By Dana Mattioli, Jonathan D. Rockoff and David Benoit 

Michael Pearson runs a drug company, but that doesn't mean he wants to spend money on science.

By contrast, science is prized at the company he wants to buy, Allergan Inc. The Botox maker spends 17% of its revenue on research and development, higher than many of its rivals.

That culture clash and Mr. Pearson's reputation as an aggressive cost cutter are among the main reasons Allergan long resisted merger overtures from Mr. Pearson's Valeant Pharmaceuticals International Inc., a person familiar with Allergan's thinking said.

Valeant and Allergan are on "completely opposite sides of the drug industry," said Ronny Gal, a Sanford C. Bernstein analyst.

That dichotomy raises a central question of this takeover battle: Do investment needs of the drug business make it fundamentally different, or can it be rolled up and squeezed just like any other industry?

As Valeant and its partner in pursuit of Allergan, activist investor William Ackman, unveiled the nearly $46 billion offer on Tuesday, they confirmed many of the target's worst fears. Valeant said it would pare R&D spending after merging the companies.

About 20% of the combined companies' 28,000 employees would be cut, though that could include Valeant staff, Mr. Pearson said.

"When we went through and analyzed the cuts, these are not people touching the customers, these are people sitting in offices. We don't need people sitting in offices," he said.

Valeant offered to swap each Allergan share for $48.30 in cash and 0.83 Valeant share. Based on Valeant's closing price Monday in the U.S., the deal values Allergan at $152.89 a share, or roughly $46 billion. Valeant said the offer was a premium to Allergan's price of $116.63 on April 10, the day before Mr. Ackman's Pershing Square Capital Management LP reached the 5% ownership level at which it soon would have to disclose its holding. Pershing Square's stake later grew to nearly 10%.

Allergan's stock closed 15% higher Tuesday at $163.65 on the New York Stock Exchange. Valeant's shares rose 7.5% to $135.41 on the NYSE.

Allergan said its board and advisers would "carefully review and consider" the offer.

To close followers of Valeant, the Laval, Quebec, company's intentions should come as no surprise. Seen as a maverick in the health-care industry, Mr. Pearson is a serial acquirer known to take over companies for their products, cut away research spending and then try to boost revenue by moving the products through Valeant's sales force.

The acquisition-heavy strategy focuses more on extracting cost savings and tax benefits from deals than on seeking growth through scientific advances.

Valeant spent about 3% of its revenue on R&D last year. In 2007, a year before Mr. Pearson joined the company, the figure was 12%. The company has made 100 acquisitions or joint ventures since Mr. Pearson took over and has $17.4 billion in debt. Valeant's board includes several deal makers, and the company's chief financial officer is a former banker from Goldman Sachs Group Inc.

While controversial in the health-care industry and on Wall Street, Mr. Pearson's strategy has delivered for Valeant shareholders. Since he took the helm, the company's stock has risen more than 900%.

Valeant posted $842 million in revenue and $1.2 million in profit in 2007. Last year the company had $5.77 billion in revenue and posted an $866 million loss as it integrated its nearly $9 billion acquisition of Bausch & Lomb.

A central part of Mr. Pearson's approach is using acquisitions to lower its tax rate through a structure called a tax inversion. Valeant, which had been based in California, in 2010 merged with Canada's Biovail and changed its domicile to Canada. Valeant's resulting tax rate below 5% gives it an edge on competition from the U.S.

Though Valeant said the rate would go up in a pairing with Allergan, ultimately it expected to reap tax savings since the Irvine, Calif., target pays taxes at much higher U.S. rates.

Mr. Pearson said in an interview that he and Allergan CEO David Pyott first talked about a potential merger about 18 months ago and that Allergan rejected the overture a few weeks later.

Mr. Pearson said he sought to rekindle the talks this February. After a meeting was canceled and analysts suggested that Allergan wasn't interested in a stock deal with Valeant, Mr. Pearson decided to take the matter public, he said.

Mr. Ackman at a news conference Tuesday with Mr. Pearson crowed about Valeant's cost consciousness, pointing to its ability to achieve higher-than-expected savings in earlier deals, such as the one for Bausch & Lomb. "They really have a perfect track record of achieving synergies," Mr. Ackman said.

Valeant didn't meet with many of Bausch & Lomb's top managers after buying the company last year from private-equity owners Warburg Pincus LLC and instead moved quickly to lay them off, people familiar with the matter said. Valeant reported that by the end of this year it would be able to save $850 million a year by cutting overlapping costs with Bausch & Lomb.

Mr. Ackman said he came to appreciate Mr. Pearson's penny pinching at a meeting in which the activist investor requested a Chipotle burrito for lunch instead of the salad being served. When Mr. Pearson's assistant brought in the burrito, the CEO requested $20 from Mr. Ackman to cover the cost.

Mr. Pearson assured Valeant shareholders on Tuesday that Mr. Ackman was footing the bill for the news conference.

Write to Dana Mattioli at dana.mattioli@wsj.com, Jonathan D. Rockoff at jonathan.rockoff@wsj.com and David Benoit at david.benoit@wsj.com

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