By Jonathan D. Rockoff and Liz Hoffman 

Valeant Pharmaceuticals International Inc. said Sunday it would buy Salix Pharmaceuticals Ltd. for about $10 billion, a return to its big deal-making ways after a failed bid for Botox maker Allergan Inc. last year.

Quebec-based Valeant said it would pay $158 a share in cash for Salix. That is just above Friday's closing price of $157.85 for the Raleigh, N.C., drug company's shares, which had risen recently on reports of a potential deal.

The deal will take Valeant into a growing, multibillion-dollar market for drugs treating stomach disorders like traveler's diarrhea. Valeant estimates the overall U.S. market for stomach-disorder treatments is $5 billion and growing 5% a year, while Salix's sales are growing even faster than that.

Yet the deal will come at a cost for Valeant, roughly doubling its debt to $31 billion, according to Chief Executive Michael Pearson.

Also, Salix is a tarnished asset. In November, Salix disclosed a revision to its wholesale-inventory levels that suggested demand for its drugs might not be as high as previously thought. In recent months, the company's chief financial officer and chief executive have left.

Valeant expects to lose out on about $500 million in sales this year as distributors reduce drug inventory levels to adjust for the accounting issues, Mr. Pearson said.

Valeant sells eye and skin drugs. It had signaled in recent months that it would focus on growing its own businesses, after the company had failed to win Allergan. The Botox maker, which was bought by Actavis PLC for $66 billion , criticized Valeant as a deal machine.

Mr. Pearson said Valeant's fourth-quarter results, released Sunday, showed that the company was growing its own business substantially. Valeant reported total revenue of $8.3 billion last year, up 43% over the prior year.

Write to Jonathan D. Rockoff at Jonathan.Rockoff@wsj.com and Liz Hoffman at liz.hoffman@wsj.com

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