By Tamara Audi And Andy Pasztor 

LOS ANGELES--The driver of a truck involved in a train crash north of Los Angeles on Tuesday has been arrested on suspicion of a felony hit-and-run, according to police officials in Oxnard, where the crash occurred.

A commuter-rail train struck the tractor-trailer truck sitting on the tracks around 5:45 a.m. Tuesday in Southern California's Ventura County, injuring more than 20. The impact engulfed the truck in flames, and four cars of the Metrolink train derailed, three of them sliding on their sides.

The 54-year-old driver accidentally had driven his truck onto the tracks, became stuck, and then fled the scene, police said at a news conference late Tuesday afternoon.

Oxnard Police identified the driver of the truck as Jose Alejandro Sanchez Ramirez of Yuma, Ariz. A police spokesman said Mr. Ramirez has a valid commercial drivers' license. He pulled onto the tracks driving a 2005 F-450 truck with a trailer in tow, police said.

Ventura County officials said Tuesday that of the 28 injured and taken to area hospitals, 20 have been released. Another eight patients remain hospitalized, including four in intensive care. Two additional passengers who didn't seek hospital treatment at the scene on Tuesday later showed up at area hospitals for treatment, emergency officials said.

Authorities said some victims suffered serious head injuries and broken limbs.

Service on two Amtrak lines running along the California coast were disrupted for the day, train officials said.

The collision occurred in the city of Oxnard as the train headed toward Los Angeles, about 65 miles away.

As the commuter train carrying 50 people and crew sped along the coast in the predawn dark, the truck driver made a right turn onto the tracks at the rail crossing, police said.

The train crew saw the truck on the tracks and was able to slow down significantly before impact, said officials with Metrolink, which operates Southern California's commuter rail system.

Oxnard Assistant Police Chief Jason Benites said the driver was found walking unharmed and "very unsettled" about a mile from the crash.

Metrolink spokesman Scott Johnson said the train cars didn't crumple in the crash because of new technology that Metrolink has invested in that disperses impact energy.

The crash is the second at that crossing, according to Oxnard Mayor Tim Flynn. Last year, two people in a vehicle died when a train hit a car at the crossing. Mr. Flynn said the city was already considering constructing a bridge at the spot.

Union Pacific, which owns the rails, maintains the crossing arm and lights at the site. According to a Union Pacific spokesman, the crossing lights and gate were working before the crash. It is unclear if they were functioning properly at the time of the crash--a question that federal investigators will examine.

The National Transportation Safety Board has dispatched a "go team"--composed of specialists in the fields related to the accident--to the scene. Usually, the NTSB will first obtain the "black-box" recorder from the train. The officials also typically administer drug and alcohol tests to the engineer and driver and seek phone records, to see if calling or texting was involved.

In the past few years, train accidents and derailments have become a larger focus of the safety board's efforts. Crashes involving both passenger trains and freight trains, particularly those transporting oil, have prompted a variety of safety recommendations. Including the Ventura crash, four of the NTSB's nine current major investigations involve rail accidents.

The collision comes on the heels of a Feb. 3 train-SUV collision in Valhalla, N.Y., in which five Metro-North Railroad passengers and the driver of the vehicle were killed. The NTSB's preliminary report on that crash, which was released Monday, didn't identify a probable cause of the crash, nor did it address issues such as why the sport-utility vehicle wound up on the railroad tracks or how safety at crossings might be improved. The final results of the investigation could take a year or more.

A Metrolink commuter train was involved in a major crash outside L.A. in 2008, when it struck another train and killed 25 people.

That accident, attributed to an engineer failing to respond to a stop signal while he was texting, prompted a nationwide debate over enhanced anticollision safeguards designed to automatically apply a train's brakes in such circumstances. Metrolink was the first major commuter line in the U.S. to install so-called positive train control systems, which also detect excessive speeds, though they aren't intended to deal with the type of train-vehicle accident that occurred Tuesday.

Deborah Hersman, the safety board's former chairman, said on CNN that California train lines "lead the nation when it comes to fatalities at grade crossings." She said that nationwide, about 120 fatalities occur each year at crossings where tracks and roadways intersect at the same level.

Write to Tamara Audi at tammy.audi@wsj.com and Andy Pasztor at andy.pasztor@wsj.com

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