By Jonathan D. Rockoff 
 

In the latest turn in one of the most dramatic acquisition attempts in recent years, Actavis PLC said Monday that it would pay $66 billion in cash and stock for Allergan Inc.-a deal that appears to have thwarted a hostile takeover of the Botox maker.

Under the terms, Actavis would pay $219 a share with nearly 60% of the deal in cash and the rest in stock, it said. The combined company is expected to have a roughly 15% tax rate, according to Actavis's planned presentation on the deal that was reviewed by The Wall Street Journal.

"We will create a top-10 pharmaceutical company," Actavis Chief Executive Brent Saunders said in a conference call Monday. The deal could close in the second quarter of next year subject to shareholder and regulatory approvals.

The companies appear to have shielded Allergan from a hostile takeover by Valeant Pharmaceuticals International Inc., which had bid $53 billion for Allergan but had indicated more recently it may raise its offer. Valeant and activist investor William Ackman since April have been seeking to seal a deal.

Valeant CEO Michael Pearson said the company would review Actavis's offer but indicated the price was now too steep for a counteroffer.

"Valeant cannot justify to its own shareholders paying a price of $219 or more per share for Allergan," Mr. Pearson said. "We will remain focused on delivering strong organic results and evaluating acquisition opportunities as we always have: prudently, in a disciplined manner, and in the best interests of our shareholders."

Shares of Actavis rose 1.5% to $247 Monday, while Allergan shares increased 5.7% to $210.

The moves Monday reflect many of the big trends in deal making. Interest in health-care transactions has been particularly high this year, which has been a robust one for mergers and acquisitions. Actavis, as well as Valeant, was an early adopter of the so-called inversion strategy that has increased in popularity, in which a U.S. company pursues an overseas merger to capture a lower foreign tax rate and other overseas tax perks.

Once based in Parsippany, N.J., Actavis inverted to Ireland when it bought Warner Chilcott last year. Analysts have predicted that a combination with Actavis could shave hundreds of millions of dollars next year from the tax bill of Allergan, which is based in Irvine, Calif.

If Actavis loses Allergan to another company, Actavis would receive a breakup fee typical of the industry, a person familiar with the matter said.

The boards of Actavis and Allergan have blessed the deal, the person said.

A combination would produce at least $1.8 billion in synergies, while keeping about $1.7 billion in research and development spending between the two companies-roughly $400 million less than what the companies would have spent separately, Mr. Saunders said.

Since the spring,Allergan has been trying to fend off Valeant, which teamed up with Mr. Ackman and his hedge fund Pershing Square Capital Management LP to buyAllergan.

Allergan, a maker of Botox and other antiwrinkle drugs, is an attractive target because it is the leading player in a $5 billion world-wide cosmetic-medicine market that industry officials believe is ripe for significant growth.

Under CEO David Pyott, Allergan sales have often risen 10% or more year over year, more than many pharmaceutical companies.

"I see this as an Olympic torch which will be handed over to the Actavis team," Mr. Pyott said.

Allergan, a maker of Botox and other antiwrinkle drugs, is an attractive target because it is the leading player in a $5 billion world-wide cosmetic-medicine market that industry officials believe is ripe for significant growth.

Actavis, which would be led by Mr. Saunders and Actavis Executive Chairman Paul Bisaro, projects it can maintain such strong levels of growth companywide. It forecasts at least 10% of organic revenue growth over the next few years.

The combined company would make for one of the world's biggest pharmaceutical companies, selling eye, skin and stomach drugs with $23 billion in 2015 sales and more than 30,000 employees.

Its top-selling product would be Botox, which Allergan has been extending into medical uses beyond an antiwrinkle treatment. Mr. Saunders indicated Actavis would continue Allergan's efforts to expand Botox sales.

"It's a product that will be around forever, and Allergan has proven they know how to create markets for it," he said.

Other potential combinations have also sprung up around Allergan and Actavis this year, creating a complex web in which some companies have shifted roles between predator and prey.

This summer, for example, Allergan held talks to buySalix Pharmaceuticals Ltd. Such a deal would have made Allergan bigger and more complicated for Valeant to buy, but those talks ended.

And while Actavis explored a deal for Allergan, Pfizer Inc. for a time pursued a takeover of Actavis, a person familiar with the matter has said. Actavis rejected such a deal, the person said. Actavis has been hungry, earlier this year buying Forest Laboratories Inc. for $25 billion.

David Benoit contributed to this article.

Write to Jonathan D. Rockoff at Jonathan.Rockoff@wsj.com

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