AI software for robotics...NVDA CEO discusses AI Robotics. PDYN

Low float , cash rich PDYN about to get found by AI crowd.

Huge ripper at anytime as they have been doing to many other quality unknown AI stocks

Link
https://stkt.co/AsMtZMIs
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Monksdream Monksdream 2 months ago
APTO new 52 week low
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dcaf7 dcaf7 2 months ago
Abstracts for EHA presentations are available. Title of one of two Tuspetinib abstracts is "SAFETY AND EFFICACY OF TUSPETINIB AS MONOTHERAPY ANDCOMBINED WITH VENETOCLAX IN A PHASE 1/2 TRIAL OF PATIENTS WITHRELAPSED OR REFRACTORY (R/R) ACUTE MYELOID LEUKEMIA (AML)". From the abstract: Objective responses were observed (overall CRc=16.9%) in pts receiving 80 mg TUS/400 mg VEN: FLT3-WT(n=49, CRc:14.3%), FLT3-MUT (n=15, CRc: 26.7%) including pts with prior FLT3i treatment (n=12, CRc=33.3%),prior VEN treated (n=48, CRc=16.7%), VEN-naรฏve (n=17, CRc= 17.6%), RAS-mutated (n=11, CRc=9.1%), andTP53 mutated (n=17, CRc=17.6%) pts. No objective responses were observed at 40mg TUS with VEN,indicating a dose-related response.
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dcaf7 dcaf7 3 months ago
A new corporate presentation has been issued. It has updated clinical data with Tus/Ven doublet obtained in 60 evaluable patients. Previous analysis presented at ASH was done in 36 patients. Interesting, they show only waterfall plot on slide 16, no tables with all nuances. I manually counted all CRc there and ended up with number 11. So, it gives a CRc rate of 11/60, or 18%. In ASH presentation it was 9/36, or 25%. I think 18% is too low for evaluable population. Looks like Tus is not so powerful drug to be used as a single agent or in combination with Ven in R/R patients. Therefore, Aptose has no other choice but to run a triplet trial hoping for more favorable results.
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kojak007 kojak007 3 months ago
Hi tartia. I sent you a message on the tcon board: Hi Tartia,
I have no idea how this is possible. I guess its dead now. What do you think?
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dcaf7 dcaf7 4 months ago
20% probability of success
Published 03/27/2024, 05:28 PM
On Wednesday, Jones Trading adjusted its outlook on Aptose Biosciences (NASDAQ:APTO), lowering the price target to $5 from the previous $12, while maintaining a Buy rating on the company's stock. The adjustment comes as Aptose Biosciences shifts its development focus towards a new drug combination for treating Acute Myeloid Leukemia (AML).

The firm highlighted that Aptose's immediate strategy will concentrate on a triplet combination therapy involving tuspetinib, venetoclax, and HMA for first-line AML treatment. A pilot study for this combination is slated to begin in the summer, with initial findings expected to be presented at the American Society of Hematology (ASH) conference.

Meanwhile, the development for relapsed/refractory AML has been paused to improve strategic positioning, with data to be shared at the European Hematology Association (EHA) 2024 conference.

Jones Trading noted that if Aptose demonstrates clear clinical benefits in the first-line setting, it may lead to enhanced business development opportunities as compared to the relapsed/refractory AML setting. Still, the firm also pointed out that a capital overhang is a significant pressure point for both the stock and its clinical development progress.

The company's current cash position stands at $18.6 million, which is expected to fund operations through August 2024. Jones Trading has updated its financial model to reflect the new strategic direction towards first-line AML treatment, estimating unadjusted peak sales of approximately $250 million, assuming a 20% probability of success and a 40% market penetration among patients unfit for intensive chemotherapy.

In light of these developments and other minor changes across the model, Jones Trading reiterated its Buy rating but reduced the price target for Aptose Biosciences to $5. The firm believes that despite the lowered target, the company's stock remains a positive investment opportunity.
https://www.investing.com/news/company-news/aptose-biosciences-target-cut-maintains-buy-rating-on-new-drug-development-93CH-3355850
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Zeppo Zeppo 4 months ago
Asking ourselves the obvious question, is APTO any closer to commercialization of product? My answer is NO, and I imagine yet another reverse split will be on the horizon in a year. Dilutions will take the stock below $1.00 again without any announcements of a stand-alone Phase 3 test anywhere......IMHO.
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dcaf7 dcaf7 4 months ago
Not sure that increase in plasma concentration from 1 uM to 2-3 uM will help much. They don't report responses in 11 new AML patients they studied. Most disappointing is that they stopped developing Tus/Ven doublet as potentially registrational combination. They have good data with Flt3mut patients and now instead of working in this direction, they offer you to focus on triple combination project for which they don't have any preliminary data. A lousy strategy and Rice is a lousy leader.
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Tartiaboy Tartiaboy 4 months ago
I was very happy to see that Lux is still alive. I don't think Aptose has the resources to develop it at this time. It's a shame. They really squandered this opportunity. In any event it is news that will keep my interest in Aptose alive. I haven't listened to the cc yet. They still have a huge $ problem and I think Hanmi is calling the shots.
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dcaf7 dcaf7 4 months ago
Here is what Bejar said at ASH in December, โ€œBrisk patient enrollment in our APTIVATE trial has led to a fast-growing database that includes many more patients at various stages of treatment. We look forward to reporting our next set of data in the first quarter of 2024.โ€ I think, it should happen at earing call. Last chance to impress investors?
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Monksdream Monksdream 4 months ago
APTO under $2
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Zardiw Zardiw 4 months ago
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Tartiaboy Tartiaboy 4 months ago
I still hold a speculative position in TCON. I am expecting binary news before EOM. Out of 46 pts. they had 4 responses by BICR and 7 by Investigator review. It is right on the edge of meeting the target. If met I see $1+ immediately, it not perhaps 10 cents immediately. If you want to discuss, let's do so on the Ihub TCON board.

