By Julie Steinberg and Chelsey Dulaney 

U.S. Bancorp said its profit grew 2.4% in the most recent quarter as its revenue and average total loans increased, though a key measure of lending profitability edged down.

Earnings met Wall Street estimates, while revenue came in slightly below. Shares were little changed in early afternoon trading.

The bank posted earnings of $1.43 billion, up from $1.4 billion in the prior-year period. On a per-share basis, earnings rose to 76 cents from 73 cents a year ago.

Revenue at the Minneapolis-based bank rose 1.9% to $4.91 billion.

Analysts had expected 76 cents a share in earnings and $4.95 billion in revenue, according to Thomson Reuters.

Net interest margin, an important measure of lending profitability, edged down to 3.08% from 3.35% a year earlier. Net interest margin measures how much a bank earns from the difference between what it pays out on deposits and what it gets on loans and investments.

Like other regional banks, U.S. Bancorp has faced a tough environment in which low interest rates have limited interest income and have pushed down net interest margin.

Bank executives on a call with analysts Wednesday discussed the interest-margin compression at length and said they expect it to continue in the second quarter. U.S. Bancorp Chairman and Chief Executive Richard Davis said that he expects rates to rise this year and that when they do, "so many things will start to improve," including the margin metric.

U.S. Bancorp and other regional banks have in recent years invested in so-called noninterest income businesses that generate stable fees and help offset interest-related declines. Chief Operating Officer Andrew Cecere in an interview said the bank is gaining market share in its corporate trust business, and has also invested in its business that services hedge and mutual funds.

Regarding capital markets, another area the bank has expanded in, Mr. Cecere said: "To the extent there are opportunities to grow that business, we'll continue to build it."

The bank said average total loans rose by 5.1%, and Mr. Davis said he is aiming toward 6% loan growth year-over-year by the end of the year, though he said the bank won't lower its credit quality standards to achieve that figure.

Executives on Wednesday also said they were interested in looking at the assets being sold by General Electric Co. as part of its plan to significantly scale back its finance arm.

Write to Julie Steinberg at julie.steinberg@wsj.com and Chelsey Dulaney at Chelsey.Dulaney@wsj.com

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