By Lisa Beilfuss 

Botox maker Allergan PLC agreed to buy Kythera Biopharmaceuticals Inc., which is preparing to launch an injection aimed at reducing so-called double chins, for about $2.1 billion in cash and stock.

Dublin-based Allergan will pay $75 a share for Kythera, representing a 24% premium over Tuesday's closing price.

Kythera is about to launch Kybella, its injection to banish the double chin. The treatment got approval from the U.S. Food and Drug Administration in April. Chief Executive Keith Leonard has said that Kybella will generate at least $500 million in domestic sales and eventually match that level in international sales.

Allergan said Wednesday that the acquisition immediately enhances Allergan's facial aesthetics portfolio with the addition of Kybella.

Actavis acquired Allergan in a deal valued at $70.5 billion, the biggest from 2014. The deal ended one of the year's more dramatic takeover battles in which Dublin-based Actavis beat out Valeant Pharmaceuticals International Inc. for Allergan.

Like Actavis's deal for Allergan, Allergan's deal for Kythera will benefit in part from the acquirer using its lower-tax foreign addresses as springboards for acquisitions in the U.S., which has one of the world's highest corporate tax rates. This tax trend has been particularly popular among drug deals.

Kythera has said it would begin its targeted rollout of Kybella this month, starting with a small group of top dermatologists and plastic surgeons, who would serve as "faculty" to train other physicians. Mr. Leonard has said that Kybella would be more widely available starting in August.

Kythera has said that the double chin, called submental fullness in the medical community, is a common yet undertreated affliction that affects men and women alike and is the result of both genetics and weight.

The FDA in April approved Kybella to treat patients in up to six sessions, at least a month apart. Patients will receive dozens of shots per 15 to 20 minute session. Most patients will need four sessions to obtain the desired outcome, Kythera has said.

Since going public in 2012, Kythera hasn't reported a profit.

Write to Lisa Beilfuss at lisa.beilfuss@wsj.com

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