dont all be so negative 2005 will be prm year deals in the bio area are on the cards as more and more will join or be taken over to develop r&d spending and to save money.i feel that it want be long before prm and oxb will be taken out by larger companies.so with grow in the shares and it could produce a monster drug and plus a possible bid comming makes them one hairy stock ,but a stock worth holding on too.in 3 to five years i can see only two stocks left astra zen, glaxo,and about 3 bio left.prm will either be one of the winners or my feelings taken out(£1.00) or higher.