I am watching a painful demise here for APTO.
👍️ 1
kojak007 kojak007 4 months ago
Hi Tartia,
Are you still in TCON? I was thinking maybe they can actually indeed reach the 11.25% by BICR. Since beginning of 2023 thy are dosing with the double dose at 600. More data from that group could actually turn the needle. What do you think?
Greetings
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Monksdream Monksdream 4 months ago
APTO new 52 week lo
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Tartiaboy Tartiaboy 4 months ago
Unfortunately, I believe we have already seen a Hanmi takeover. They are just interested in TUS.
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spiderman3600 spiderman3600 4 months ago
I think our only hope is a Hamni takeover.
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Zeppo Zeppo 4 months ago
This is what happens after reverse splits when there is no perceived improvement to the business plan........let alone revenues
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Monksdream Monksdream 4 months ago
APTO new 52 week low
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Tartiaboy Tartiaboy 5 months ago
I have been rotating from APTO primarily into VINC over the past month. Also holding VSTM and ONCT.
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dcaf7 dcaf7 5 months ago
Some thoughts on Rice.
Rice has an interesting career. โ€œHe served as Head of the Laboratory of Antiviral Drug Mechanisms and Manager of the HIV Clinical Interface Laboratory for the National Cancer Institute (NCI), National Institutes of Health from 1992 to 1998. In this position, Dr. Rice directed the activities of several projects targeting new ways to treat HIV and other infectious diseases. From 1989 to 1992, he was professor of Pediatric Hematology and Oncology at Emory University School of Medicine, where he built a program to identify new molecular structures as antiviral targetsโ€. So, he was in hematology/oncology, but it was not related to oncology. Then, from Aug 1998 to Aug 2003 he worked as a CEO of Achillion Pharmaceuticals, an anti-infective pharmaceutical company. Under his leadership no drug was approved. From 2003 to 2013 he served as a CEO of Cylene Pharmaceuticals. The company was working on oral CK2 protein kinase inhibitor, CX-4945, in patients with advanced solid tumors, or multiple myeloma. This drug is still in clinical trials, not even close to FDA approval. Their second drug was Quarfloxin, a selective binder for MYC GQ structure. Is it related to APTO-253? Anyway, later quarfloxin was discarded due to its poor bioavailability. Isnโ€™t it a familiar theme? And from 2013 to the present, Rice has been a CEO of Lorus/Aptose Biosciences. The result of his work as a leader of Aptose is two failed drugs, APTO-253 and Luxeptinib. Point is that during his very long career in biotech industry as a CEO, Rice was not able to bring any drug to the market. I hope Tuspetinib is his last chance.
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dcaf7 dcaf7 5 months ago
Would you like to share your greener pastures?
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Tartiaboy Tartiaboy 5 months ago
Hello All. I have not posted here in a while but have continued to follow the discussions. As always, thank you Decaf for the information you share.

