ZURICH—UBS AG will plead guilty to one count of wire fraud and pay a $203 million fine for its role in an interest-rate rigging scheme, after the U.S. Justice Department revoked an earlier agreement to settle the matter with Switzerland's largest bank.

In a statement Wednesday, Zurich-based UBS said the Justice Department had revoked a non-prosecution agreement after the bank allegedly violated the terms of a 2012 settlement related to interest-rate manipulation.

The Justice Department voided the agreement, which specified UBS would "commit no United States crime whatsoever" for a two-year period following the settlement, after an investigation into the global foreign exchange market that included the bank.

UBS said it hasn't been charged in the foreign exchange investigation and that the new fines won't affect its earnings.

Write to Neil MacLucas at neil.maclucas@wsj.com

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