By Jonathan D. Rockoff 

Pfizer Inc. on Tuesday lifted its full-year outlook as its newly-launched treatments for cancer, heart disease and other conditions drove growth in the second quarter.

Overall, Pfizer's quarterly revenue fell 7%, to $11.9 billion, but it would have risen 1% excluding currency impacts thanks largely to new drugs.

The results were the latest positive sign from Pfizer, which has confronted sizable sales losses in the last several years as patents expired on a string of blockbuster drugs. Pfizer has also been struggling with generic competition for former blockbusters such as cholesterol fighter Lipitor and, more recently, pain pill Celebrex.

Yet many of the drops in sales are fading. In the second quarter, new drugs such as blood-thinner Eliquis, rheumatoid-arthritis pill Xeljanz and breast-cancer therapy Ibrance helped propel sales. Another contributor was the latest version of its Prevnar pneumonia vaccine, a franchise whose sales rose 37%, to $1.5 billion.

Pfizer is counting on more new products, now in development, to lift future sales. For the year, the company's research and development costs are running 7% higher than during the same period last year, largely because 40% of Pfizer drug candidates are in the most advanced--and expensive--stages of development, according to company officials.

For the quarter, Pfizer posted a profit of $2.63 billion, or 42 cents a share, down from $2.91 billion, or 45 cents a share, in the prior-year period, hurt by the strong dollar and generic competition. Excluding certain items, per-share earnings were 56 cents.

Pfizer's most advanced drug candidates are still a few years away from hitting the market. Also, R&D has always been risky and may not deliver the products Pfizer seeks. The quarter offered another reminder, as Pfizer said it was halting its efforts exploring the sale of Lipitor over the counter after a study found patients weren't able to appropriately manage use of the pills without a doctor.

Pfizer Chief Executive Ian Read said the company will remain on the hunt for more acquisitions, such as its $16 billion purchase of generic-injectable maker Hospira Inc., which is expected to close later this year, to complement the company's own growth efforts. Because adding Hospira will strengthen Pfizer's business selling older drugs, Mr. Read signaled an interest in deals that would add patent-protected medicines.

"I prefer a deal to strengthen our innovative business, as I think we've done a considerable bit to strengthen our established business," Mr. Read said.

Pfizer said it continues exploring a possible split of the company into two firms: one focused on patent-protected medicines and another for established medicines. Pfizer has spent $332 million over the last 1 1/2 years setting up separate accounting systems, registering different legal entities and generally preparing for a potential split, the company said.

By the time Pfizer makes a decision whether to split by the end of 2016, the total cost will probably surpass $1 billion, Chief Financial Officer Frank D'Amelio said in an interview. "It's the cost of giving ourselves the option," he said.

By the time Pfizer makes a decision whether to split by the end of 2016, the total cost will probably surpass $1 billion, Mr. D'Amelio said. "It's the cost of giving ourselves the option," he said.

Pfizer said it is now expecting $2.01 to $2.07 a share in adjusted earnings for the full year, up from its previous forecast for $1.95 to $2.05 a share in earnings. The company lifted the bottom end of its revenue outlook by $1 billion, now calling for $45 billion to $46 billion in revenue.

Chelsey Dulaney contributed to this article

Write to Jonathan D. Rockoff at Jonathan.Rockoff@wsj.com

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