By Chelsey Dulaney 

Endo International PLC agreed to buy Par Pharmaceutical Holdings Inc. from private-equity firm TPG for about $8 billion in cash and stock, giving Dublin-based Endo further access to profitable generic drugs.

Par, which TPG took private in 2012 for about $1.9 billion, has a portfolio of nearly 100 products, including oral solids and injectables. Endo said the combined company would have a generics business that ranks among the top five by U.S. sales.

The deal follows Endo losing a bid to buy Salix Pharmaceuticals Ltd. in March after being outbid by Valeant Pharmaceuticals International Inc.

Shares in Endo slipped 3.5% to $82.34 in midday trading on the Nasdaq Stock Market.

The deal for Par, based in Chestnut Ridge, N.Y., includes 18 million shares--valued at roughly $1.5 billion, based on Friday's close--and $6.5 billion in cash. The deal has a total value of $8.05 billion, which includes a small amount of debt assumption, and is expected to close in the second half of the year.

The deal comes about 15 months after Endo relocated to Ireland through a "tax inversion" deal with Canada's Paladin Labs Inc. Such deals, in which U.S. companies acquired foreign rivals and redomiciled in low-tax companies, spiked last year before the Treasury Department moved to make inversions more difficult and less lucrative.

Companies like Endo that closed inversion deals before the new rules took effect in September have been snapping up U.S. companies to further leverage the tax advantages gained through their overseas moves. Endo earlier this year bought Pennsylvania-based Auxilium Pharmaceuticals Inc. for $2.6 billion, and it completed a deal to buy New Jersey-based DAVA Pharmaceuticals Inc. in August.

Endo expects $175 million in operational and tax synergies from the Par purchase. Endo sees the deal adding to its adjusted per-share earnings within a year and forecast double-digit growth in 2016.

The deals for DAVA and Boca Pharmacal have been important for Endo's generic-drug segment, which jumped 68% in the latest quarter.

The pharmaceutical industry has been a particularly hot sector for deal-making lately, as companies take advantage of a favorable mergers-and-acquisitions environment to buy up rivals to add to their sales.

Last year was the best year for mergers in the industry since Dealogic began keeping records in 1995.

So far this year, Pfizer Inc. has struck a $16 billion deal to buy Hospira Inc., Merck & Co. bought antibiotic makerCubist Pharmaceuticals Inc. for $8.4 billion, and Alexion Pharmaceuticals Inc. agreed to pay a 124% premium to buy Synageva BioPharma Corp.

Liz Hoffman contributed to this article.

Write to Chelsey Dulaney at Chelsey.Dulaney@wsj.com

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