AstraZeneca's Brilinta Fails Arterial Disease Drug Trial
October 04 2016 - 5:20AM
Dow Jones News
AstraZeneca PLC said its prescription blood-thinning medicine
Brilinta failed to show a benefit over standard treatment in
peripheral artery disease in a large clinical trial, denting the
company's growth ambitions for one of its most important drugs.
The U.K.-based drugmaker said Tuesday that Brilinta was no
better than generic blood-thinner clopidogrel at reducing heart
problems in people with peripheral artery disease, a condition in
which a buildup of fatty deposits in the arteries restricts blood
flow to the leg muscles.
The failure cuts off a source of significant growth for
Brilinta: peripheral artery disease affects around 8.5 million
people in the U.S. according to the Centers for Disease Control and
Prevention. Success could have boosted the drugs' sales by around
$2 billion at peak, according to an estimate by UBS.
The result will put pressure on the company's ambition to
increase sales of Brilinta to $3.5 billion by 2023, an important
part of its overall target to nearly double revenue to $45 billion
in the same period. AstraZeneca unveiled those goals to fend off an
unwanted takeover approach from U.S. rival Pfizer Inc. nearly two
years ago. Brilinta sales were $619 million in 2015.
The drugmaker is plowing significant investment into a huge
clinical trial program for Brilinta, aimed at expanding its use.
The drug is already marketed as a treatment for people who have
suffered a heart attack, to lower their risk of having a second
one.
Those efforts have met with mixed results. Earlier this year,
another large trial failed to show that Brilinta was any better
than aspirin at preventing stroke.
Sean Bohen, Executive Vice President, Global Medicines
Development and Chief Medical Officer at AstraZeneca, said he was
disappointed with the results but said they didn't effect the
"proven benefits of Brilinta in acute coronary syndrome and
post-myocardial infarction patients," referring to those who have
suffered a heart attack.
Shares in AstraZeneca were down 1.0% at £ 49.93 on Tuesday
morning.
Write to Denise Roland at Denise.Roland@wsj.com
(END) Dow Jones Newswires
October 04, 2016 05:05 ET (09:05 GMT)
Copyright (c) 2016 Dow Jones & Company, Inc.
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