After serious deliberation I decided it was time to begin liquidating my APTO shares. I have been selling for the past month. There is no ONE reason. It is a cumulation of factors. I feel that Rice has lost his credibility and APTO will struggle for the foreseeable future. I will continue to monitor and may buy back shares at a later date.
On to greener pasteurs.
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spiderman3600 spiderman3600 5 months ago
Thanks decaf. Sounds like a good backup plan.
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dcaf7 dcaf7 5 months ago
In recently posted Hanmi 2024 1Q IR presentation, you can see Tuspetinib data on slide 18. Nothing new there but you have an impression that it is their own data. If Aptose needs a partner to start triplet in 1st line patients, Hanmi would be the best candidate.
https://www.hanmipharm.com/file/admin/ir/1707107587558.pdf
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Wolverine3 Wolverine3 5 months ago
I agree and yes I still own shares (unfortunately).
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spiderman3600 spiderman3600 5 months ago
Hamni seems to have confidence in the drug. They canโ€™t do any worse. Do you still own any shares? tia
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Wolverine3 Wolverine3 5 months ago
No, it is not a solid backup plan. This company is a disaster, totally mismanged rersources and did not execute on the drugs they have or had.
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spiderman3600 spiderman3600 5 months ago
Thanks decaf. Sounds like a solid backup plan. Hanmi definitely has the resources to finish the job.
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dcaf7 dcaf7 5 months ago
It looks like Aptose can replace their curent employees with Koreans and Hanmi will pay them salary, bonuses etc. Is it a kind of takeover? Let's start from Rice.
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dcaf7 dcaf7 5 months ago
From latest 8-K. Very interesting. What is a Hanmi's purpose?
"Hanmi will have the right to designate for employment one or more individuals that are legally able to work in the United States or Canada (each, an โ€œHanmi Nomineeโ€) to a position or positions within Aptose in applicable areas based on each Hanmi Nomineeโ€™s skills, education and experience. The parties agreed that the Hanmi Nominee shall be subject to Aptoseโ€™s usual employment rules, practices, policies, evaluation procedures, as amended from time to time and Aptose shall retain the right, in its sole discretion, to terminate such Hanmi Nomineeโ€™s appointment with Aptose for violations of Aptoseโ€™s employment rules, practices, policies and procedures. The parties also agreed that the Hanmi Nominee shall be entitled to salary, bonus, vacation, incentive payments and bonuses, expenses, allowances and any applicable benefits in amounts and to the extent consistent with employees of Aptose serving or having recently served in a similar capacity with Aptose with such amounts to be reimbursed to Aptose by Hanmi. In the event that a visa or other permit is required to be obtained to permit the Hanmi Nominee to work in the United States or Canada the parties agreed that Aptose would use its commercially reasonable efforts to assist the Hanmi Nominee with obtaining such visa or permit. The parties agreed that upon the nomination of the Hanmi Nominee that the parties would enter into a separate service agreement to outline the specific terms and conditions of the Hanmi Nomineeโ€™s appointment".
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Zeppo Zeppo 6 months ago
Is anyone surprised? The company has a perpetual green light to nowhere.
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Monksdream Monksdream 6 months ago
APTO new 52 week low
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Wolverine3 Wolverine3 6 months ago
What a piece of crap company. Total loss!
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dcaf7 dcaf7 6 months ago
On page 7 under Key findings: "We are seeking a collaboration partner to study TUS as part of a TUS/VEN/HMA triplet in 1L newly diagnosed AML patients unfit for chemotherapy with or without FLT3 mutations".
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spiderman3600 spiderman3600 6 months ago
How about a salary cut!?!?
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dcaf7 dcaf7 6 months ago
"We expect to revise our current development as follows. Assuming the net proceeds from this offering and our existing cash, cash equivalents and short-term investments, a net proceeds from the concurrent private placement offering, a committed equity facility, and ATM we plan to, (i) complete our ongoing APTIVATE clinical trial studying TUS and TUS/VEN, (ii) pause enrollment in the LUX G3 study and (iii) evaluate other costs reductions in general and administrative expenses."
Not a word about registrational trial?
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Wolverine3 Wolverine3 6 months ago
Thanks
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dcaf7 dcaf7 6 months ago
A short video with Akriti Jain, MD, describing Tuspetinib data. She is particularly excited about effect of Tusp in Flt3mut patients.
https://www.healio.com/news/hematology-oncology/20240118/video-promising-monotherapy-treatment-for-challenging-to-treat-aml
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dcaf7 dcaf7 7 months ago
From 3rdQ earning call, "Extension into HR-MDS and CMML planned: 4Q2023". Will they announce it today or tomorrow?
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dcaf7 dcaf7 7 months ago
December corporate presentation posted. Most important info is on slide 26, "$10M financing combined with the $4M 2nd tranche from Hanmi extends cash runway to the end of Q3/2024 and delivers data from TUS/VEN Doublet in AML by 2Q/2024". This slide shows that they are still planning to initiate an MDS trial in 2023. Good luck. They have three days left to accomplish it. And of course, a delay. Now TUS/VEN/HMA triplet pilot arm for 1L AML will start in 2ndQ24. In ESH presentation, it was end of 2023. Slide 5 shows CR rate for patients with prior-VEN failures demonstrated in other studies. In one study, it was 15%, almost same as for TUS/VEN combination in Flt3 WT patients. It is important, since they need to establish and negotiate with FDA a certain CR rate to beat in pivotal study.
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dcaf7 dcaf7 7 months ago
I don't know. My guess is G3 formulation is not good enough. Otherwise they would deliver good news.
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Wolverine3 Wolverine3 7 months ago
I know LUX is dead, but do you know the reasoning? Is there a clinical hold or just just lack of efficacy?
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dcaf7 dcaf7 7 months ago
Lux AML study is not recruiting.
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dcaf7 dcaf7 7 months ago
Possibly, but the answer is nobody knows. Discussing a possibility of a single arm Tus/Ven study at ESH, Rice said that we need to search contemporary publications to establish what a control arm looks like. Merry Christmas to you too!
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nferna nferna 7 months ago
What about this S1, is that not ugly?

Expected to be ugly of course, but goes to show that all other avenues were a no go
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Wolverine3 Wolverine3 7 months ago
I will take it, thanks
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spiderman3600 spiderman3600 7 months ago
Thanks decaf! In your opinion, are these results better then anything else thatโ€™s available? tia. Merry Christmas!
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