ACAMBIS for BULLS & BEARS

Goldman Sachs increased holding

"On 19 October 2005, Acambis received notification that, as of the close of
business on 17 October 2005, following a purchase of shares, The Goldman Sachs
Group, Inc., ("GS Inc") of 85 Broad Street, New York, NY 10004, USA, was
interested in a total of 4,312,161 ordinary shares of 10p each, representing a
4.02% holding of Acambis' issued share capital."


Previous RNS

"01 September 2005

On 31 August 2005, Acambis received notification that, as of the close of
business on 25 August 2005, following a purchase of shares, The Goldman Sachs
Group, Inc., ("GS Inc") of 85 Broad Street, New York, NY 10004, USA, was
interested in a total of 3,248,396 ordinary shares of 10p each, representing a
3.03% holding of Acambis' issued share capital."