By Jonathan D. Rockoff, Dana Mattioli and Liz Hoffman 

Teva Pharmaceutical Industries Ltd.'s bid to combine with the generic-drug business of Allergan PLC would vault the Israeli company into the top ranks of global drug makers and further a remodeling of the industry by a few players that were relatively unknown just a few years ago.

A deal, valued at more than $40 billion, could be announced as early as Monday, according to people familiar with the matter. It would combine Teva, the world's largest generic-drug company by sales, with the third-largest competitor in the market.

Teva had a market value of $60 billion before The Wall Street Journal reported on the possible sale Saturday. The company would join other drug makers including Allergan and Valeant Pharmaceuticals International Inc., which through voracious deal making have come to wield outsize influence in the pharmaceutical industry.

The tumult in the drug industry will likely continue. Teva is now expected to drop its bid for rival Mylan NV, and Mylan is expected to continue its pursuit of Perrigo Co. PLC, free of its unwanted suitor.

Still, Perrigo has rebuffed Mylan's offer, and Perrigo Chief Executive Joseph Papa reiterated that opposition in an interview on Sunday. A deal with Mylan would undercut the company's growth rate and earnings multiple, he said.

"We still believe the Mylan offer substantially undervalues Perrigo," Mr. Papa said.

Such midsize companies have largely driven the breakneck pace of consolidation in the drug industry in recent years--part of a broader boom in mergers and acquisitions--as they take advantage of cheap debt and in some cases low tax rates secured by relocating overseas, while drawing on the approval of investors who have driven their shares higher. Meanwhile, bigger, more-established rivals have largely been on the sidelines of major deal making.

Other segments of the health-care industry also have been hotbeds of merger activity lately, including insurers. Within the past month, Anthem Inc. agreed to buy Cigna Corp., and Aetna Inc. struck an agreement to acquire Humana Inc., in deals valued at a combined $82 billion.

Last year Teva had $9.1 billion in generic-drug sales, according to EvaluateSHYPharma, about 12% of the world market. The company said it already accounts for one in six drug prescriptions in the U.S. But much of its business is in no-name generic medicines sold at lower prices. Nearly half of Teva's $20.3 billion in sales last year were from the off-patent generic copies of drugs.

By adding Allergan's business, which reported $6.6 billion in sales last year, Teva would have revenue significantly greater than that of better-known, branded-drug companies such as Cialis maker Eli Lilly & Co., which reported $19.6 billion in sales last year. Teva also discussed including Allergan's drug-distribution business in the sale, which would add another $2 billion in annual revenue, but as of Sunday evening the unit wasn't part of the deal, according to a person familiar with the talks.

The deal could give the combined company a market value exceeding that of Lilly, which stood at $94 billion on Friday.

Meanwhile, Allergan plans to use proceeds from a deal with Teva to continue its acquisition spree and to pay down debt it has built up, according to a person familiar with the matter.

Allergan became one of the top 10 drug companies by sales this year when Actavis bought the maker of wrinkle treatment Botox for nearly $70 billion, and renamed itself.

In a sign of its continuing ambition, Dublin-based Allergan announced a deal on Sunday, saying it will pay $560 million upfront for Naurex Inc. and its antidepressant-drug candidate.

Allergan's 1,000 low-priced products include branded generic drugs, over-the-counter medicines and generic versions of well-known pharmaceuticals such as the OxyContin pain treatment and Concerta, which treats attention-deficit-hyperactivity-disorder.

To be sure, an agreement by Teva to buy Allergan's generic-drugs business is expected to attract antitrust scrutiny from regulators. Teva may need to sell off products with about $500 million in yearly sales to win approval, Evercore ISI analyst Umer Raffat estimates.

A deal with Allergan would largely give Teva what it has been seeking from a Mylan deal: Increased scale in the hotly competitive generic-drug market, and an opportunity to pursue further cost reductions that could help it cope with the end of a wave of big patent expirations.

Teva is under pressure because its top-selling product, a brand-name multiple-sclerosis treatment called Copaxone, started facing lower-priced competition in the U.S. last month.

The $70 billion-a-year generic-drugs business isn't growing like it had been, now that most of the big patent expirations for blockbuster brand-name drugs such as cholesterol fighter Lipitor have passed. In addition, the big generic-drug companies are facing new rivals from India and other countries that are competing on price.

As a result, some generic-drug companies including Allergan have been moving upmarket into lucrative brand-name drugs.

One factor that may help explain Teva's interest in the unit: The chief executive of its global generic-medicines group, Sigurdur Olafsson, knows the Allergan generics business since he had worked in a senior role there until 2014.

Teva was considering a deal for Allergan's generics business before it launched its pursuit of Mylan, according to a person familiar with the matter.

A few months after Erez Vigodman took the helm of Teva in February 2014, the company reached out to what was then Actavis about a deal, the person said. But at that time, Actavis wasn't interested in selling and dismissed the interest.

The Israeli company then shifted its interest to Mylan earlier this year.

Teva built up a 4.6% stake in Mylan as part of the effort, but Mylan's resistance has been fierce. On Thursday, a foundation set up by Mylan triggered a kind of Dutch poison pill, designed to thwart any combination.

By that time, Teva was already in serious discussions with Allergan about their own deal. Teva had increased its earlier offer, and Allergan was open to shedding its generics business this time, the person said.

Write to Jonathan D. Rockoff at Jonathan.Rockoff@wsj.com, Dana Mattioli at dana.mattioli@wsj.com and Liz Hoffman at liz.hoffman@wsj.com

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