U.S. Bancorp said its profit grew 2.4% in the most recent quarter as its revenue and average total loans increased, though a key measure of lending profitability edged down.

Earnings met Wall Street estimates, while revenue came in slightly below.

The bank posted earnings of $1.43 billion, up from $1.4 billion in the prior-year period. On a per-share basis, earnings rose to 76 cents from 73 cents a year ago.

Revenue at the Minneapolis-based bank rose 1.9% to $4.91 billion.

Analysts had expected 76 cents a share in earnings and $4.95 billion in revenue, according to Thomson Reuters.

Average total loans rose by 5.1%.

Net interest margin, an important measure of lending profitability, edged down to 3.08% from 3.35% a year earlier.

Like other regional banks, U.S. Bancorp faces a tough environment in which low interest rates have limited interest income.

Write to Julie Steinberg at julie.steinberg@wsj.com and Chelsey Dulaney at Chelsey.Dulaney@wsj.com

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