By Liz Hoffman 

Valeant Pharmaceuticals International Inc. raised the takeover price for Salix Pharmaceuticals Ltd. by about a billion dollars in a new deal that knocked out rival bidder Endo International PLC.

Valeant increased its per-share payment to $173 a share, or about $11.1 billion in total, up $15 from the $158 price Salix agreed to take from the drug company in February. The higher, all-cash price prompted Endo to withdraw its rival cash-and-stock bid, valued at $172.56 a share Friday.

Endo's bid for Salix, valued at $175 a share, or about $11.2 billion, when it was made on Wednesday, had been seen as taking longer to close and facing more uncertainty as it required a vote of Endo's shareholders. No such approval is required from Valeant shareholders.

Endo said in a news release that it has a "robust deal pipeline," indicating it may have other potential acquisitions in mind.

Valeant shares were up 2.5% in late afternoon trading in New York Monday, at $202.45, after dipping last week on news of the Endo offer. Salix shares were up 2% at $172.75, and Endo was up 2.7% at $89.65.

Salix makes drugs to treat stomach disorders, a fast-growing area of specialty pharmaceuticals.

Valeant Chief Executive Michael Pearson--coming off a bruising, failed attempt to acquire Botox maker Allegan Inc. last year--had been eager not to let Salix slip away, according to people familiar with the matter. A serial acquirer, Valeant has grown quickly in recent years by buying companies with proven drugs, then cutting costs, rather than depending on risky research in early-stage products.

Valeant announced late Monday it would sell $1.45 billion in new shares to fund the deal. Pershing Square Capital Management LP is buying 3 million shares in the offering worth about $600 million, according to a person familiar with the matter. That would boost Pershing Square's stake in Valeant to above 5%.

Valeant got more comfortable with the bump after it sold more debt than expected last week at low interest rates and also determined its $500 million in planned cost cuts at the combined companies looked conservative, executives told investors on a call Monday, the person said.

As part of Valeant's recut deal, announced Monday, Salix increased by $100 million, to about $450 million, the breakup fee it would owe Valeant if it were to walk away from their agreement. That would have added to the cost for Endo of mounting any new offer for Salix.

Salix also agreed to shorten, to May 1 from Aug. 20, the date until which Valeant must keep its offer on the table. If the offer's conditions--principally, that a majority of Salix shareholders agree to sell their stock--haven't been satisfied by April 8, Valeant's offer will drop back to $158 a share.

Valeant first announced its agreement to buy Salix for about $10 billion in February. Endo, a fast-growing, smaller drug maker run by a former Valeant executive, then swooped in last week with a rival bid.

Deal-making is at the heart of Valeant's strategy, and it said it has done more than 100 transactions including joint ventures since Mr. Pearson took the helm in 2008.

Drug companies have been active deal makers as they seek to cut costs and gain other advantages amid a number of headwinds in the industry. Last year, $268 billion in pharmaceutical mergers and acquisitions were announced globally, more than double the volume in 2013 and the biggest total since Dealogic began keeping records in 1995. This year is off to an even faster start, with more than $65 billion of transactions announced, compared with $39 billion over the same period in 2014.

Tax considerations are also fueling the activity. A number of U.S. drug companies have bought foreign rivals and moved their tax locales to countries with lower corporate rates in deals known as inversions. As the U.S. moved last year to clamp down on such transactions, those companies that had already managed to invert, like Valeant and Endo, intensified their hunt for deals in the U.S.

Last fall, Salix called off a planned inversion deal of its own after the U.S. Treasury implemented rules aimed at deterring such deals. Around the same time, Allergan held takeover talks with Salix as the Botox maker attempted to fend off a hostile takeover bid from Valeant. Valeant itself had inverted years earlier and boasts a tax rate of less than 5%.

After Allergan walked away from Salix-- and agreed to be bought by another inverted company, Actavis PLC--Salix sought another buyer. The bidding process ultimately drew five suitors, all based abroad or soon to be. Endo, which inverted in early 2014, was one of them, but its bid of $150 a share fell short of Valeant's.

In November, Salix disclosed a backlog of wholesaler inventory that suggested demand for its top drugs might not be as high as previously thought. Its CEO later resigned, and the company lowered its earnings guidance.

Write to Liz Hoffman at liz.hoffman@wsj.com

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