By Jeannette Neumann 

MADRID--Ana Botín announced her second major round of management changes at Banco Santander SA, further reshaping the Spanish bank she took over from her father last year.

Juan Rodríguez Inciarte, a senior executive vice president, is stepping down from the board of directors for "personal reasons" and will leave Santander in December after a 30-year career there, the bank said Tuesday. Mr. Rodríguez Inciarte, a board member since 2008, is widely considered to have been an ally of Emilio Botín, the former chairman. Mr. Rodríguez Inciarte wasn't immediately available to comment.

Santander said that Rami Aboukhair will replace Enrique García Candelas as Spain country head, and Mr. García Candelas will become vice chairman of Santander's unit in Portugal.

Mr. Aboukhair worked closely with Ms. Botín when she led the bank's U.K. unit and launched a product called the 1-2-3 account, seeking to attract new clients with higher interest rates for deposits than competitors. Mr. Aboukhair has overseen the rollout of that product in Spain in recent months.

Ms. Botín became executive chairman after her father's death in September. Two months later she appointed Chief Financial Officer José Antonio Álvarez as chief executive, replacing a confidante of her father's, and moved about half the management team into new positions. Tuesday's announcements deepen her imprint on a bank that her father had transformed from the world's 152nd-largest bank by assets in 1986 to the 19th when he died.

"Our goal in making these changes is to have the best qualified professionals in the right roles," Ms. Botín said in a statement, adding that the changes complete a management overhaul overseen by her and Mr. Álvarez.

Santander also announced the creation of a separate board to oversee the bank's Spain unit. Rodrigo Echenique, a Santander vice chairman and longtime confidante of both Mr. Botín and his daughter, will chair the new board.

"This will bring its governance structure in line with the group model which exists in other country subsidiaries," Santander said in the statement. The bank's other main units, including those in the U.K., Brazil and the U.S., have their own separate boards. The Spanish unit had previously been overseen by the Santander group board.

Javier San Félix will lead the retail bank in Santander's U.K. unit, and Ignacio Benjumea, general secretary of the board, will be replaced by Jaime Pérez Renovales, who had worked at Santander before leaving to join the Spanish government for several years. Mr. Benjumea will serve on Santander's group board in a nonexecutive role and on the board for the Spain unit.

Write to Jeannette Neumann at jeannette.neumann@wsj.com

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