SkyePharma PLC ("the Company")
Notification of Major Interest in Shares
In accordance with the Companies Act 1985 (as amended) the Company was informed
on 27 December 2006 that Lehman Brothers International (Europe) ("Lehman") had
decreased their holding by 27,615,141 since their last filing on 18 December
2006. Lehman's revised holding amounts to 48,699,054 Ordinary Shares of 10p
each, representing 6.46% of the issued share capital of the Company.
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