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1 month ago
Allurion Presents Data on the Allurion Balloon and AI-Powered Virtual Care Suite with and without GLP-1s to Optimize Muscle Mass and Increase Weight Loss
Four abstracts presented at the European Congress on Obesity
Data indicate potential synergies of Allurionβs swallowable ProcedurelessTM intragastric balloon (the βAllurion Balloonβ) and Virtual Care Suite (VCS) (together, the βAllurion Programβ) with normal dosing of GLP-1s, building upon previous data on the combination of the Allurion Program with low-dose GLP-1s
GLP-1s used in combination with the VCS lead to an average of 6.1% increase in lean body mass, indicating that maintaining muscle may be possible even at normal doses for GLP-1s with Allurionβs AI-powered behavioral support
Allurion Balloon in combination with GLP-1s leads to an average of 21.2% reduction in body weight, potentially representing an option for patients with severe obesity seeking an alternative to bariatric surgery
2,000 patients using the Allurion Program without GLP-1s showed an average of 12.4% reduction in body weight with a 9.8% increase in muscle mass, underscoring the safety and effectiveness of the Allurion Balloon as a standalone therapy
NATICK, Mass.--(BUSINESS WIRE)-- Allurion Technologies, Inc. (βAllurionβ or the βCompanyβ) (NYSE: ALUR), a pioneer in metabolically healthy weight loss, today announced the presentation of four abstracts at the European Congress on Obesity (ECO) taking place in Malaga, Spain, May 11-14, 2025. These studies highlight the transformative impact of the Allurion Balloon and the Virtual Care Suite (VCS)βthe AI-powered digital platform that includes Coach Irisβon weight loss outcomes and lean body mass preservation.
In one study of 138 patients prescribed GLP-1s with normal dose escalation who used the VCS, patients increased lean body mass by an average of 6.1%, increased muscle mass by an average of 6.4%, and decreased fat mass by an average of 10.2% after four months of using the VCS, indicating that Allurionβs AI-driven behavioral support may help patients maintain muscle, even at normal or high doses of GLP-1 therapy.
In another study of 60 patients who were treated with the Allurion Balloon and then semaglutide, patients achieved an average of 21.2% reduction in total body weight and improvements in metabolic parameters over a 10-month period. This combination therapy approach led to outcomes similar to those achieved with bariatric surgery.1
βThe combination of the Allurion Program and semaglutide represents a significant advancement in weight loss,β said Dr. Roberta Ienca, physician at Nuova Villa Claudia Clinic, Rome, Italy, who oversaw this study. βWhile using low doses of semaglutide in combination with the Allurion Program may be preferable in most patients, there is a role for using normal dosing and escalation schedules as well, especially in patients with severe obesity seeking an alternative to bariatric surgery. This innovative approach may also address the challenges of weight regain often seen with the use of GLP-1 medications alone, potentially providing a more sustainable path to achieving and maintaining a healthier weight.β
Two other studies pertaining to the Allurion Program were also presented at ECO.
In one study, 43 patients prescribed GLP-1s who used the VCS achieved an average of 17.3% reduction in total body weight at nine months. Improved weight loss outcomes were observed in this study compared to the weight loss observed in US studies where the VCS was not used. Such other studies reported an average of 15.2% total body weight loss for patients prescribed tirzepatide and an average of 7.9% total body weight loss for patients prescribed semaglutide, each at 12 months2. These outcomes suggest that AI-driven interventions can play a crucial role in augmenting traditional treatment methods.
In another study, which was a large single-center experience of 2000 patients treated between 2017 and 2024 with the Allurion Program, patients achieved an average weight reduction of 12.4% after four months with an average of 9.8% increase in muscle mass after six months. These results demonstrate a potentially safe, effective, and scalable program for obesity clinics.
Details of the Presentations are as follows:
Title: Optimizing Body Composition and Lean Mass Preservation: The Value of AI-Powered Digital Platforms and Health Coaches for Patients on GLP-1 Medications
Presenter: Bill Nadeau, RD, Vice President, Medical Affairs, Allurion
Title: The New Era of Combination Weight Loss Treatments: The Swallowable Gastric Balloon Program and the Anti-Obesity Medication Semaglutide
Title: Enhancing Weight Loss Outcomes with GLP-1 Medications: The Role of AI-Powered Digital Platforms and Health Coaches
Presenter: Bill Nadeau, RD, Vice President, Medical Affairs, Allurion
Presenter: Roberta Ienca, MD, Weight Management Center, Nuova Villa Claudia Clinic, Rome, Italy
Title: Exceptional Outcomes and Safety Profile in the First 2,000 Patients Treated with the Allurion Balloon Program at a Single Spanish Bariatric Center
Presenter: Adelardo Caballero, MD, Instituto de Obesidad, Madrid, Spain
About Allurion
Allurion is a pioneer in metabolically healthy weight loss. The Allurion Program is a weight-loss platform that combines the Allurion Gastric Balloon, the worldβs first and only swallowable, ProcedurelessTM gastric balloon for weight loss, the Allurion Virtual Care Suite, including the Allurion Mobile App for consumers and Allurion Insights for healthcare providers featuring the Iris AI Platform, and the Allurion Connected Scale. The Allurion Virtual Care Suite is also available to providers separately from the Allurion Program to help customize, monitor, and manage weight-loss therapy for patients regardless of their treatment plan. The Allurion Gastric Balloon is an investigational device in the United States.
For more information about Allurion and the Allurion Virtual Care Suite, please visit www.allurion.com.
