Wal-Mart Stores Inc. said Tuesday the co-founders of its Chinese e-commerce venture have announced their departures, thrusting a central part of the retailer's China strategy into transition.

Yihaodian Chairman Yu Gang and Chief Executive Liu Junling, both veterans of Dell who launched the company in 2008, are leaving to pursue their next venture, Wal-Mart spokesman Dan Toporek said in a statement. Wal-Mart, which holds a 51% stake in the company, said it will look for new leaders for the business.

"We are pleased with the success Yihaodian has had in China, and will work to accelerate that growth," Mr. Toporek said.

The founders' departure may open a door for Wal-Mart to play a larger role in Yihaodian's day-to-day operations, which it has long aimed to do. Wal-Mart has for years tried to connect the two companies' logistics so that they could work in sync. But there have been integration challenges, with resistance within Yihaodian, according to a person familiar with the two companies' partnership. Over the years it has also pushed to increase its stake in the business, according to people familiar with the matter, but hasn't had success thus far. Wal-Mart declined to comment.

Wal-Mart is trying to improve its Chinese operations in part by shifting its focus from expanding its brick-and-mortar presence to China's online shopping boom. At a news conference in Beijing in April, Chief Executive Doug McMillon emphasized the importance of China to the retailer which derives more than a quarter of its earnings outside of the U.S., but said he would rather see the company move slowly than make mistakes growing fast.

Its store operations in China have been stumbling. Traffic in its more than 400 Chinese stores has fallen over the past three years and was down 8.9% in the most recent quarter though sales rose slightly. Even at the slower pace, the company plans to open 115 new stores across China by 2017.

Shifting gears, Wal-Mart is now working to link Yihaodian with its 400 stores to allow shoppers to order products on their mobile devices and pick them up in its stores or have them delivered to their homes.

Wal-Mart was one of the first retailers to set up online in China, acquiring a majority stake in Yihaodian in 2012. However, Yihaodian is still tiny compared with e-commerce giant Alibaba Group Holding Ltd. and second-largest player JD.com.

Yihaodian's niche has been strong grocery sales, but competition in the groceries has heated up in the past year, as local Chinese retailers have gone online and many startups have entered the field to sell everything from imported avocados to dishwashing detergent.

Yihaodian, which means No. 1 Store, has begun expanding from groceries to offer a wider array of products including consumer products, appliances and apparel. It is one of the largest sellers of shelf-stable milk in China, benefiting from the perceived safety of U.S. food in the region. The site focuses on a "value conscious female," who lives in large cities, Neil Ashe, Wal-Mart's head of e-commerce, said in a June investor presentation.

Write to Sarah Nassauer at sarah.nassauer@wsj.com and Laurie Burkitt at laurie.burkitt@wsj.com

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