Ion Mobility Spectrometry and REIMS
Direct-from-sample Ionization Deliver Greater Clarity, Confidence
and Speed to Routine LC-MS and MS Analyses
Waters Corporation (NYSE:WAT) at the 63rd conference of the
Society of Mass Spectrometry announced the introduction of new
technologies and innovations for mass spectrometry, intended to
give laboratories greater levels of detail for every analysis.
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Waters New Vion IMS QTof Mass
Spectrometer (Photo: Business Wire)
The introductions include the new Waters® Vion IMS QTof Mass
Spectrometer, a new bench-top tandem mass spectrometer featuring
ion mobility and REIMS Research System with iKnife Sampling,
combining direct-from-sample ionization with high-performance
time-of-flight (ToF) mass spectrometry.
Waters also expanded its family of solid phase extraction
products with the first-of-its-kind Oasis PRiME HLB and added to
its portfolio of protein separation columns with the ACQUITY UPLC®
Glycoprotein BEH Amide Column for glycan analysis.
Vion IMS QTof Mass SpectrometerCombining the benefits of
high-resolution tandem mass spectrometry and ion mobility
separation in a bench top instrument, the Waters® Vion IMS QTof
Mass Spectrometer brings clarity and confidence to routine
analyses. Ion mobility removes spectral interferences and generates
collision cross-section (CCS) values for every ion, giving
scientists more information than they can get from traditional
LC-MS experiments. Waters intends to commence shipments of the Vion
IMS QTof Mass Spectrometer in the second half of this year.
“More than a decade of experience in ion mobility has gone into
the design of our Vion IMS QTof instrument. For scientists involved
in sample screening, metabolite identification, or classical ‘omics
experiments, their ability to detect and identify all sample
analytes in single analysis at the bench has reached a new level,”
said Gary Harland, Director, Mass Spectrometry Product Management,
Waters Division. “Regardless of how many analytes there are in a
sample, and regardless of the concentrations which they are present
in, Vion IMS QTof empowers laboratories to respond better to
analytical challenges and succeed in meeting their scientific and
business objectives.”
As routine analyses involve increasingly complex samples,
scientists often rely on high-resolution mass spectrometry.
However, increasing mass resolution alone does not always lead to
better answers. By separating ions from one another based on their
shape, mass and charge, ion mobility provides an additional
dimension of separation. The selectivity of ion mobility refines
spectra and allows the instrument to discriminate sample ions from
chromatographically co-eluting compounds and background
interferences - bringing clarity to every spectrum, and enabling
the confident characterization of compounds.
UNIFI Scientific Information System SoftwareThe UNIFI®
Scientific Information System, Version 1.8, is a new release of the
software with features intended to enhance laboratory productivity.
Today's announcement coincides with the introduction of the Vion™
IMS QTof Mass Spectrometer which is the first Waters mass
spectrometer to be fully supported on UNIFI.
New features of this release of UNIFI software include: Support
of the Vion IMS QTof MS System; native atmospheric pressure gas
chromatography (APGC) control, time-of-flight (Tof) multiple
reaction monitoring (MRM) support, support of collision cross
section (CCS) data, and Tof quantitative and qualitative workflows
providing a comprehensive, single software solution.
REIMS Research System with iKnife SamplingCombining
direct-from-sample ionization with high performance time-of-flight
mass spectrometry and powerful, intuitive analytics, the Rapid
Evaporative Ionization Mass Spectrometry™ (REIMS™) Research System
with iKnife™ Sampling System eliminates the need for sample
preparation and chromatographic separation, providing food,
microbiology and tissue researchers with near-instantaneous data
acquisition.
Using Waters REIMS Research System with iKnife Sampling,
researchers can quickly and easily differentiate samples from one
another and confidently identify the differentiating features,
allowing greater insight into the chemical and biological systems
under investigation. In REIMS, direct, rapid heating of the samples
leads to the formation of vapor that is rich in sample-specific
chemical information. The vapor is taken directly into the mass
spectrometer (Xevo® G2-XS QTof or SYNAPT® G2-Si HDMS) where the
molecules are analyzed by time-of-flight mass spectrometry.
“The new system will deliver REIMS technology into the hands of
many more scientists working in important areas such as research
into food fraud and adulteration, where we anticipate its impact
could be game-changing”, said Brian Smith, Vice President of Mass
Spectrometry Operations at Waters.
Oasis PRiME HLBThe Oasis® PRiME HLB, a first-of-its-kind,
next-generation solid phase extraction (SPE) product that provides
cleaner samples in less time and with less effort for LC and LC-MS
analyses. Oasis PRiME HLB cartridges and multiwell plates simplify
and speed up extraction protocols to ensure consistent,
reproducible LC and LC-MS results. Laboratories can now process
samples up to 40% faster and deliver samples that are up to 70%
cleaner with fewer LC-MS matrix effects than samples prepared using
other extraction techniques. Oasis PRiME HLB Sorbent is available
immediately worldwide.
“Whether doing bioanalysis, food analysis or forensic
toxicological screening by LC and LC-MS, few things are more
important to getting quality analytical results than a clean
sample. That is why today’s scientists need three things from a
sample preparation protocol – simplicity, speed, and cleaner
eluates,” said Mike Yelle, Vice President, Consumables Business
Unit, Waters Division. “For scientists working with samples
containing proteins, fats or lipids, Oasis PRiME HLB fulfills all
three requirements and is now the gold standard for solid phase
extraction.”
HILIC-based Glycoprotein ColumnThe new ACQUITY UPLC®
Glycoprotein BEH Amide 300Å 1.7-µm Column enables biopharmaceutical
companies to better understand where glycan molecules are located
within the therapeutic proteins they are developing. Identifying
the precise location of glycans within a protein structure is
essential to delivering safe and effective biotherapeutic
proteins.
The novel, patent-pending ACQUITY UPLC BEH Amide technology,
assists scientists in obtaining reproducible glycan-related
chromatographic and mass spec information at the intact protein,
fragment, or peptide levels. Designed to be used with Waters
ACQUITY UPLC systems, this new glycoprotein analysis column
provides unprecedented resolution using MS-compatible HILIC
separations. Laboratories can now resolve different glycoproteins
and glycopeptides, determine where both N-linked and O-linked
glycans are located within the protein, as well as better
understand glycan modifications and patterns. Combining these
capabilities with mass spectrometric analysis provides far greater
information about glycoprotein structure than has been previously
available.
“Waters has been leading the way in innovative solutions for
glycan analysis to help our biopharmaceutical customers solve the
challenges they face with their traditional glycan workflows. The
new ACQUITY UPLC Glycoprotein BEH Amide Column, joins a family of
market leading disruptive technologies, including our
Biopharmaceutical Platform Solution with UNIFI® for
characterization, and our most recent GlycoWorks™ RapiFluor-MS™
N-Glycan sample preparation kits,” said Mike Yelle, Vice President
of Waters’ Consumable Business Unit.
About Waters Corporation (www.waters.com)For more
than 50 years, Waters Corporation has created business advantages
for laboratory-dependent organizations by delivering practical and
sustainable innovation to enable significant advancements in such
areas as healthcare delivery, environmental management, food
safety, and water quality, consumer products and high-value added
chemicals worldwide.
Pioneering a connected portfolio of separations science,
laboratory information management, mass spectrometry and thermal
analysis, Waters technology breakthroughs and laboratory solutions
provide an enduring platform for customer success.
With revenue of $1.99 billion in 2014, Waters is driving
scientific discovery and operational excellence for customers
worldwide.
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Waters CorporationChris Orlando, 508-482-2623Public
Relations ManagerChris_Orlando@waters.com
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