Forward-Looking Statements
This press release contains certain forward-looking statements within the meaning of the U.S. federal and state securities laws. These forward-looking statements generally are identified by the words βbelieve,β βproject,β βexpect,β βanticipate,β βestimate,β βintend,β βstrategy,β βfuture,β βopportunity,β βplan,β βtarget,β βmay,β βshould,β βwill,β βwould,β βwill be,β βwill continue,β βwill likely result,β and similar expressions and include statements regarding the expected benefit of a combination approach of the Allurion Program and GLP-1 use for weight loss management, market acceptance of such new combined therapies, the uniqueness of Allurionβs product and service offerings and other statements about future events that reflect the current beliefs and assumptions of Allurionβs manage
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3 months ago
Allurion Announces Initial Results on the Combination of the Allurion Program With Low-dose GLP-1 Therapy to Optimize Muscle Mass and GLP-1 Adherence
Average Total Weight Loss of 20% With 15% Increase in Lean Body Mass After 8 Months of Combined Therapy
NATICK, Mass.--(BUSINESS WIRE)-- Allurion Technologies, Inc. (βAllurionβ or the βCompanyβ) (NYSE: ALUR), a company dedicated to ending obesity, today announced initial results on the combination of the Allurion Program with low-dose GLP-1 therapy to optimize muscle mass and GLP-1 adherence.
52 patients treated with the Allurion Balloon were started on 0.25mg semaglutide after completing their first month of balloon therapy. The dose of semaglutide was increased to no greater than 1.0mg over the subsequent 6 months. After 8 months of this combination approach, average total body weight loss was 20.3%, and lean body mass increased by 15% from 59.6% to 68.5%. All patients remained adherent to the GLP-1 medication through 8 months.
βI believe combining the Allurion Balloon with low-dose GLP-1 therapy has several advantages,β said Dr. Luigi Flagiello, bariatric surgeon at Clinica Ruesch who oversaw this case series. βThese results indicate that a combination approach increases weight loss and that by using lower doses of GLP-1s, patients do not experience as many side effectsβincluding muscle wastingβand have improved adherence. Patients may also be benefiting from two distinct physiological impacts: satiety induction from the balloon and reduced hunger from the GLP-1.β
Previous studies in patients undergoing GLP-1 therapy have demonstrated reductions in lean mass of approximately 40% as a proportion of total weight lost1 and have also shown that 30% of patients discontinue GLP-1 therapy within the first month and 58% discontinue before reaching a clinically meaningful health benefit2, due in part to side effects, dose escalation required for continued weight loss, and cost. Semaglutide dosing is typically increased to 2.4mg, over two times higher than the maximum dose of 1.0mg used in the combination approach.
βMuscle wasting and lack of adherence are significant challenges for GLP-1s, and this initial data suggests that a combination approach that leverages Allurionβs full programβwhich includes the balloon, our Virtual Care Suite, and our behavior change programβmay be a compelling solution,β said Dr. Shantanu Gaur, Founder and CEO of Allurion. βWe plan on building upon this promising initial data and are optimistic that this could become a new standard of care for patients who want metabolically healthy weight loss.β
Additional data on the combination approach is being collected as part of this case series and is expected to be presented at upcoming medical meetings.
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5 months ago
Allurion Announces Plans To Optimize Muscle Mass During GLP-1 Therapy In Combination With the Allurion Program
NATICK, Mass.--(BUSINESS WIRE)-- Allurion Technologies, Inc. (βAllurionβ or the βCompanyβ) (NYSE: ALUR), a company dedicated to ending obesity, today announced its intention to initiate a clinical study on the combination of the Allurion Program with GLP-1 agonists to improve muscle mass and overall body composition.
Previous studies in patients undergoing GLP-1 therapy have demonstrated reductions in lean mass of approximately 40% as a proportion of total weight lost.1 In contrast, in previous studies, patients treated with the Allurion Balloon in combination with the Allurion Virtual Care Suite have demonstrated strong patient outcomes in which patients lose weight while maintaining, and in some cases, increasing, muscle mass. In one study of 571 patients, patients treated with the Allurion Balloon gained 5.6% in lean body mass while losing 14% of their total body weight over four months.2 In another study of 167 patients, patients treated with the Allurion Balloon experienced a weight reduction of 15.7% with no change in muscle mass.
βReductions in lean mass and muscle wasting are significant unmet needs in the GLP-1 space, and our early data suggests that we may have a powerful tool in achieving more metabolically healthy weight loss,β said Dr. Shantanu Gaur, Founder and CEO of Allurion. βThe goal of our study would be to prove that, by combining the Allurion Balloon and Allurion Virtual Care Suite with GLP-1 therapy, patients can lose significant weight while increasing muscle mass and improving overall body composition. We are optimistic that this would be a significant addition to the possibilities of GLP-1 therapies and, if proven, could become the gold standard for obesity care.β
About Allurion
Allurion is dedicated to ending obesity. The Allurion Program is a weight-loss platform that combines the Allurion Gastric Balloon, the worldβs first and only swallowable, procedure-lessTM gastric balloon for weight loss, the Allurion Virtual Care Suite, including the Allurion Mobile App for consumers and Allurion Insights for healthcare providers featuring the Iris AI Platform, and the Allurion Connected Scale. The Allurion Virtual Care Suite is also available to providers separately from the Allurion Program to help customize, monitor, and manage weight-loss therapy for patients regardless of their treatment plan. The Allurion Gastric Balloon is an investigational device in the United States.
For more information about Allurion and the Allurion Virtual Care Suite, please visit www.allurion.com.
Forward-Looking Statements