By Angela Chen And Anna Wilde Mathews 

UnitedHealth Group Inc. on Thursday reported a 29% increase in March quarter earnings and raised its full-year guidance as the health insurer benefits from growth in its health-services business and a lower impact from medical costs.

Shares of UnitedHealth, up 50% over the past year, rose 3.4% to $121.33 in late-afternoon trading. The stock fell 2.2% Wednesday after hospital operator HCA Holdings Inc. reported a better-than-expected outlook for the March quarter, raising concerns about higher health-care costs for insurers.

UnitedHealth, like its fellow health insurers, has sought to contain costs related to medical care, particularly as expensive, high-profile treatments for hepatitis C and cancer enter the market. As the biggest insurer, UnitedHealth is seen as a bellwether, and its views on spending trends are closely monitored.

The company said its medical-care ratio, a key industry metric that reflects the portion of insurance premiums used for patient care, fell about 1% to 81.1% from a year earlier. Helping the ratio was the company's higher revenue from premiums, which jumped 13% to $31.68 billion in the first quarter.

Dan Schumacher, chief financial officer of the health-insurance unit UnitedHealthcare, said the company had planned for a modest increase but "has not seen any acceleration in underlying utilization" of health services in the first quarter.

Dave Wichman, president of parent UnitedHealth Group, flagged the company's "clinical engagement strategies and our ability to manage medical costs," particularly strategies on inpatient hospital costs. The company also pointed to its efforts to shift away from reimbursing health-care providers with fees for each service.

Meanwhile, Optum--UnitedHealth's health-services arm--saw revenue rise 15% to $12.8 billion. Within the group, revenue from OptumHealth rose 27% to $3.3 billion. OptumHealth provides care-delivery and health-management services for third-party payers like employers, payers and government entities.

"Looks like other payers have decided to continue to trust Optum despite its affiliation with" UnitedHealth, said Mizuho Securities USA analyst Sheryl Skolnick.

The company raised its full-year revenue outlook by $2 billion to $143 billion and increased per-share earnings expectations to a range of $6.15 to $6.30 from the previous range of $6.00 to $6.25. Analysts polled by Thomson Reuters were expecting earnings of $6.21 a share and revenue of $141.68 billion.

UnitedHealth's revised year outlook includes the costs of 10 cents per share from the proposed combination with Catamaran Corp.

In March, UnitedHealth agreed to acquire Catamaran, the fourth-largest pharmacy-benefit manager in the U.S. by volume of prescriptions processed, for $12.8 billion in cash. The deal was seen helping UnitedHealth to bulk up its pharmacy-benefit business amid growing concern from employers and insurers about the rising costs of cutting-edge drugs.

Larry Renfro, chief executive of Optum, said Thursday that the company believes it should be able to retain the business of health plans that are clients of Catamaran, even though they compete with UnitedHealth Group's insurance arm.

The company will have to provide "transparency" and "privacy and security around information and data," he said, but "as long as we execute, we should be fine."

For the period ended March 31, UnitedHealth posted earnings of $1.41 billion, or $1.46 a share, up from $1.1 billion, or $1.10 a share, a year earlier.

Revenue improved 13% to $35.76 billion.

Analysts had projected a per-share profit of $1.35 and revenue of $34.63 billion.

"First-quarter results suggest to us that [UnitedHealth] is now firmly back in growth mode," Susquehanna Financial Group analyst Chris Rigg said.

Write to Angela Chen at angela.chen@dowjones.com and Anna Wilde Mathews at anna.mathews@wsj.com

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