However, it is also true that PSA screening has revolutionized the diagnosis of PC. The disease is being identified and treated at a much earlier stage than was possible before the PSA era. The PSA test offers the only approach to early diagnosis in general and routine use today. PSA screening is gaining popularity worldwide and is well established in the practices of urologists, internists and general practitioners. The problems and uncertainties are clearly not compelling enough to discourage this widespread use.