also today:
the mice & neural stem cells story (California)
Cells' Capability In Mouse Brain Tissue Repair Revealed By UCSF Stem Cell Study
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In collaboration with other UCSF neuroscientists, as well as neurosurgeons, Kuo is currently exploring whether neural stem cells of the SVZ can respond to damage outside the ventricle region and, if so, whether inflammation in the traumatized area prevents the stem cells from restoring the tissue.
And he wonders whether the epilepsy that can occur in stroke and trauma patients, often years after the injury, results from unsuccessful attempts by the progeny of neural stem cells to make synaptic connections with other cells in the damaged region.
Numerous other UCSF labs are also investigating neural stem cells in the SVZ of the embryonic and postnatal brain, with an eye toward developing therapies for Parkinson’s, epilepsy and ALS, says Arnold Kriegstein, MD, PhD, the John G. Bowes Endowed Chair in Stem Cell and Tissue Biology and director of the UCSF Institute for Regeneration Medicine.
And like the neural stem cells they study, these scientists are collaborating, making connections aimed at building new material. "As such," says Kriegstein, "their work demonstrates the power of synergy."
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