By Barbara Kollmeyer, MarketWatch

MADRID (MarketWatch) -- Losses for European stock markets picked up pace on Friday and turned lower as investors fretted over whether a prior-session rout -- fueled by weak Chinese data -- was the start of a trend. Broker moves weighed on shares of Sanofi SA, but lifted shares of Nokia Corp. Shares of Celesio AG were up on buyout news.

Gainers overtook decliners on the Stoxx Europe 600 index , which fell 0.5% to 330.87. The index closed 1% lower to 332.69 on Thursday for the biggest one-day percentage loss since early December, while in the U.S., the Dow industrials (DJI) suffered the worst loss in five weeks.

Shares of Celesio AG jumped more than 5%, the biggest gainer on the main European index. On Thursday, U.S. drug distribution group McKesson Corp. (MCK) said it had agreement from German conglomerate Franz Haniel & Cie, a major shareholder in Celesio, to sell its 50% stake in the company for 23.50 euros a share. McKesson also persuaded Elliot Management to release convertible bonds in the company.

Nokia (NOK) rose 1.3% after analysts at Societe Generale lifted shares to buy from hold, citing a buying opportunity after Thursday's 11% share-price fall. Nokia shares fell on disappointing results, but analysts at SocGen said there was some hope in upwardly revised guidance for intellectual-property license fees from EUR500 million to EUR600 million annually, due to higher fees expected from Microsoft Corp. (MSFT).

Shares of Sanofi SA (SNY) fell 2% after the pharmaceutical group was cut to neutral from buy at Citigroup, where analysts said consensus downgrades are likely, given recent pipeline/divisional disappointments. Losses for the heavyweight weighed on the French CAC 40 index , down 0.6% to 4,256.

Also in the drug space, shares of Novartis AG (NVS) dropped 1%. The company said it would request re-examination of its serelaxin treatment in acute heart failure for conditional marketing-authorization in the EU, following a negative opinion from the European Medicines Agency's Committee for Medical Products for Human Use.

Sentiment was worsening as the morning progressed, matched by a decline for U.S. stock futures. Asia stocks posted sharp losses overnight, with the Hong Kong Hang Seng index dropping 1.2% and the Nikkei 225 index losing close to 2%.

"There's a number of reasons why investors are feeling a little down in the dumps at the moment," said Craig Erlam, market analyst with Alpari U.K., in a note. "Corporate-earnings season has been mixed from an investor standpoint, and disappointing from an economic one. Companies have continued to focus on the bottom-line growth driven by cost-cutting rather than investment and stronger revenues, which is what we'll need to see if the recovery is going to gather pace this year."

Within other indexes, the German DAX 30 fell 0.4% to 9,595.73, while the FTSE 100 index lost 0.3% to 6,753.81.

of Legrand SA ... after Credit Suisse upgraded to neutral from underperform, saying the compay could offset sluggish growth with increased acquisition activity.

SAP AG (SAP) was cut to hold from buy at Berenberg by analysts who cited risks around potential mergers and acquisition activity that could trigger integration and earnings risks for its cloud market.

Sanofi SA (SNY) was cut to neutral from buy at Citigroup as analysts said consensus downgrades are likely given recent pipeline/divisional disappointments.

Wacker Chemie AG was cut to underweight from neutral at J.P. Morgan, which said shareshave strongly outperformed the market in the last three months but that's based on a polysilicon supply shortage which they don't see happening.

Compass Group was cut to neutral from overweight and IVS Group was cut to neutral from ovewreight at J.P> Morgan

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