By Sara Sjolin, MarketWatch

LONDON (MarketWatch) -- Europe's benchmark stock index moved lower on Monday, with AstraZeneca PLC leading the charge south after rejecting a sweetened Pfizer Inc. offer, while mining firms declined on added signs of a slowdown in the Chinese housing market.

The Stoxx Europe 600 index gave up 0.1% to close at 338.51, but came off session lows after a higher open for U.S. stocks. The pan-European index on Friday marked its fifth straight winning week.

Posting the biggest loss in the benchmark Monday, AstraZeneca shares (AZN) tumbled 11% after the U.K. drug maker rejected a "final" offer from Pfizer Inc. (PFE) at 55 pounds a share ($92.48). AstraZeneca's Chairman Leif Johansson said the offer is only a minor improvement over the previous bids and continued "to fall short."

Some mining firms were also adding pressure in Europe, falling on signs that the Chinese real-estate market continues to cool. Beijing's prices for second-home purchases dropped in April by the most in two years, while newly-built residential-housing price gains eased for the sixth straight month, according to data from China's National Bureau of Statistics.

 
   Shares of Rio Tinto PLC   (RIO) dropped 1.9% and BHP Billiton PLC  (BHP)  gave up 0.6%. 
 

The AstraZeneca slide and the losses for miners weighed on the FTSE 100 index . The U.K.'s benchmark erased 0.2% to close at 6,844.55.

More broadly, investors watched the latest flare-up in tensions between Ukraine and Russia, with clashes in Ukraine's east continuing over the weekend.

"With the Ukrainian presidential election scheduled for May 25, markets are worrying the tensions will rise ahead of the elections as rebels who want to vote in eastern parts of Ukraine say they want to join Russia," market strategists at ETX Capital said in a note.

Italian slide

Among country's indexes, Italy's FTSE MIB index fell 1.6% to 20,318.46, as more than 20 companies in the benchmark traded without the right to their latest dividends, according to Bloomberg.

Shares of UniCredit SpA lost 1.5%, Banco Popolare SC lost 0.7%, and Telecom Italia SpA closed down 0.5%.

Germany's DAX 30 index ended 0.3% higher at 9,659.39, and France's CAC 40 index gained 0.3% to 4,469.76.

Shares of Deutsche Bank AG (DB) shaved off 1.7% in Frankfurt after the bank said on Sunday it plans to raise 8 billion euros ($10.97 billion), with EUR1.75 billion coming from Qatar's Paramount Holdings Services Ltd.

Also in Frankfurt, shares of K+S AG rose 1.7% to EUR26.50 a share after Citigroup lifted its price target on the chemicals firm to EUR28 from EUR23.

And in Paris, shares of GDF Suez SA picked up 1.3% after the power group said it signed a deal to supply Japan's Tohoku Electric Power Co. liquefied natural gas from the U.S., over a 20-year period.

Outside the major country-specific indexes, shares of Ryanair Holdings PLC rallied 11% after the budget airliner said profit should grow this fiscal year, after reporting a drop in full-year profit for the year ending March 31. The jump in Ryanair shares helped push Ireland's ISEQ Overall Index up 2.6% to 4,776.61.

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