By Ryan Tracy, Eyk Henning and Emily Glazer 

Large European banks including Deutsche Bank AG and Banco Santander SA are likely to fail the U.S. Federal Reserve's stress test over shortcomings in how they measure and predict potential losses and risks, according to people familiar with the matter.

The expected rebuke would mark the second year large foreign banks, which were drawn into the Fed's stress test regime in 2014, failed to meet the U.S. regulator's expectations for risk management. As banks have bulked up their capital cushions to ensure they can withstand losses in periods of turmoil, the Fed has increasingly focused on more "qualitative" issues in its stress tests, including whether banks accurately measure potential losses in credit portfolios, collect risk exposure data accurately and have strong internal controls.

Failing the stress tests would likely subject the U.S. units of Deutsche Bank and Banco Santander to restrictions on paying dividends to their European parent companies or other shareholders. Santander is already under such a restriction after failing its first stress test run last year. Deutsche Bank is undergoing the U.S. stress test process for the first time this year.

Both Deutsche Bank and Santander passed European Central Bank stress tests in October. Those tests focused on whether the banks had enough capital to withstand a two-year recession but didn't assess such things as governance, risk management, and other more subjective factors like the Fed's test.

The Fed's Board of Governors in Washington will disclose partial results of the test on March 5 and full results on March 11, including any capital restrictions. Last year, the board met just ahead of releasing the results to vote on whether banks should fail the tests for "qualitative" reasons. It ultimately rejected Citigroup Inc. as well as U.S. units of Santander, HSBC PLC and RBS PLC on such grounds. It cited the foreign banks for "significant deficiencies" in their capital planning process. It hasn't disclosed such a board meeting yet this year. The Fed declined to comment on specific banks.

Deutsche Bank Trust Corp. is expected to be found adequately capitalized by the Fed but will likely receive a warning on qualitative shortcomings, according to people familiar with the matter.

"Deutsche Bank Trust Corporation, which represents less than 5% of Deutsche Bank AG's total assets, was pleased to participate" in the stress tests this year, a spokeswoman said, adding the bank "will know our results after the Federal Reserve's announcements."

Deutsche Bank is currently in a remediation process with the Fed over flaws in areas ranging from its regulatory reporting, risk control, monitoring and compliance systems, these people added. The bank has also been reprimanded by the Fed for flaws in its regulatory reporting, The Wall Street Journal reported last year. In a letter to Deutsche Bank executives in December, a senior official with the Federal Reserve Bank of New York said reports produced by some of the bank's U.S. arms "are of low quality, inaccurate and unreliable. The size and breadth of errors strongly suggest that the firm's entire U.S. regulatory reporting structure requires wide-ranging remedial action."

At the time of the report, a Deutsche Bank spokesman said the German bank has "been working diligently to further strengthen our systems and controls and are committed to being best in class" and said the bank is spending EUR1 billion ($1.35 billion) globally and appointing 1,300 people, including about 500 compliance, risk and technology employees in the U.S.

A person familiar with the matter said Santander is also likely to fail for qualitative reasons, rather than because the stress test depleted its capital below regulatory minimums.

A Santander spokesman declined to comment on Friday.

Santander has been working to fix the issues since receiving a rebuke on its stress test last year, but suffered a setback in September when the Fed said the bank had paid an unauthorized dividend, violating restrictions placed on the firm after its failure on the 2014 stress test in March of that year.

The Fed forced Santander's parent company to reimburse the U.S. unit for the dividend, barred it from additional dividend payouts and required it to beef up internal controls. At the time, Santander declined to comment. Ana Patricia Botín, the Spanish firm's new executive chairman, has vowed to improve the banks' regulatory compliance.

The expected Fed action comes amid a continuing tussle between the U.S. regulator and foreign banks over what the Fed views as potential vulnerabilities at overseas firms with large U.S. operations. The Fed wants European banks to adhere to stricter rules and fix flaws that could potentially destabilize a firm to the point it needs support from the American central bank, as happened during the 2008 financial crisis.

Last year it adopted a rule forcing Deutsche Bank, Santander, and other foreign banks operating in the U.S. to form U.S.-based holding companies that adhere to strict risk-management standards and add potentially billions of dollars more in capital to meet minimum capital requirements at the U.S. units.

The so-called qualitative part of the stress test has become increasingly important since the Fed started doing the tests after the 2008 financial crisis. While the central part of the test measures whether a bank has enough capital to keep lending during a deep recession, the "qualitative" aspect of the test includes more subjective factors such as how the bank manages the stress-test process and incorporates past lessons and concerns. It also takes into account how a bank handles costly litigation and manages its technology systems.

For banks, managing the stress test process is costly. A person at one bank subject to the test said the firm has invested upward of $50 million on personnel and systems in the last year alone in an effort to improve the quality of its data gathering and computer models, among other stress test-related expenses.

"You don't fundamentally understand the level of effort required until you are in the program," this person said.

-Jeannette Neumann contributed to this article.

Write to Ryan Tracy at ryan.tracy@wsj.com, Eyk Henning at eyk.henning@wsj.com and Emily Glazer at emily.glazer@wsj.com

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