By Peter Loftus 

Merck & Co. is getting out of the business of making Claritin allergy medicines and Coppertone sunscreens, selling off its over-the-counter business to Bayer AG for $14.2 billion.

Tuesday's deal is just the latest in a wave of mergers and acquisitions that is reshaping the global pharmaceutical industry. Many drug companies are narrowing their focus, dropping out of noncore businesses and bulking up where they have the size and expertise to generate significant sales growth.

Pfizer Inc. is offering more than $106 billion to get AstraZeneca PLC's promising cancer medicines--though Astra has rejected the bid. Eli Lilly & Co. is doubling down on animal drugs and vaccines, while Novartis AG is paying up to $16 billion for GlaxoSmithKline PLC's cancer medicines.

The deals would leave fewer competitors with larger revenue streams in each segment of the drug business, from prescription medicines and vaccines to drugs for livestock and pets.

The narrowing of focus carries some risks, leaving companies more vulnerable to setbacks in their remaining businesses, analysts and industry officials say.

"Companies are being told by their shareholders to focus on what they are historically the best at," said Mark Schoenebaum, a pharmaceutical industry analyst with ISI Group. "That varies from company to company. So companies are buying their strengths and selling their weaknesses."

The recent merger activity includes two large unsolicited overtures: Pfizer's bid for AstraZeneca and Valeant Pharmaceutical Industries Ltd.'s nearly $46 billion offer for Allergan Inc., the maker of Botox.

Bayer's agreement to buy Merck's consumer-product business adds to a stable of such brands, including Bayer's namesake aspirin and the Aleve pain reliever. Merck and Bayer's combined nonprescription businesses had total sales of $7.4 billion in 2013.

Bayer, based in Leverkusen, Germany, expects the Merck deal to make it the No. 2 over-the-counter drug company by global sales, Bayer Chief Executive Marijn Dekkers said Tuesday. Ranking No. 1 will be the OTC businesses of Novartis and GlaxoSmithKline, which the companies plan to combine into a joint venture with $10 billion in yearly sales from such products as Excedrin pain medicine and Aquafresh toothpaste.

The biggest OTC companies are consolidating to help them compete more effectively for shelf space in large retail pharmacy chains such as Walgreen Co., Dr. Dekkers said.

Merck, based in Whitehouse Station, N.J., has a strong presence in U.S. retailers but not as much market share overseas. "We now have an opportunity to take the Merck product brands and make them more global," Dr. Dekkers said.

That opportunity is stronger in emerging-market countries such as China and Brazil than it is in developed European markets that already have established brands, Dr. Dekkers said. The deal will also help Bayer expand its market share in the U.S. and give it an entry into the market for foot-care products such as shoe inserts, via Merck's Dr. Scholl's brand.

The acquisition is Bayer's second-biggest ever, after its $17 billion purchase of Germany's Schering AG in 2006.

Merck and Bayer also agreed to form a collaboration to co-develop and market certain prescription heart drugs, including Bayer's Adempas, a treatment for a form of high blood pressure. Merck will pay Bayer $1 billion upfront, plus potential additional milestone payments of up to $1.2 billion if sales goals are reached.

Merck is slimming down after bulking up with its 2009 acquisition of Schering-Plough Corp. of the U.S., which brought in the OTC and consumer products business. That unit had $1.9 billion in sales last year, down 3% from the year before, constituting about 4% of Merck's total revenue.

Merck said in January it was exploring options for the OTC business because it didn't have a strong presence outside North America. To gain global scale, Merck would have needed to make hefty acquisitions, Merck Chief Executive Kenneth Frazier said Tuesday.

Merck also said in January it was exploring options for its division that makes drugs and vaccines for pets and livestock, which had $3.4 billion in sales last year. But Merck has decided to keep its animal-health unit, Mr. Frazier said Tuesday, because it already has a strong global presence and a leading market position, in contrast to the consumer business.

"We should be looking for opportunities to augment our already leading animal-health franchise," he said.

Merck is narrowing its focus mainly to the parts of its prescription-drug business and research pipeline it sees as the most promising. These include an experimental cancer drug, MK-3475, which analysts say has multibillion-dollar sales potential if it reaches the market. Merck has submitted the drug to the U.S. Food and Drug Administration and expects a decision by late October, the company said Tuesday.

Merck said it would use the $8 billion to $9 billion in after-tax proceeds from the Bayer deal to fund the development of MK-3475, to license or acquire other drugs, and to return capital to shareholders. Merck shares fell 2.6% on Tuesday, while Bayer slipped 1%.

Michael Calia, Neetha Mahadevan and Jonathan D. Rockoff contributed to this article.

Write to Peter Loftus at peter.loftus@wsj.com

Subscribe to WSJ: http://online.wsj.com?mod=djnwires

Novartis (NYSE:NVS)
Historical Stock Chart
From Mar 2024 to Apr 2024 Click Here for more Novartis Charts.
Novartis (NYSE:NVS)
Historical Stock Chart
From Apr 2023 to Apr 2024 Click Here for more Novartis Charts.